CN104435799A - Traditional Chinese medicine granules for treating kidney failure and inspection method thereof - Google Patents
Traditional Chinese medicine granules for treating kidney failure and inspection method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses traditional Chinese medicine granules for treating kidney failure. The traditional Chinese medicine granules for treating kidney failure are characterized by being prepared from the following main raw materials in parts by weight: 6-12 parts of astragalus membranaceus, 10-20 parts of salvia miltiorrhiza, 20-30 parts of semen raphani, 8-16 parts of radix cyathulae, 3-9 parts of pangolin, 3-9 parts of fructus psoraleae, 9-18 parts of lalang grass rhizome, 5-15 parts of turpinia formosana, 12-18 parts of oyster, 5-13 parts of radix saposhnikoviae and 15-25 parts of angelica sinensis. The detection method is simple, the detection result is reliable, and clinical diagnosis and treatment are much facilitated. The traditional Chinese medicine granules for treating kidney failure disclosed by the invention have a treatment principle of relaxing bowels and descending turbid, tonifying spleen and eliminating dampness, and activating blood circulation and dissipating stasis, and can start from adjusting qi, blood, yin and yang of viscera for improving the functional state of a human body, effectively enhancing immunity, furthest protecting a residual glomerulus function, and comprehensively improving symptoms.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of instant particles as Chinese medicine and the method for inspection thereof for the treatment of renal failure.
Background technology
Chronic renal failure (CRF) is also known as chronic renal insufficiency, refer to the chronic progressive external Renal lesion that a variety of causes causes, cause the obvious atrophy of kidney, its basic function can not be maintained, clinical appearance is with metabolite retention, water, electrolyte, acid base imbalance, each system involvement of whole body is the clinical syndrome of main manifestations, also referred to as uremia.From protopathy onset to renal insufficiency, can be the several years interval time to more than ten years.Chronic renal failure is the severe stage of renal insufficiency.The cause of disease: the cause of disease of chronic renal failure accounts for first place with various constitutional and secondary glomerulonephritis, secondly be that congenital urinary system malformation is (as renal hypoplasia, congenital polycystic kidney, vesicoureteral reflux etc.), hereditary is (as hereditary nephritis, medullary cystic disease of kidney, Fanconi syndrome etc.) in general systemic disease with renal arteriolosclerosis, hypertension, connective tissue diseases etc. are common, in recent years, the protopathy of CRF changes to some extent, renal interstitial tubule damages the CRF caused and is also subject to people's attention gradually, diabetic nephropathy, autoimmunity and connective tissue disease renal damage, the CRF caused is also on the rise.Clinical manifestation: chronic renal failure has influence on each organs and systems, diversified clinical manifestation can be caused, but, before the nephronloss of 80%, or before GFP drops to 25ml/ minute, without any symptom or little biochemical change can be only had, in the chronic progressive diseases such as such as polycystic kidney, even if GFR is lower than 10ml/ minute, also can not have symptom, this is caused by the huge adaptation of remaining nephron.Chronic renal failure mainly causes following various clinical pathological changes late period: 1. water, electrolyte, acid base imbalance: namely the basic function of kidney regulates water, electrolyte, acid-base balance, during renal insufficiency, due to its excretion or metabolic dysfunction, water in various degree will inevitably be caused, electrolyte, acid base imbalance, but, different with ARF, CRF in its very long course of disease due to the various compensatory mechanism of body, these metabolism disorders seem not fairly obvious sometimes, in fact, when light moderate CRF, the kidney losing partial function still more fully discharges the material or refuse that produce in various exogenous absorption and body, when normal renal function loses about 70%, generally only there will be part water, electrolyte, acid base imbalance, only have when renal function declines further, and take in or produce too much water in body, electrolyte, acid or alkaline matter just there will be obvious clinical manifestation.2. sugar, fat, protein and disorder of amino acid catabolism.3. each system dysfunction: 1. digestive system; 2. cardiovascular system; 3. respiratory system; 4. nervous system; 5. blood system; 6. motor system; 7. change of skin; 8. immune system; , all there is obstacle in various degree in 9. hormonal system.
The first-selected hemodialysis of Modern medical therapy chronic renal failure, its object one extends patient vitals, improves patients ' life quality; Two is for renal transplantation provides favourable opportunity, but the hemodialysis of routine is each 3 hours, 2 ~ 3 times weekly, dialyse frequently and bring a lot of complication to patient, and dialysis somewhat expensive, a lot of patient cannot bear, and hemodialysis can only take stopgap measures, can not effect a permanent cure, chronic renal insufficiency develops into the chronic renal failure phase, abnormalities of sugar/lipid metabolism, anemia increase the weight of, these are all that hemodialysis cann't be solved, and simultaneously due to the non-physiologic of dialysis, can produce multiple untoward reaction in dialysis procedure or after dialysis.
In the method for existing cooperation hemodialysis chronic renal failure, Authorization Notice No. CN 102688414 B (application number 201210210548.X) discloses a kind of instant particles as Chinese medicine tablet for the treatment of uremia's complication of hemodialysis, it is characterized in that: described instant particles as Chinese medicine tablet is only made up of as crude drug the Radix Astragali, Radix Codonopsis, Rhizoma Dioscoreae, Semen Coicis, Flos Carthami, Radix Et Rhizoma Rhei, Herba Orostachyos, Herba Dendrobii, Arillus Longan, Herba Taraxaci, Radix Angelicae Sinensis, the Fructus Kochiae, Thallus Laminariae (Thallus Eckloniae), Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, Radix Phytolaccae, Radix Morindae Officinalis, Coriolous Dersicolor (Fr.) Quel, Fructus Psoraleae and Radix Et Caulis Acanthopanacis Senticosi, Authorization Notice No. CN 102716339 B (application number 201210224055.1) patent discloses the uremic instant particles as Chinese medicine of a kind of cooperation hemodialysis, it is characterized in that, in described instant particles as Chinese medicine, the weight portion of each component is: Herba Cissampelotis pareiae 10-20 weight portion, Radix Glehniae 20-30 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 weight portion, Radix Paeoniae Alba 25-35 weight portion, Concha Ostreae 10-20 weight portion, Herba Ecliptae 30-40 weight portion, Cortex Dictamni 10-20 weight portion, Radix Rehmanniae Preparata 20-30 weight portion, Flos Chrysanthemi 15-25 weight portion, Radix Cyathulae 20-30 weight portion, Herba Plantaginis 10-20 weight portion, Folium Pyrrosiae 10-20 weight portion, Radix Ophiopogonis 30-40 weight portion, Fructus Lycii 25-35 weight portion, Herba Epimedii 10-20 weight portion, Radix Et Rhizoma Rhei 60-70 weight portion, Herba Schizonepetae 10-20 weight portion, Natrii Sulfas 15-25 weight portion, Caulis Spatholobi 25-35 weight portion and Rhizoma Polygonati 30-40 weight portion.
As can be seen here: Chinese medicine chronic renal failure can alleviate clinical symptoms, protection residual renal function, delays PD, postpones the time must dialysed with renal transplantation, is more and more subject to the attention of domestic and international medical circle.Chronic renal failure belongs to Chinese medicine obstruction and rejection, edema, the categories such as poison, asthenia of drowning, Chinese medicine thinks that with the passing of time this disease delays or exopathogen invasion and attack, overstrain internal injury, cause function deficient, turbid damp is stopped over, three Jiao of being jammed, ascending or descending movement of vital Qi is not normal, though the state of an illness is critical, syndrome is complicated, and deficiency in origin and excess in superficiality runs through course of disease main pathogenesis all the time.Deficiency in origin is based on spleen kidney yang (gas) void, and mark is real in turbid damp, noxious water, blood stasis, and strengthening vital QI to eliminate pathogenic factors is answered in treatment.
Summary of the invention
For the deficiencies in the prior art; an object of the present invention is to provide a kind of instant particles as Chinese medicine for the treatment of renal failure; with ventilation quality, invigorating spleen to remove dampness, activating blood circulation to dissipate blood stasis for Therapeutic Principle; can start with from adjustment internal organs negative and positive of qi and blood; improve function of human body state; effective raising immunity, makes remaining glomerular function be protected to greatest extent, improves symptom comprehensively.Another object of the present invention is just to provide the method for inspection of above-mentioned instant particles as Chinese medicine.
Technical scheme of the present invention is:
A kind of instant particles as Chinese medicine for the treatment of renal failure, take off the primary raw material stating weight proportion to be prepared from: Radix Astragali 6-12 part, Radix Salviae Miltiorrhizae 10-20 part, Semen Raphani 20-30 part, Radix Cyathulae 8-16 part, Squama Manis 3-9 part, Fructus Psoraleae 3-9 part, Rhizoma Imperatae 9-18 part, Turpinia pomifera(Roxb) D O. 5-15 part, Concha Ostreae 12-18 part, Radix Saposhnikoviae 5-13 part, Radix Angelicae Sinensis 15-25 part.
Treat an instant particles as Chinese medicine for renal failure, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 8-10 part, Radix Salviae Miltiorrhizae 13-18 part, Semen Raphani 23-28 part, Radix Cyathulae 10-14 part, Squama Manis 5-7 part, Fructus Psoraleae 5-7 part, Rhizoma Imperatae 13-15 part, Turpinia pomifera(Roxb) D O. 8-13 part, Concha Ostreae 14-16 part, Radix Saposhnikoviae 8-10 part, Radix Angelicae Sinensis 18-23 part.
Treat an instant particles as Chinese medicine for renal failure, more preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: the Radix Astragali 9 parts, Radix Salviae Miltiorrhizae 16 parts, Semen Raphani 25 parts, Radix Cyathulae 12 parts, Squama Manis 6 parts, Fructus Psoraleae 6 parts, Rhizoma Imperatae 14 parts, Turpinia pomifera(Roxb) D O. 11 parts, Concha Ostreae 15 parts, Radix Saposhnikoviae 9 parts, Radix Angelicae Sinensis 20 parts.
Above-mentioned a kind of preparation method for the treatment of the instant particles as Chinese medicine of renal failure, step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 5-15 hour (preferably soaking 10 hours), are placed on the upper low baking temperature of iron plate and dry 6-14 minute slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 80-120 mesh sieve (preferred mistake 100 mesh sieve), be placed in the close gauze of matter stand-by;
(3) medicated bag wrapping tighten in step (2) is placed in non iron container, after adding 3-8 DEG C cold water soak 3-5 hour, after slow fire decocts 30-50 hour slowly (preferred slow fire decocts 40 hours slowly), intense fire decocts 8 minutes, take out medicated bag, leave standstill 15 hours, get supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
The method of inspection of the above-mentioned instant particles as Chinese medicine prepared, step is as follows: 1) get this product 6-10g, solubilizer 20-30ml, backflow 30-40 minute, filter, collect filtrate solvent evaporated, residue adds 1-3 water dissolution doubly, extracts 1-4 time in the ethyl acetate adding 10-20ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 1-5ml and dissolves, as need testing solution; 2) separately get control medicinal material 6-10g, add water 60-80ml, boils 10-40 minute, and filter, filtrate water bath method, residue solubilizer 60-80ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
According to the foregoing method of inspection, preferred scheme is: get this product 7-9g, solubilizer 23-28ml, reflux 33-38 minute (preferred, to get this product 8g, solubilizer 25ml, reflux 35 minutes).
According to the foregoing method of inspection, preferred scheme is: residue adds 1.5-2.5 water dissolution doubly (preferred, residue adds the water dissolution of 2 times).
According to the foregoing method of inspection, preferred scheme is: get control medicinal material 7-9g, and add water 65-75ml, boils 18-28 minute (preferred, get control medicinal material 8g, add water 70ml, boils 23 minutes).
Best using method: be the therapeutic effect making the present invention reach best, for making the present invention reach optimum therapeuticing effect, the instant particles as Chinese medicine that the present invention makes, one day 3 times, each 30ml 7 days is a course for the treatment of.
The pharmacological effect of each crude drug is respectively:
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cure mainly: weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae (Classification system: Salvia miltiorrhiza Bunge) has another name called Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, Arisaema balansae Engl. etc.For dicotyledon Lamiaceae Salvia belongs to perennial vertical herbage plant, root manure is thick, outer vermilion, interior white, meat, and leaf is often imparipinnate leaf, top life or axillary-racemes; Bract lanceolar, calyx is bell, band purple, corolla hyacinthine, and style far ultraviolet is stretched, pyrene black, oval, and nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Semen Raphani: Semen Raphani, another name Semen Raphani, trailing plants white chessman, Semen Raphani, nature and flavor: property is put down, acrid in the mouth, sweet.Gui Jing: return lung, spleen, stomach warp.Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.
Radix Cyathulae: nature and flavor: sweet, micro-hardship, flat.Gui Jing: return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.Cure mainly: for amenorrhea carcinoma, retention of placenta, arthralgia, sufficient health clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Squama Manis: Squama Manis (Classification system: Manis) is the general designation belonged to Squama Manis section Squama Manis, blood circulation promoting and dispersing pathogen accumulation; To stimulate the menstrual flow stimulating milk secretion; Eliminating carbuncle is burst hard.Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Agalactia; Carbuncle; Scrofula.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Fructus Psoraleae: nature and flavor: pungent, bitter, temperature.Gui Jing: return kidney, spleen channel.Effect: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.Cure mainly: for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Rhizoma Imperatae: Rhizoma Imperatae is the rhizome of grass perennial herb Herba Imperatae.Season in spring and autumn two excavates.Dry.Removing fibrous root and film quality sheath, cutting is raw to be used or parch to black use.Another name: Rhizoma Imperatae, manage, Ru Gen, Lan Gen.Cure mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.For spitting blood, hematuria, pyretic stranguria, edema, jaundice, dysuria, calentura excessive thirst, gastric heat is vomitted the sound of vomiting, coughs.
Turpinia pomifera(Roxb) D O.: have another name called two to point sword at, seven cun of nails, be root or the leaf of the sharp sharp Turpinia pomifera(Roxb) D O. of Staphyleaceae Turpinia pomifera(Roxb) D O. platymiscium.The property of medicine: bitter in the mouth, cold in nature.Composition: its leaf is containing ursolic acid, and chromocor compound rutin, also contains myristic acid, daucosterol etc.Find according to modern pharmacological research, this medical instrument has antibacterial, antiinflammatory, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, for traumatic injury, and spleen enlargement, pharyngolaryngitis etc.
Concha Ostreae: Concha Ostreae is one of food being rich in zinc element (every 100g zinc content 9.39mg, is rich in protein-zinc), belongs to Ostreidae (the true Concha Ostreae of Ostreidae) or Yan Ha section (Aviculidae pearl oyster), salty, is slightly cold; Return liver, gallbladder, kidney channel.Function: medicine for calming liver and calming endopathic wind; Yin-nourishing drug.On accept and hold back, treatment is dizzy, just rare.There are convergence, calmness, removing toxic substances, analgesic effect.
Radix Saposhnikoviae: Radix Saposhnikoviae another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds. be the name of a kind of medicinal herbs, herbaceos perennial, Gui Jing: urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Effect: Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic, cures mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Cure mainly: for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Present invention also offers the application of above-mentioned instant particles as Chinese medicine at preparation treatment renal failure complication of hemodialysis.
Beneficial effect of the present invention: adopt instant particles as Chinese medicine of the present invention, it can be good at the complications for the treatment of renal failure and being brought by hemodialysis, as skin pruritus and malnutrition, it is high that the present invention has curative effect, short treating period, the advantage of instant effect, can the basic controlling state of an illness.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds treats the instant particles as Chinese medicine of renal failure, take off the primary raw material stating weight proportion to be prepared from (getting 10g for every part): the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 10 parts, Semen Raphani 20 parts, Radix Cyathulae 8 parts, Squama Manis 3 parts, Fructus Psoraleae 3 parts, Rhizoma Imperatae 9 parts, Turpinia pomifera(Roxb) D O. 5 parts, Concha Ostreae 12 parts, Radix Saposhnikoviae 5 parts, Radix Angelicae Sinensis 15 parts.
Above-mentioned a kind of method of inspection for the treatment of the instant particles as Chinese medicine of renal failure, step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 5 hours, are placed on the upper low baking temperature of iron plate and dry 6 minutes slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 80 mesh sieves, be placed in the close gauze of matter stand-by;
(3) be placed in non iron container by the medicated bag wrapping tighten in step (2), add the cold water soak of 3 DEG C after 3 hours, after slow fire decocts 30 hours slowly, intense fire decocts 8 minutes, takes out medicated bag, leaves standstill 15 hours, gets supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
According to the method for inspection of the instant particles as Chinese medicine prepared recited above, step is as follows: 1) get this product 6g, solubilizer 20ml, refluxes 30 minutes, filter, collect filtrate solvent evaporated, residue adds the water dissolution of 1 times, extracts 1 time in the ethyl acetate adding 10ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 1-5ml and dissolves, as need testing solution; 2) separately get control medicinal material 6g, add water 60ml, boils 10 minutes, and filter, filtrate water bath method, residue solubilizer 60ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
Typical case one: Qin XX, female, 48 years old, patients with renal failure, first visit in January, 2013, hemodialysis half a year, 1 time weekly.Long-term inappetence, weak, ochriasis is dark turbid, spiritlessness and weakness, tending to vomit of feeling sick, skin itching, and edema of lower limbs oliguria walks, constipation with dry stool, and hematochrome is 5 grams, dimly pale tongue, and tongue coating dirt is thick and greasy, pulse condition stringy and rolling pulse number, presses strong.
Take the embodiment of the present invention 1 gained instant particles as Chinese medicine, every day 3 times, each 30ml, take 2 courses for the treatment of, namely only urine is cumulative for vomiting and nausea, and edema is shown in and disappears, and free movement of the bowels, patient is conscious, and spirit takes a turn for the better, and strength has increasing.Check serum creatinine and blood urea nitrogen also decline to some extent.Under the close fit of patient, treat and to start to extend dialysis interval time after two weeks, continue to take embodiment 1 gained electuary, complexion is comparatively moistened, spirit is refreshing suitable, know hungry wish food, two is just as usual, and conscious strength increases, take a walk every day 2 to 3 hours, unconsciously tired, and known through result of laboratory test, after stopping dialysis, the state of an illness is basicly stable.
Embodiment 2 one kinds treats the instant particles as Chinese medicine of renal failure, take off the primary raw material stating weight proportion to be prepared from (getting 5g for every part): the Radix Astragali 12 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Raphani 30 parts, Radix Cyathulae 16 parts, Squama Manis 9 parts, Fructus Psoraleae 9 parts, Rhizoma Imperatae 18 parts, Turpinia pomifera(Roxb) D O. 15 parts, Concha Ostreae 18 parts, Radix Saposhnikoviae 13 parts, Radix Angelicae Sinensis 25 parts.
Above-mentioned a kind of method of inspection for the treatment of the instant particles as Chinese medicine of renal failure, step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 15 hours, are placed on the upper low baking temperature of iron plate and dry 14 minutes slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 120 mesh sieves, be placed in the close gauze of matter stand-by;
(3) be placed in non iron container by the medicated bag wrapping tighten in step (2), add the cold water soak of 8 DEG C after 5 hours, after slow fire decocts 50 hours slowly, intense fire decocts 8 minutes, takes out medicated bag, leaves standstill 15 hours, gets supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
According to the method for inspection of the instant particles as Chinese medicine prepared recited above, step is as follows: 1) get this product 10g, solubilizer 30ml, refluxes 40 minutes, filter, collect filtrate solvent evaporated, residue adds 1-3 water dissolution doubly, extracts 4 times in the ethyl acetate adding 20ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 1-5ml and dissolves, as need testing solution; 2) separately get control medicinal material 10g, add water 80ml, boils 40 minutes, and filter, filtrate water bath method, residue solubilizer 80ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
Typical case two Liu so-and-so, man, 56 years old, retired worker.With " two lower limbs edema recurrent exerbation 6 years, vomiting, hypourocrinia 2 weeks ", be admitted to hospital on November 12nd, 2009.Patient has more than 10 years of type ii diabetes, diagnosing diabetes nephropathy before more than 6 years.Check BP:160/100mmHg, blood BUN:55.70mmol/L, Cr:665 μm ol/L, through being diagnosed as diabetic nephropathy, chronic renal failure after being admitted to hospital comprehensively.Patient is weak, breathe hard, fear of cold, and urine amount more obviously reduces, and light red tongue has indentation white and thin fur, and soft pulse is soft, and differential diagnosis in tcm is deficiency of spleen-YANG and kidneyYANG, accumulate in turbid poison.Because patient age is comparatively large, the state of an illness is also relatively more serious, and doctor advised takes embodiment 1 gained instant particles as Chinese medicine.
Take the embodiment of the present invention 2 gained instant particles as Chinese medicine, check blood BUN:26.05mmol/L after 2 weeks, Cr:405 μm of ol/L, controlling of blood pressure is up to standard, and doctor exhorts and must adhere to taking embodiment 2 gained instant particles as Chinese medicine, suitably keeps on a diet, eat greasy food less, through 20 hemodialysis in half a year, and take embodiment 2 gained instant particles as Chinese medicine, serum creatinine maintains 350-400 μm of about ol/L always.
Embodiment 3 one kinds treats the instant particles as Chinese medicine of renal failure, take off the primary raw material stating weight proportion to be prepared from (getting 15g for every part): the Radix Astragali 8 parts, Radix Salviae Miltiorrhizae 13 parts, Semen Raphani 23 parts, Radix Cyathulae 10 parts, Squama Manis 5 parts, Fructus Psoraleae 5 parts, Rhizoma Imperatae 13 parts, Turpinia pomifera(Roxb) D O. 8 parts, Concha Ostreae 14 parts, Radix Saposhnikoviae 8 parts, Radix Angelicae Sinensis 18 parts.
Above-mentioned a kind of method of inspection for the treatment of the instant particles as Chinese medicine of renal failure, step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 8 hours, are placed on the upper low baking temperature of iron plate and dry 8 minutes slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 90 mesh sieves, be placed in the close gauze of matter stand-by;
(3) be placed in non iron container by the medicated bag wrapping tighten in step (2), add the cold water soak of 5 DEG C after 3.5 hours, after slow fire decocts 35 hours slowly, intense fire decocts 8 minutes, takes out medicated bag, leaves standstill 15 hours, gets supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
According to the method for inspection of the instant particles as Chinese medicine prepared recited above, step is as follows: 1) get this product 7g, solubilizer 23ml, refluxes 33 minutes, filter, collect filtrate solvent evaporated, residue adds the water dissolution of 1.5 times, extracts 2 times in the ethyl acetate adding 13ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 1-5ml and dissolves, as need testing solution; 2) separately get control medicinal material 7g, add water 65ml, boils 20 minutes, and filter, filtrate water bath method, residue solubilizer 65ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
Embodiment 4 one kinds treats the instant particles as Chinese medicine of renal failure, take off the primary raw material stating weight proportion to be prepared from (getting 20g for every part): the Radix Astragali 10 parts, Radix Salviae Miltiorrhizae 18 parts, Semen Raphani 28 parts, Radix Cyathulae 14 parts, Squama Manis 7 parts, Fructus Psoraleae 7 parts, Rhizoma Imperatae 15 parts, Turpinia pomifera(Roxb) D O. 13 parts, Concha Ostreae 16 parts, Radix Saposhnikoviae 10 parts, Radix Angelicae Sinensis 23 parts.
Above-mentioned a kind of method of inspection for the treatment of the instant particles as Chinese medicine of renal failure, step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 12 hours, are placed on the upper low baking temperature of iron plate and dry 12 minutes slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 110 mesh sieves, be placed in the close gauze of matter stand-by;
(3) be placed in non iron container by the medicated bag wrapping tighten in step (2), add the cold water soak of 7 DEG C after 4.5 hours, after slow fire decocts 45 hours slowly, intense fire decocts 8 minutes, takes out medicated bag, leaves standstill 15 hours, gets supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
5, the method for inspection of the instant particles as Chinese medicine prepared according to claim 4, step is as follows: 1) get this product 9g, solubilizer 28ml, refluxes 38 minutes, filter, collect filtrate solvent evaporated, residue adds the water dissolution of 2.5 times, extracts 3 times in the ethyl acetate adding 18ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 4ml and dissolves, as need testing solution; 2) separately get control medicinal material 9g, add water 75ml, boils 30 minutes, and filter, filtrate water bath method, residue solubilizer 75ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
Embodiment 5 one kinds treats the instant particles as Chinese medicine of renal failure, take off the primary raw material stating weight proportion to be prepared from (getting 30g for every part): the Radix Astragali 9 parts, Radix Salviae Miltiorrhizae 16 parts, Semen Raphani 25 parts, Radix Cyathulae 12 parts, Squama Manis 6 parts, Fructus Psoraleae 6 parts, Rhizoma Imperatae 14 parts, Turpinia pomifera(Roxb) D O. 11 parts, Concha Ostreae 15 parts, Radix Saposhnikoviae 9 parts, Radix Angelicae Sinensis 20 parts.
Above-mentioned a kind of method of inspection for the treatment of the instant particles as Chinese medicine of renal failure, step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 10 hours, are placed on the upper low baking temperature of iron plate and dry 10 minutes slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 100 mesh sieves, be placed in the close gauze of matter stand-by;
(3) be placed in non iron container by the medicated bag wrapping tighten in step (2), add the cold water soak of 6 DEG C after 4 hours, after slow fire decocts 40 hours slowly, intense fire decocts 8 minutes, takes out medicated bag, leaves standstill 15 hours, gets supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
According to the method for inspection of the instant particles as Chinese medicine prepared recited above, step is as follows: 1) get this product 8g, solubilizer 25ml, refluxes 35 minutes, filter, collect filtrate solvent evaporated, residue adds the water dissolution of 2 times, extracts 2 times in the ethyl acetate adding 15ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 1-5ml and dissolves, as need testing solution; 2) separately get control medicinal material 8g, add water 70ml, boils 23 minutes, and filter, filtrate water bath method, residue solubilizer 70ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
A kind of instant particles as Chinese medicine clinical practice for the treatment of renal failure of test example 1 embodiment 5 gained: screen 400 routine patients in 4 hospitals, before test 7 days, Continuous Observation is carried out to this crowd, record symptom and change, be equally divided into 2 groups, experimental group and matched group, treatment group takes products obtained therefrom of the present invention, and matched group uses/take other medicine (medicine as conventional therapy chronic renal failures such as NIAODUQING instant particles as Chinese medicine and Ai Xi Te).Effective: after taking this product, malaise symptoms improves substantially; Invalid: after taking this instant particles as Chinese medicine, malaise symptoms without significant change, patient condition with treatment before no significant difference.Result is as shown in table 1.Result is as shown in table 1.
Table 1:
Prove through clinical trial, instant particles as Chinese medicine of the present invention is in treatment chronic renal failure, and total effective rate is 99.5%, and successful, than matched group good effect, makes the state of an illness of patient be stablized; And any burden can not be caused to the health of patient.Instant particles as Chinese medicine instant effect of the present invention, can reach the object alleviating rapidly patient's misery, be a kind of instant particles as Chinese medicine for the treatment of renal failure safely and effectively.
Claims (8)
1. treat the instant particles as Chinese medicine of renal failure for one kind, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Astragali 6-12 part, Radix Salviae Miltiorrhizae 10-20 part, Semen Raphani 20-30 part, Radix Cyathulae 8-16 part, Squama Manis 3-9 part, Fructus Psoraleae 3-9 part, Rhizoma Imperatae 9-18 part, Turpinia pomifera(Roxb) D O. 5-15 part, Concha Ostreae 12-18 part, Radix Saposhnikoviae 5-13 part, Radix Angelicae Sinensis 15-25 part.
2. the instant particles as Chinese medicine for the treatment of renal failure according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Astragali 8-10 part, Radix Salviae Miltiorrhizae 13-18 part, Semen Raphani 23-28 part, Radix Cyathulae 10-14 part, Squama Manis 5-7 part, Fructus Psoraleae 5-7 part, Rhizoma Imperatae 13-15 part, Turpinia pomifera(Roxb) D O. 8-13 part, Concha Ostreae 14-16 part, Radix Saposhnikoviae 8-10 part, Radix Angelicae Sinensis 18-23 part.
3. the instant particles as Chinese medicine for the treatment of renal failure according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: the Radix Astragali 9 parts, Radix Salviae Miltiorrhizae 16 parts, Semen Raphani 25 parts, Radix Cyathulae 12 parts, Squama Manis 6 parts, Fructus Psoraleae 6 parts, Rhizoma Imperatae 14 parts, Turpinia pomifera(Roxb) D O. 11 parts, Concha Ostreae 15 parts, Radix Saposhnikoviae 9 parts, Radix Angelicae Sinensis 20 parts.
4. the preparation method of the instant particles as Chinese medicine of the treatment renal failure according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Fructus Psoraleae, Radix Cyathulae and Radix Angelicae Sinensis are placed in white vinegar to soak 5-15 hour (preferably soaking 10 hours), are placed on the upper low baking temperature of iron plate and dry 6-14 minute slowly, dry in the air cool stand-by;
(2) by the Radix Astragali, Semen Raphani, Turpinia pomifera(Roxb) D O., Rhizoma Imperatae, Radix Salviae Miltiorrhizae, Squama Manis, Concha Ostreae, Radix Saposhnikoviae and the slender roll of medicated paper or gauze fine grinding of step (1) gained crude drug, cross 80-120 mesh sieve (preferred mistake 100 mesh sieve), be placed in the close gauze of matter stand-by;
(3) medicated bag wrapping tighten in step (2) is placed in non iron container, after adding 3-8 DEG C cold water soak 3-5 hour, after slow fire decocts 30-50 hour slowly (preferred slow fire decocts 40 hours slowly), intense fire decocts 8 minutes, take out medicated bag, leave standstill 15 hours, get supernatant stand-by;
(4) step (3) gained supernatant is placed in intense fire in marmite to be fried open, puts into Mel, fully stir thawing with ferrum spoon, cool, bottle and obtain instant particles as Chinese medicine.
5. the method for inspection of the instant particles as Chinese medicine prepared according to claim 4, it is characterized in that: step is as follows: 1) get this product 6-10g, solubilizer 20-30ml, backflow 30-40 minute, filter, collect filtrate solvent evaporated, residue adds 1-3 water dissolution doubly, extracts 1-4 time in the ethyl acetate adding 10-20ml at every turn, merge extractive liquid, evaporate to dryness ethyl acetate, residue adds methanol 1-5ml and dissolves, as need testing solution; 2) separately get control medicinal material 6-10g, add water 60-80ml, boils 10-40 minute, and filter, filtrate water bath method, residue solubilizer 60-80ml, is made in the same way of control medicinal material solution; 3) according to thin layer chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with toluene-ethyl acetate-formic acid for developing solvent, launch, take out, dry, spray, with 10% ethanol solution of sulfuric acid, is heated to spot development at 100 DEG C clear, inspects under putting ultra-violet lamp; 4) in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, blueness, the green fluorescence speckle of aobvious same color.
6. the method for inspection according to claim 5, is characterized in that: get this product 7-9g, solubilizer 23-28ml, reflux 33-38 minute (preferred, to get this product 8g, solubilizer 25ml, reflux 35 minutes).
7. the method for inspection according to claim 5, is characterized in that: residue adds 1.5-2.5 water dissolution doubly (preferred, residue adds the water dissolution of 2 times).
8. the method for inspection according to claim 5, is characterized in that: get control medicinal material 7-9g, and add water 65-75m1, boils 18-28 minute (preferred, get control medicinal material 8g, add water 70ml, boils 23 minutes).
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| CN105168664A (en) * | 2015-10-19 | 2015-12-23 | 管遵信 | Traditional Chinese medicine for treating chronic renal failure |
| CN105412635A (en) * | 2015-11-26 | 2016-03-23 | 湖州品创孵化器有限公司 | Drug for treating uremia and preparation method thereof |
| CN105878419A (en) * | 2014-11-06 | 2016-08-24 | 李汝芬 | Compound preparation cooperating with hemodialysis for treatment of chronic renal failure and preparation method thereof |
| CN106235329A (en) * | 2016-07-29 | 2016-12-21 | 林少忠 | A kind of functional food treating metabolic syndrome and preparation method thereof |
| CN110068647A (en) * | 2019-05-29 | 2019-07-30 | 四川新绿色药业科技发展有限公司 | A kind of thin-layer identification method of citron granule |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105878419A (en) * | 2014-11-06 | 2016-08-24 | 李汝芬 | Compound preparation cooperating with hemodialysis for treatment of chronic renal failure and preparation method thereof |
| CN105168664A (en) * | 2015-10-19 | 2015-12-23 | 管遵信 | Traditional Chinese medicine for treating chronic renal failure |
| CN105412635A (en) * | 2015-11-26 | 2016-03-23 | 湖州品创孵化器有限公司 | Drug for treating uremia and preparation method thereof |
| CN106235329A (en) * | 2016-07-29 | 2016-12-21 | 林少忠 | A kind of functional food treating metabolic syndrome and preparation method thereof |
| CN110068647A (en) * | 2019-05-29 | 2019-07-30 | 四川新绿色药业科技发展有限公司 | A kind of thin-layer identification method of citron granule |
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