CN104437128A - Nanometer magnetic hemodialysis membrane and preparation method thereof - Google Patents
Nanometer magnetic hemodialysis membrane and preparation method thereof Download PDFInfo
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- CN104437128A CN104437128A CN201410626542.XA CN201410626542A CN104437128A CN 104437128 A CN104437128 A CN 104437128A CN 201410626542 A CN201410626542 A CN 201410626542A CN 104437128 A CN104437128 A CN 104437128A
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Abstract
The invention provides a nanometer magnetic hemodialysis membrane and a preparation method thereof, and the nanometer magnetic hemodialysis membrane relates to the field of biological materials. The nanometer magnetic hemodialysis membrane comprises the following components in parts by weight: 25-40 parts of polymethyl methacrylate, 6-12 parts of polymer modified magnetic nanoparticles, 5-15 parts of polyacrylamide and 24-45 parts of a solvent, wherein the dialysis membrane is a hollow fiber membrane, the average inside diameter is 155-245 microns, the wall thickness is 32-45 microns, the solvent is acetone and DMAC, and the mass ratio of the acetone to the DMAC is (0.5-1):1. The preparation method of the nanometer magnetic hemodialysis membrane adopts a wet and dry method preparation process. The nanometer magnetic hemodialysis membrane provided by the invention can effectively provide biocompatibility and protein adsorption resistance to effectively reduce blood protein adsorption resulting from long-term use, and has high water ultrafiltration performance and small molecule dialysis transmittance, thus being a hemodialysis membrane material with excellent application prospect.
Description
Technical field
The invention belongs to technical field of biological material, particularly the preparation method of a kind of nano-magnetic hemodialysis membrane and this hemodialysis membrane.
Background technology
Hemodialysis membrane is the principle utilizing pellicle, by the solute gradient of film both sides, osmotic gradient and hydraulic pressure gradient, removes to reach the moisture that in toxin and body, retention is too much, simultaneously required in added body material, and maintains the object of electrolyte and acid-base balance.
Polymethyl methacrylate is also a kind of conventional Hemodialysis Membrane Material, and it has good hydrophily, be characterized in higher to the transmitance of urea and small-molecule substance, and film forming elastomer is better.But shortcoming is, Long-Time Service, film surface is easily polluted by hemalbumin, and Long contact time also can cause hematoblastic gathering, therefore needs to add to carry out modification or interpolation other materials, to extend its service life to polymethyl methacrylate.
Along with the development of nanometer technology, the nano magnetic particle in nano material receives the continuous concern of medical circle, and multiple magnetic Nano material has been applied to thermotherapy, nuclear magnetic resonance and technical field of biology now.In technical field of biology, the magnetic nanoparticle after modification, because possessing good biocompatibility and anti-protein adsorption, using, having prospect of the application widely in variety carrier material.
Application number is the patent document preparation method of absorption Hemodialysis Membrane Material " a kind of low-density lipoprotein is affine " of 201110106503.3, and disclose a kind of preparation method of dialysis membrane, the method comprises: Hemodialysis Membrane Material prerinse process; Be placed in plasma processor chamber, first pass into inert gas pass into again activated gas to atmosphere composition constant, carry out plasma treatment; Immerse in heparin solution, add coupling agent oscillating reactions, repeatedly clean with PBS cushioning liquid oscillation cleaning, clear water and be filtered dry, obtain the affine absorption Hemodialysis Membrane Material of low-density lipoprotein.
It can thus be appreciated that, this technical scheme introduces active reactive group by atmospheric low-temperature plasma activation modification processing method, to improve hydrophily and the blood compatibility on polymer membrane materials surface, reducing to cause blockage effect because of fouling membrane in dialysis procedure, is also a kind of feasible method of modifying.
Summary of the invention
The technical problem that the present invention solves: for above-mentioned deficiency, overcome the defect of prior art, the object of this invention is to provide a kind of nano-magnetic hemodialysis membrane and preparation method thereof.
Technical scheme of the present invention: a kind of nano-magnetic hemodialysis membrane, comprises each component of following mass fraction: polymethyl methacrylate 25-40 part, macromolecule modified nano magnetic particle 6-12 part, polyacrylamide 5-15 part and solvent 24-45 part;
Wherein, dialysis membrane is hollow-fibre membrane, and mean inside diameter is 155-245 μm, wall thickness 32-45 μm;
Wherein, solvent is acetone and DMAC, and both mass ratios are 0.5-1:1.
As preferably, described macromolecule modified nano magnetic particle is polyethylene glycol or albumin modified Nano Fe
3o
4particle.
As preferably, described macromolecule modified nano magnetic particle is starch conversion super-paramagnetism nano Fe
3o
4particle.
As preferably, described macromolecule modified nano magnetic particle is polyacrylic acid modified NiFe2O4.
As preferably, in solvent, the mass ratio of acetone and DMAC is 2:3.
A preparation method for nano-magnetic hemodialysis membrane, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 35-65 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.01-0.06MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 65%-80%, temperature 55-70 DEG C;
(4) adjusting spinning solution pressure tank is 0.3-0.6MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 400-600r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
Beneficial effect: nano-magnetic hemodialysis membrane provided by the invention, is utilize modified magnetic nanoparticle performance, joins among polymethyl methacrylate, the hollow-fibre membrane prepared by wet-dry change.
Magnetic nanoparticle, there is specific area large, the feature that surface-active is high, but also easily reunite and oxidation, utilize after high polymer carries out modification to it, effect gets a promotion, and the performance of magnetic nanoparticle that different modified-high polymers obtains is also variant, by the superparamagnetism ferrite magnetic material of polyethylene glycol and albumin modification, there is higher biocompatibility and anti-protein adsorption performance; Also be there is by the superparamagnetism ferrite magnetic material of starch conversion and polyacrylic acid modified NiFe2O4 the feature improving biocompatibility, therefore, above-mentioned material is joined among polymethyl methacrylate, its biocompatibility and anti-protein adsorption performance can be effectively provided, the hemalbumin absorption that effective reduction Long-Time Service causes, and there is higher water ultrafiltration performance and Small molecular dialysis transmitance, be the good Hemodialysis Membrane Material of a kind of prospect of the application.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
Embodiment 1:
A kind of nano-magnetic hemodialysis membrane, dialysis membrane is hollow-fibre membrane, comprises each component of following mass fraction: polymethyl methacrylate 25 parts, poly ethyldiol modified nanometer Fe
3o
4particle 6 parts, polyacrylamide 5 parts and solvent 24 parts, solvent is acetone and DMAC, and both mass ratios are 0.5:1.
Prepare nano-magnetic hemodialysis membrane according to preparation method provided by the invention, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 35 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.01MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 65%, temperature 55 DEG C;
(4) adjusting spinning solution pressure tank is 0.3MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 400r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
The mean inside diameter of the doughnut of preparation is 158 μm, wall thickness 33 μm.
Measure the nano-magnetic hemodialysis membrane of preparation, its water ultrafiltration is 34.8mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.3%; Urea permeability 173 P
m10
4cmmin
-1; Cobastab
12transmitance 86 P
m10
4cmmin
-1; Hot strength is 44.1MPa.
Embodiment 2:
A kind of nano-magnetic hemodialysis membrane, dialysis membrane is hollow-fibre membrane, comprises each component of following mass fraction: polymethyl methacrylate 30 parts, albumin modified Nano Fe
3o
4particle 7 parts, polyacrylamide 5 parts and solvent 29 parts, solvent is acetone and DMAC, and both mass ratios are 2:3.
Prepare nano-magnetic hemodialysis membrane according to preparation method provided by the invention, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 35 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.01MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 65%, temperature 55 DEG C;
(4) adjusting spinning solution pressure tank is 0.3MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 400r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
The mean inside diameter of the doughnut of preparation is 158 μm, wall thickness 33 μm.
Measure the nano-magnetic hemodialysis membrane of preparation, its water ultrafiltration is 35.3mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.4%; Urea permeability 174 P
m10
4cmmin
-1; Cobastab
12transmitance 85 P
m10
4cmmin
-1; Hot strength is 43.7MPa.
Embodiment 3:
A kind of nano-magnetic hemodialysis membrane, dialysis membrane is hollow-fibre membrane, comprises each component of following mass fraction: polymethyl methacrylate 35 parts, starch conversion super-paramagnetism nano Fe
3o
4particle 9 parts, polyacrylamide 10 parts and solvent 34 parts, solvent is acetone and DMAC, and both mass ratios are 2:3.
Prepare nano-magnetic hemodialysis membrane according to preparation method provided by the invention, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 50 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.04MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 75%, temperature 65 DEG C;
(4) adjusting spinning solution pressure tank is 0.5MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 500r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
The mean inside diameter of the doughnut of preparation is 187 μm, wall thickness 40 μm.
Measure the nano-magnetic hemodialysis membrane of preparation, its water ultrafiltration is 35.5mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.3%; Urea permeability 173 P
m10
4cmmin
-1; Cobastab
12transmitance 84 P
m10
4cmmin
-1; Hot strength is 43.9MPa.
Embodiment 4:
A kind of nano-magnetic hemodialysis membrane, dialysis membrane is hollow-fibre membrane, comprises each component of following mass fraction: polymethyl methacrylate 38 parts, polyacrylic acid modified NiFe
2o
4particle 9 parts, polyacrylamide 11 parts and solvent 40 parts, solvent is acetone and DMAC, and both mass ratios are 1:1.
Prepare nano-magnetic hemodialysis membrane according to preparation method provided by the invention, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 50 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.04MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 75%, temperature 65 DEG C;
(4) adjusting spinning solution pressure tank is 0.5MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 500r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
The mean inside diameter of the doughnut of preparation is 230 μm, wall thickness 42 μm.
Measure the nano-magnetic hemodialysis membrane of preparation, its water ultrafiltration is 35.5mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.4%; Urea permeability 176 P
m10
4cmmin
-1; Cobastab
12transmitance 85 P
m10
4cmmin
-1; Hot strength is 44.7MPa.
Embodiment 5:
A kind of nano-magnetic hemodialysis membrane, dialysis membrane is hollow-fibre membrane, comprises each component of following mass fraction: polymethyl methacrylate 40 parts, polyacrylic acid modified NiFe
2o
4particle 12 parts, polyacrylamide 12 parts and solvent 45 parts, solvent is acetone and DMAC, and both mass ratios are 1:1.
Prepare nano-magnetic hemodialysis membrane according to preparation method provided by the invention, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 65 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.06MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 80%, temperature 70 C;
(4) adjusting spinning solution pressure tank is 0.6MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 600r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
The mean inside diameter of the doughnut of preparation is 244 μm, wall thickness 45 μm.
Measure the nano-magnetic hemodialysis membrane of preparation, its water ultrafiltration is 35.7mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.4%; Urea permeability 178 P
m10
4cmmin
-1; Cobastab
12transmitance 86 P
m10
4cmmin
-1; Hot strength is 43.7MPa.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (6)
1. a nano-magnetic hemodialysis membrane, is characterized in that, comprises each component of following mass fraction: polymethyl methacrylate 25-40 part, macromolecule modified nano magnetic particle 6-12 part, polyacrylamide 5-15 part and solvent 24-45 part;
Wherein, dialysis membrane is hollow-fibre membrane, and mean inside diameter is 155-245 μm, wall thickness 32-45 μm;
Wherein, solvent is acetone and DMAC, and both mass ratios are 0.5-1:1.
2. nano-magnetic hemodialysis membrane according to claim 1, is characterized in that: described macromolecule modified nano magnetic particle is polyethylene glycol or albumin modified Nano Fe
3o
4particle.
3. nano-magnetic hemodialysis membrane according to claim 1, is characterized in that: described macromolecule modified nano magnetic particle is starch conversion super-paramagnetism nano Fe
3o
4particle.
4. nano-magnetic hemodialysis membrane according to claim 1, is characterized in that: described macromolecule modified nano magnetic particle is polyacrylic acid modified NiFe2O4.
5. nano-magnetic hemodialysis membrane according to claim 1, is characterized in that: in solvent, the mass ratio of acetone and DMAC is 2:3.
6. a preparation method for nano-magnetic hemodialysis membrane according to claim 1, is characterized in that, adopt wet-dry change preparation technology, preparation process is as follows:
(1) prepare spinning solution, it is even that each component puts into spinning solution in-tank mixing, after vacuum de-soak, is preheated to 35-65 DEG C;
(2) take deionized water as core liquid, adjustment core hydraulic is 0.01-0.06MPa;
(3) be coagulating bath with DMSO, in coagulating bath, the concentration of DMSO is 65%-80%, temperature 55-70 DEG C;
(4) adjusting spinning solution pressure tank is 0.3-0.6MPa, and temperature 54 DEG C, spinneret temperature 42 DEG C, the rotating speed arranging surge drum is 400-600r/min, starts to carry out spinning, can prepare nano-magnetic hemodialysis membrane.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105727771A (en) * | 2016-01-29 | 2016-07-06 | 东华大学 | Heparinoid-modified polyvinyl alcohol hydrogel thin nano-compound hematodialysis film and preparation method thereof |
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EP2561923A1 (en) * | 2011-08-23 | 2013-02-27 | Gambro Lundia AB | Graft copolymers |
CN103229053A (en) * | 2010-07-27 | 2013-07-31 | 西北大学 | Devices and methods for filtering blood plasma |
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2014
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103229053A (en) * | 2010-07-27 | 2013-07-31 | 西北大学 | Devices and methods for filtering blood plasma |
EP2561923A1 (en) * | 2011-08-23 | 2013-02-27 | Gambro Lundia AB | Graft copolymers |
Non-Patent Citations (1)
Title |
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DIMOSTHENIS STAMOPOULOS等: ""Utilization of nanobiotechnology in haemodialysis:mock-dialysis experiments on homocysteine"", 《NEPHROLOGY DIALYSIS TRANSPLANTATION》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105727771A (en) * | 2016-01-29 | 2016-07-06 | 东华大学 | Heparinoid-modified polyvinyl alcohol hydrogel thin nano-compound hematodialysis film and preparation method thereof |
CN105727771B (en) * | 2016-01-29 | 2018-04-20 | 东华大学 | Nano combined hemodialysis membrane of polyvinyl alcohol hydrogel thin layer that a kind of heparan is modified and preparation method thereof |
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Application publication date: 20150325 |