CN104491365A - Medicine for treating mammary gland hyperplasia and preparation thereof - Google Patents
Medicine for treating mammary gland hyperplasia and preparation thereof Download PDFInfo
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- CN104491365A CN104491365A CN201410778001.9A CN201410778001A CN104491365A CN 104491365 A CN104491365 A CN 104491365A CN 201410778001 A CN201410778001 A CN 201410778001A CN 104491365 A CN104491365 A CN 104491365A
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- cyclomastopathy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a medicine for treating mammary gland hyperplasia. The medicine disclosed by the invention is composed of the following components: fructus trichosanthis, platycodon grandiflorum, dandelion, liquorice, semen brassicae, Chinese angelica, root of common peony, turtle shell, radix bupleuri, white atractylodes rhizome, white paeony root, poria cocos, fructus forsythiae, radices trichosanthis, thunberg fritillary bulb, pangolin, and selfheal. The invention further discloses preparation and use methods of the medicines. The medicine disclosed by the invention is rapid in treatment effect, free from toxic and side effects, treated in both symptoms and root causes and thorough to treat.
Description
Technical field
The invention belongs to pure Chinese medicine formula technical field, particularly a kind of medicine and preparation thereof for the treatment of cyclomastopathy.
Background technology
Cyclomastopathy is that cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, and its pathogenic factor is mainly due to endocrine hormone imbalance.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.About there is the women of 70% ~ 80% to have cyclomastopathy in various degree according to investigations, be more common in the women of 25 ~ 45 years old.
The current traditional Chinese medical science is to the treatment of cyclomastopathy, with removing heat from the lung and dissipating phlegm, promoting the circulation of QI the chest stuffiness relieving, invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, warming the lung to eliminate phlegm, promoting the circulation of QI eliminating stagnation, removing obstruction in the collateral to relieve pain, nourishing the lung to arrest cough, nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, air making-up and spleen enlivening, dampness diuretic, nourish blood yin fluid astringing, suppressing liver-YANG, easing the affected liver to relieve pain, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting blood circulation to restore menstrual flow, detumescence and apocenosis, clearing away liver-fire, Disperse hepatic depression is principle, partly can overcome western medical treatment produces effects bad, time is long, the shortcoming that can not fully recover, but, current Chinese traditional treatment medicine used, such as application number is: the Chinese patent of 201110231774.1 discloses a kind of Chinese herbal and crude drugs preparations for the treatment of cyclomastopathy, by Fructus Trichosanthis, Gueldenstaedtia verna, Cornu Cervi, Pseudobulbus Cremastrae Seu Pleiones, Lepidogrammitis drymoglossoides (Bak.) Ching, Herba Erodii, Rhizoma Bolbostematis, Radix Cynanchi Amplexicaulis, Radix Rubiae, the compositions such as Squama Manis.Application number is: the Chinese patent of 200910244916.0 discloses a kind of Chinese medicine composition for the treatment of cyclomastopathy, by Radix Salviae Miltiorrhizae, and Folium Citri tangerinae, Semen Vaccariae, Fructus Toosendan, Eupolyphaga Seu Steleophaga, the compositions such as Spina Gleditsiae.But the effect both finding in practice is slow, unsatisfactory curative effect, and also there is the shortcoming of curing the symptoms, not the disease.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the object of the present invention is to provide a kind of medicine and preparation thereof for the treatment of cyclomastopathy, this medication effect is fast, has no side effect, treating both the principal and secondary aspects of a disease, thorough treatment.
To achieve these goals, the technical solution used in the present invention is:
Treat a medicine for cyclomastopathy, be made up of the medicine of following weight portion:
Fructus Trichosanthis 15-20g, Radix Platycodonis 8-12g, Herba Taraxaci 15-30g, Radix Glycyrrhizae 6-12g, Semen Sinapis Albae 6-10g, Radix Angelicae Sinensis 15-25g, Radix Paeoniae Rubra 10-15g, Carapax Trionycis 20-30g, Radix Bupleuri 6-10g, Rhizoma Atractylodis Macrocephalae 15-25g, Radix Paeoniae Alba 20-30g, Poria 10-20g, Fructus Forsythiae 8-12g, Radix Trichosanthis 8-12g, Bulbus Fritillariae Thunbergii 4-6g, Squama Manis 3-5g, Spica Prunellae 10-15g.
The method of preparation and use of medicine of the present invention, get medicine by weight, Bulbus Fritillariae Thunbergii and Squama Manis pulverizing, all the other medicines are inserted in decocting device, put suitable quantity of water (flooding medicine), by drug immersion one hours, after boiled with big fire, reduce to after little fire endures 15 minutes and pour out medicinal liquid, add suitable quantity of water again, endure second time, after boiled with big fire, reduce to after little fire endures 20 minutes and pour out medicinal liquid, add suitable quantity of water again, endure third time, after boiled with big fire, reduce to after little fire endures 25 minutes and pour out medicinal liquid, three gained medicinal liquid mixing, to take after mixing it with water Bulbus Fritillariae Thunbergii powder and Squama Manis powder, divide and take for three times, one after each meal.
Or got medicine by weight, mixing is dried, wear into dry medicated powder, incapsulate, each serving 15-20 gram, every day three times.
The present invention with hard masses softening and resolving, removing obstruction in the collateral to relieve pain, dispersing the stagnated live-QI to relieve the stagnation of QI, Disperse hepatic depression, promoting blood circulation to restore menstrual flow, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, removing heat from the lung and dissipating phlegm, promoting the circulation of QI the chest stuffiness relieving, invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, warming the lung to eliminate phlegm, promoting the circulation of QI eliminating stagnation, nourishing the lung to arrest cough, nourishing YIN for suppressing the hyperactive YANG, elevate a turnable ladder yang-energy, air making-up and spleen enlivening, dampness diuretic, the yin fluid astringing that nourishes blood, suppressing liver-YANG, easing the affected liver to relieve pain, detumescence and apocenosis, clearing away liver-fire for ultimate principle, there is instant effect, the feature had no side effect.
Detailed description of the invention
Embodiments of the present invention are described in detail below in conjunction with embodiment.
Each component pharmacological action of the present invention is:
Fructus Trichosanthis: sweet, cold.Return lung, stomach, large intestine channel.Effect: removing heat from the lung and dissipating phlegm, promoting the circulation of QI the chest stuffiness relieving, laxation relieving constipation.
Radix Platycodonis: bitter, pungent is flat.Return lung meridian.Effect: lung qi dispersing dispelling phlegm and relieving sore-throat, evacuation of pus, dispersing and elevation lung qi.
Herba Taraxaci: bitter, sweet, cold.Return liver, stomach warp.Effect: heat-clearing and toxic substances removing, dampness removing is treating stranguria.
Radix Glycyrrhizae: sweet, flat.Return spleen, stomach, lung, heart channel.Effect: invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, heat-clearing and toxic substances removing.
Semen Sinapis Albae: pungent, temperature.Return lung meridian.Effect: warming the lung to eliminate phlegm, promoting the circulation of QI eliminating stagnation, removing obstruction in the collateral to relieve pain.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, heart spleen channel.Effect: enrich blood, promoting blood circulation and stopping pain, intestine moistening.
Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Effect: clearing away heat and cooling blood, stasis-dispelling and pain-killing.
Carapax Trionycis: salty, cold.Return Liver Channel.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving.
Radix Bupleuri: bitter, pungent, is slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Effect: air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Effect: nourish blood yin fluid astringing, suppressing liver-YANG, easing the affected liver to relieve pain.
Poria: sweet, light is flat.GUIXIN, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves,
Fructus Forsythiae: bitter, is slightly cold.Return lung, the heart, gallbladder meridian.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Radix Trichosanthis: micro-hardship, sweet, is slightly cold.Attach to the lung and stomach meridians.Effect: clearing away heat and promoting production of body fluid, detumescence and apocenosis.
Bulbus Fritillariae Thunbergii: bitter, cold.Return lung, heart channel.Effect: removing heat-phlegm, mass dissipating and swelling eliminating,
Squama Manis: salty, is slightly cold.Return liver, stomach warp.Effect: promoting blood circulation to restore menstrual flow, stimulating milk secretion, detumescence and apocenosis.
Spica Prunellae: bitter, acrid, cold.Return liver, gallbladder meridian.Effect: clearing away liver-fire, Disperse hepatic depression, blood pressure lowering.
Above medicine all can be bought in common Chinese shop and obtain.
Drug regimen of the present invention has the feature of promoting blood circulation to restore menstrual flow, removing heat-phlegm, removing toxic substances, mass dissipating and swelling eliminating, eliminating carbuncle eliminating stagnation, nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, clearing away heat and cooling blood, stasis-dispelling and pain-killing, air making-up and spleen enlivening, dampness diuretic, clearing away liver-fire, can reach the object for the treatment of cyclomastopathy, be below some embodiments of the present invention.
Embodiment one
Clinical experiment object:
Lee, female, 25 years old, enclosed mass 4cm × 2.8cm in hospital's ultrasound diagnosis breast.Pain in breast is invalid through integrative therapy.
Use the present embodiment medicine: Fructus Trichosanthis 20g, Radix Platycodonis 10g, Herba Taraxaci 30g, Radix Glycyrrhizae 10g, Semen Sinapis Albae 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 15g, Carapax Trionycis 30g, Radix Bupleuri 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 20g, Poria 15g, Fructus Forsythiae 12g, Radix Trichosanthis 12g, Bulbus Fritillariae Thunbergii 6g, Squama Manis 4g, Spica Prunellae 10g.
Usage: got medicine by weight, Bulbus Fritillariae Thunbergii and Squama Manis pulverizing, all the other medicines are inserted in decocting device, put suitable quantity of water, by drug immersion one hours, after boiled with big fire, reduce to after little fire is endured minute and pour out medicinal liquid, add suitable quantity of water again, endure second time, after boiled with big fire, reduce to after little fire endures 20 minutes and pour out medicinal liquid, add suitable quantity of water again, endure third time, after boiled with big fire, reduce to after little fire endures 25 minutes and pour out medicinal liquid, three gained medicinal liquid mixing, taking after mixing it with water Bulbus Fritillariae Thunbergii powder and Squama Manis powder, point to take for three times, is be potion, one after each meal, takes on the 1st.
Effect: after three doses, pain disease subtracts greatly, then continues to take twelve formulas of Chinese materia medica, cures enclosed mass completely and disappears, without any symptom, disappear through ultrasound diagnosis enclosed mass.
Embodiment two
Clinical experiment object:
Poplar, female, 28 years old, enclosed mass 3cm × 1.8cm in hospital's ultrasound diagnosis breast.Pain in breast is invalid through integrative therapy.
Use the present embodiment medicine: Fructus Trichosanthis 15g, Radix Platycodonis 8g, Herba Taraxaci 15g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 10g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 15g, Carapax Trionycis 20g, Radix Bupleuri 6g, Rhizoma Atractylodis Macrocephalae 25g, Radix Paeoniae Alba 30g, Poria 10g, Fructus Forsythiae 8g, Radix Trichosanthis 8g, Bulbus Fritillariae Thunbergii 6g, Squama Manis 3g, Spica Prunellae 10g.
Usage: consistent with embodiment one.
Effect: after three doses, pain disease subtracts greatly, then continues to take ten doses, cures enclosed mass completely and disappears, without any symptom, disappear through ultrasound diagnosis enclosed mass.
Embodiment three
Clinical experiment object:
Wang, female, 39 years old, enclosed mass 4.2cm × 3.5cm in hospital's ultrasound diagnosis breast.Pain in two breast, has no result through integrative therapy.
Use the present embodiment medicine: Fructus Trichosanthis 20g, Radix Platycodonis 12g, Herba Taraxaci 30g, Radix Glycyrrhizae 12g, Semen Sinapis Albae 10g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 15g, Carapax Trionycis 30g, Radix Bupleuri 6g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 30g, Poria 20g, Fructus Forsythiae 8-12g, Radix Trichosanthis 12g, Bulbus Fritillariae Thunbergii 4g, Squama Manis 3g, Spica Prunellae 15g.
Usage: consistent with embodiment one.
Effect: after four doses, pain disease subtracts greatly, then continues to take twelve formulas of Chinese materia medica, cures enclosed mass completely and disappears, without any symptom, disappear through ultrasound diagnosis enclosed mass.
Embodiment four
Clinical experiment object:
Deng, female, 45 years old, enclosed mass 2.9cm × 1.5cm in hospital's ultrasound diagnosis breast.Pain in two breast, has no result through integrative therapy.
Use the present embodiment medicine: Fructus Trichosanthis 16g, Radix Platycodonis 10g, Herba Taraxaci 20g, Radix Glycyrrhizae 10g, Semen Sinapis Albae 8g, Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 12g, Carapax Trionycis 22g, Radix Bupleuri 8g, Rhizoma Atractylodis Macrocephalae 20g, Radix Paeoniae Alba 22g, Poria 15g, Fructus Forsythiae 10g, Radix Trichosanthis 10g, Bulbus Fritillariae Thunbergii 5g, Squama Manis 5g, Spica Prunellae 12g.
Usage: consistent with embodiment one.
Effect: after three doses, pain disease subtracts greatly, enclosed mass deliquescing, then continues to take ten doses, cures enclosed mass completely and disappears, without any symptom, disappear through ultrasound diagnosis enclosed mass.
Embodiment five
Clinical experiment object:
Wu, female, 45 years old, enclosed mass 3.2cm × 2.5cm in hospital's ultrasound diagnosis breast.Pain in single breast, has no result through integrative therapy.
Use the present embodiment medicine: Fructus Trichosanthis 15g, Radix Platycodonis 12g, Herba Taraxaci 20g, Radix Glycyrrhizae 12g, Semen Sinapis Albae 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 12g, Carapax Trionycis 22g, Radix Bupleuri 6g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 22g, Poria 15g, Fructus Forsythiae 12g, Radix Trichosanthis 12g, Bulbus Fritillariae Thunbergii 6g, Squama Manis 4g, Spica Prunellae 12g.
Usage: consistent with embodiment one.
Effect: after three doses, pain disease subtracts greatly, enclosed mass deliquescing, then continues to take ten doses, cures enclosed mass completely and disappears, without any symptom, disappear through ultrasound diagnosis enclosed mass.
The therapeutic outcome of the routine patient of Continuous Observation 122, the treated effect of the present invention to cyclomastopathy reaches 100%, and cure rate reaches more than 92%, and wherein effectively refer to that symptom alleviates, pain alleviates, enclosed mass deliquescing.And healing refers to that patient symptom all disappears or substantially disappears, enclosed mass is not visible under B ultrasonic, and lasting such as six months long period does not recur.
Another kind of usage of the present invention, got medicine by weight, mixing is dried, and wears into dry medicated powder, incapsulates, and in dry medicated powder, each serving 15-20 gram, every day three times is potion.This can play same effect by FAXIA, but take effect than liquor taking method slightly slow, but this method is more convenient, and patient can select according to self-condition.
Claims (4)
1. treat a medicine for cyclomastopathy, it is characterized in that, be made up of the medicine of following weight portion:
Fructus Trichosanthis 15-20g, Radix Platycodonis 8-12g, Herba Taraxaci 15-30g, Radix Glycyrrhizae 6-12g, Semen Sinapis Albae 6-10g, Radix Angelicae Sinensis 15-25g, Radix Paeoniae Rubra 10-15g, Carapax Trionycis 20-30g, Radix Bupleuri 6-10g, Rhizoma Atractylodis Macrocephalae 15-25g, Radix Paeoniae Alba 20-30g, Poria 10-20g, Fructus Forsythiae 8-12g, Radix Trichosanthis 8-12g, Bulbus Fritillariae Thunbergii 4-6g, Squama Manis 3-5g, Spica Prunellae 10-15g.
2. a kind of medicine for the treatment of cyclomastopathy according to claim 1, is characterized in that, be made up of the medicine of following weight portion:
Fructus Trichosanthis 20g, Radix Platycodonis 10g, Herba Taraxaci 30g, Radix Glycyrrhizae 10g, Semen Sinapis Albae 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Rubra 15g, Carapax Trionycis 30g, Radix Bupleuri 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 20g, Poria 15g, Fructus Forsythiae 12g, Radix Trichosanthis 12g, Bulbus Fritillariae Thunbergii 6g, Squama Manis 4g, Spica Prunellae 10g.
3. prepare a method for the medicine for the treatment of cyclomastopathy described in claim 1 or 2, it is characterized in that, comprise the steps:
Got medicine by weight, Bulbus Fritillariae Thunbergii and Squama Manis pulverizing, all the other medicines are inserted in decocting device, put suitable quantity of water, by drug immersion one hour, after boiled with big fire, reduce to after little fire is endured minute and pour out medicinal liquid, then add suitable quantity of water, endure second time, after boiled with big fire, reduce to after little fire endures 20 minutes and pour out medicinal liquid, then add suitable quantity of water, endure third time, after boiled with big fire, reduce to after little fire endures 25 minutes and pour out medicinal liquid, three gained medicinal liquid mixing, are mixed into Bulbus Fritillariae Thunbergii powder and Squama Manis powder.
4. prepare a method for the medicine for the treatment of cyclomastopathy described in claim 1 or 2, it is characterized in that, comprise the steps:
Got medicine by weight, mixing is dried, and wears into dry medicated powder, incapsulates.
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CN102698211A (en) * | 2012-06-29 | 2012-10-03 | 鲁道宗 | Chinese medicinal formulae for treating breast lobular hyperplasia and adenofibrome of breast |
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