CN104447854A - Preparation method of phosphatidic acid sodium - Google Patents
Preparation method of phosphatidic acid sodium Download PDFInfo
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- CN104447854A CN104447854A CN201410625592.6A CN201410625592A CN104447854A CN 104447854 A CN104447854 A CN 104447854A CN 201410625592 A CN201410625592 A CN 201410625592A CN 104447854 A CN104447854 A CN 104447854A
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- phosphatidic acid
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- phosphatidic
- sodium
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Abstract
The invention relates to a preparation method of phosphatidic acid sodium, which belongs to the technical field of fine chemical engineering. The preparation method is characterized in that soybean phosphatidic acid, rapeseed phosphatidic acid and cotton seed phosphatidic acid are adopted as raw materials, the phosphatidic acid is dissolved in a certain amount of normal butanol, a phosphatidic acid solution is heated to a certain temperature, a 95% ethanol solution of sodium hydroxide is added while the solution is stirred to obtain phosphatidic acid sodium precipitates. The precipitates are washed by 95% ethanol for two times and then dried to obtain a phosphatidic acid sodium product.
Description
Technical field
A preparation method for phosphatidic acid sodium, belongs to technical field of fine.
Technical background
Phosphatidic acid sodium is a kind of important tensio-active agent, can be used for Fine Chemical and biomedicine field, also has important use in recent liposome research field.China is the production and supplyment big country of soybean oil, Ye Shi phosphatide big producing country.China in 2012 produces soybean oil per year and reaches 1,170 ten thousand tons, and its by product can obtain the phospholipid prod of about 50,000 tons.Add rapeseed phosphatide and cottonseed phosphatide, its potential phosphatide output reaches about 150,000 tons.In these phosphatide, only have soybean phospholipid to obtain better exploitation, rapeseed phosphatide and cottonseed phosphatide are not still effectively developed mostly.One of converted products of these phosphatide is exactly phosphatidic acid, and thus China's phosphatidic acid distant view output is considerable.Therefore the preparation of phosphatidic acid sodium not only has important practical significance to the utilization of soybean phospholipid, rapeseed phosphatide and cottonseed phosphatide, also to Fine Chemical and biomedicine field significant.Preparation about phosphatidic acid sodium is domestic at present also not to be reported, the invention discloses a kind of preparation method of phosphatidic acid sodium, for the phosphatidic acid sodium preparation of industrial requirement opens a kind of new approach.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of phosphatidic acid sodium.The method is with soybean phospholipid acid, the sour and cottonseed phosphatidic acid of rapeseed phosphatide for raw material, and phosphatidic acid is dissolved in a certain amount of propyl carbinol, and heating phosphatidic acid solution, to certain temperature, adds sodium hydroxide 95% ethanolic soln while stirring, obtains phosphatidic acid sodium and precipitates.Precipitation obtains phosphatidic acid sodium product with after 2 dryings of 95% washing with alcohol.
Technical scheme of the present invention: the preparation method that the object of the present invention is to provide a kind of phosphatidic acid sodium.The method is with soybean phospholipid acid, rapeseed phosphatide acid and cottonseed phosphatidic acid are raw material, taking 100 grams of phosphatidic acids is dissolved in 1000mL ~ 2000mL propyl carbinol, heating phosphatidic acid solution is to 35 ~ 45 DEG C, stir with the rotating speed of 200 revs/min, while stirring, sodium hydroxide 95% ethanolic soln of 250mL40% is evenly added in 60 ~ 90 minutes, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes, filter cake 250mL95% washing with alcohol 2 times, more than 120 grams these products are obtained after vacuum-drying, in its product, the content of phosphatidic acid calcium reaches more than 75% after measured.
Beneficial effect of the present invention: a kind of preparation method of phosphatidic acid sodium, provides a kind of simple and feasible method for preparing phosphatidic acid sodium, and the method is that the phosphatidic acid sodium preparation of industrial requirement opens a kind of new approach.
Embodiment
Embodiment 1
Take 100 grams of soybean phospholipids acid-soluble in 1000mL propyl carbinol, heating phosphatidic acid solution is to 45 DEG C, stir with the rotating speed of 200 revs/min, while stirring, sodium hydroxide 95% ethanolic soln of 250mL40% is evenly added in 90 minutes, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes.Filter cake 250mL95% washing with alcohol 2 times, obtain 120.6 grams of these products after vacuum-drying, in its product, the content of phosphatidic acid sodium reaches 75.8% after measured.
Embodiment 2
Take 100 grams of soybean phospholipids acid-soluble in 2000mL propyl carbinol, heating phosphatidic acid solution is to 35 DEG C, stir with the rotating speed of 200 revs/min, while stirring, sodium hydroxide 95% ethanolic soln of 250mL40% is evenly added in 60 minutes, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes.Filter cake 250mL95% washing with alcohol 2 times, obtain 121.7 grams of these products after vacuum-drying, in its product, the content of phosphatidic acid calcium reaches 75.1% after measured.
Embodiment 3
Take 100 grams of soybean phospholipids acid-soluble in 1500mL propyl carbinol, heating phosphatidic acid solution is to 30 DEG C, stir with the rotating speed of 200 revs/min, while stirring, sodium hydroxide 95% ethanolic soln of 250mL40% is evenly added in 80 minutes, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes.Filter cake 250mL95% washing with alcohol 2 times, obtain 121.2 grams of these products after vacuum-drying, in its product, the content of phosphatidic acid calcium reaches 76.4% after measured.
Embodiment 4
Take 100 grams of rapeseed phosphatides acid-soluble in 1500mL propyl carbinol, heating phosphatidic acid solution is to 30 DEG C, stir with the rotating speed of 200 revs/min, while stirring, sodium hydroxide 95% ethanolic soln of 250mL40% is evenly added in 70 minutes, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes.Filter cake 250mL95% washing with alcohol 2 times, obtain 123.2 grams of these products after vacuum-drying, in its product, the content of phosphatidic acid calcium reaches 77.8% after measured.
Embodiment 5
Taking 100 grams of cottonseed phosphatidic acids is dissolved in 1500mL propyl carbinol, heating phosphatidic acid solution is to 45 DEG C, stir with the rotating speed of 200 revs/min, while stirring, sodium hydroxide 95% ethanolic soln of 250mL40% is evenly added in 90 minutes, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes.Filter cake 250mL95% washing with alcohol 2 times, obtain 124.1 grams of these products after vacuum-drying, in its product, the content of phosphatidic acid calcium reaches 75.3% after measured.
Claims (6)
1. the preparation method of a phosphatidic acid sodium, it is characterized in that with soybean phospholipid acid, the sour and cottonseed phosphatidic acid of rapeseed phosphatide for raw material, taking 100 grams of phosphatidic acids is dissolved in 1000mL ~ 2000mL propyl carbinol, heating phosphatidic acid solution is to 35 ~ 45 DEG C, stir with the rotating speed of 200 revs/min, while stirring, in 60 ~ 90 minutes, evenly add sodium hydroxide 95% ethanolic soln of 250mL40%, finish and continue stirring 10 minutes, normal temperature leaves standstill suction filtration after 30 minutes.Filter cake 250mL95% washing with alcohol 2 times, obtain more than 120 grams these products after vacuum-drying, in its product, the content of phosphatidic acid sodium reaches more than 75% after measured.
2. the preparation method of a kind of phosphatidic acid sodium according to claim 1, is characterized in that the solvent of dissolved phosphorus resin acid is propyl carbinol, the solvent of dissolved hydrogen sodium oxide is 95% ethanol.
3. the preparation method of a kind of phosphatidic acid sodium according to claim 1, it is characterized in that phosphatidic acid used can be soybean phospholipid acid, can be rapeseed phosphatide acid, also can be cottonseed phosphatidic acid.
4. the preparation method of a kind of phosphatidic acid sodium according to claim 1, is characterized in that alkali used is sodium hydroxide;
5. the preparation method of a kind of phosphatidic acid sodium according to claim 1, it is characterized in that the temperature of reaction of phosphatidic acid and sodium hydroxide is 35 ~ 45 DEG C, the reaction times is 60 ~ 90 minutes.
6. the preparation method of a kind of phosphatidic acid sodium according to claim 1, is characterized in that phosphatidic acid and the ratio of 95% ethanol are 1: 10 ~ 1: 20 (g: mL).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410625592.6A CN104447854B (en) | 2014-11-06 | 2014-11-06 | Preparation method of phosphatidic acid sodium |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410625592.6A CN104447854B (en) | 2014-11-06 | 2014-11-06 | Preparation method of phosphatidic acid sodium |
Publications (2)
| Publication Number | Publication Date |
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| CN104447854A true CN104447854A (en) | 2015-03-25 |
| CN104447854B CN104447854B (en) | 2017-01-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410625592.6A Expired - Fee Related CN104447854B (en) | 2014-11-06 | 2014-11-06 | Preparation method of phosphatidic acid sodium |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109517007A (en) * | 2017-09-20 | 2019-03-26 | 丰益(上海)生物技术研发中心有限公司 | A kind of preparation method of phosphatide |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096814A (en) * | 1993-06-25 | 1994-12-28 | 杨鹄昉 | The quick preparation technology of natural phospholipid soap powder and single stage method thereof |
| CN1263098A (en) * | 1999-12-30 | 2000-08-16 | 清华大学 | Preparation method of saturated phosphatidate and its salts |
| JP2001078792A (en) * | 1999-09-14 | 2001-03-27 | Nof Corp | Production of phosphatidic acid alkali metal salt or phosphatidic acid ammonium salt |
| JP2001342196A (en) * | 2000-06-02 | 2001-12-11 | Nof Corp | Method for producing high-purity acidic phospholipid |
-
2014
- 2014-11-06 CN CN201410625592.6A patent/CN104447854B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096814A (en) * | 1993-06-25 | 1994-12-28 | 杨鹄昉 | The quick preparation technology of natural phospholipid soap powder and single stage method thereof |
| JP2001078792A (en) * | 1999-09-14 | 2001-03-27 | Nof Corp | Production of phosphatidic acid alkali metal salt or phosphatidic acid ammonium salt |
| CN1263098A (en) * | 1999-12-30 | 2000-08-16 | 清华大学 | Preparation method of saturated phosphatidate and its salts |
| JP2001342196A (en) * | 2000-06-02 | 2001-12-11 | Nof Corp | Method for producing high-purity acidic phospholipid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109517007A (en) * | 2017-09-20 | 2019-03-26 | 丰益(上海)生物技术研发中心有限公司 | A kind of preparation method of phosphatide |
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| CN104447854B (en) | 2017-01-18 |
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