CN104474222A - Traditional Chinese medicine for treating angina pectoris - Google Patents

Traditional Chinese medicine for treating angina pectoris Download PDF

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Publication number
CN104474222A
CN104474222A CN201410726793.5A CN201410726793A CN104474222A CN 104474222 A CN104474222 A CN 104474222A CN 201410726793 A CN201410726793 A CN 201410726793A CN 104474222 A CN104474222 A CN 104474222A
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angina pectoris
chinese medicine
radix
traditional chinese
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高伟
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/83Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
    • A61K36/835Aquilaria
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives

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Abstract

Invention relates to a traditional Chinese medicine for treating angina pectoris. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 6 parts of prepared radix aconiti carmichaeli slices, 9 parts of radix pseudostellariae, 6 parts of cassia twig, 6 parts of angelica sinensis, 6 parts of agilawood, 9 parts of trichosanthes kirilowii maxim, 6 parts of rocambole, 6 parts of human placenta and 5 parts of honey-fried licorice root. Clinical experiments prove that the traditional Chinese medicine can be used for safely and effectively treating the angina pectoris.

Description

A kind of Chinese medicine being used for the treatment of angina pectoris
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of angina pectoris.
Background technology
definition
Angina pectoris, names of disease of tcm, refers to pained pole danger severe one.Its clinical characters is soldier's so large pain of the heart, and locked mouth of very then gritting one's teeth, companion sees pale complexion, and cold sweat goes out, deadly cold hand and foot, and faint pulse being about to disappear is main clinical manifestation.For be different from pit of the stomach tract pain (namely stomach alkane pain, ancient book or be " pained ", " epigastric pain "), therefore named.Primary disease is found in the diseases such as modern Western medicine angina pectoris, acute myocardial infarction.See pained, precordial pain with cold limbs, epigastric pain with cold limbs due to adverseness of heat bar.Angina pectoris usually deficient and excessive syndromes appearing together clinically, shows as the syndrome of deficiency in origin and excess in superficiality.The method of giving consideration to both the incidental and fundamental is taked in treatment more.。
symptom
Pareordia has an intense pain, and often has pale complexion concurrently, and feeling oppressed sense in ambition, very then occurs the phenomenons such as profuse sweating, cold extremities, cyanosis, faint pulse being about to disappear.As given treatment to not in time, often can threat to life.About the description of angina pectoris symptom in TCM Document, close with the coronary heart disease of doctor trained in Western medicine, myocardial infarction.
etiology and pathogenesis
The etiology and pathogenesis of angina pectoris, mainly with motive deficiency of heart-YANG for this, blood stasis expectorant turbid for mark.Heart governing blood and vessels, blood flows round without stopping in the blood vessel, must rely the promotion of the motive.After people in middle age, all virtual loss of cloudy the vivid YANG QI, or because of improper diet and overtiredness, or because of disorder of emotion, make the motive further not enough, or cause deficiency of heart-YANG to decline further, the unable promotion blood of yang-energy, blood is moderate, then stay and be the stasis of blood; Homogeny of clear fluid and blood, stasis then body fluid is also stagnant, or diet enters delicious food savoury more, impairing the spleen and stomach, dysfunction of the spleen in transportation, and body fluid is poly-and be expectorant, phlegm and blood stasis, hinders in heart arteries and veins, stagnation of QI and blood may bring about pain.
distinguish and control
Angina pectoris can be divided into acute stage and catabasis, depending on the clinical manifestation determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs that they are different.
acute stage
1. heart-yang collapse.Card is shown in that pareordia has an intense pain, chest pain radiating to the back, backache radiating to the heart, continues not understand or frequently show effect, pale complexion, dripping cold sweat, cardiopalmus of losing heart, cold extremities, faint pulse being about to disappear, and tongue is dull, and tongue is white.2. accumulation of heat internal organs is real.Card is shown in acutely pained, flushed complexion, dysphoria, and asthma can not be put down sleeping, abundant expectoration, abdominal distention, constipation with dry stool, and purplish tongue is dim, yellow and greasy fur and doing, stringy and rolling pulse number.3. qi depression to blood stasis.Card is shown in acutely pained, doublely sees chest distress, and side of body rib distension, eructation is frequent, and irritable, body of the tongue is dim ecchymosis, and deep and stringy pulse is puckery.
catabasis
1. blood stasis due to qi deficiency.Card is shown in angina pectoris, and uncomfortable in chest, activity postemphasis, alleviates during rest, companion see lose heart, weak, sweating, cardiopalmus, corpulent tongue is large, has indentation, ecchymosis or petechia, or colour of the tongue is dull, and white and thin fur, stringy and thready pulse is unable.2. deficiency of both QI and YIN.Except angina pectoris, card is shown in and loses heart, weak, vexed, pharyngoxerosis, large dry stool, or has low grade fever, red tongue, thready and rapid pulse without strength or see intermittent pulse.Control cloudy two benefits of suitable gas, its stasis of blood of doubleization.3. hyperactivity of YANG due to deficiency of YIN.Card is shown in the vertigo, flushed complexion, irritable, dysphoria with feverish sensation in the chest palms and soles, constipation with dry stool, stringy and rolling pulse number, red tongue, and yellow and thin fur is done.Patients' blood one to higher, and has eating and drinking without temperance and long-term smoking, history of drinking history more.
Medical material present Research involved in the present invention is as follows:
RADIX ACONITILATERALIS PREPARATA [source] this product is the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..[nature and flavor] are pungent, sweet, hot greatly; Poisonous.[return through] GUIXIN, kidney, spleen channel.[function cures mainly] recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.[usage and dosage] 3 ~ 15g.
Radix Pseudostellariae [source] this product is the dried root of pinkwort Radix Ginseng Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm..Summer excavates when stem and leaf major part is withered, cleans, removing fibrous root, puts after slightly scalding in boiling water and dries or directly dry.[nature and flavor] sweet, micro-hardship, flat.[return through] returns spleen, lung meridian.[function cures mainly] replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.[usage and dosage] 9 ~ 30g.
Ramulus Cinnamomi [source] this product is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or [nature and flavor] acrid, sweet, warm are dried in section.[return through] GUIXIN, lung, urinary bladder channel.[function cures mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.[usage and dosage] 3 ~ 9g.
Radix Angelicae Sinensis [source] this product is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.[usage and dosage] 6 ~ 12g.
Lignum Aquilariae Resinatum [source] this product is the timber that Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum Aquilaria sinensis (Lour.) Gilg contains resin.The whole year all can gather, and extracts resiniferous timber, removes not resiniferous part, dries in the shade.[nature and flavor] are pungent, bitter, tepor.[return through] returns spleen, stomach, kidney channel.[function cures mainly] promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.[usage and dosage] 1.5 ~ 6g.
The fruit that Fructus Trichosanthis [source] is cucurbitaceous plant Fructus Trichosanthis.Peel surface started to have white lead and for time faint yellow, can gather to fruit maturation in the Beginning of Winter the Frost's Descent.Connect fruit stem to cut, fruit stem is knitted bunchiness, first piles up 2 ~ 3 days within doors, then be hung on shady and cool ventilation place and dry (about 2 months); Then cut off fruit stem, wrap up one by one with soft paper, to keep color and luster.Prevent from wounding and break, otherwise easy to be infested mouldy.[nature and flavor] sweet in the mouth; Micro-hardship; [return through] cold in nature returns lung; Stomach; Large intestine channel
[function cures mainly] removing heat-phlegm; Wide born of the same parents' eliminating stagnation; Moisturize laxation.Main cough due to lung-heat; The thoracic obstruction; Quench one's thirst; Constipation; Carbuncle sore tumefacting virus [usage and dosage] 9 ~ 20g.
Bulbus Allii Macrostemonis head [source] this product is the dry bulb of liliaceous plant Allium macrostemon Allium macrostemon Bge. or Chinese onion Allium chinensis G. Don.Summer, Qiu Erji excavate, and clean, removing fibrous root, steam thoroughly or put in boiling water and scald thoroughly, dry.[nature and flavor] are pungent, bitter, temperature.[return through] returns lung, stomach, large intestine channel.[function cures mainly] activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.[usage and dosage] 5 ~ 9g.
Radix Glycyrrhizae Preparata [source] this product is the Preparation process product of Radix Glycyrrhizae.[process of preparing Chinese medicine] gets clean Radix Glycyrrhizae tabellae, adds cooked Mel and a little boiled water, slightly vexed after mixing thoroughly, fries to yellow to buff, takes out, dry in the air cool time tack-free.Every 100 jin with cooked Mel 25 ~ 30 jin.[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.[usage and dosage] 1.5 ~ 9g.[attention] should not with Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui with using.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of angina pectoris, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing angina pectoris.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for angina pectoris, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: RADIX ACONITILATERALIS PREPARATA 6 parts, Radix Pseudostellariae 9 parts, Ramulus Cinnamomi 6 parts, Radix Angelicae Sinensis 6 parts, Lignum Aquilariae Resinatum 6 parts, Fructus Trichosanthis 9 parts, 6 parts, Bulbus Allii Macrostemonis head, Radix Glycyrrhizae Preparata 5 parts.
Inventor thinks that angina pectoris motive deficiency of heart-YANG is for this, and blood stasis expectorant is turbid is mark, the unable promotion blood of yang-energy, and inventor's blood is moderate, then stay and be the stasis of blood, and body fluid is poly-and be expectorant, phlegm and blood stasis, hinders in heart arteries and veins, stagnation of QI and blood may bring about pain.Therefore assembly is our.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1.1 clinical datas are originally organized 68 routine cases and are out-patient, and clinical manifestation all has ictal chest pain in various degree, show as pareordia compressing, stuffy or constriction.This research is person 68 example altogether, man 38 example, female 3O example; 29 years old ~ 68 years old age (49 years old ± 19 years old); The course of disease 2 years ~ 28 years.Check that the ST section of showed different is forced down, T popin is smooth through electrocardiogram, load test or be inverted.Other diseases is got rid of in ultrasoundcardiogram, CT and relevant inspection.Meet the diagnostic criteria of " Chinese medical disease Standardization of diagnosis and curative effect " formulation about the thoracic obstruction of State Administration of Traditional Chinese Medicine's promulgation.
The decoct that the oral the present invention of 1.2 Therapeutic Method obtains according to specific embodiment 1, every day 3 times.10 doses is 1 course for the treatment of, continuously treatment 3 the observe the curative effect course for the treatment of.
1.3 criterions of therapeutical effect are with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".Clinical cure: clinical symptom disappearance, electrocardiogram and kinetocardiogram without exception; Effective: clinical symptoms is clearly better, but electrocardiogram still has non-specific ST section and T ripple extremely; Invalid; Without significant change before and after treatment.
2 results
Cure 46 examples in 68 examples, effective 20 examples, invalid 2 examples, total effective rate is 97%.
Visible, the medicine that the present invention obtains can safe and effective treatment angina pectoris, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: RADIX ACONITILATERALIS PREPARATA 6g, Radix Pseudostellariae 9g, Ramulus Cinnamomi 6g, Radix Angelicae Sinensis 6g, Lignum Aquilariae Resinatum 6g, Fructus Trichosanthis 9g, Bulbus Allii Macrostemonis head 6g, Radix Glycyrrhizae Preparata 5g; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of angina pectoris.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: RADIX ACONITILATERALIS PREPARATA 6g, Radix Pseudostellariae 9g, Ramulus Cinnamomi 6g, Radix Angelicae Sinensis 6g, Lignum Aquilariae Resinatum 6g, Fructus Trichosanthis 9g, Bulbus Allii Macrostemonis head 6g, Placenta Hominis 6g, Radix Glycyrrhizae Preparata 5g; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of angina pectoris.Oral, daily once.
Specific embodiment 3
Take: RADIX ACONITILATERALIS PREPARATA 6g, Radix Pseudostellariae 9g, Ramulus Cinnamomi 6g, Radix Angelicae Sinensis 6g, Lignum Aquilariae Resinatum 6g, Fructus Trichosanthis 9g, Bulbus Allii Macrostemonis head 6g, Radix Glycyrrhizae Preparata 5g; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of angina pectoris.Oral, every bu is taken for twice sooner or later.

Claims (1)

1. be used for the treatment of a Chinese medicine for angina pectoris, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: RADIX ACONITILATERALIS PREPARATA 6 parts, Radix Pseudostellariae 9 parts, Ramulus Cinnamomi 6 parts, Radix Angelicae Sinensis 6 parts, Lignum Aquilariae Resinatum 6 parts, Fructus Trichosanthis 9 parts, 6 parts, Bulbus Allii Macrostemonis head, Radix Glycyrrhizae Preparata 5 parts.
CN201410726793.5A 2014-12-04 2014-12-04 Traditional Chinese medicine for treating angina pectoris Pending CN104474222A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1745795A (en) * 2004-09-08 2006-03-15 湖南德海制药有限公司 Medicine for preventing and treating coronary heart disease and preparation method thereof
CN101028415A (en) * 2006-12-28 2007-09-05 龚文君 Oral Chinese medicine for treating phlegm-heat obstructive rheumatic heart disease
CN102048939A (en) * 2010-12-30 2011-05-11 袁岳鹏 Medicament for treating sinus bradycardia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1745795A (en) * 2004-09-08 2006-03-15 湖南德海制药有限公司 Medicine for preventing and treating coronary heart disease and preparation method thereof
CN101028415A (en) * 2006-12-28 2007-09-05 龚文君 Oral Chinese medicine for treating phlegm-heat obstructive rheumatic heart disease
CN102048939A (en) * 2010-12-30 2011-05-11 袁岳鹏 Medicament for treating sinus bradycardia

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
刘日善: ""加味丹参饮治疗冠心病68例临床观察"", 《中西医结合心脑血管病杂志》 *
刘玉敏: ""经方治疗急症举隅"", 《河南中医》 *
张仲雄: ""桂枝附子汤治疗内科急症"", 《湖南中医杂志》 *
张国华等主编: "《心系病名方》", 30 September 2013 *
李明富: "《中医内科学》", 31 August 2000 *
陈锐: ""张伯臾心痹、真心痛治验"", 《中国社区医师》 *

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Application publication date: 20150401