CN104474285A - Traditional Chinese medicine decoction for treating ulcerative colitis and preparation method of traditional Chinese medicine decoction - Google Patents

Traditional Chinese medicine decoction for treating ulcerative colitis and preparation method of traditional Chinese medicine decoction Download PDF

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CN104474285A
CN104474285A CN201410842658.7A CN201410842658A CN104474285A CN 104474285 A CN104474285 A CN 104474285A CN 201410842658 A CN201410842658 A CN 201410842658A CN 104474285 A CN104474285 A CN 104474285A
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chinese medicine
medicine decoction
herba
ulcerative colitis
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张冬
郝秀仙
薛莉
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K2236/30Extraction of the material
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    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses traditional Chinese medicine decoction for treating ulcerative colitis and a preparation method of the traditional Chinese medicine decoction. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicines in parts by weight: 25-40 parts of caesalpinia minax hance, 20-35 parts of fructus leonuri, 23-41 parts of bletilla, 8-17 parts of gnaphalium japonicum, 11-26 parts of codonopsis pilosula, 15-23 parts of bighead atractylodes rhizome, 9-16 parts of glossogyne tenuifolia, 5-12 parts of bodinier caper, 8-13 parts of fructus corni and 3-7 parts of dandelion.The traditional Chinese medicine has a good treatment effect, and no toxic or side effects during treatment, and avoids recurrence after curing.

Description

A kind of Chinese medicine decoction for the treatment of ulcerative colitis and preparation method thereof
Technical field
The present invention relates to a kind of medicine being used for the treatment of ulcerative colitis, belong to the field of Chinese medicines.
Background technology
Ulcerative colitis is a kind of agnogenic rectum and colonitis type of disease, may be relevant with Nervous and Mental Factors to infection, heredity, immunity, is Immunoinflammatory Disorders, the genus traditional Chinese medical science " intestinal is warded off ", " hemorrhoidal hamorrhage ", the sick category such as " having loose bowels ".Be mainly feelings will unsuccessful, eating and drinking without temperance, eating cold and uncooked food excessively, addicted to food, sweet greasy to cause taste impaired, raw in water is wet, strongly fragrant and heat-transformation, and pent up large intestine, internal organs gas is smooth, and coagulation of QI-blood forms." Jing Yue's complete work is had loose bowels ": " have loose bowels this, invariably by taste, if eating and drinking without temperance, frequently, so that taste are injured in daily life, then water be instead wet, and paddy be anti-stagnant, the gas of elite, can not defeatedization, are cause to close dirt decline and dysentery work ".Primary disease is multiple is born in 20 ~ 40 years old crowd, men and women's no significant difference.Western medicine primary disease effect is undesirable, and side effect is many.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of therapeutic effect good, the Chinese medicine decoction of the ulcerative colitis had no side effect
For solving the problems of the technologies described above, the technical solution used in the present invention is:
The Chinese medicine decoction for the treatment of ulcerative colitis of the present invention, be made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 25-40 part, Fructus Leonuri 20-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 23-41 part, spire Herba Gnaphalii Affinis 8-17 part, Radix Codonopsis 11-26 part, Rhizoma Atractylodis Macrocephalae 15-23 part, Herba bidentis parviflorae 9-16 part, Cortex capparis Bodinieri radicis 5-12 part, Fructus Corni 8-13 part, Herba Taraxaci 3-7 part.
Preferably, the Chinese medicine decoction of described treatment ulcerative colitis is made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 25 parts, Fructus Leonuri 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 23 parts, spire Herba Gnaphalii Affinis 8 parts, Radix Codonopsis 11 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba bidentis parviflorae 9 parts, Cortex capparis Bodinieri radicis 5 parts, Fructus Corni 8 parts, Herba Taraxaci 3 parts.
Preferably, the Chinese medicine decoction of described treatment ulcerative colitis is made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 40 parts, Fructus Leonuri 35 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 41 parts, spire Herba Gnaphalii Affinis 17 parts, Radix Codonopsis 26 parts, the Rhizoma Atractylodis Macrocephalae 23 parts, Herba bidentis parviflorae 16 parts, Cortex capparis Bodinieri radicis 12 parts, Fructus Corni 13 parts, Herba Taraxaci 7 parts.
Preferably, the Chinese medicine decoction of described treatment ulcerative colitis makes Semen Caesalpiniae Minacis 30 parts by the Chinese medicine of following parts by weight, Fructus Leonuri 28 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts, spire Herba Gnaphalii Affinis 12 parts, Radix Codonopsis 17 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Herba bidentis parviflorae 13 parts, Cortex capparis Bodinieri radicis 8 parts, Fructus Corni 10 parts, Herba Taraxaci 5 parts.
The present invention also provides the preparation method of the Chinese medicine decoction of described treatment ulcerative colitis, comprises the following steps:
(1) get described medical material according to weight proportion, adding weight is medical material gross weight 5-8 water doubly, and 50-60 degree Celsius is soaked 10-18 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained.
Preferably, before immersion, the medical material in step (1) is ground to form 300-500 object powder.
The water temperature gradient that the invention provides in a kind of step (2) is elevated to the mode of boiling, specifically: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
One, general data:
This Chinese medicine decoction is applied to clinical observation case 105 example, wherein man 69 example, female 36 example, 25 ~ 70 years old age.The shortest person's two weeks of the course of disease, most elder reaches half a year.
Two, diagnostic criteria:
(1) stool is rare clearly or as water sample, borborygmus of suffering from abdominal pain, fear of cold lack of appetite; (2) namely stomachache rush down, and rush down urgently lower, stool being yellowish-brown is dirty smelly, burning sensation of the anus, can with heating; (3) abdominal distention distending pain, defecates smelly as loses ovum, rushing down rear alleviation of pain, indigestion and loss of appetite, belching and acid regurgitation; (4) stomachache increased borborygmus and diarrhea, often send out because feelings will is smooth, rushing down rear pain delays; (5) large loose stool is thin, and accompany indigestion food, slightly oil-feed is greasy, just secondaryly increases, with spiritlessness and weakness; (6) rise morning and have loose bowels, stool accompanies indigestion food, umbilicus abdomen cold type of pain, and happiness is warm, coldness of the body with chills.
Three, usage and dosage:
Get Semen Caesalpiniae Minacis 30 grams, Fructus Leonuri 28 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 grams, spire Herba Gnaphalii Affinis 12 grams, Radix Codonopsis 17 grams, the Rhizoma Atractylodis Macrocephalae 18 grams, Herba bidentis parviflorae 13 grams, Cortex capparis Bodinieri radicis 8 grams, Fructus Corni 10 grams, Herba Taraxaci 5 grams.Grind to form 700 object powder, add the water that weight is medical material gross weight 7 times, 55 degrees Celsius are soaked 16 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 4 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 25 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
Four, criterion of therapeutical effect:
(1) fully recover: stool is normal, other transference cures, and Clinical Laboratory is normal; (2) effective: times of defecation obviously reduces, other symptoms are improved; (3) invalid; Symptom has no improvement.
Five, therapeutic effect:
In this clinical observation case, take medicine 10-60 days, recovery from illness 86 example, effective 14 examples, invalid 5 examples.Treatment by Chinese herbs of the present invention is effective, and toxic and side effects does not occur treatments period, and no longer recurs after curing.
Detailed description of the invention
embodiment 1
The Chinese medicine decoction of the treatment ulcerative colitis that the present embodiment provides is made up of the Chinese medicine of following weight grams: Semen Caesalpiniae Minacis 40 grams, Fructus Leonuri 35 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 41 grams, spire Herba Gnaphalii Affinis 17 grams, Radix Codonopsis 26 grams, the Rhizoma Atractylodis Macrocephalae 23 grams, Herba bidentis parviflorae 16 grams, Cortex capparis Bodinieri radicis 12 grams, Fructus Corni 13 grams, Herba Taraxaci 7 grams.
The preparation method of the Chinese medicine decoction of above-mentioned treatment ulcerative colitis, comprises the following steps:
Get above-mentioned Chinese medicine, grind to form 400 object powder, add the water that weight is medical material gross weight 8 times, 55 degrees Celsius are soaked 18 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 5 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 30 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
embodiment 2
The Chinese medicine decoction of the treatment ulcerative colitis that the present embodiment provides is made up of the Chinese medicine of following weight grams: Semen Caesalpiniae Minacis 25 grams, Fructus Leonuri 20 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 23 grams, spire Herba Gnaphalii Affinis 8 grams, Radix Codonopsis 11 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Herba bidentis parviflorae 9 grams, Cortex capparis Bodinieri radicis 5 grams, Fructus Corni 8 grams, Herba Taraxaci 3 grams.
The preparation method of the Chinese medicine decoction of above-mentioned treatment ulcerative colitis, comprises the following steps:
Get above-mentioned Chinese medicine, grind to form 400 object powder, add the water that weight is medical material gross weight 67 times, 55 degrees Celsius are soaked 14 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 3 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 25 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
embodiment 3
The Chinese medicine decoction of the treatment ulcerative colitis that the present embodiment provides is made up of the Chinese medicine of following weight grams: Semen Caesalpiniae Minacis 36 grams, Fructus Leonuri 33 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 39 grams, spire Herba Gnaphalii Affinis 15 grams, Radix Codonopsis 24 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Herba bidentis parviflorae 11 grams, Cortex capparis Bodinieri radicis 10 grams, Fructus Corni 11 grams, Herba Taraxaci 6 grams.
The preparation method of the Chinese medicine decoction of above-mentioned treatment ulcerative colitis, comprises the following steps:
Get above-mentioned Chinese medicine, grind to form 400 object powder, add the water that weight is medical material gross weight 7 times, 55 degrees Celsius are soaked 13 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 3 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 25 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
model case
Case 1:
Week certain, man, 49 years old, continuous 1 week laxativeness, every day 2 times sooner or later, have minute quantity blood mucus just, blood condition was normal.Take decoction prepared by Chinese medicine decoction of the present invention to suffer from diarrhoea after 5 days stopping; Continue to take defecated once a day after 30 days; Check not containing blood mucus just after 60 days, recovery from illness.
Case 2:
Song, man, 64 years old, variable interval was suffered from diarrhoea, and every day at least 3 times, have grade fever symptom, leg joint is ached.Take decoction diarrhea frequency reduction after 3 days prepared by Chinese medicine decoction of the present invention, heating paresthesia disappears; Suffer from diarrhoea after 7 days disappearance, leg joint is ached disappearance, within 2 days, once defecates; Continue to take and checked after 30 days, recovery from illness.

Claims (7)

1. treat the Chinese medicine decoction of ulcerative colitis for one kind, be made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 25-40 part, Fructus Leonuri 20-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 23-41 part, spire Herba Gnaphalii Affinis 8-17 part, Radix Codonopsis 11-26 part, Rhizoma Atractylodis Macrocephalae 15-23 part, Herba bidentis parviflorae 9-16 part, Cortex capparis Bodinieri radicis 5-12 part, Fructus Corni 8-13 part, Herba Taraxaci 3-7 part.
2. the Chinese medicine decoction for the treatment of ulcerative colitis according to claim 1, be made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 25 parts, Fructus Leonuri 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 23 parts, spire Herba Gnaphalii Affinis 8 parts, Radix Codonopsis 11 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba bidentis parviflorae 9 parts, Cortex capparis Bodinieri radicis 5 parts, Fructus Corni 8 parts, Herba Taraxaci 3 parts.
3. the Chinese medicine decoction for the treatment of ulcerative colitis according to claim 1, be made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 40 parts, Fructus Leonuri 35 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 41 parts, spire Herba Gnaphalii Affinis 17 parts, Radix Codonopsis 26 parts, the Rhizoma Atractylodis Macrocephalae 23 parts, Herba bidentis parviflorae 16 parts, Cortex capparis Bodinieri radicis 12 parts, Fructus Corni 13 parts, Herba Taraxaci 7 parts.
4. the Chinese medicine decoction for the treatment of ulcerative colitis according to claim 1, be made up of the Chinese medicine of following parts by weight: Semen Caesalpiniae Minacis 30 parts, Fructus Leonuri 28 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts, spire Herba Gnaphalii Affinis 12 parts, Radix Codonopsis 17 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Herba bidentis parviflorae 13 parts, Cortex capparis Bodinieri radicis 8 parts, Fructus Corni 10 parts, Herba Taraxaci 5 parts.
5. the preparation method of the Chinese medicine decoction of the treatment ulcerative colitis described in above-mentioned any one claim, comprises the following steps:
(1) get described medical material according to weight proportion, adding weight is medical material gross weight 5-8 water doubly, and 50-60 degree Celsius is soaked 10-18 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained.
6. preparation method according to claim 5, is characterized in that, before immersion, the medical material in step (1) is ground to form 300-500 object powder.
7. preparation method according to claim 5, is characterized in that, the mode that the water temperature gradient in step (2) is elevated to boiling is: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
CN201410842658.7A 2014-12-30 2014-12-30 Traditional Chinese medicine decoction for treating ulcerative colitis and preparation method of traditional Chinese medicine decoction Pending CN104474285A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008534666A (en) * 2005-04-08 2008-08-28 エーケーエル インフラメトリー リミティド Anti-inflammatory preparation
CN102949619A (en) * 2012-09-25 2013-03-06 荣成市崖头美全口腔诊所 Traditional Chinese medicine composition for treating colitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008534666A (en) * 2005-04-08 2008-08-28 エーケーエル インフラメトリー リミティド Anti-inflammatory preparation
CN102949619A (en) * 2012-09-25 2013-03-06 荣成市崖头美全口腔诊所 Traditional Chinese medicine composition for treating colitis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
崔淑云等: "中药补脾散治疗溃疡性结肠炎远期疗效观察", 《吉林中医药》 *
高秀云等: "自拟补肾化瘀愈疡汤治疗溃疡性结肠炎疗效观察", 《医学综述》 *

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