CN104491088A - Traditional Chinese medicine composition for treating hepatic calculus and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hepatic calculus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hepatic calculus and a preparation method thereof. The composition is prepared from the following medicinal materials in parts by weight: 31-49 parts of lysimachia christinae hance, 23-38 parts of herba artemisiae scopariae, 10-16 parts of salviae miltiorrhizae, 5-13 parts of herba ecliptae, 9-18 parts of cuttlebone, 3-12 parts of cortex dictamni, 5-16 parts of fructus mume, 3-7 parts of radix paeoniae alba, 3-9 parts of eucommia ulmoides, 2-8 parts of poria cocos and 10-17 parts of corydalis tuber. The composition is reasonable in formula and convenient and safe to take, no toxic or side effect is discovered, and clinical verification proves that the composition has exact and remarkable curative effects. Years of clinical observation indicates that the preparation has the functions of nourishing yin to calm the liver, nourishing yin, reducing internal fire, diminishing inflammation, relieving bladder and eliminating stone, and has an effective rate of over 90 percent when used for treating cholecystolithiasis and hepatolithiasis due to liver-yin deficiency and interior dampness-heat.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of liver and bile stone.Belong to medical art.
Background technology
Liver, cholelithiasis belong to the category of the diseases such as the traditional Chinese medical science " rib tumor " " stomachache " " stomachache ".Etiology and pathogenesis mostly is depression of liver-QI, the liver losing its smoothly moving state, the gallbladder being attached to the liver, and gallbladder loses catharsis, qi depression to blood stasis, damp and hot retardance, pents up petrochemical industry, decocts into calculus, and stagnate biliary tract, liver and gall mechanism of qi is not changed, so for suffering from.
Cholelithiasis is common clinical, frequently-occurring disease, in recent years Patients with Cholelithiasis cumulative year after year especially.The scheme of current clinical conventional treatment liver and bile stone comprises doctor trained in Western medicine operation, lithotripsy in treatment and Chinese patent medicine oral medication etc.One large drawback of operative treatment liver and bile stone is exactly remnants and the recurrence of postoperative calculus.Lithotripsy in treatment is only applicable to gallbladder microlith, cures not thorough, easily recurs; The misery that bile duct excision causes patient is large, and costly, is not suitable for wage-earners patient.The Chinese patent medicine for the treatment of liver and bile stone at present is on the market very different again, calculus dissolving and excreting weak effect, for the postoperative remnant gallstone rate of minimizing, and prevention recurrence of hepatolithiasis poor effect especially.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of effective to liver and bile stone, price is low, therapeutic effect good and do not recur Chinese medicine composition, also provide a kind of its preparation method simultaneously.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
The Chinese medicine composition for the treatment of liver and bile stone of the present invention is made up of the medical material of following portions by weight: Herba Lysimachiae 31-49 part, Herba Artemisiae Scopariae 23-38 part, Radix Salviae Miltiorrhizae 10-16 part, ecliptae herba 5-13 part, Os Sepiae 9-18 part, Cortex Dictamni 3-12 part, Fructus Mume 5-16 part, Radix Paeoniae Alba 3-7 part, Cortex Eucommiae 3-9 part, Poria 2-8 part, Rhizoma Corydalis 10-17 part.
As optimization formula scheme, Chinese medicine composition of the present invention is made up of the medical material of following portions by weight: Herba Lysimachiae 36-40 part, Herba Artemisiae Scopariae 28-33 part, Radix Salviae Miltiorrhizae 12-14 part, ecliptae herba 8-10 part, Os Sepiae 13-15 part, Cortex Dictamni 6-11 part, Fructus Mume 9-13 part, Radix Paeoniae Alba 4-6 part, Cortex Eucommiae 6-8 part, Poria 4-7 part, Rhizoma Corydalis 13-15 part.
Further, Chinese medicine composition of the present invention is made up of the medical material of following portions by weight: Herba Lysimachiae 38 parts, Herba Artemisiae Scopariae 30 parts, Radix Salviae Miltiorrhizae 13 parts, ecliptae herba 9 parts, Os Sepiae 14 parts, Cortex Dictamni 9 parts, Fructus Mume 10 parts, the Radix Paeoniae Alba 5 parts, the Cortex Eucommiae 7 parts, 6 parts, Poria, Rhizoma Corydalis 14 parts.
Further, Chinese medicine composition of the present invention is made up of the medical material of following portions by weight: Herba Lysimachiae 36 parts, Herba Artemisiae Scopariae 28 parts, Radix Salviae Miltiorrhizae 12 parts, ecliptae herba 8 parts, Os Sepiae 13 parts, Cortex Dictamni 6 parts, Fructus Mume 9 parts, the Radix Paeoniae Alba 4 parts, the Cortex Eucommiae 6 parts, 4 parts, Poria, Rhizoma Corydalis 13 parts.
Further, Chinese medicine composition of the present invention is made up of the medical material of following portions by weight: Herba Lysimachiae 40 parts, Herba Artemisiae Scopariae 33 parts, Radix Salviae Miltiorrhizae 14 parts, ecliptae herba 10 parts, Os Sepiae 15 parts, Cortex Dictamni 11 parts, Fructus Mume 13 parts, the Radix Paeoniae Alba 6 parts, the Cortex Eucommiae 8 parts, 7 parts, Poria, Rhizoma Corydalis 15 parts.
The present invention also provides the preparation method of described Chinese medicine composition, comprises the following steps:
(1) get Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, ecliptae herba according to weight proportion, adding weight is medical material gross weight 10-14 water doubly, and 65-70 degree Celsius is soaked 18-25 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained, concentration of liquid medicine become relative density at 60 DEG C to be the thick paste of 1.15 ~ 1.25;
(4) Os Sepiae, Cortex Dictamni, Fructus Mume, the Radix Paeoniae Alba, the Cortex Eucommiae, Poria, Rhizoma Corydalis are ground to form 500-800 object fine powder;
(5) by the mixing of the fine drug powder of the thick paste of step (3), step (4) end, stir and mix evenly, dry and make granule.
Preferably, by the medical material grind into powder in step (1), the size of powder is between 300-500 order.
The mode that the water temperature gradient that the invention provides in a kind of step (2) is elevated to boiling is: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.Gradient increased temperature decocting method can better by the constituents extraction in medical material out.
The instructions of taking of Chinese medicine granules of the present invention: every day three times, each 6-10 gram, after meal warm water delivery service.
Beneficial effect of the present invention:
Formula of the present invention is reasonable, and taking convenience safety, does not find toxic and side effects, clinical verification determined curative effect, significantly.Clinical observation for many years shows, this medical instrument has yin nourishing easing the affected liver, nourishing YIN to lower pathogenic fire, anti-inflammatory and choleretic calculus function, treatment deficiecny of liver-YIN, the cholelithiasis of retention of damp-heat in the interior, the effective percentage of calculus of intrahepatic duct are up to more than 90%, this medicine can also be used for reducing postoperative remnant gallstone rate simultaneously, prevention recurrence of hepatolithiasis, for preoperative conditioning and postoperative consolidation, Be very effective.And Chinese drug preparation cost of the present invention is low, non-relapse after healing, relieves the misery of extensive patients, creates good economic benefit and social benefit.
1) compared with the chemotherapeutic agent of Current therapeutic, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, and improves the quality of life of patient.
2) multi-medicament component is contained in Chinese medicine composition of the present invention, action target spot is numerous, pharmacological evaluation shows it and existing gallstone treatment medicine has significant synergism in lithodialysis, and significantly can reduce the constipation symptom that Drug therapy causes, improve patient for the acceptance of chemotherapy and compliance.
Detailed description of the invention
Embodiment 1
The Chinese medicine composition of the present embodiment is made up of the medical material of following weight grams: Herba Lysimachiae 38 grams, Herba Artemisiae Scopariae 30 grams, Radix Salviae Miltiorrhizae 13 grams, ecliptae herba 9 grams, Os Sepiae 14 grams, Cortex Dictamni 9 grams, Fructus Mume 10 grams, the Radix Paeoniae Alba 5 grams, the Cortex Eucommiae 7 grams, 6 grams, Poria, Rhizoma Corydalis 14 grams.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps:
(1) get Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, ecliptae herba according to weight proportion, by medical material grind into powder, the size of powder is 400 orders, and adding weight is medical material gross weight 10-14 water doubly, and 68 degrees Celsius are soaked 20 hours.
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 28 minutes, filter to obtain medicinal liquid and medicinal residues; The mode that water temperature gradient is elevated to boiling is: water temperature raises 10 degrees Celsius in every 4 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes.Gradient increased temperature decocting method can better by the constituents extraction in medical material out.
(3) medicinal residues are repeated step (1) and step (2) 4 times, merge the medicinal liquid of gained, concentration of liquid medicine become relative density at 60 DEG C to be the thick paste of 1.20;
(4) Os Sepiae, Cortex Dictamni, Fructus Mume, the Radix Paeoniae Alba, the Cortex Eucommiae, Poria, Rhizoma Corydalis are ground to form 600 object fine powders;
(5) by the mixing of the fine drug powder of the thick paste of step (3), step (4) end, stir and mix evenly, dry and make granule.
Embodiment 2
The Chinese medicine composition of the present embodiment is made up of the medical material of following weight grams: Herba Lysimachiae 36 grams, Herba Artemisiae Scopariae 28 grams, Radix Salviae Miltiorrhizae 12-gram, ecliptae herba 8 grams, Os Sepiae 13 grams, Cortex Dictamni 6 grams, Fructus Mume 9 grams, the Radix Paeoniae Alba 4 grams, the Cortex Eucommiae 6 grams, 4 grams, Poria, Rhizoma Corydalis 13 grams.
The preparation method of the Chinese medicine composition of the present embodiment, comprises the following steps:
(1) get Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, ecliptae herba according to weight proportion, add the water that weight is medical material gross weight 10 times, 65 degrees Celsius are soaked 18 hours;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20 minutes, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2 times, merge the medicinal liquid of gained, concentration of liquid medicine become relative density at 60 DEG C to be the thick paste of 1.15;
(4) Os Sepiae, Cortex Dictamni, Fructus Mume, the Radix Paeoniae Alba, the Cortex Eucommiae, Poria, Rhizoma Corydalis are ground to form 500 object fine powders;
(5) by the mixing of the fine drug powder of the thick paste of step (3), step (4) end, stir and mix evenly, dry and make granule.
By the medical material grind into powder in step (1), the size of powder is 300 orders.
The mode that the water temperature gradient that the invention provides in a kind of step (2) is elevated to boiling is: water temperature raises 10 degrees Celsius in every 3 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes.Gradient increased temperature decocting method can better by the constituents extraction in medical material out.
Embodiment 3
The Chinese medicine composition of the present embodiment is made up of the medical material of following weight grams: Herba Lysimachiae 40 grams, Herba Artemisiae Scopariae 33 grams, Radix Salviae Miltiorrhizae 14 grams, ecliptae herba 10 grams, Os Sepiae 15 grams, Cortex Dictamni 11 grams, Fructus Mume 13 grams, the Radix Paeoniae Alba 6 grams, the Cortex Eucommiae 8 grams, 7 grams, Poria, Rhizoma Corydalis 15 grams.
The present invention also provides the preparation method of described Chinese medicine composition, comprises the following steps:
(1) get Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, ecliptae herba according to weight proportion, add the water that weight is medical material gross weight 14 times, 70 degrees Celsius are soaked 25 hours;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 30 minutes, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 5 times, merge the medicinal liquid of gained, concentration of liquid medicine become relative density at 60 DEG C to be the thick paste of 1.25;
(4) Os Sepiae, Cortex Dictamni, Fructus Mume, the Radix Paeoniae Alba, the Cortex Eucommiae, Poria, Rhizoma Corydalis are ground to form 800 object fine powders;
(5) by the mixing of the fine drug powder of the thick paste of step (3), step (4) end, stir and mix evenly, dry and make granule.
By the medical material grind into powder in step (1), the size of powder is 500 orders.
The mode that water temperature gradient is elevated to boiling is: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.Gradient increased temperature decocting method can better by the constituents extraction in medical material out.
Embodiment 4 clinical trial
Choose 560 routine outpatient services and inpatient carries out clinical trial, these patients, according to Clinical symptom and sign, are aided with ultrasonic, abdomen plain film, lab testing and are diagnosed as liver and bile stone.The oldest 69 years old, reckling 15 years old, the most elder of the course of disease 13 years, the shortest 1 week, cholelithiasis 420 example, simple calculus of intrahepatic duct 83 example, liver inside and outside bile duct stone 57 example, the maximum 5.2*2.6cm of calculus, minimum 0.4*0.3cm.
The medicine taking embodiment 1 obtained carries out clinical trial to above-mentioned patient, and each serving with 8g, day three times is oral, within one month, is a course for the treatment of, checks patient condition after three courses for the treatment of.
Criterion is:
Cure: symptom, sign disappear, laboratory, imaging examination calculus disappears.
Effective: symptom, sign alleviate, laboratory, imaging examination calculus is comparatively front to be reduced or diminishes.
Invalid: symptom, sign alleviate not obvious, imaging examination calculus volume amount is unchanged.
Experimental result shows: cure patient 350 example, account for total number of persons 62.5%; Effective patient 196 example, accounts for total number of persons 35%; Refractory patient 14 example, accounts for total number of persons 2.5%, the total effective rate 97.5% of embodiment 1, proves that the present invention has obvious therapeutic effect to liver and bile stone.
Embodiment 5 model case
1. Liu, man, 47 years old, has chronic cholecystitis, informal dress XIAOYAN LIDAN PIAN usually, maintains the state of an illness.In recent years, often there is right Upper abdominal pain, between have angor to show effect, then accompany nauseating during every pain, vomiting, after vomiting, pain is slightly alleviated, all be admitted to hospital do emergency treatment after each outbreak and inject the treatment such as dolantin, assisted transfusion, time serious, have vomiting band blood, not obvious by hemostatic needle effect, at institute expert treatment of blood transfusion first quarter moon, do not feel any better.Take Drug therapy of the present invention, every day 3 times, each 8 grams, after 5 days, symptom takes a turn for the better, and a small amount of diet of energy, no longer vomits, pain relief, vomitus depletion of blood, without melena, this medicine of following the service, after treatment is after 1 month, and diet is normal, it is 0.8 × 0.7cm size that row B ultrasonic shows that calculus reduces disease, to consolidate again after 2 months disease and disappears, after 1 month further consultation B ultrasonic have no in gallbladder have calculus to visit and, add again 1 course for the treatment of subsequently, with examining 2 years no abnormality seens, healthy.
2, Zhang, female, 42 years old, there is History of Coronary Heart Disease, diet is not good at ordinary times, time have upper right abdomen paroxysmal pain, uncomfortable in chest full swollen, sometimes vomiting is had, bitter taste, unit have a medical check-up row B ultrasonic be shown with cholelithiasis merge biliary tract infection, examine and see shoulder ache, cold sensation of aching, general weakness, because there being heart disease cannot perform the operation or lithotripsy in treatment, maximum calculus about 0.6 × 1.0cm size, with this Drug therapy every day 3 times, each 8 grams, remission after 15 days, diet increases, the heavy pain of 2 months right shoulder back ofs the body acid disappears, and check B ultrasonic shows that calculus is 0.3 × 0.8cm size; After following the service after treatment in 2 months, the display of further consultation B ultrasonic has no calculus and occurs, having no recurrence, getting well with examining 1 year half.
3, Zhang, man, 64 years old, because acute pancreatitis is in hospital before taking the present invention, going out gallbladder through hospital's ultrasound diagnosis has 2 unknown objects, size 1.8 centimetres/1.6 centimetres, after taking the present invention, discharge black cholesterol crystal body, then do ultrasound diagnosis, black unknown object disappears.
Claims (8)
1. treat a Chinese medicine composition for liver and bile stone, it is characterized in that, described Chinese medicine composition is made up of the medical material of following portions by weight: Herba Lysimachiae 31-49 part, Herba Artemisiae Scopariae 23-38 part, Radix Salviae Miltiorrhizae 10-16 part, ecliptae herba 5-13 part, Os Sepiae 9-18 part, Cortex Dictamni 3-12 part, Fructus Mume 5-16 part, Radix Paeoniae Alba 3-7 part, Cortex Eucommiae 3-9 part, Poria 2-8 part, Rhizoma Corydalis 10-17 part.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the medical material of following portions by weight: Herba Lysimachiae 36-40 part, Herba Artemisiae Scopariae 28-33 part, Radix Salviae Miltiorrhizae 12-14 part, ecliptae herba 8-10 part, Os Sepiae 13-15 part, Cortex Dictamni 6-11 part, Fructus Mume 9-13 part, Radix Paeoniae Alba 4-6 part, Cortex Eucommiae 6-8 part, Poria 4-7 part, Rhizoma Corydalis 13-15 part.
3. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the medical material of following portions by weight: Herba Lysimachiae 38 parts, Herba Artemisiae Scopariae 30 parts, Radix Salviae Miltiorrhizae 13 parts, ecliptae herba 9 parts, Os Sepiae 14 parts, Cortex Dictamni 9 parts, Fructus Mume 10 parts, the Radix Paeoniae Alba 5 parts, the Cortex Eucommiae 7 parts, 6 parts, Poria, Rhizoma Corydalis 14 parts.
4. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the medical material of following portions by weight: Herba Lysimachiae 36 parts, Herba Artemisiae Scopariae 28 parts, Radix Salviae Miltiorrhizae 12 parts, ecliptae herba 8 parts, Os Sepiae 13 parts, Cortex Dictamni 6 parts, Fructus Mume 9 parts, the Radix Paeoniae Alba 4 parts, the Cortex Eucommiae 6 parts, 4 parts, Poria, Rhizoma Corydalis 13 parts.
5. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the medical material of following portions by weight: Herba Lysimachiae 40 parts, Herba Artemisiae Scopariae 33 parts, Radix Salviae Miltiorrhizae 14 parts, ecliptae herba 10 parts, Os Sepiae 15 parts, Cortex Dictamni 11 parts, Fructus Mume 13 parts, the Radix Paeoniae Alba 6 parts, the Cortex Eucommiae 8 parts, 7 parts, Poria, Rhizoma Corydalis 15 parts.
6. the method for the Chinese medicine composition of preparation described in above-mentioned any one claim, is characterized in that, comprise the following steps:
(1) get Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Salviae Miltiorrhizae, ecliptae herba according to weight proportion, adding weight is medical material gross weight 10-14 water doubly, and 65-70 degree Celsius is soaked 18-25 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained, concentration of liquid medicine become relative density at 60 DEG C to be the thick paste of 1.15 ~ 1.25;
(4) Os Sepiae, Cortex Dictamni, Fructus Mume, the Radix Paeoniae Alba, the Cortex Eucommiae, Poria, Rhizoma Corydalis are ground to form 500-800 object fine powder;
(5) by the mixing of the fine drug powder of the thick paste of step (3), step (4) end, stir and mix evenly, dry and make granule.
7. the preparation method of Chinese medicine composition according to claim 6, is characterized in that, by the medical material grind into powder in step (1), the size of powder is between 300-500 order.
8. the preparation method of Chinese medicine composition according to claim 6, is characterized in that, the mode that the water temperature gradient in step (2) is elevated to boiling is: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
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