CN104435662A - Medicine for treating arteriosclerosis and preparation method thereof - Google Patents

Medicine for treating arteriosclerosis and preparation method thereof Download PDF

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Publication number
CN104435662A
CN104435662A CN201410628204.XA CN201410628204A CN104435662A CN 104435662 A CN104435662 A CN 104435662A CN 201410628204 A CN201410628204 A CN 201410628204A CN 104435662 A CN104435662 A CN 104435662A
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China
Prior art keywords
medicine
radix ophiopogonis
arteriosclerotic
rhizoma arisaematis
hours
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CN201410628204.XA
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Chinese (zh)
Inventor
陈丽芳
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Individual
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Individual
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Priority to CN201410628204.XA priority Critical patent/CN104435662A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicine for treating arteriosclerosis. The medicine is mainly prepared by the following steps: repeatedly decocting Chinese herbal medicines such as flowers carthami, radix ophiopogonis, mangnolia officinalis, herba fibraureae recisae, rhizoma arisaematis and cortex albiziae as raw materials with a slow fire; taking out herb residues; mixing a liquid medicine, then putting into a marmite and decocting for 2-4 hours; concentrating the liquid medicine into a thick paste; adding conventional auxiliary materials, preparing a clinically acceptable medicine, and then packaging, so as to obtain the finished product. The medicine disclosed by the invention is used for clearing heat, promoting diuresis, and promoting blood circulation to remove meridian obstruction; and arteriosclerosis can be treated.

Description

One treats arteriosclerotic medicine and preparation method thereof
Technical field
The present invention relates to one and treat arteriosclerotic medicine, being related specifically to a kind of take Chinese herbal medicine as the arteriosclerotic medicine for the treatment of prepared by raw material, the invention still further relates to the preparation method of this medicine.
Background technology
Arteriosclerosis is one of common angiopathy, reason mainly hypertension and the hyperlipemia of morbidity, in addition, smoking, obesity, diabetes, hypomotility, tense situation, advanced age, family's medical history, short-tempered etc. also can cause arteriosclerosis.Its main manifestations be ductus arteriosus wall thicken, hardening, to follow the string, luminal stenosis.Arteriosclerosis can cause blood supply insufficiency, has a strong impact on the health of people.At present, treat arteriosclerotic Western medicine a lot, but generally there is the shortcomings such as treatment cost is high, side effect is large.In addition, also have the arteriosclerotic Chinese medicine of a lot for the treatment of, but great majority has the shortcoming such as therapeutic effect difference, treatment cycle length.
Summary of the invention
The present invention aims to provide the arteriosclerotic medicine for the treatment of that a kind of cure rate is high, treatment cost is low, have no side effect.
The preparation method of this medicine is provided to be another goal of the invention of the present invention.
Medicine of the present invention is made up of the raw material of following mass ratio:
Flos Carthami 5-15 10-20 Radix Ophiopogonis
Cortex Magnoliae Officinalis 6-22 Caulis Fibraureae 12-26
Rhizoma Arisaematis 8-18 Cortex Albiziae 3-12
Specifically be made up of the raw material of following mass ratio:
Flos Carthami 10 Radix Ophiopogonis 15
Cortex Magnoliae Officinalis 12 Caulis Fibraureae 20
Rhizoma Arisaematis 16 Cortex Albiziae 8
The preparation method of medicine of the present invention is:
Flos Carthami, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Caulis Fibraureae, Rhizoma Arisaematis and Cortex Albiziae are added the clear water of 60-100 weight portions, 0.5-1.5 hours at a simmer, after repeatedly decocting 3 times, take out medicinal residues, marmite is put in 3 medicinal liquid mixing and decocts 2-4 hours, concentration of liquid medicine is become paste, then adds customary adjuvant, make the medicament of clinical acceptance.
Have between each medicine in prescription of the present invention and be added complementary and synergism, clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, can treat all kinds arteriosclerosis, and have no side effect.
The present invention is that inventor is through repeatedly studying, progressively improve, last successful a kind of curative effect treats arteriosclerotic medicine preferably, for showing that medicine of the present invention is to arteriosclerotic therapeutic effect, the present invention has carried out clinical observation to the arteriosclerotic that 210 examples take this medicine, and selection has arteriosclerotic 209 example of comparability as a control group.Treatment group patient takes medicine of the present invention every day three times, and the morning, noon and afternoon respectively once, once take 5 grams of medicines, and matched group patient takes the arteriosclerotic oral drugs of conventional therapy.Treat after one month, therapeutic outcome is in table 1
Table 1 treatment group and treatment of control group result synopsis
Cure Effectively Cure rate Effective percentage
Treatment group 151 examples 178 examples 71.90% 84.76%
Matched group 103 examples 129 examples 49.28% 61.72%
Treatment group is compared matched group and is had higher cure rate and effective percentage, thinks thus, and Drug therapy arteriosclerosis of the present invention has good effect, and through the Ureteral Calculus of month, takes medicine of the present invention and do not occur any toxic and side effects.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but does not form any limitation of the invention.
Embodiment 1
Raw material (kg) is prepared according to following weight:
Flos Carthami 1.0, Radix Ophiopogonis 1.5, Cortex Magnoliae Officinalis 1.2, Caulis Fibraureae 2.0, Rhizoma Arisaematis 1.6 and Cortex Albiziae 0.8.
Above-mentioned 8.1kg Chinese herbal medicine is put into marmite, adds the clear water of 8.5kg, 0.5-1.5 hours at a simmer, after repeatedly decocting 3 times, take out medicinal residues, concentration of liquid medicine is become paste, then adds customary adjuvant, make the powder of clinical acceptance, after packaging, obtain finished product.
Embodiment 2
Raw material (kg) is prepared according to following weight:
Flos Carthami 1.3, Radix Ophiopogonis 1.6, Cortex Magnoliae Officinalis 1.8, Caulis Fibraureae 1.5, Rhizoma Arisaematis 1.3 and Cortex Albiziae 0.7.
Above-mentioned 8.2kg Chinese herbal medicine is put into marmite, add the clear water of 9.0kg, 1.5 hours at a simmer, after repeatedly decocting 3 times, take out medicinal residues, marmite is put in 3 medicinal liquid mixing again and decocts 3 hours, concentration of liquid medicine is become paste, then the paste medicine of gained dried, grind, encapsulated, after packaging finished product.

Claims (3)

1. treat an arteriosclerotic medicine, it is characterized in that described medicine is made up of the raw material of following mass ratio:
Flos Carthami 5-15 10-20 Radix Ophiopogonis
Cortex Magnoliae Officinalis 6-22 Caulis Fibraureae 12-26
Rhizoma Arisaematis 8-18 Cortex Albiziae 3-12.
2. the arteriosclerotic medicine for the treatment of according to claim 1, is characterized in that described medicine is made up of the raw material of following mass ratio:
Flos Carthami 10 Radix Ophiopogonis 15
Cortex Magnoliae Officinalis 12 Caulis Fibraureae 20
Rhizoma Arisaematis 16 Cortex Albiziae 8.
3. the preparation method of the arteriosclerotic medicine for the treatment of according to claim 1, it is characterized in that Flos Carthami, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Caulis Fibraureae, Rhizoma Arisaematis and Cortex Albiziae are added the clear water of 60-100 weight portions by the method, 0.5-1.5 hours at a simmer, after repeatedly decocting 3 times, take out medicinal residues, marmite is put in 3 medicinal liquid mixing and decocts 2-4 hours, concentration of liquid medicine is become paste, then add customary adjuvant, make the medicament of clinical acceptance.
CN201410628204.XA 2014-11-11 2014-11-11 Medicine for treating arteriosclerosis and preparation method thereof Pending CN104435662A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410628204.XA CN104435662A (en) 2014-11-11 2014-11-11 Medicine for treating arteriosclerosis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410628204.XA CN104435662A (en) 2014-11-11 2014-11-11 Medicine for treating arteriosclerosis and preparation method thereof

Publications (1)

Publication Number Publication Date
CN104435662A true CN104435662A (en) 2015-03-25

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ID=52882923

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Application Number Title Priority Date Filing Date
CN201410628204.XA Pending CN104435662A (en) 2014-11-11 2014-11-11 Medicine for treating arteriosclerosis and preparation method thereof

Country Status (1)

Country Link
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1310019A (en) * 2001-02-28 2001-08-29 南京中医药大学 Maizhenhua extract as coronary heart disease treating medicine and its preparation
CN1491701A (en) * 2003-09-08 2004-04-28 姚根管 Medicine for treating sympthetic nerve disorder
KR20140032200A (en) * 2012-09-06 2014-03-14 영남대학교 산학협력단 Composition for inhibiting cellular senescence comprising juglanin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1310019A (en) * 2001-02-28 2001-08-29 南京中医药大学 Maizhenhua extract as coronary heart disease treating medicine and its preparation
CN1491701A (en) * 2003-09-08 2004-04-28 姚根管 Medicine for treating sympthetic nerve disorder
KR20140032200A (en) * 2012-09-06 2014-03-14 영남대학교 산학협력단 Composition for inhibiting cellular senescence comprising juglanin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
郑弼芳等: "多联疗法治疗脑血管疾病28例", 《现代中西医结合杂志》 *

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Application publication date: 20150325

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