CN104472500A - Pesticide composition containing benzenecarbothioamide and triazole fungicide - Google Patents

Abstract

The invention discloses a pesticide composition containing benzenecarbothioamide and a triazole fungicide and relates to the technical field of pesticides. The pesticide composition disclosed by the invention consists of benzenecarbothioamide and the triazole fungicide, wherein the benzenecarbothioamide is 3-bromo-N-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-yl)-1H-pyrazol-5-formamide and the triazole fungicide is any one of hexaconazole, flutriafol, tebuconazole, difenoconazole and epoxiconazole and the mass ratio of the benzenecarbothioamide to the triazole fungicide is 100: 1 to 1: 100. The pesticide composition and a pesticide preparation thereof have an obvious synergistic effect compared with that of a single dosage and can be used for effectively preventing and treating crop diseases and pests, so that the dosage of pesticides is reduced and the preventing and treating costs are lowered, and the drug resistance of plant diseases and insect pests on the pesticide composition can be further delayed while the insecticidal and bactericidal activities are improved.

Description

Containing the composition pesticide of thiobenzamide and triazole bactericidal agent

Technical field

The present invention relates to technical field of pesticide, especially relate to the composition pesticide of insecticide and fungicide compounding, specifically relate to a kind of composition pesticide containing thiobenzamide and triazole bactericidal agent.

Background technology

In recent years, along with the development of scale of agricultural production and the expansion gradually of Greenhouse area, continuous cropping and continuous cropping cropping pattern more and more general.Crops also there occurs disease while generation insect pest, but at present when preventing and treating these damage by disease and insect, peasant household is that not only do not reach synergistic effect, easily play antagonism on the contrary, drug effect declines by insecticide and bactericide at will existing mixed existing use.This unscientific medication, cause again medicament using dosage to increase, cause the waste of medicament, the residue of pesticide on crops exceed standard, and are unfavorable for the protection of environment.For this reason, need the more compound synergics of exploitation, can desinsection again can the combination medicament of sterilization.

Chinese invention patent CN103109816A discloses thiobenzamide compounds and application thereof, and the general structure 1 of thiobenzamide compounds is:

Have the thiobenzamide compounds of above-mentioned general formula 1, not only have high activity to lepidoptera pest, and also have beyond thought high activity to sucking pest (as rice fulgorid), this compounds has well double controlling and acts on and comprehensive function.The applicant is chlorine according to the preferred R1 of general formula 1, and R2 is methyl, and with reference to the method in Chinese patent CN103109816A, synthesize Compound I of the present invention (hereinafter referred to as thiobenzamide), structural formula is as follows:

Although Compound I (i.e. thiobenzamide) is also the same with thiobenzamide compounds have outstanding insecticidal effect.But its long-term single use, easily develops immunity to drugs, insecticidal activity declines.Find through lot of experiments, thiobenzamide and triazole bactericidal agent are composite, not only play synergistic effect, and also delay the pesticide resistance of damage by disease and insect to thiobenzamide and triazole bactericidal agent, raising control efficiency; Extend the service life of two kinds of medicaments simultaneously, reduce the development cost of new medicament.

Up to now, there is not yet thiobenzamide and the composite relevant report of triazole bactericidal agent agent.

Summary of the invention

The object of the invention is to: for above-mentioned Problems existing, provide a kind of by thiobenzamide and composite composition pesticide, its pesticidal preparations of triazole bactericidal agent and apply.This composition pesticide and pesticidal preparations thereof have obvious synergistic effect relative to single dose, can effectively preventing diseases and pests of agronomic crop, reduce the using dosage of agricultural chemicals, reduce cost accounting, while raising bactericidal and insecticidal activity, also delay the pesticide resistance of damage by disease and insect to composition pesticide.

For realizing above-mentioned object, technical scheme of the present invention is:

Containing the composition pesticide of thiobenzamide and triazole bactericidal agent; be made up of thiobenzamide and triazole bactericidal agent; wherein; thiobenzamide is the bromo-N-of 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide; in order to ensure that composition pesticide has better control efficiency and synergistic effect, the weight ratio of thiobenzamide and triazole bactericidal agent is 100:1 ~ 1:100.

Preferably, the weight ratio of described thiobenzamide and triazole bactericidal agent is 40:1 ~ 1:40.

Further preferably, the weight ratio of described thiobenzamide and triazole bactericidal agent is 20:1 ~ 1:20.

In the present invention, the structural formula of described thiobenzamide is as follows:

Triazole bactericidal agent is organic heterocyclic compounds; the feature such as there is efficient, wide spectrum, low-residual, the lasting period is long, interior absorption is strong; have protection concurrently, treat, root out and fumigation action, apart from outside significant preventing disease theraping effect, triazole type medicament also has stronger regulating action to the growth of plant.The preferred triazole bactericidal agent of the present invention is the one in Flutriafol, Tebuconazole, own azoles alcohol, Difenoconazole, epoxiconazole.Further preferably, triazole bactericidal agent is selected oneself the one in azoles alcohol, Flutriafol, Tebuconazole.

Flutriafol (flutriafol), chemical name is α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol, it has the bactericidal activity of wide spectrum, its mechanism of action and feature are the biosynthesis of Antifungi cell ergosterol, thus cause the growth of cell wall rupture and suppression mycelia.

Tebuconazole (tebuconazole): CAS 107534-96-3; chemical name is RS)-1-(4-chlorphenyl)-4; 4-dimethyl-3-(1H-1; 2; 4 triazol-1-yl methyl) penta-3-alcohol; be a kind of efficient, wide spectrum, interior absorption triazole bactericidal agent, have protection, treat, root out three zones, fungicidal spectrum is wide, the lasting period is long.

Own azoles alcohol (hexaconazole): CAS 79983-71-4; chemical name is (RS)-2-(2; 4-dichlorophenyl)-1-(1H-1; 2; 4-triazol-1-yl)-oneself-2-alcohol, the disease caused fungi especially Basidiomycota and Ascomycota has protection and the therapeutic action of broad spectrum activity.

Difenoconazole (difenoconazole): CAS 119446-68-3; chemical name is suitable; the chloro-4-of trans-3-[4-methyl-2-1H-1; 2; 4-triazol-1-yl methyl)-1; 3-bis-mute pentane-2-base) phenyl 4-chlorphenyl ether, interior absorption sterilization, tool protection and therapeutic action.

Epoxiconazole (epoxiconazole): CAS 106325-08-0; chemical name is (2RS; 3RS)-1-[3-(2 monochloro-benzene base)-2; 3 one epoxy-2-(4 phenyl-monofluoride base) propyl group] one 1 hydrogen 1; 2; 4 one triazoles, the triazole bactericidal agent developed by BASF Aktiengesellschaft, has protection and therapeutic action concurrently.

The present invention also provides a kind of pesticidal preparations preventing and treating agricultural pest, and be made up of the above-mentioned composition pesticide containing thiobenzamide and triazole bactericidal agent and auxiliary material, wherein, described composition pesticide accounts for 0.1% ~ 80% of described pesticidal preparations gross weight.Further preferably, above-mentioned composition pesticide accounts for 1% ~ 50% of pesticidal preparations gross weight.

Above-mentioned auxiliary material is the mixture of a kind of and auxiliary agent in solid carrier or liquid-carrier.Any carrier and the auxiliary agent that are generally used for composition pesticide all can use.

Solid carrier comprises one or more in fused calcium magnesium phosphate, potassium chloride, chitin, urea, ammonium sulfate, diammonium phosphate, sodium silicate, superphosphate, humic acid, ammonium chloride, zinc sulphate, borax, montmorillonite, white carbon, precipitated calcium carbonate, diatomite, kaolin, bentonite.

Liquid-carrier comprises one or more in water, 1-METHYLPYRROLIDONE, trimethylbenzene, two wires oil, methyl naphthalene, methyl oleate, C10 aromatic hydrocarbons, dimethyl formamide, vegetable oil, cyclohexanone.

Above-mentioned auxiliary agent comprises surfactant, wetting dispersing agent, also can add one or more in other conventional functionality auxiliary agents such as antifreezing agent, thickener, defoamer, disintegrant, film forming agent if desired.

Wetting dispersing agent comprises NNO, lauryl sodium sulfate, neopelex, sodium lignin sulfonate, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid, pull open in powder, alkylbenzenesulfonate, calcium dodecyl benzene sulfonate, naphthalenesulfonate formaldehyde condensation compound, alkylphenol polyoxyethylene phosphate, polymeric polycarboxylic acid salt, alkyl benzene sulfonate calcium salt, polycarboxylate, alkylnaphthalene sulfonate, aliphatic amine polyoxyethylene ether, naphthalene sulfonic acid-formaldehyde condensation product sodium salt one or more.

Surfactant comprises one or more in alkylphenol polyoxyethylene, calcium dodecyl benzene sulfonate, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene, phenethyl phenol polyethenoxy ether, alkylaryl polyoxyethylene polyoxypropylene ether, styrylphenol polyoxyethylene ether, fatty alcohol-polyoxyethylene ether.

Film forming agent comprises carboxymethyl cellulose or methylcellulose.Antifreezing agent comprises one or more in glycerine, propane diols, urea, ethylene glycol, isopropyl alcohol.Binding agent comprises one or more in starch, sucrose, methylcellulose, ethyl cellulose, polyvinyl alcohol.Disintegrant comprises sodium carbonate or sodium sulphate.Thickener comprises one or more in xanthans, polyvinyl alcohol, aluminium-magnesium silicate, gum Arabic.Defoamer is organosilicon.Warning colouration is famille rose, acid red or magenta.

Pesticidal preparations of the present invention can be mixed with granule, seed treatment formulations, ultra low volume liquids, water dispersible granules, wetting powder or suspending agent according to the method that this area is general.Wherein as preferred, the embodiment of seed treatment formulations provided by the invention is seed treatment dry powder doses, suspension seed-coating agent, seed treatment microcapsule suspending agent.

Composition pesticide of the present invention and pesticidal preparations can be used by commonsense method, as spraying cauline leaf process, also can soil treatment, and such as solid root spreads fertilizer over the fields or liquid fills with root, can also dress seed, to soak seed or seed pelleting uses.

The present invention also provides above-mentioned and contains the composition pesticide of thiobenzamide and triazole bactericidal agent and above-mentioned a kind of application preventing and treating the pesticidal preparations of agricultural pest, namely its application in controlling crop diseases and insect pests is referred to, as insects such as the aphids on water rice hopper, wheat midge, various crop, the various diseases on the crop such as wheat sharp eyespot, rice sheath blight disease also can be prevented and treated.

Owing to adopting technique scheme, beneficial effect of the present invention is:

1, composition pesticide of the present invention and pesticidal preparations thereof have obvious synergistic function, and it not is simple superposition that thiobenzamide and triazole bactericidal agent combine.Toxicity Determination shows, their mixture co-toxicity coefficients in certain proportion are greater than 120.Equally, field medicine effect test result also shows, when active ingredient dosage is fewer than single dose, the control efficiency of control wheat sharp eyespot, wheat midge, rice sheath blight disease is higher than single dose, improve control efficiency, decrease dosage, decrease the harmful effect of using ecology of agricultural chemicals, also reduce drug cost.

2, composition pesticide of the present invention, thiobenzamide is different from the triazole bactericidal agent mechanism of action, complementation is played after composite, overcome the shortcoming that long-term single use easily produces resistance, slow down the pesticide resistance of damage by disease and insect to these two kinds of medicaments, extend service life of medicament, play not only can desinsection but also can cure the disease simultaneously, strong adaptability.

Embodiment

Below by embodiment, the invention will be further described.It should be noted that, the embodiment of the present invention is only used for the present invention is described, instead of limitation of the present invention.Thiobenzamide in following embodiment all refers to the material of its chemistry bromo-N-of 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide by name; the former medicine of the thiobenzamide used is synthesized by laboratory, and other former medicines used and preparation are commercial.

For determining thiobenzamide and the composite synergistic effect of triazole bactericidal agent, the applicant's used these two kinds of compositions to carry out control wheat sharp eyespot and Toxicity Determination of rice sheath blight disease, synergy adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect.

Computational methods are:

The EC50*100 of the EC50/B agent of toxicity index T I (B)=standard agent A

The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A

Theoretical toxicity index TTI (AB)=percentage+T I (B) the * B percentage in mixture of TI (A) * A in mixture

Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100

In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B

Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TT I) of mixture actual measurement toxicity index (ATI)/mixture] × 100

Evaluation criterion is: co-toxicity coefficient >=120 show as synergistic effect; Co-toxicity coefficient≤80 show as antagonism; 80< co-toxicity coefficient <120 shows as summation action.

Toxicity Determination embodiment one: thiobenzamide is tested with own azoles alcohol, the composite Toxicity Determination to rice sheath blight disease of Flutriafol respectively.

Test method: " NYT 1156.5-2006 farm-chemical indoor determination test rule bactericide the 5th part: suppress Rhizoctonia solani Kuhn test Broad Bean Leaves method ".And press Sun Yun abundant method calculating co-toxicity coefficient, the results are shown in Table 1 ~ table 2.

Table 1 thiobenzamide and the composite Toxicity Determination result to rice sheath blight disease of own azoles alcohol

Medicament	EC50(mg/L)	Actual measurement toxicity index	Theoretical malicious index	Co-toxicity coefficient
					Thiobenzamide (A)	211.85	0.06	/	/
Own azoles alcohol (B)	0.12	100.00	/	/
					A:B＝1:110	0.108	111.11	99.10	112.1
A:B＝1:100	0.095	126.32	99.01	127.6
					A:B＝1:90	0.089	134.83	98.90	136.3
A:B＝1:80	0.088	136.36	98.77	138.1
					A:B＝1:70	0.085	141.18	98.59	143.2
A:B＝1:60	0.081	148.15	98.36	150.6
					A:B＝1:50	0.077	155.84	98.04	159.0
A:B＝1:40	0.071	169.01	97.56	173.2
					A:B＝1:30	0.073	164.38	96.78	169.9
A:B＝1:20	0.07	171.43	95.24	180.0
					A:B＝1:10	0.068	176.47	90.91	194.1
A:B＝1:5	0.071	169.01	83.34	202.8
					A:B＝1:3	0.083	144.58	75.01	192.7
A:B＝1:1	0.136	88.24	50.03	176.4
					A:B＝3:1	0.274	43.80	25.04	174.9
A:B＝5:1	0.417	28.78	16.71	172.2

A:B＝10:1	0.75	16.00	9.14	175.0
					A:B＝20:1	1.51	7.95	4.82	165.0
A:B＝30:1	2.24	5.36	3.28	163.3
					A:B＝40:1	2.92	4.11	2.49	164.8
A:B＝50:1	3.75	3.20	2.02	158.7
					A:B＝60:1	4.86	2.47	1.70	145.7
A:B＝70:1	5.75	2.09	1.46	142.5
					A:B＝80:1	6.26	1.92	1.29	148.5
A:B＝90:1	7.63	1.57	1.15	136.2
					A:B＝100:1	9.33	1.29	1.05	122.9
A:B＝110:1	12.48	0.96	0.96	100.5

From result of the test table 1: thiobenzamide and own azoles alcohol are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of rice sheath blight disease, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 160, shows that synergistic effect is very remarkable.

Table 2 thiobenzamide and the composite indoor joint toxicity measuring result to rice sheath blight disease of Flutriafol

Medicament	EC50(mg/L)	Actual measurement toxicity index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	218.46	1.68	/	/
Flutriafol (C)	3.68	100.00	/	/
					A:C＝1:110	3.14	117.20	99.11	118.2
A:C＝1:100	2.95	124.75	99.03	126.0
					A:C＝1:90	2.71	135.79	98.92	137.3
A:C＝1:80	2.58	142.64	98.79	144.4
					A:C＝1:70	2.55	144.31	98.62	146.3
A:C＝1:60	2.48	148.39	98.39	150.8
					A:C＝1:50	2.34	157.26	98.07	160.4
A:C＝1:40	2.29	160.70	97.60	164.6
					A:C＝1:30	2.24	164.29	96.83	169.7
A:C＝1:20	2.17	169.59	95.32	177.9
					A:C＝1:10	2.1	175.24	91.06	192.4
A:C＝1:5	2.36	155.93	83.61	186.5
					A:C＝1:2	3.05	120.66	67.23	179.5
A:C＝1:1	3.98	92.46	50.84	181.9
					A:C＝5:1	11.17	32.95	18.07	182.3
A:C＝10:1	19.7	18.68	10.62	175.9
					A:C＝20:1	33.56	10.97	6.37	172.2
A:C＝30:1	46.05	7.99	4.86	164.6
					A:C＝40:1	54.08	6.80	4.08	166.7
A:C＝50:1	65.75	5.60	3.61	154.9
					A:C＝60:1	75.86	4.85	3.30	147.2
A:C＝70:1	84.34	4.36	3.07	142.2
					A:C＝80:1	85.26	4.32	2.90	148.9

A:C＝90:1	97.63	3.77	2.76	136.3
					A:C＝100:1	112.33	3.28	2.66	123.3
A:C＝110:1	128.48	2.86	2.57	111.4

Result of the test from table 2: thiobenzamide and Flutriafol are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of rice sheath blight disease, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 164, shows that synergistic effect is very remarkable.

Toxicity Determination embodiment two: thiobenzamide is tested with Tebuconazole, Difenoconazole, the composite Toxicity Determination to wheat sharp eyespot of epoxiconazole respectively.

Test method: adopt mycelial growth rate method to measure, thiobenzamide and triazole bactericidal agent are diluted to respectively the liquid of variable concentrations with sterile water, join in the PDA medium after thawing in proportion, make the flat board containing variable concentrations bactericide, by prior cultured wheat sharp eyespot germ bacterium cake (7mm is placed in dull and stereotyped central authorities), on the basis of preliminary experiment, every medicament arranges several variable concentrations gradient, often process and repeat for 4 times, with the culture medium flat plate of not pastille for contrast.Postvaccinal culture dish is placed in 25 DEG C and cultivates 4d, then measure colony diameter, calculate the mycelial growth inhibition rate of each process thus.And press Sun Yun abundant method calculating co-toxicity coefficient.The results are shown in Table 3 ~ table 5.

Table 3 thiobenzamide and the composite indoor joint toxicity measuring result to wheat sharp eyespot of Tebuconazole

Medicament	EC50(mg/L)	Actual measurement toxicity index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	215.58	0.40	/	/
Tebuconazole (D)	0.86	100.00	/	/
					A:D＝1:110	0.75	114.67	99.10	115.7
A:D＝1:100	0.67	128.36	99.01	129.6
					A:D＝1:90	0.63	136.51	98.91	138.0
A:D＝1:80	0.61	140.98	98.77	142.7
					A:D＝1:70	0.58	148.28	98.60	150.4
A:D＝1:60	0.57	150.88	98.37	153.4
					A:D＝1:50	0.57	150.88	98.05	153.9
A:D＝1:40	0.53	162.26	97.57	166.3
					A:D＝1:30	0.52	165.38	96.79	170.9
A:D＝1:20	0.5	172.00	95.26	180.6
					A:D＝1:10	0.48	179.17	90.95	197.0
A:D＝1:4	0.57	150.88	80.08	188.4
					A:D＝1:1	0.95	90.53	50.20	180.3
A:D＝4:1	2.28	37.72	20.32	185.6

A:D＝10:1	5.16	16.67	9.45	176.3
					A:D＝20:1	9.39	9.16	5.14	178.1
A:D＝30:1	14.45	5.95	3.61	164.8
					A:D＝40:1	17.95	4.79	2.83	169.4
A:D＝50:1	23.81	3.61	2.35	153.6
					A:D＝60:1	26.86	3.20	2.03	157.6
A:D＝70:1	30.55	2.82	1.80	156.2
					A:D＝80:1	35.47	2.42	1.63	148.9
A:D＝90:1	39.82	2.16	1.49	144.6
					A:D＝100:1	45.28	1.90	1.39	137.1
A:D＝110:1	58.64	1.47	1.30	113.1

From result of the test table 3: thiobenzamide and Tebuconazole are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat sharp eyespot, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 164, shows that synergistic effect is very remarkable.

Table 4 thiobenzamide and the composite indoor joint toxicity measuring result to wheat sharp eyespot of epoxiconazole

Medicament	EC50(mg/L)	Actual measurement toxicity index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	213.66	0.44	/	/
Epoxiconazole (E)	0.93	100.00	/	/
					A:E＝1:110	0.91	102.20	99.10	103.1
A:E＝1:100	0.76	122.37	99.01	123.6
					A:E＝1:90	0.67	138.81	98.91	140.3
A:E＝1:80	0.62	150.00	98.77	151.9
					A:E＝1:70	0.59	157.63	98.60	159.9
A:E＝1:60	0.60	155.00	98.37	157.6
					A:E＝1:50	0.63	147.62	98.05	150.6
A:E＝1:40	0.54	172.22	97.57	176.5
					A:E＝1:30	0.51	182.35	96.79	188.4
A:E＝1:20	0.51	182.35	95.26	191.4
					A:E＝1:9	0.49	189.80	90.04	210.8
A:E＝1:4	0.59	157.63	80.09	196.8
					A:E＝1:1	0.98	94.90	50.22	189.0
A:E＝4:1	2.39	38.91	20.35	191.2
					A:E＝9:1	5.18	17.95	10.39	172.8
A:E＝20:1	10.21	9.11	5.18	176.0
					A:E＝30:1	14.38	6.47	3.65	177.3
A:E＝40:1	18.74	4.96	2.86	173.3
					A:E＝50:1	25.85	3.60	2.39	150.7
A:E＝60:1	28.92	3.22	2.07	155.5
					A:E＝70:1	34.46	2.70	1.84	146.9
A:E＝80:1	38.54	2.41	1.66	145.0
					A:E＝90:1	43.8	2.12	1.53	138.8

A:E＝100:1	48.19	1.93	1.42	135.8
					A:E＝110:1	61.34	1.52	1.33	113.8

From result of the test table 4: thiobenzamide and epoxiconazole are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat sharp eyespot, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 170, shows that synergistic effect is very remarkable.

Table 5 thiobenzamide and the composite indoor joint toxicity measuring result to wheat sharp eyespot of Difenoconazole

Medicament	EC50(mg/L)	Actual measurement toxicity index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	216.23	0.86	/	/
Difenoconazole (F)	1.85	100.00	/	/
					A:F＝1:110	1.76	105.11	99.11	106.1
A:F＝1:100	1.44	128.47	99.02	129.7
					A:F＝1:90	1.41	131.21	98.91	132.7
A:F＝1:80	1.35	137.04	98.78	138.7
					A:F＝1:70	1.27	145.67	98.60	147.7
A:F＝1:60	1.21	152.89	98.37	155.4
					A:F＝1:50	1.19	155.46	98.06	158.5
A:F＝1:40	1.12	165.18	97.58	169.3
					A:F＝1:30	1.04	177.88	96.80	183.8
A:F＝1:20	1.07	172.90	95.28	181.5
					A:F＝1:10	1.08	171.30	90.99	188.3
A:F＝1:4	1.21	152.89	80.17	190.7
					A:F＝1:1	1.98	93.43	50.43	185.3
A:F＝4:1	4.56	40.57	20.68	196.1
					A:F＝10:1	9.6	19.27	9.87	195.3
A:F＝20:1	18.35	10.08	5.58	180.8
					A:F＝30:1	27.14	6.82	4.05	168.2
A:F＝40:1	33.87	5.46	3.27	166.8
					A:F＝50:1	41.7	4.44	2.80	158.5
A:F＝60:1	46.3	4.00	2.48	161.1
					A:F＝70:1	55.64	3.32	2.25	147.6
A:F＝80:1	65.21	2.84	2.08	136.4
					A:F＝90:1	70.8	2.61	1.95	134.3
A:F＝100:1	81.14	2.28	1.84	124.1
					A:F＝110:1	98.07	1.89	1.75	107.9

From result of the test table 5: thiobenzamide and Difenoconazole are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat sharp eyespot, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 166, shows that synergistic effect is very remarkable.

Indoor bioassay test example three: thiobenzamide respectively with own azoles alcohol, Flutriafol, Tebuconazole, the composite indoor joint toxicity measuring to wheat midge of epoxiconazole.Synergy adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect.

Computational methods are:

Actual measurement toxicity index (ATI)=(standard agent LC50/ reagent agent LC50) × 100

In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B

Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TT I) of mixture actual measurement toxicity index (AT I)/mixture] × 100

Evaluation criterion: when CTC≤80, then composition shows as antagonism, and as 80 < CTC < 120, then composition shows as summation action, and when CTC >=120, then composition shows as synergistic effect.

Test method: adopt infusion process to measure, medicament acetone diluted is become variable concentrations, the midge worm larva that picking is neat, physiological status is consistent is tested, take out after being flooded 30s in the funnel that examination worm is made at the filter paper that medicament is housed, suck unnecessary liquid with blotting paper, put into the insect box that wetting filter paper is housed.Use clear water and cosolvent respectively in contrast.Often process test and be no less than 60, repeat 3 times.Insect box being placed in temperature is 20 DEG C, and relative air humidity is in the temperature of about 80%.After 3d and 5d, the death condition of checkout facility, and calculate corrected mortality, death standard shrinks with polypide or can not normally creep.Adopt the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluate mixed effect.

Table 6 thiobenzamide and the composite joint toxicity measuring result to wheat midge of own azoles alcohol

Medicament	LC50(mg/L)	Actual measurement toxicity index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	8.43	100.00	/	/
Own azoles alcohol (B)	184.67	4.56	/	/
					A:B＝110:1	8.21	102.68	99.14	103.6
A:B＝100:1	6.84	123.25	99.06	124.4
					A:B＝90:1	6.53	129.10	98.95	130.5
A:B＝80:1	6.22	135.53	98.82	137.1
					A:B＝70:1	6.05	139.34	98.66	141.2
A:B＝60:1	5.89	143.12	98.44	145.4

A:B＝50:1	5.78	145.85	98.13	148.6
					A:B＝40:1	5.54	152.17	97.67	155.8
A:B＝30:1	5.35	157.57	96.92	162.6
					A:B＝20:1	5.08	165.94	95.46	173.8
A:B＝9:1	4.76	177.10	90.46	195.8
					A:B＝5:1	5.24	160.88	84.09	191.3
A:B＝2:1	6.58	128.12	68.19	187.9
					A:B＝1:1	9.12	92.43	52.28	176.8
A:B＝1:4	21.25	39.67	23.65	167.7
					A:B＝1:9	36.68	22.98	14.11	162.9
A:B＝1:20	57.45	14.67	9.11	161.1
					A:B＝1:30	70.39	11.98	7.64	156.7
A:B＝1:40	79.54	10.60	6.89	153.8
					A:B＝1:50	88.68	9.51	6.44	147.7
A:B＝1:60	94.62	8.91	6.13	145.4
					A:B＝1:70	102.38	8.23	5.91	139.3
A:B＝1:80	110.58	7.62	5.74	132.7
					A:B＝1:90	118.73	7.10	5.61	126.5
A:B＝1:100	125.18	6.73	5.51	122.2

From result of the test table 6: thiobenzamide and own azoles alcohol are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat midge, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 150, shows that synergistic effect is very remarkable.

Table 7 thiobenzamide and the composite joint toxicity measuring result to wheat midge of Flutriafol

Medicament	LC50(mg/L)	Survey malicious index	Theoretical malicious index	Co-toxicity coefficient
					Thiobenzamide (A)	8.6	100.00	/	/
Flutriafol (C)	176.58	4.87	/	/
					A:C＝110:1	8.34	103.12	99.14	104.0
A:C＝100:1	6.72	127.98	99.06	129.2
					A:C＝90:1	6.47	132.92	98.95	134.3
A:C＝80:1	6.18	139.16	98.83	140.8
					A:C＝70:1	6.01	143.09	98.66	145.0
A:C＝60:1	5.83	147.51	98.44	149.8
					A:C＝50:1	5.95	144.54	98.13	147.3
A:C＝40:1	5.51	156.08	97.68	159.8
					A:C＝30:1	5.32	161.65	96.93	166.8
A:C＝20:1	5.04	170.63	95.47	178.7
					A:C＝10:1	4.81	178.79	91.35	195.7
A:C＝5:1	5.18	166.02	84.15	197.3
					A:C＝3:1	6.14	140.07	76.22	183.8
A:C＝1:1	9.08	94.71	52.44	180.6
					A:C＝1:5	24.16	35.60	20.73	171.8

A:C＝1:10	38.62	22.27	13.52	164.7
					A:C＝1:20	57.37	14.99	9.40	159.5
A:C＝1:30	69.23	12.42	7.94	156.5
					A:C＝1:40	77.56	11.09	7.19	154.2
A:C＝1:50	85.56	10.05	6.74	149.2
					A:C＝1:60	92.47	9.30	6.43	144.6
A:C＝1:70	100.11	8.59	6.21	138.3
					A:C＝1:80	105.24	8.17	6.04	135.2
A:C＝1:90	112.34	7.66	5.92	129.4
					A:C＝1:100	119.38	7.20	5.81	123.9
A:C＝1:110	134.45	6.40	5.73	111.7

From result of the test table 7: thiobenzamide and Flutriafol are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat midge, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 154, shows that synergistic effect is very remarkable.

Table 8 thiobenzamide and the composite joint toxicity measuring result to wheat midge of Tebuconazole

Medicament	LC50(mg/L)	Survey malicious index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	8.26	100.00	/	/
Tebuconazole (D)	198.52	4.16	/	/
					A:D＝110:1	7.16	115.36	99.14	116.4
A:D＝100:1	6.85	120.58	99.05	121.7
					A:D＝90:1	6.56	125.91	98.95	127.3
A:D＝80:1	6.43	128.46	98.82	130.0
					A:D＝70:1	6.37	129.67	98.65	131.4
A:D＝60:1	6.12	134.97	98.43	137.1
					A:D＝50:1	5.93	139.29	98.12	142.0
A:D＝40:1	5.62	146.98	97.66	150.5
					A:D＝30:1	5.45	151.56	96.91	156.4
A:D＝20:1	5.31	155.56	95.44	163.0
					A:D＝10:1	4.75	173.89	91.29	190.5
A:D＝3:1	6.36	129.87	76.04	170.8
					A:D＝1:1	9.25	89.30	52.08	171.5
A:D＝1:3	16.83	49.08	28.12	174.5
					A:D＝1:10	38.84	21.27	12.87	165.2
A:D＝1:20	57.51	14.36	8.72	164.6
					A:D＝1:30	71.36	11.58	7.25	159.6
A:D＝1:40	82.45	10.02	6.50	154.2
					A:D＝1:50	93.78	8.81	6.04	145.8
A:D＝1:60	102.36	8.07	5.73	140.8
					A:D＝1:70	108.75	7.60	5.51	137.8
A:D＝1:80	112.68	7.33	5.34	137.2
					A:D＝1:90	126.59	6.53	5.21	125.1

A:D＝1:100	131.94	6.26	5.11	122.5
					A:D＝1:110	145.76	5.67	5.02	112.8

From result of the test table 8: thiobenzamide and Tebuconazole are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat midge, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 150, shows that synergistic effect is very remarkable.

Table 9 thiobenzamide and the composite joint toxicity measuring result to wheat midge of epoxiconazole

Medicament	LC50(mg/L)	Actual measurement toxicity index	Theoretical toxicity index	Co-toxicity coefficient
					Thiobenzamide (A)	8.38	100.00	/	/
Epoxiconazole (E)	205.47	4.08	/	/
					A:E＝110:1	8.25	101.58	99.14	102.5
A:E＝100:1	6.57	127.55	99.05	128.8
					A:E＝90:1	6.54	128.13	98.95	129.5
A:E＝80:1	6.26	133.87	98.82	135.5
					A:E＝70:1	5.93	141.32	98.65	143.3
A:E＝60:1	6.11	137.15	98.43	139.3
					A:E＝50:1	5.78	144.98	98.12	147.8
A:E＝40:1	5.25	159.62	97.66	163.4
					A:E＝30:1	4.96	168.95	96.91	174.3
A:E＝20:1	4.47	187.47	95.43	196.4
					A:E＝10:1	5.13	163.35	91.28	179.0
A:E＝9:1	5.4	155.19	90.41	171.7
					A:E＝4:1	6.14	136.48	80.82	168.9
A:E＝1:1	9.64	86.93	52.04	167.0
					A:E＝1:4	21.28	39.38	23.26	169.3
A:E＝1:10	39.26	21.34	12.80	166.8
					A:E＝1:20	59.73	14.03	8.65	162.3
A:E＝1:30	71.41	11.74	7.17	163.6
					A:E＝1:40	80.75	10.38	6.42	161.7
A:E＝1:50	95.47	8.78	5.96	147.3
					A:E＝1:60	105.63	7.93	5.65	140.4
A:E＝1:70	109.28	7.67	5.43	141.2
					A:E＝1:80	114.57	7.31	5.26	139.0
A:E＝1:90	118.64	7.06	5.13	137.6
					A:E＝1:100	131.35	6.38	5.03	126.9
A:E＝1:110	148.76	5.63	4.94	114.0

From result of the test table 9: thiobenzamide and epoxiconazole are all greater than 120 by weight time composite between 100:1 ~ 1:100 to the co-toxicity coefficient of wheat midge, show as synergistic effect.Especially proportioning is within the scope of 40:1 ~ 1:40, and the co-toxicity coefficient of each process is all greater than 161, shows that synergistic effect is very remarkable.

Formulation Example:

Below in conjunction with specific embodiment, the present invention is further described, but does not limit the invention to these embodiments.For the purpose of unification, listed embodiment below, dispersant and emulsifier all adopt abbreviation or commercial disignation; Percentage in formula is all weight percentage; CK1-CK24 is comparative example.

One, the embodiment of granule

Preparation method: thiobenzamide, triazole bactericidal agent, Ricinate, binding agent, carrier are mixed by formula rate, granulation the granule of pesticidal preparations of the present invention.

Embodiment 1 0.4% thiobenzamide own azoles alcohol granule (1:1)

Thiobenzamide 0.2%, own azoles alcohol 0.2%, NNO 2%, lauryl sodium sulfate 1%, fused calcium magnesium phosphate phosphorus 3%, potassium chloride 1%, white carbon 2%, chitin 1.5%, urea supplies 100%.

Embodiment 2 0.1% thiobenzamide own azoles alcohol granule (1:1)

Thiobenzamide 0.05%, own azoles alcohol 0.05%, sodium lignin sulfonate 1.5%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 1%, ammonium sulfate 3%, diammonium phosphate 10%, potassium chloride 10%, starch 1%, urea supplies 100%.

Embodiment 3 5% thiobenzamide own azoles alcohol granule (4:1)

Thiobenzamide 4%, own azoles alcohol 1%, sodium lignin sulfonate 2%, pulls open powder 1.2%, ammonium sulfate 3%, diammonium phosphate 10%, starch 1%, and urea 20%, borax supplies 100%.

CK1:1% thiobenzamide granule: thiobenzamide 1%, NNO 2%, lauryl sodium sulfate 1%, fused calcium magnesium phosphate phosphorus 3%, potassium chloride 1%, white carbon 2%, chitin 1.5%, urea supplies 100%.

CK2:1% own azoles alcohol granule: own azoles alcohol 1%, NNO 2%, lauryl sodium sulfate 1%, fused calcium magnesium phosphate phosphorus 3%, potassium chloride 1%, white carbon 2%, chitin 1.5%, urea supplies 100%.

Embodiment 4 0.3% thiobenzamide Flutriafol granule (1:2)

Thiobenzamide 0.1%, Flutriafol 0.2%, calcium lignosulfonate 1%, pulls open powder 2%, fused calcium magnesium phosphate 3%, ammonium sulfate 3%, diammonium phosphate 6%, white carbon 1.5%, and humic acid 10%, urea supplies 100%.

Embodiment 5 5% thiobenzamide Flutriafol granule (1:1)

Thiobenzamide 2.5%, Flutriafol 2.5%, NNO 3%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 1%, potassium chloride 3%, diammonium phosphate 6%, white carbon 1.5%, montmorillonite supplies 100%.

CK3:1% Flutriafol granule: Flutriafol 1%, NNO 3%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 1%, potassium chloride 3%, diammonium phosphate 6%, white carbon 1.5%, montmorillonite supplies 100%.

Embodiment 6 0.6% thiobenzamide Tebuconazole granule (1:1)

Thiobenzamide 0.3%, Tebuconazole 0.3%, sodium lignin sulfonate 1%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 2%, potassium chloride 3%, ammonium chloride 6%, zinc sulphate 1%, starch 1.5%, urea supplies 100%.

CK4:1% Tebuconazole granule: Tebuconazole 1%, sodium lignin sulfonate 1%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 2%, potassium chloride 3%, ammonium chloride 6%, zinc sulphate 1%, starch 1.5%, urea supplies 100%

Embodiment 7 11% thiobenzamide Tebuconazole granule (1:10)

Thiobenzamide 1%, Tebuconazole 10%, sodium lignin sulfonate 2.5%, alkylbenzenesulfonate 1%, potassium chloride 2.5%, fused calcium magnesium phosphate 3%, diammonium phosphate 2%, white carbon 2%, urea 20%, diatomite supplies 100%.

Embodiment 8 0.5% thiobenzamide Difenoconazole granule (4:1)

Thiobenzamide 0.4%, Difenoconazole 0.1%, sodium lignin sulfonate 2.5%, calcium dodecyl benzene sulfonate 0.5%, potassium chloride 2.5%, fused calcium magnesium phosphate 3%, sodium silicate 1%, sucrose 1%, urea 20%, diatomite supplies 100%.

CK5:1% Difenoconazole granule: Difenoconazole 1%, sodium lignin sulfonate 2.5%, calcium dodecyl benzene sulfonate 0.5%, potassium chloride 2.5%, fused calcium magnesium phosphate 3%, sodium silicate 1%, sucrose 1%, urea 20%, diatomite supplies 100%.

Embodiment 9 1% thiobenzamide epoxiconazole granule (4:1)

Thiobenzamide 0.8%, epoxiconazole 0.2%, NNO 3%, alkylbenzenesulfonate 1%, potassium chloride 2.5%, fused calcium magnesium phosphate 3%, zinc sulphate 1%, superphosphate 1%, white carbon 5%, urea supplies 100%.

CK6:1% epoxiconazole granule (0.8:0.2): epoxiconazole 1%, NNO 3%, alkylbenzenesulfonate 1%, potassium chloride 2.5%, fused calcium magnesium phosphate 3%, zinc sulphate 1%, superphosphate 1%, white carbon 5%, urea supplies 100%.

Two, the preparation of seed treatment formulations

(1) suspension seed-coating agent preparation technology: thiobenzamide and triazole bactericidal agent, surfactant or wetting dispersing agent are mixed by formula rate, then suitable quantity of water is added, use sand mill wet-milling, then material is transferred in shearing still, add film forming agent, thickener, antifreezing agent, defoamer, warning colouration and remaining water, meet standard through high speed shear to viscosity, particle diameter, obtain the suspension seed-coating agent of pesticidal preparations of the present invention.

Embodiment 10 10% thiobenzamide own azoles alcohol suspension seed-coating agent (1:9)

Thiobenzamide 1%, own azoles alcohol 9k%, naphthalenesulfonate formaldehyde condensation compound 2.5%, sodium lignin sulfonate 2%, carboxymethyl cellulose 2%, xanthans 1.5%, organosilicon 0.05%, glycerine 2%, carmine 0.2%, water is mended to 100%.

Embodiment 11 8% thiobenzamide Flutriafol suspension seed-coating agent (3:1)

Thiobenzamide 2%, Flutriafol 5%, NNO 2%, alkylphenol polyoxyethylene phosphate 1%, sodium lignin sulfonate 1%, polyvinyl alcohol 2%, propane diols 2%, acid red 0.5%, water supplies 100%.

Embodiment 12 16% thiobenzamide Tebuconazole suspension seed-coating agent (3:1)

Thiobenzamide 12%, Tebuconazole 4%, NNO 1%, sodium lignin sulfonate 1.5%, alkylbenzenesulfonate 1%, methylcellulose 2%, glycerine 2%, azogeramine %, water supplies 100%.

Embodiment 13 5% thiobenzamide difenoconazole suspending seed-dressing agent (1:1)

Thiobenzamide 2.5%, Difenoconazole 2.5%, polymeric polycarboxylic acid salt 3%, lauryl sodium sulfate 1%, polyvinyl alcohol 2%, glycerine 2%, carmine 0.4%, water supplies 100%.

Embodiment 14 11% thiobenzamide epoxiconazole suspension seed-coating agent (1:10)

Thiobenzamide 1%, epoxiconazole 10%, NNO 3%, alkylbenzenesulfonate 1%, methylcellulose 2.5%, glycerine 2%, carmine 0.4%, organosilicon 0.1%, water supplies 100%.

(2) preparation technology of seed treatment dry powder doses:

By formula rate by thiobenzamide, triazole bactericidal agent, surfactant or wetting dispersing agent, add film forming agent, binding agent, warning colouration and solid carrier carry out pulverizing and mixing, and obtain the seed treatment dry powder doses of pesticidal preparations of the present invention.

Embodiment 15 15% thiobenzamide own azoles alcohol seed treatment dry powder doses (2:1)

Thiobenzamide 10%, own azoles alcohol 5%, sodium lignin sulfonate 3%, alkylbenzenesulfonate 1%, methylcellulose 2.5%, azogeramine %, white carbon 5%, kaolin supplies 100%.

CK7:5% thiobenzamide seed treatment dry powder doses: thiobenzamide 5%, sodium lignin sulfonate 3%, alkylbenzenesulfonate 1%, methylcellulose 2.5%, azogeramine %, white carbon 5%, kaolin supplies 100%.

CK8:5% own azoles alcohol seed treatment dry powder doses: own azoles alcohol 5%, sodium lignin sulfonate 3%, alkylbenzenesulfonate 1%, methylcellulose 2.5%, azogeramine %, white carbon 5%, kaolin supplies 100%.

Embodiment 16 12% thiobenzamide Flutriafol seed treatment dry powder doses (1:5)

Thiobenzamide 2%, Flutriafol 10%, polymeric polycarboxylic acid salt 3k%, lauryl sodium sulfate 2.5k%, polyvinyl alcohol 3%, carmine 1%, white carbon 5%, diatomite supplies 100%.

CK9:5% Flutriafol seed treatment dry powder doses: Flutriafol 5%, polymeric polycarboxylic acid salt 3%, lauryl sodium sulfate 2.5%, polyvinyl alcohol 3%, carmine 1%, white carbon 5%, diatomite supplies 100%.

Embodiment 17 8% thiobenzamide Tebuconazole seed treatment dry powder doses (1:3)

Thiobenzamide 2%, Tebuconazole 6%, naphthalenesulfonate formaldehyde condensation compound 2%, neopelex 2%, carboxymethyl cellulose 3%, carmine 0.8%, diatomite 10%, white carbon 2%, kaolin supplies 100%.

CK10:5% Tebuconazole seed treatment dry powder doses: Tebuconazole 5%, naphthalenesulfonate formaldehyde condensation compound 2%, neopelex 2%, carboxymethyl cellulose 3%, carmine 0.8%, diatomite 10%, white carbon 2%, kaolin supplies 100%.

Embodiment 18 11% thiobenzamide Difenoconazole seed treatment dry powder doses (1:10)

Thiobenzamide 1%, Difenoconazole 10%, naphthalenesulfonate formaldehyde condensation compound 1%, neopelex 2.52%, methylcellulose 2.6%, carmine 0.6%, white carbon 2%, precipitated calcium carbonate 5%, kaolin supplies 100%.

CK11:5% Difenoconazole seed treatment dry powder doses: Difenoconazole 5%, naphthalenesulfonate formaldehyde condensation compound 1%, neopelex 2.52%, methylcellulose 2.6%, carmine 0.6%, white carbon 2%, precipitated calcium carbonate 5%, kaolin supplies 100%.

Embodiment 19 10% thiobenzamide epoxiconazole seed treatment dry powder doses (9:1)

Thiobenzamide 9%, epoxiconazole 1%, sodium lignin sulfonate 2%, alkylbenzenesulfonate 3%, neopelex 1%, methylcellulose 2%, carmine 0.5%, starch 3%, white carbon 10%, bentonite supplies 100%.

CK12:1% epoxiconazole seed treatment dry powder doses: epoxiconazole 1%, sodium lignin sulfonate 2%, alkylbenzenesulfonate 3%, neopelex 1%, methylcellulose 2%, carmine 0.5%, starch 3%, white carbon 10%, bentonite supplies 100%.

Three, the preparation of ultra low volume liquids

The preparation technology of ultra low volume liquids: by formula rate by thiobenzamide, triazole bactericidal agent, surfactant or wetting dispersing agent, surfactant and liquid-carrier carry out mixing to former medicine and are dissolved into transparency liquid completely, obtain the ultra low volume liquids of pesticidal preparations of the present invention.

Embodiment 20 11% thiobenzamide own azoles alcohol ultra low volume liquids (10:1)

Thiobenzamide 10%, own azoles alcohol 1%, 1-METHYLPYRROLIDONE 15%, trimethylbenzene 10%, alkylphenol polyoxyethylene 3%, calcium dodecyl benzene sulfonate 1%, two wires oil subsidy foot 100%.

CK13:5% thiobenzamide ultra low volume liquids: thiobenzamide 5%, 1-METHYLPYRROLIDONE 15%, trimethylbenzene 10%, alkylphenol polyoxyethylene 3%, calcium dodecyl benzene sulfonate 1%, two wires oil subsidy foot 100%.

CK14:1% own azoles alcohol ultra low volume liquids: own azoles alcohol 1%, 1-METHYLPYRROLIDONE 15%, trimethylbenzene 10%, alkylphenol polyoxyethylene 3%, calcium dodecyl benzene sulfonate 1%, two wires oil subsidy foot 100%

Embodiment 21 8% thiobenzamide own azoles alcohol ultra low volume liquids (1:3)

Thiobenzamide 2%, own azoles alcohol 6%, 1-METHYLPYRROLIDONE 10%, methyl naphthalene 10%, fatty alcohol-polyoxyethylene ether 2%, calcium dodecyl benzene sulfonate 2%, methyl oleate supplies 100%.

Embodiment 22 8.4% thiobenzamide Flutriafol ultra low volume liquids (1:20)

Thiobenzamide 0.4%, Flutriafol 8%, 1-METHYLPYRROLIDONE 15%, trimethylbenzene 10%, polyoxyethylene nonylphenol ether 1%, castor oil polyoxyethylene ether 2%, calcium dodecyl benzene sulfonate 1.5%, C10 aromatic hydrocarbons supplies 100%.

CK15:1% Flutriafol ultra low volume liquids: Flutriafol 1%, 1-METHYLPYRROLIDONE 15%, trimethylbenzene 10%, polyoxyethylene nonylphenol ether 1%, castor oil polyoxyethylene ether 2%, calcium dodecyl benzene sulfonate 1.5%, C10 aromatic hydrocarbons supplies 100%.

Embodiment 23 6.2% thiobenzamide Tebuconazole ultra low volume liquids (30:1)

Thiobenzamide 6%, Tebuconazole 0.2%, 1-METHYLPYRROLIDONE 4%, dimethyl formamide 8%, alkylphenol polyoxyethylene 3%, calcium dodecyl benzene sulfonate 2%, vegetable oil supplies 100%.

CK16:1% Tebuconazole ultra low volume liquids: Tebuconazole 1%, 1-METHYLPYRROLIDONE 4%, dimethyl formamide 8%, alkylphenol polyoxyethylene 3%, calcium dodecyl benzene sulfonate 2%, vegetable oil supplies 100%.

Embodiment 24 6.2% thiobenzamide epoxiconazole ultra low volume liquids (1:30)

Thiobenzamide 0.2%, epoxiconazole 6%, 1-METHYLPYRROLIDONE 4%, dimethyl formamide 8%, alkylphenol polyoxyethylene 3%, calcium dodecyl benzene sulfonate 2%, vegetable oil supplies 100%.

Embodiment 25 6% thiobenzamide epoxiconazole ultra low volume liquids (5:1)

Thiobenzamide 5%, epoxiconazole 1%, 1-METHYLPYRROLIDONE 10%, methyl oleate 5%, phenethyl phenol polyethenoxy ether 1.5%, alkylaryl polyoxyethylene polyoxypropylene ether 3%, two wires oil subsidy foot 100%.

CK17:1% epoxiconazole ultra low volume liquids: epoxiconazole 1%, 1-METHYLPYRROLIDONE 10%, methyl oleate 5%, phenethyl phenol polyethenoxy ether 1.5%, alkylaryl polyoxyethylene polyoxypropylene ether 3%, two wires oil subsidy foot 100%.

Embodiment 26 10% thiobenzamide Difenoconazole ultra low volume liquids (4:1)

Thiobenzamide 8%, Difenoconazole 2%, 1-METHYLPYRROLIDONE 5%, cyclohexanone 5%, castor oil polyoxyethylene ether 1%, alkylaryl polyoxyethylene polyoxypropylene ether 3%, trimethylbenzene supplies 100%

CK18:1% Difenoconazole ultra low volume liquids: Difenoconazole 1%, 1-METHYLPYRROLIDONE 5%, cyclohexanone 5%, castor oil polyoxyethylene ether 1%, alkylaryl polyoxyethylene polyoxypropylene ether 3%, trimethylbenzene supplies 100%.

Four, the preparation of wetting powder

Preparation technology: active ingredient thiobenzamide, triazole bactericidal agent, dispersant, wetting agent, solid carrier are mixed, after airslide disintegrating mill is pulverized, stirs 30min, obtains the wetting powder of pesticidal preparations of the present invention.

Embodiment 27:41% thiobenzamide own azoles alcohol wetting powder (40:1)

Thiobenzamide 40%, own azoles alcohol 1%, NNO 4%, lauryl sodium sulfate 2%, white carbon 10%, diatomite supplies 100%.

Embodiment 28:50% thiobenzamide own azoles alcohol wetting powder (1:4)

By thiobenzamide 10%, own azoles alcohol 40%, pull open powder 1%, NNO 3%, lauryl sodium sulfate 1%, kaolin supplies 100%.

Embodiment 29:10.5% thiobenzamide own azoles alcohol wetting powder (1:20)

By thiobenzamide 0.5%, own azoles alcohol 10%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 2%, NNO 1%, lauryl sodium sulfate 1%, kaolin supplies 100%.

Embodiment 30:20.5% thiobenzamide Flutriafol wetting powder (40:1)

By thiobenzamide 20%, Flutriafol 0.5%, NNO 3%, alkylnaphthalene sulfonate 2%, white carbon 10%, bentonite supplies 100%.

Embodiment 31:22% thiobenzamide Flutriafol wetting powder (1:10)

By thiobenzamide 2%, Flutriafol 20%, NNO 2%, sodium lignin sulfonate 2%, alkyl benzene sulfonate calcium salt 1%, white carbon 5%, kaolin supplies 100%.

Embodiment 32:21% thiobenzamide Tebuconazole wetting powder (1:20)

By thiobenzamide 1%, Tebuconazole 20%, polycarboxylate 3%, sodium lignin sulfonate 2%, white carbon 5%, kaolin supplies 100%.

Embodiment 33:12% thiobenzamide epoxiconazole wetting powder (1:5)

By thiobenzamide 2%, epoxiconazole 10%, alkylnaphthalene sulfonate 3.5%, lauryl sodium sulfate 1%, white carbon 18%, kaolin supplies 100%.

Embodiment 34:31% thiobenzamide Difenoconazole wetting powder (1:30)

By thiobenzamide 1%, Difenoconazole 30%, alkylnaphthalene sulfonate 3.5%, polycarboxylate 0.5%, lauryl sodium sulfate 1%, kaolin supplies 100%.

Five, the preparation of water dispersible granules

Preparation technology: active ingredient thiobenzamide, triazole bactericidal agent, dispersant, wetting agent, binding agent, disintegrant, solid carrier are mixed, after airslide disintegrating mill is pulverized, granulating and drying sieves and obtains the water dispersible granules of pesticidal preparations of the present invention.

Embodiment 35:21% thiobenzamide diniconazole water dispersible granule (20:1)

Thiobenzamide 20%, own azoles alcohol 1%, aliphatic amine polyoxyethylene ether 4%, alkylnaphthalene sulfonate 2%, starch 3%, bentonite supplies 100%.

Embodiment 36:41% thiobenzamide diniconazole water dispersible granule (1:40)

Thiobenzamide 1, own azoles alcohol 40%, polycarboxylate 2%, sodium lignin sulfonate 3%, starch 3%, kaolin supplies 100%.

Embodiment 37:80% thiobenzamide diniconazole water dispersible granule (1:3)

Thiobenzamide 20, own azoles alcohol 60%, polycarboxylate 2.5%, sodium lignin sulfonate 2%, methylcellulose 2%, white carbon supplies 100%.

Embodiment 38:51% thiobenzamide Flutriafol water dispersible granules (50:1)

Thiobenzamide 50%, Flutriafol 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 2%, lauryl sodium sulfate 3%, starch 3%, kaolin supplies 100%.

Embodiment 39:21% thiobenzamide Flutriafol water dispersible granules (20:1)

Thiobenzamide 20%, Flutriafol 1%, sodium lignin sulfonate 3%, lauryl sodium sulfate 2%, ethyl cellulose 2%, diatomite supplies 100%.

Embodiment 40:20.5% thiobenzamide tebuconazole water dispersible granule (40:1)

By thiobenzamide 20%, Tebuconazole 0.5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 2%, alkylbenzenesulfonate 2%, starch 2%, kaolin supplies 100%.

Embodiment 41:42% thiobenzamide epoxiconazole water dispersant (1:20)

Thiobenzamide 2%, epoxiconazole 40%, sodium lignin sulfonate 2.5%, alkylbenzenesulfonate 3%, starch 2%, ammonium sulfate 2%, bentonite supplies 100%.

Embodiment 42:12% thiobenzamide epoxiconazole water dispersant (5:1)

Thiobenzamide 10%, epoxiconazole 2%, NNO 1%, sodium lignin sulfonate 2%, alkylbenzenesulfonate 3%, polyvinyl alcohol 2%, sodium carbonate 2%, kaolin supplies 100%.

Embodiment 43:33% thiobenzamide difenoconazole water dispersible granule (1:10)

Thiobenzamide 3%, Difenoconazole 30%, NNO 2%, alkylbenzenesulfonate 1.5%, methylcellulose 2%, sodium sulphate 2%, kaolin supplies 100%.

Embodiment 44:11% thiobenzamide difenoconazole water dispersible granule (10:1)

Thiobenzamide 10%, Difenoconazole 1%, NNO 2%, alkylbenzenesulfonate 1.5%, starch 2%, sodium sulphate 2%, kaolin supplies 100%.

Six, the preparation of suspending agent

Preparation technology: antifreezing agent, thickener and water are mixed, mixes through high speed shear, add thiobenzamide, triazole bactericidal agent and surfactant successively, abrading-ball 2 ~ 3 hours in ball crusher, the suspending agent of obtained pesticidal preparations of the present invention.

Embodiment 45 8.8% thiobenzamide hexaconazole suspending agent (10:1)

Thiobenzamide 8%, own azoles alcohol 0.8%, aluminium-magnesium silicate 0.3%, NNO 1%, styrylphenol polyoxyethylene ether 3.5%, calcium dodecyl benzene sulfonate 1%, glycerine 1.5%, water supplies 100%.

Embodiment 46 5.5% thiobenzamide hexaconazole suspending agent (1:10)

Thiobenzamide 0.5%, own azoles alcohol 5%, xanthans 0.2%, styrylphenol polyoxyethylene ether 3.5%, calcium dodecyl benzene sulfonate 1%, glycerine 1.5%, water supplies 100%.

Embodiment 47 8.2% thiobenzamide Flutriafol suspending agent (1:40)

Thiobenzamide 0.2%, Flutriafol 8%, xanthans 0.2%, styrylphenol polyoxyethylene ether 2.5%, fatty alcohol-polyoxyethylene ether 1.5%, sodium lignin sulfonate 1%, urea 1.5%, water supplies 100%.

Embodiment 48 10.5% thiobenzamide Flutriafol suspending agent (20:1)

Thiobenzamide 10%, Flutriafol 0.5%, gum Arabic 0.2%, styrylphenol polyoxyethylene ether 2.5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 1.5%, sodium lignin sulfonate 1%, glycerine 1.5%, water supplies 100%.

CK19:10% thiobenzamide suspending agent

Thiobenzamide 10%, gum Arabic 0.2%, styrylphenol polyoxyethylene ether 2.5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 1.5%, sodium lignin sulfonate 1%, glycerine 1.5%, water supplies 100%.

Embodiment 49 6.3% thiobenzamide tebuconazole suspension concentrates (20:1)

Thiobenzamide 6%, Tebuconazole 0.3%, xanthans 0.5%, styrylphenol polyoxyethylene ether 3%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 2%, calcium dodecyl benzene sulfonate 0.5%, ethylene glycol 1.5%, water supplies 100%.

Embodiment 50 20.2% thiobenzamide tebuconazole suspension concentrates (1:100)

Thiobenzamide 0.2%, Tebuconazole 20%, xanthans 0.5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4%, calcium dodecyl benzene sulfonate 1.5%, isopropyl alcohol 2%, water supplies 100%.

Embodiment 51 6.6% thiobenzamide difenoconazole suspending agent (10:1)

Thiobenzamide 6%, Difenoconazole 0.6%, aluminium-magnesium silicate 0.5%, polyoxyethylene nonylphenol ether 2%, sodium lignin sulfonate 2%, calcium dodecyl benzene sulfonate 1.5%, glycerine 1%, water supplies 100%.

Embodiment 52 12.3% thiobenzamide difenoconazole suspending agent (1:40)

Thiobenzamide 0.3%, Difenoconazole 12%, aluminium-magnesium silicate 0.5%, styrylphenol polyoxyethylene ether 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, calcium dodecyl benzene sulfonate 1.5%, urea 1%, water supplies 100%.

Embodiment 53 5.5% thiobenzamide epoxiconazole suspension concentrate (10:1)

Thiobenzamide 5%, epoxiconazole 0.5%, xanthans 0.4%, polyoxyethylene nonylphenol ether 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, calcium dodecyl benzene sulfonate 1.5%, glycerine 1%, water supplies 100%.

Embodiment 54 20.2% thiobenzamide epoxiconazole suspension concentrate (100:1)

Thiobenzamide 20%, epoxiconazole 0.2%, aluminium-magnesium silicate 0.5%, di-2-ethylhexylphosphine oxide methyl naphthalene sulfonic acid 1%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 2%, styrylphenol polyoxyethylene ether 3%, ethylene glycol 1%, water supplies 100%.

Field efficacy embodiment:

In order to clear and definite thiobenzamide and triazole bactericidal agent alone with time mixed to the control efficiency of rice sheath blight disease and sugarcane aphid, and can the result of clear and definite Toxicity Determination (i.e. synergistic effect) be confirmed in field, present invention applicant at home different regions has carried out a large amount of field trials.Thiobenzamide is called for short sulfo-in following complex preparation.

Field efficacy embodiment 1:

Prevent and treat wheat rust test method: with reference to pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating Cereal Rust (leaf rust, bar rust, stem rust), adopt broadcast application dispenser when sowing whole ground.

Control wheat midge test method: with reference to pesticide field efficacy medicine test criterion (two) the 78th part insecticide control wheat midge, adopt broadcast application dispenser when sowing whole ground.

Contrast medicament: be CK1-CK6, be self-control.

Table 10 thiobenzamide and the composite result of the test of preventing and treating wheat rust and wheat midge of triazole bactericidal agent

Be applied to and prevent and treat wheat rust, thiobenzamide and composite embodiment 1,2,3 (active ingredient dosage the is 135 grams/ha) preventive effect of own azoles alcohol are higher than contrast single dose 5% thiobenzamide granule (formulation rate is 450 grams/ha) more than 82.61%, and preventive effect is higher than 1% own azoles alcohol granule (formulation rate is 225 grams/ha) more than 10.69%.Be applied to control wheat midge, thiobenzamide and composite embodiment 1,2,3 (active ingredient dosage the is 135 grams/ha) preventive effect of own azoles alcohol are higher than contrast single dose 5% thiobenzamide granule (formulation rate is 450 grams/ha) more than 9.78%, and preventive effect is higher than 1% own azoles alcohol granule (formulation rate is 225 grams/ha) more than 83.43%.Equally, when preventing and treating wheat rust and wheat midge, when active ingredient dosage is more less than single dose, the control efficiency of embodiments of the invention 4 ~ 9 is higher than each contrast single dose.Show that composition pesticide provided by the invention and preparation thereof have synergistic effect relative to single dose.

Field efficacy embodiment 2:

Prevent and treat wheat rust test method: with reference to pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating Cereal Rust (leaf rust, bar rust, stem rust), adopt dressing methods dispenser.

Control wheat midge test method: with reference to pesticide field efficacy medicine test criterion (two) the 78th part insecticide control wheat midge, adopt dressing methods dispenser.

Contrast medicament: CK7-CK12 is self-control.

Table 11 thiobenzamide and the composite result of the test of preventing and treating wheat rust and wheat midge of triazole bactericidal agent

As can be seen from result of the test table 11, under the prerequisite that active ingredient dosage is less relative to single dose, the preventive effect of the composition pesticide pesticide-germicide that the embodiment of the present invention 10 ~ 19 provides, higher than each single dose, shows that composition pesticide provided by the invention and preparation thereof have synergistic effect relative to single dose.

Field efficacy embodiment 3:

Prevent and treat wheat rust test method: with reference to pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating Cereal Rust (leaf rust, bar rust, stem rust).The test method of control wheat midge and computational methods: with reference to GB/T 24501.2-2009 stripe rust of wheat, midge worm Prevention Technique specification part 2: wheat midge.

Application method: adopt ultra low volume spraying.Contrast medicament: CK13-CK18 is self-control.

Table 12 thiobenzamide and the composite result of the test of preventing and treating wheat rust and wheat midge of triazole bactericidal agent

As can be seen from result of the test table 12, under the prerequisite that active ingredient dosage is less relative to single dose, the preventive effect of the composition pesticide pesticide-germicide that the embodiment of the present invention 20 ~ 26 provides, higher than each single dose, shows that composition pesticide provided by the invention and preparation thereof have synergistic effect relative to single dose.

Field efficacy embodiment 4:

Prevent and treat wheat rust test method: with reference to pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating Cereal Rust (leaf rust, bar rust, stem rust).

The test method of control wheat midge and computational methods: with reference to GB/T 24501.2-2009 stripe rust of wheat, midge worm Prevention Technique specification part 2: wheat midge.

Application method: conventional spraying.

Contrast medicament: CK19:10% thiobenzamide suspending agent, self-control.CK20:30% diniconazole water dispersible granule, registration card: PD20132419, Shanxi Thompson Biological Technology Co., Ltd., commercial.CK21:12.5% Flutriafol suspending agent, registration card number: PD20130373, Fengdeng Pesticide Co., Ltd., Jiangsu, commercial.CK22:430 grams per liter tebuconazole suspension concentrates, registration card: PD20050216, Bayer Bitterfeld GmbH crop science company, commercial.CK23:10% difenoconazole water dispersible granule, registration card: PD20131284, Shaanxi Meibang Pesticide Co., Ltd., commercial.CK24:30% epoxiconazole suspension concentrate, registration card: PD20131832, Shaanxi Meibang Pesticide Co., Ltd., commercial.Test result is in table 13:

Table 13 thiobenzamide and the composite field control effectiveness test result of preventing and treating wheat rust and wheat midge of triazole bactericidal agent

As can be seen from result of the test table 13, test is under the identical prerequisite of active ingredient dosage, the preventive effect of the composition pesticide that the embodiment of the present invention 27 ~ 53 provides and preparation as insecticiding sterilization thereof is higher than each single dose, show that Pesticidal combination provided by the invention and preparation thereof have synergistic effect relative to single dose, the preventive effect to wheat rust, midge insect pest worm can be improved.And the control efficiency of above-mentioned composition pesticide and preparation thereof 14d after medicine still can reach more than 82%, the composition pesticide lasting period of the present invention is long.

Claims (9)

1. contain the composition pesticide of thiobenzamide and triazole bactericidal agent; it is characterized in that: described composition pesticide is made up of thiobenzamide and triazole bactericidal agent; described thiobenzamide is the bromo-N-of 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide, and the weight ratio of described thiobenzamide and triazole bactericidal agent is 100:1 ~ 1:100.

2. the composition pesticide containing thiobenzamide and triazole bactericidal agent according to claim 1, is characterized in that: described triazole bactericidal agent is any one in own azoles alcohol, Flutriafol, Tebuconazole, Difenoconazole, epoxiconazole.

3. the composition pesticide containing thiobenzamide and triazole bactericidal agent according to claim 2, is characterized in that: described triazole bactericidal agent is any one in own azoles alcohol, Flutriafol, Tebuconazole.

4. the composition pesticide containing thiobenzamide and triazole bactericidal agent according to claim 1,2 or 3, is characterized in that: the weight ratio of described thiobenzamide and triazole bactericidal agent is 40:1 ~ 1:40.

5. the composition pesticide containing thiobenzamide and triazole bactericidal agent according to claim 4, is characterized in that: the weight ratio of described thiobenzamide and triazole bactericidal agent is 20:1 ~ 1:20.

6. prevent and treat the pesticidal preparations of agricultural pest for one kind, it is characterized in that: the composition pesticide containing thiobenzamide and triazole bactericidal agent according to any one of claim 1-5 and auxiliary material form, wherein, described composition pesticide accounts for 0.1% ~ 80% of described pesticidal preparations gross weight.

7. a kind of pesticidal preparations preventing and treating agricultural pest according to claim 6, is characterized in that: described composition pesticide accounts for 1% ~ 50% of described pesticidal preparations gross weight.

8. a kind of pesticidal preparations preventing and treating agricultural pest according to claim 6 or 7, is characterized in that: the formulation of described pesticidal preparations is granule, seed treatment formulations, ultra low volume liquids, water dispersible granules, wetting powder or suspending agent.

9. a kind of application of pesticidal preparations in controlling crop diseases and insect pests preventing and treating agricultural pest according to any one of claim 6-8.