CN104473168A - Processing method for increasing solubility and bioavailability of fat-soluble active component - Google Patents
Processing method for increasing solubility and bioavailability of fat-soluble active component Download PDFInfo
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- CN104473168A CN104473168A CN201410823533.XA CN201410823533A CN104473168A CN 104473168 A CN104473168 A CN 104473168A CN 201410823533 A CN201410823533 A CN 201410823533A CN 104473168 A CN104473168 A CN 104473168A
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- active ingredients
- liposoluble active
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- 238000003672 processing method Methods 0.000 title claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 25
- 239000002245 particle Substances 0.000 claims abstract description 21
- 239000008107 starch Substances 0.000 claims abstract description 15
- 235000019698 starch Nutrition 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 8
- 238000005516 engineering process Methods 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 claims abstract description 4
- 239000004480 active ingredient Substances 0.000 claims description 27
- 239000000243 solution Substances 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 6
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 4
- 230000001186 cumulative effect Effects 0.000 claims description 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 4
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- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 3
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- 239000011648 beta-carotene Substances 0.000 claims description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 3
- 229960002747 betacarotene Drugs 0.000 claims description 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 2
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 2
- 235000021466 carotenoid Nutrition 0.000 claims description 2
- -1 carotenoids compound Chemical class 0.000 claims description 2
- 210000000170 cell membrane Anatomy 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 235000012754 curcumin Nutrition 0.000 claims description 2
- 239000004148 curcumin Substances 0.000 claims description 2
- 229940109262 curcumin Drugs 0.000 claims description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 2
- 229930003935 flavonoid Natural products 0.000 claims description 2
- 150000002215 flavonoids Chemical class 0.000 claims description 2
- 235000017173 flavonoids Nutrition 0.000 claims description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 2
- 235000012680 lutein Nutrition 0.000 claims description 2
- 239000001656 lutein Substances 0.000 claims description 2
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 2
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- 239000001751 lycopene Substances 0.000 claims description 2
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 2
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- 235000005875 quercetin Nutrition 0.000 claims description 2
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- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 2
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a processing method for increasing the solubility and the bioavailability of a fat-soluble active component and belongs to the technical field of processing of modern nutritional foods.Water-soluble starch particles are used as carriers, and a nanoscale fat-soluble active component-starch particle compound is prepared with a nano suspension technology, so that the water solubility as well as absorption and utilization effects of the fat-soluble active component are improved. The method can significantly increase the solubility and the bioavailability of insoluble food active components and can be applied to various fields of foods, medicines, daily chemicals and the like.
Description
Technical field
The present invention relates to a kind of processing method improving liposoluble active ingredients solubility and bioavilability, belong to modern nutraceutical processing technique field.
Background technology
Along with society's science and technology and expanding economy, the conversion of life style and the deterioration of environment, China's spectrum of disease changes, and diabetes, hypertension, obesity chronic diseases increasing number, the crowd of sub-health state is also more and more huger.Meanwhile, the health care of people consciousness is also more and more stronger, and medical idea is changed to prevention and health care type by therapeutic type after being ill.By healthy lifestyles, by means preventing chronic diseases such as diet nutritionals, be just more and more taken seriously.
Functional food to have become in consumer's recipe prevention due to its significant physiological function or has reduced the important channel that chronic disease occurs.But, many natural activity components exist that fusing point is high, poorly water-soluble, oxidizable decomposition, the characteristic such as not easily digested, therefore design effective active component transmission system is just becoming this field research emphasis to the utilization rate improving bioactivator.At present, the external main natural nutrient production and supply commercial city such as Roche Group, DSM, BASF develops the microcapsules of natural nutrient and emulsion resist technology and defines the production and sales of scale; For the product of domestic natural nutrient enterprise, then majority uses as first gradating material.For these reasons, the present invention studies in detail a kind of processing method improving liposoluble active ingredients solubility and bioavilability.
Summary of the invention
The object of the present invention is to provide a kind of processing method improving liposoluble active ingredients solubility and bioavilability, the method has that technique is simple, strong operability, security are high, significantly can increase solubility and the bioavilability of slightly solubility food active component, its range of application can relate to multiple fields such as food, medicine, household chemicals.
Object of the present invention is realized by following technical proposals: with water soluble starch particle for carrier, prepare nanoscale liposoluble active ingredients-amylum grain compound by nanometer suspension technology, thus improve the water-soluble of liposoluble active ingredients and absorb effect.Concrete steps are as follows:
(1) water soluble starch particle is dissolved in the sodium-acetate buffer of pH7.0,0.1mol/L, is made into the uniform solution that mass concentration is 5%-30%;
(2) liposoluble active ingredients is dissolved in ethanolic solution, is made into the uniform solution that mass concentration is 5-300 mg/mL;
(3) utilize above-mentioned two kinds of uniform solution composite to carry out by mixed solution cumulative volume 200mL, water soluble starch particle and liposoluble active ingredients weight proportion 2:1-200:1, constantly stir isothermal reaction 5-120 min at 30-70 DEG C simultaneously;
(4) be placed in sonication device, control power is 200-600W, at 0-10 DEG C, process 2-20min;
(5) centrifugal treating, carries out vacuum drying treatment by obtained supernatant, namely obtains the liposoluble active ingredients-amylum grain compound with good solubility and bioavilability.
In order to realize patent of the present invention better, the molecular weight 10 of water soluble starch particle
7-10
8g/mol, molecular density 7%-10%, average chain length DP 10-12, mean particle size 30-100 nm; Liposoluble active ingredients comprises carotenoids compound, flavonoids etc., as beta carotene, resveratrol, Co-Q10, lutein, lycopene, curcumin, Quercetin, capsicim etc.
Zetasizer Nano ZS nano-particle size analysis instrument is adopted to measure the mean particle size of liposoluble active ingredients-amylum grain compound at 30-150 nm, liposoluble active ingredients solubility in aqueous improves 20-150 doubly simultaneously, and cell membrane permeability improves more than 5 times.
The present invention has following advantage:
1) the present invention makes full use of the abundant starch of china natural resources and natural plants chemicals, designs the protection of effective liposoluble active ingredients and transportation system, improves food quality, improve slowly-releasing effect and targeting.
2) step of the present invention is easy, and be easy to operation, reaction condition is controlled, advantage of lower cost, and adopts clean green production process, substantially pollution-free to environment.
3) the present invention makes the solubility of natural liposoluble active ingredients significantly improve, existence is solubilised state from crystalline transformation, finally be loaded in water miscible transportation system, these all will improve body absorption, the metabolism of nutrient greatly, thus improve its bioavailability, reach the real supply of nutrient, meet the healthy demand of consumers in general to product better, improve the general level of the health and the living standard of people.
4) product that prepared by the present invention can be applicable to multiple fields such as food, medicine, household chemicals, and market prospects are very good, and economic benefit is wide.
Detailed description of the invention
Illustrate content of the present invention further below in conjunction with example, but the content that the present invention protects not only is confined to example below.
Embodiment 1
By water soluble starch particle (molecular weight 1.5 × 10
7g/mol, molecular density 9.5%, average chain length DP 10.2, mean particle size 80.4nm) sodium-acetate buffer that is dissolved in pH7.0,0.1mol/L is made into the uniform solution that mass concentration is 5%; Beta carotene is dissolved in ethanolic solution and is made into the uniform solution that mass concentration is 5mg/mL; Mix above-mentioned two kinds of uniform solution by mixed solution cumulative volume 200mL, water soluble starch particle with liposoluble active ingredients weight proportion 200:1, constantly stir isothermal reaction 5 min at 70 DEG C simultaneously; Be placed in sonication device, control power is 600W, at 0 DEG C, process 20min; Centrifugal treating, carries out vacuum drying treatment by obtained supernatant, namely obtains the liposoluble active ingredients-amylum grain compound with good solubility.Mean particle size 100.5 nm in liposoluble active ingredients-amylum grain compound measured by employing Zetasizer Nano ZS nano-particle size analysis instrument, liposoluble active ingredients solubility is in aqueous increased to 1452.1 μ g/mL from 18.5 μ g/mL simultaneously, improve about 78.5 times, in Caco-2 cell model, film infiltration coefficient is from 0.43 × 10
-6cm/s is increased to 8.65 × 10
-6cm/s, improves about 20.1 times.
Embodiment 2
By water soluble starch particle (molecular weight 1.0 × 10
8g/mol, molecular density 7.1%, average chain length DP11.8, mean particle size 98.6nm) sodium-acetate buffer that is dissolved in pH7.0,0.1mol/L is made into the uniform solution that mass concentration is 30%; Co-Q10 is dissolved in ethanolic solution and is made into the uniform solution that mass concentration is 300 mg/mL; Mix above-mentioned two kinds of uniform solution by mixed solution cumulative volume 200mL, water soluble starch particle with liposoluble active ingredients weight proportion 2:1, constantly stir isothermal reaction 120 min at 30 DEG C simultaneously; Be placed in sonication device, control power is 200W, at 10 DEG C, process 2min; Centrifugal treating, carries out vacuum drying treatment by obtained supernatant, namely obtains the liposoluble active ingredients-amylum grain compound with good solubility.Granular size 134.6 nm in liposoluble active ingredients-amylum grain compound measured by employing Zetasizer Nano ZS nano-particle size analysis instrument, liposoluble active ingredients solubility is in aqueous increased to 1148.6 μ g/mL from 42.7 μ g/mL simultaneously, improve about 26.9 times, in Caco-2 cell model, film infiltration coefficient is from 0.85 × 10
-6cm/s is increased to 5.01 × 10
-6cm/s, improves about 5.9 times.
Concrete case study on implementation described herein only illustrates as to the present invention's spirit and part Experiment.Those skilled in the art in the invention can make various amendment or supplement or adopt similar mode to substitute to described concrete case study on implementation, but can't depart from spirit of the present invention or surmount the scope that appended claims defines.
Claims (6)
1. one kind is improved the processing method of liposoluble active ingredients solubility and bioavilability, it is characterized in that with water soluble starch particle for carrier, nanoscale liposoluble active ingredients-amylum grain compound is prepared by nanometer suspension technology, thus improve the water-soluble of liposoluble active ingredients and absorb effect, in turn include the following steps:
(1) water soluble starch particle is dissolved in the sodium-acetate buffer of pH7.0,0.1mol/L, is made into the uniform solution that mass concentration is 5%-30%;
(2) liposoluble active ingredients is dissolved in ethanolic solution, is made into the uniform solution that mass concentration is 5-300 mg/mL;
(3) utilize above-mentioned two kinds of uniform solution composite to carry out by mixed solution cumulative volume 200mL, water soluble starch particle and liposoluble active ingredients weight proportion 2:1-200:1, constantly stir isothermal reaction 5-120 min at 30-70 DEG C simultaneously;
(4) be placed in sonication device, control power is 200-600W, at 0-10 DEG C, process 2-20min;
(5) centrifugal treating, carries out vacuum drying treatment by obtained supernatant, namely obtains the liposoluble active ingredients-amylum grain compound with good solubility and bioavilability.
2. the processing method of raising liposoluble active ingredients solubility according to claim 1 and bioavilability, is characterized in that: the molecular weight 10 of water soluble starch particle
7-10
8g/mol, molecular density 7%-10%, average chain length DP 10-12, mean particle size 30-100 nm.
3. the processing method of raising liposoluble active ingredients solubility according to claim 1 and bioavilability, it is characterized in that: liposoluble active ingredients comprises carotenoids compound, flavonoids, as beta carotene, resveratrol, Co-Q10, lutein, lycopene, curcumin, Quercetin, capsicim.
4. the processing method of raising liposoluble active ingredients solubility according to claim 1 and bioavilability, is characterized in that liposoluble active ingredients-amylum grain compound mean particle size is 30-150 nm.
5. the processing method of raising liposoluble active ingredients solubility according to claim 1 and bioavilability, is characterized in that liposoluble active ingredients solubility in aqueous improves 20-150 doubly.
6. the processing method of raising liposoluble active ingredients solubility according to claim 1 and bioavilability, is characterized in that the cell membrane permeability of liposoluble active ingredients improves more than 5 times.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410823533.XA CN104473168A (en) | 2014-12-26 | 2014-12-26 | Processing method for increasing solubility and bioavailability of fat-soluble active component |
| PCT/CN2014/095850 WO2016101317A1 (en) | 2014-12-26 | 2014-12-31 | Processing method for increasing solubility and bioavailability of fat-soluble active component |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410823533.XA CN104473168A (en) | 2014-12-26 | 2014-12-26 | Processing method for increasing solubility and bioavailability of fat-soluble active component |
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| CN104473168A true CN104473168A (en) | 2015-04-01 |
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| WO (1) | WO2016101317A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111449248A (en) * | 2019-11-25 | 2020-07-28 | 郑州轻工业大学 | Granular starch lipid complex with low glycemic index and preparation method thereof |
| CN111493323A (en) * | 2020-04-16 | 2020-08-07 | 江南大学 | Preparation method of fat-soluble vitamin particles for beverage |
| CN114041598A (en) * | 2021-11-26 | 2022-02-15 | 江南大学 | Processing method for improving quality and enhancing efficiency of fat-soluble plant compound and application |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112906821B (en) * | 2021-03-24 | 2023-09-01 | 中国科学院古脊椎动物与古人类研究所 | Starch grain species identification method and device and electronic equipment |
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- 2014-12-26 CN CN201410823533.XA patent/CN104473168A/en active Pending
- 2014-12-31 WO PCT/CN2014/095850 patent/WO2016101317A1/en active Application Filing
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| CN114041598A (en) * | 2021-11-26 | 2022-02-15 | 江南大学 | Processing method for improving quality and enhancing efficiency of fat-soluble plant compound and application |
| CN114041598B (en) * | 2021-11-26 | 2023-03-28 | 江南大学 | Processing method for improving quality and enhancing efficiency of fat-soluble plant compound and application |
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| WO2016101317A1 (en) | 2016-06-30 |
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