CN104474163A - Traditional Chinese medicine granules for treating egg drop syndrome of chickens and preparation method thereof - Google Patents
Traditional Chinese medicine granules for treating egg drop syndrome of chickens and preparation method thereof Download PDFInfo
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- CN104474163A CN104474163A CN201410671376.5A CN201410671376A CN104474163A CN 104474163 A CN104474163 A CN 104474163A CN 201410671376 A CN201410671376 A CN 201410671376A CN 104474163 A CN104474163 A CN 104474163A
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- 239000008187 granular material Substances 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title claims abstract description 18
- 208000011580 syndromic disease Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 241000287828 Gallus gallus Species 0.000 title abstract description 13
- 235000013330 chicken meat Nutrition 0.000 title abstract 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 9
- 229930006000 Sucrose Natural products 0.000 claims abstract description 9
- 239000005720 sucrose Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 239000012567 medical material Substances 0.000 claims description 2
- -1 mixing Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 241000411851 herbal medicine Species 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 2
- 238000010298 pulverizing process Methods 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract 2
- 238000007873 sieving Methods 0.000 abstract 2
- 241000893536 Epimedium Species 0.000 abstract 1
- 240000006509 Gynostemma pentaphyllum Species 0.000 abstract 1
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 abstract 1
- 244000047734 Paederia foetida Species 0.000 abstract 1
- 235000019116 Paederia foetida Nutrition 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 230000001584 effect on egg Effects 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 description 27
- 238000004519 manufacturing process Methods 0.000 description 6
- 102000002322 Egg Proteins Human genes 0.000 description 5
- 108010000912 Egg Proteins Proteins 0.000 description 5
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- 208000015181 infectious disease Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000003101 oviduct Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
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- 208000024891 symptom Diseases 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
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- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 210000000991 chicken egg Anatomy 0.000 description 2
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- 235000020188 drinking water Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 241000271566 Aves Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 210000001739 intranuclear inclusion body Anatomy 0.000 description 1
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- 231100000915 pathological change Toxicity 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000005570 vertical transmission Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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Abstract
The invention discloses a traditional Chinese medicine granule for treating egg drop syndrome of chickens and a preparation method thereof, belonging to the field of pharmaceutical preparations of traditional herbal medicines with undetermined structures. The traditional Chinese medicine granule mainly comprises the following raw materials in parts by weight: 5-8 parts of acanthopanax, 4-6 parts of gynostemma pentaphylla, 4-6 parts of rhizoma alismatis, 2-5 parts of epimedium and 1-3 parts of paederia scandens. Decocting the 7 traditional Chinese medicines in water, filtering decoction, concentrating into extract, drying, pulverizing, adding sucrose, mixing, granulating, sieving with 10 mesh sieve, drying, and sieving with 10 mesh sieve. The traditional Chinese medicine composition has obvious treatment effect on egg drop syndrome of chickens, takes effect quickly, has no medicine residue, has no toxic or side effect, and has good application prospect in the breeding industry.
Description
Technical field
The invention belongs to the pharmaceutical preparation that traditional herbal medicines does not determine structure, specifically a kind of Chinese medicine granules being used for the treatment of egg drop syndrome and preparation method thereof.
Background technology
Egg drop syndrome is the infectious disease of a kind of non-evident sympton caused by birds adenovirus, and reveal any symptoms is that bird inlay egg production obviously declines.Chicken all easy infection egg drop syndromes at any age, and by the egg production of impact whole laying period after catching an illness.Primary disease mostly is vertical transmission, and by fetal infection chicken, chicken group starts toxin expelling when laying rate reaches more than 50%, and bamboo telegraph; Also can horizontal transmission, many approach such as incubator tray, feces, immune syringe needle, drinking water by polluting are propagated, and propagate comparatively slow and in discontinuity, and cage bird are propagated soon than flat poultry.
The clinical symptoms of egg drop syndrome: infected chicken is without obvious clinical symptoms, and main manifestations is sudden groupment egg drop reduction, declines 20% ~ 38%, even up to 50% than normal.The lighten of sick just eggshell, then produce abnormal-shape egg, eggshell rough picture grains of sand sample, eggshell thinning cracky, soft-shelled egg increases.Analysing visible ovary to diminish, atrophy, there is hemorrhage and catarrhal inflammation in uterus and Fallopian tube mucosa.Fallopian tube body of gland edema, monocyte infiltration, mucosal epithelial cells degeneration necrosis, pathological change is can see nuclear inclusion in cell.
Summary of the invention
The present invention is exactly the problem declined to solve chicken egg productivity, and provides a kind of Chinese medicine granules being used for the treatment of egg drop syndrome and preparation method thereof.
Composition principle of the present invention is: Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; Herb Gynostemmae Pentaphylli replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing; Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, expels the heat-evil; Herba Epimedii kidney invigorating and YANG supporting, expelling wind and removing dampness; Fevervine promoting digestion and invigorating the stomach, preventing phlegm from forming and stopping coughing, heat clearing away is envied, pain relieving.All medicines share, warming the kidney and strengthening the spleen, blood circulation promoting and blood stasis dispelling.
The present invention realizes according to following technical scheme.
Be used for the treatment of a Chinese medicine granules for egg drop syndrome, it is made by the raw material of following weight:
Radix Et Caulis Acanthopanacis Senticosi 5 ~ 8 parts, Herb Gynostemmae Pentaphylli 4 ~ 6 parts
Rhizoma Alismatis 4 ~ 6 parts, Herba Epimedii 2 ~ 5 parts,
Fevervine 1 ~ 3 part.
Above-mentioned a kind of Chinese medicine granules being used for the treatment of egg drop syndrome, preferred weight part proportioning of 5 taste Chinese medicines is:
Radix Et Caulis Acanthopanacis Senticosi 6 parts, Herb Gynostemmae Pentaphylli 6 parts,
Rhizoma Alismatis 5 parts, Herba Epimedii 3 parts,
Fevervine 1 part.
A kind of preparation method being used for the treatment of the Chinese medicine granules of egg drop syndrome, take Radix Et Caulis Acanthopanacis Senticosi 5 ~ 8 parts, Herb Gynostemmae Pentaphylli 4 ~ 6 parts, Rhizoma Alismatis 4 ~ 6 parts, Herba Epimedii 2 ~ 5 parts, fevervine 1 ~ 3 part, add the water of above-mentioned medical material 8-12 times amount, decoct 2-3 time, each 1.5-2 hour, collecting decoction, filter, the extractum of relative density 1.28 when being concentrated into 80 DEG C, dry rear pulverizing for 60 ~ 70 DEG C, the ratio equaling 15 in extractum sucrose (v w) adds flavoring agent sucrose, mixing, granulate, cross 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm), 60 DEG C of oven dry, after 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm), obtain.
The present invention of such design provides a kind of Chinese medicine granules being used for the treatment of egg drop syndrome for poultry farming, has instant effect, determined curative effect, drug residue free, feature without any side effects, and convenient transportation, easy to use.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be described in detail.
One, embodiment
Embodiment 1: take Radix Et Caulis Acanthopanacis Senticosi 50g, Herb Gynostemmae Pentaphylli 40g, Rhizoma Alismatis 40g, Herba Epimedii 20g, fevervine 20g, add the water of 1700ml, decoct 2 times, each 2 hours, collecting decoction, filter, be concentrated into relative density 1.28(80 DEG C) extractum, 60 ~ 70 DEG C dry after pulverize, add 170g sucrose, mixing, makes granule and crosses 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm), 60 DEG C of oven dry, after 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm).
Embodiment 2: take Radix Et Caulis Acanthopanacis Senticosi 60g, Herb Gynostemmae Pentaphylli 50g, Rhizoma Alismatis 40g, Herba Epimedii 40g, fevervine 30g, add the water of 2200ml, decoct 2 times, each 2 hours, collecting decoction, filter, be concentrated into relative density 1.28(80 DEG C) extractum, 60 ~ 70 DEG C dry after pulverize, add 220g sucrose, mixing, makes granule and crosses 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm), 60 DEG C of oven dry, after 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm).
Embodiment 3: take Radix Et Caulis Acanthopanacis Senticosi 60g, Herb Gynostemmae Pentaphylli 60g, Rhizoma Alismatis 50g, Herba Epimedii 30g, fevervine 10g, add the water of 2100ml, decoct 2 times, each 2 hours, collecting decoction, filter, be concentrated into relative density 1.28(80 DEG C) extractum, 60 ~ 70 DEG C dry after pulverize, add 210g sucrose, mixing, makes granule and crosses 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm), 60 DEG C of oven dry, after 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm).
Embodiment 4: take Radix Et Caulis Acanthopanacis Senticosi 80g, Herb Gynostemmae Pentaphylli 60g, Rhizoma Alismatis 60g, Herba Epimedii 30g, fevervine 20g, add the water of 2500ml, decoct 2 times, each 2 hours, collecting decoction, filter, be concentrated into relative density 1.28(80 DEG C) extractum, 60 ~ 70 DEG C dry after pulverize, add 250g sucrose, mixing, makes granule and crosses 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm), 60 DEG C of oven dry, after 10 mesh sieves (sieve aperture internal diameter: 2000 μm ± 70 μm).
Two, clinical trial
Administering mode: drinking water administration, adds 1kg water by 0.5g, mixed drink, continuous use 5 days, and records 5 days egg productions.
9500, chicken farm, Shandong chicken laying hen in 28 week age falls ill, chicken group egg drop reduction, and eggshell color is thin out, and produce abnormal-shape egg, eggshell is rough, and soft-shelled egg is more.Analyse and find that ovary diminishes, atrophy, there is hemorrhage and catarrhal inflammation in uterus and Fallopian tube mucosa, is diagnosed as Egg Production of Laying Hens drop syndrome.From same chicken group, select 40 plumages, be divided into two groups, often organize 20 plumages, record and respectively organize chicken egg productivity in ill 3 days.Then choosing is selected the few group of egg production and to be come into operation in the manner described above this medicine, and another group in contrast, then observes the egg production of ill chicken in 5 days after administration.
Result of the test shows 23 pieces, the non-administration of administration group chicken first 3 days common property eggs, and every day, laying rate was 38.3%; 25 pieces, non-administered group 3 days common property eggs, every day, laying rate was 41.7%; Administration group successive administration is after 5 days, 56 pieces, common property egg, and every day, laying rate was 56%, and 34 pieces, non-administered group 5 days common property eggs, every day, laying rate dropped to 34%, and this result shows that this medicine has significant therapeutic effect to egg drop syndrome.
Claims (3)
1. be used for the treatment of a Chinese medicine granules for egg drop syndrome, it is made by the raw material of following weight:
Radix Et Caulis Acanthopanacis Senticosi 5-8 part, Herb Gynostemmae Pentaphylli 4-6 part,
Rhizoma Alismatis 4-6 part, Herba Epimedii 2-5 part,
Fevervine 1-3 part.
2. a kind of Chinese medicine granules being used for the treatment of egg drop syndrome according to claim 1, is characterized in that: it is made by the raw material of following weight:
Radix Et Caulis Acanthopanacis Senticosi 6 parts, Herb Gynostemmae Pentaphylli 6 parts,
Rhizoma Alismatis 5 parts, Herba Epimedii 3 parts,
Fevervine 1 part.
3. one kind is used for the treatment of the preparation method of the Chinese medicine granules of egg drop syndrome, it is characterized in that: take Radix Et Caulis Acanthopanacis Senticosi 5-8 part, Herb Gynostemmae Pentaphylli 4-6 part, Rhizoma Alismatis 4-6 part, Herba Epimedii 2-5 part, fevervine 1-3 part, add the water of above-mentioned medical material 8-12 times amount, decoct 2-3 time, each 1.5-2 hour, collecting decoction, filter, the extractum of relative density 1.28 when being concentrated into 80 DEG C, dries and pulverizes, the ratio equaling 15 in extractum sucrose adds flavoring agent sucrose, mixing, granulates, and crosses 10 mesh sieves, dry, after 10 mesh sieves.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178053A (en) * | 2011-04-14 | 2011-09-14 | 山东和美华农牧科技股份有限公司 | Chicken feed additive for improving laying rate and hen laying period feed |
| CN102688329A (en) * | 2012-06-28 | 2012-09-26 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for preventing egg drop syndrome and preparation method thereof |
| CN103202984A (en) * | 2013-04-25 | 2013-07-17 | 青岛农业大学 | Traditional Chinese medicine composition for improving chicken immune function |
-
2014
- 2014-11-21 CN CN201410671376.5A patent/CN104474163A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178053A (en) * | 2011-04-14 | 2011-09-14 | 山东和美华农牧科技股份有限公司 | Chicken feed additive for improving laying rate and hen laying period feed |
| CN102688329A (en) * | 2012-06-28 | 2012-09-26 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for preventing egg drop syndrome and preparation method thereof |
| CN103202984A (en) * | 2013-04-25 | 2013-07-17 | 青岛农业大学 | Traditional Chinese medicine composition for improving chicken immune function |
Non-Patent Citations (1)
| Title |
|---|
| 刘富来等主编: "《禽病防治安全用药手册》", 31 January 2007, 广州科技出版社 * |
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