CN104491288A - Traditional Chinese medicine preparation for treating dysmenorrhea and preparation method and application thereof - Google Patents
Traditional Chinese medicine preparation for treating dysmenorrhea and preparation method and application thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating dysmenorrhea. The formula of each preparation comprises the following ingredients by mass: 10-15g of angelica sinensis, 10-15g of radix paeoniae alba, 10-15g of atractylodes macrocephala, 15-20g of poria cocos, 5-8g of bupleurum root, 10-12g of nutagrass flatsedge rhizome, 10-12g of radix linderae, 10-15g of dandelions, 15-20g of salvia miltiorrhiza and 3-5g of glycyrrhiza uralensis. The invention simultaneously discloses a preparation method and application of the traditional Chinese medicine preparation. According to the traditional Chinese medicine preparation, by medicinal values of all the ingredients in the traditional Chinese medicine preparation and the compatibility among all the ingredients, the traditional Chinese medicine preparation has the good effects of strengthening the spleen and harmonizing the stomach, harmonizing the liver and kidneys, promoting blood circulation to dispel blood stasis and eliminating Qi stagnation, and can be used for effectively treating dysmenorrhea.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof and application, especially belong to Chinese medicine preparation for the treatment of dysmenorrhea and preparation method thereof and application, belong to Chinese medicine formula and applied technical field.
Background technology
As everyone knows, modern female has the hardship of dysmenorrhea more, namely before and after menstrual period and menstruation, occurs the discomforts such as obvious lower abdomen spasmic pain, falling inflation or pain in the low back and legs.The reason that dysmenorrhea occurs mostly is deficient qi and blood, deficiency of both the liver and kidney, or the stagnation of QI and blood may bring about pain that qi depression to blood stasis, cold and stagnate cause.And its recurrent exerbation, do not heal year in year out, cause great misery to women, even have a strong impact on Working Life.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide that a kind of side effect is little, good effect, expense are low, therapeutic effect is Chinese medicine preparation being used for the treatment of dysmenorrhea and preparation method thereof and application significantly.
For solving the problems of the technologies described above, technical scheme of the present invention is:
The Chinese medicine preparation for the treatment of dysmenorrhea, is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively:
Radix Angelicae Sinensis 10-15g;
Radix Paeoniae Alba 10-15g;
Rhizoma Atractylodis Macrocephalae 10-15g;
Poria 15-20g;
Radix Bupleuri 5-8g;
Rhizoma Cyperi 10-12g;
Radix Linderae 10-12g;
Herba Taraxaci 10-15g;
Radix Salviae Miltiorrhizae 15-20g;
Radix Glycyrrhizae 3-5g.
Preferably, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g.
Further, the above-mentioned Chinese medicine preparation being used for the treatment of dysmenorrhea, can also comprise and fry Typhonium flagelliforme (Lodd.) Blume 3-5g; Pericarpium Citri Reticulatae Viride 3-5g.
Preferably, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g; Typhonium flagelliforme (Lodd.) Blume 5g; Pericarpium Citri Reticulatae Viride 3g.
The above-mentioned manufacture method being used for the treatment of the Chinese medicine preparation of dysmenorrhea, it is characterized in that, after the described quality proportioning being used for the treatment of each component in the Chinese medicine preparation of dysmenorrhea is mixed, carry out pulverizing and grind to form fine powder, cross 100-150 mesh sieve, then the fine powder after sieving is dropped in mixing and blending machine and fully mix, and for subsequent use according to the metering, distributing, packaging of every agent.
The application of above-mentioned Chinese medicine preparation on preparation treatment dysmenorrhea medicine.
Beneficial effect of the present invention is: the present invention is by the medical value of each component in Chinese medicine preparation, and compatibility effect each other, has invigorating the spleen and regulating the stomach, coordinates the good effects of Liver and kidney, blood circulation promoting and blood stasis dispelling, the elimination stagnation of QI, effectively can treat dysmenorrhea.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described in detail.
As follows for the pharmacology analysis situation of component in Chinese medicine preparation of the present invention:
Main component and side's justice are analyzed:
Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae: there is the effect nourishing blood, invigorate blood circulation, stimulate the menstrual flow;
Radix Bupleuri, Rhizoma Cyperi, the Radix Linderae, Pericarpium Citri Reticulatae Viride: the effect with dispersing the stagnated live-QI to relieve the stagnation of QI, regulating QI to relieve pain;
The Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae: have invigorating the spleen and regulating the stomach, coordinate effect of liver spleen;
Typhonium flagelliforme (Lodd.) Blume: have strengthen further invigorating blood circulation, blood stasis dispelling, pain relieving effect.
embodiment 1:
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 10g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 20g; Radix Bupleuri 5g; Rhizoma Cyperi 12g; Radix Linderae 12g; Herba Taraxaci 10g; Radix Salviae Miltiorrhizae 20g; Radix Glycyrrhizae 3g, carries out pulverizing and grinds to form fine powder, crosses 100 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 2:
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 10g; Rhizoma Atractylodis Macrocephalae 15g; Poria 15g; Radix Bupleuri 8g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g, carries out pulverizing and grinds to form fine powder, crosses 150 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 3:
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 12g; Radix Paeoniae Alba 12g; Rhizoma Atractylodis Macrocephalae 12g; Poria 18g; Radix Bupleuri 6g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 12g; Radix Salviae Miltiorrhizae 18g; Radix Glycyrrhizae 4g, carries out pulverizing and grinds to form fine powder, crosses 130 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 4:
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g, carries out pulverizing and grinds to form fine powder, crosses 120 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 5:
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 8g; Rhizoma Cyperi 12g; Radix Linderae 12g; Herba Taraxaci 10g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 3g; Typhonium flagelliforme (Lodd.) Blume 3g; Pericarpium Citri Reticulatae Viride 3g, carries out pulverizing and grinds to form fine powder, crosses 100 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 6:
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 10g; Radix Paeoniae Alba 10g; Rhizoma Atractylodis Macrocephalae 15g; Poria 20g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 20g; Radix Glycyrrhizae 5g; Typhonium flagelliforme (Lodd.) Blume 5g; Pericarpium Citri Reticulatae Viride 5g, carries out pulverizing and grinds to form fine powder, crosses 150 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 7
The component be used for the treatment of in the Chinese medicine preparation of dysmenorrhea by described: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g; Typhonium flagelliforme (Lodd.) Blume 5g; Pericarpium Citri Reticulatae Viride 3g, carries out pulverizing and grinds to form fine powder, crosses 150 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
For verifying the clinical effectiveness of invention formulation, carry out clinical experiment.
1, case selection standard:
All women clinically occur that before and after menstrual period and menstruation the spastic distending pain of obvious lower abdomen, falling inflation or soreness of waist pain etc. is not that the equal tool of person is as the standard selecting case.
2, diagnostic criteria
Menstrual period lower abdomen pain, Hypomenorrhea, color secretly has clot, premenstrual distending pain of the breast, and vexed gas is hot-tempered, be off one's feed, and body of the tongue is purple dimly has petechia, and tongue body is slightly fat, thin lingual fur, deep and hesitant pulse string.
3, therapeutic scheme
Treatment group takes the Chinese medicine preparation described in the embodiment of the present invention 2, every day potion, every day twice 7 days is a course for the treatment of, takes 3-5 the course for the treatment of, and matched group takes pain relieving and antiinflammatory Western medicine.
4, the course for the treatment of evaluation criteria:
Recovery from illness: symptom disappears without recurrence completely, without any discomfort symptom;
Effective: transference cure, without recurrence within 1 year;
Effective: symptom obviously alleviates, or partial symptoms disappears, and needs continual cure;
Invalid: symptom does not have any improvement, even there is the trend increased the weight of.
5, physical data
86 routine patients are out-patient.Be divided into treatment group and matched group at random.Treatment group 43 example, wherein, 22 ~ 44 years old age, average 31 years old; Matched group 43 example, 20 ~ 43 years old age, average 29 years old.In two groups, the course of disease is the longest 12 years, the shortest 2 years, average out to 4 years.Through statistical analysis, two groups of case-data there was no significant differences (P<0.05).
6, therapeutic effect:
Treatment group cures 8 examples, effective 28 examples, effective 5 examples, invalid 2 examples, and total effective rate is 95.3%; Matched group cure 2 example, effective 18 example, effective 16 example, invalid 7 example, total effective rate is 83.7%, treatment group total effective rate apparently higher than matched group, specifically in table 1.
A table 1 liang group therapeutic effect compares
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 43 | 8 | 28 | 5 | 2 | 95.3 |
| Matched group | 43 | 2 | 18 | 16 | 7 | 83.7 |
The present invention is by the medical value of each component in Chinese medicine preparation, and compatibility effect each other, has invigorating the spleen and regulating the stomach, coordinates the good effects of Liver and kidney, blood circulation promoting and blood stasis dispelling, the elimination stagnation of QI, effectively can treat dysmenorrhea.
Above detailed description of the invention does not limit the present invention in any form, and every technical scheme obtained in the mode of equivalent replacement or equivalent transformation, all drops in protection scope of the present invention.
Claims (6)
1. be used for the treatment of the Chinese medicine preparation of dysmenorrhea, it is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively:
Radix Angelicae Sinensis 10-15g;
Radix Paeoniae Alba 10-15g;
Rhizoma Atractylodis Macrocephalae 10-15g;
Poria 15-20g;
Radix Bupleuri 5-8g;
Rhizoma Cyperi 10-12g;
Radix Linderae 10-12g;
Herba Taraxaci 10-15g;
Radix Salviae Miltiorrhizae 15-20g;
Radix Glycyrrhizae 3-5g.
2. the Chinese medicine preparation being used for the treatment of dysmenorrhea according to claim 1, is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g.
3. the Chinese medicine preparation being used for the treatment of dysmenorrhea according to claim 1 and 2, is characterized in that, also comprises and fries Typhonium flagelliforme (Lodd.) Blume 3-5g; Pericarpium Citri Reticulatae Viride 3-5g.
4. the Chinese medicine preparation being used for the treatment of dysmenorrhea according to claim 1 and 2, is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Angelicae Sinensis 15g; Radix Paeoniae Alba 15g; Rhizoma Atractylodis Macrocephalae 10g; Poria 15g; Radix Bupleuri 5g; Rhizoma Cyperi 10g; Radix Linderae 10g; Herba Taraxaci 15g; Radix Salviae Miltiorrhizae 15g; Radix Glycyrrhizae 5g; Typhonium flagelliforme (Lodd.) Blume 5g; Pericarpium Citri Reticulatae Viride 3g.
5. be used for the treatment of the manufacture method of the Chinese medicine preparation of dysmenorrhea, it is characterized in that, after the described quality proportioning being used for the treatment of each component in the Chinese medicine preparation of dysmenorrhea is mixed, carry out pulverizing and grind to form fine powder, cross 100-150 mesh sieve, then the fine powder after sieving is dropped in mixing and blending machine and fully mix, and for subsequent use according to the metering, distributing, packaging of every agent.
6. the application of Chinese medicine preparation according to claim 5 on preparation treatment dysmenorrhea medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213997A (en) * | 2015-11-07 | 2016-01-06 | 邢瑞生 | A kind of Chinese medicine preparation and preparation method being used for the treatment of dysmenorrhea |
| CN105288092A (en) * | 2015-11-30 | 2016-02-03 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine preparation for treating primary dysmenorrhea and preparation method thereof |
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