CN104435582A - 一种治疗中老年抑郁症失眠的中药敷贴剂 - Google Patents
一种治疗中老年抑郁症失眠的中药敷贴剂 Download PDFInfo
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Abstract
本发明公开了一种治疗中老年抑郁症失眠的中药敷贴剂。中老年抑郁症失眠的病因病机主要在于经脉运行不畅，本发明选择中药草柏枝、梦花、太阳针、定心散、含羞草、长春花、石菖蒲、菠菜子、梵天花根、大剑叶木、柠条根、牛尾菜研末，取适量加水及蜂蜜少许调成糊状，贴敷于相应穴位，经临床试验，总有效率达到90.0％，明显高于对照组，而且无副作用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗中老年抑郁症失眠的中药敷贴剂。
背景技术
抑郁症与中医郁病相似，临床症状典型的表现包括三个维度活动的降低：情绪低落、思维迟缓、意志活动减退，另外一些患者会以躯体症状表现出为主，伴有失眠、乏力、食欲不振等。失眠是老年抑郁症的典型症状之一。针对本病，中药内服有一定的疗效，但患者不易接受或坚持，且医疗费用较高。西药起效快，但毒副作用大，停药易复发，有耐药性和成瘾性等缺点，临床使用受到一定限制。
穴位贴敷疗法集针灸和药物治疗之所长，克服内服疗法损伤脾胃之弊，还集合了针刺疗法刺激经气运行的特点，老幼虚弱之体，尤为适宜。此外，其使用相对安全，即便在临床应用时出现皮肤过敏或水泡，亦可及时中止治疗，给予对症处理，症状很快就可消失，并可继续使用。另外，其所用药物大多数为常见中草药，价格低廉，既能减轻患者的经济负担，又可节约大量药材。
穴位贴敷疗法通过药物直接刺激穴位，并通过透皮吸收，使局部药物浓度明显高于其他部位，其借助皮肤孔窍渗透到经络，药物通过经络的运行，从而达到畅气机，调阴阳的作用，有助于针对中老年个体的特殊性。
发明内容
本发明的目的是提供一种治疗中老年抑郁症失眠的中药敷贴剂。中老年抑郁症失眠的病因病机主要在于经脉运行不畅，穴位贴敷疗法治疗中老年抑郁症失眠的作用机理主要是通过调节中老年人体经气。
本发明的目的是通过以下技术方案实现的，该治疗中老年抑郁症失眠的中药敷贴剂由以下重量份的中药制成：草柏枝8-12份、梦花6-10份、太阳针6-8份、定心散15-25份、含羞草15-25份、长春花6-10份、石菖蒲3-5份、菠菜子9-12份、梵天花根30-50份、大剑叶木15-25份、柠条根20-30份、牛尾菜6-10份。
优选的：草柏枝10份、梦花8份、太阳针7份、定心散20份、含羞草20份、长春花8份、石菖蒲4份、菠菜子10份、梵天花根40份、大剑叶木20份、柠条根25份、牛尾菜8份。
制备方法 研末，取适量加水及蜂蜜少许调成糊状，搓成一元硬币大小待用。
方中：草柏枝养心、安神、止血；梦花养阴安神、明目去翳；太阳针镇心安神；定心散安心神、通经络；含羞草安神、清热、解毒；长春花镇静安神、平肝降压；石菖蒲开窍豁痰、活血、理气、散风、祛湿；皂荚根皮通利关窍、除风祛痰、杀虫；菠菜子开通关窍、利肠胃、祛风明目；梵天花根祛风除湿、暖胃健脾、舒筋通络、祛瘀活血；大剑叶木祛风湿、通经、补虚；柠条根养血滋阴；牛尾菜补气、舒筋活络、活血。
临床资料
1.一般资料 在我院随机选择60例中老年抑郁症失眠门诊患者，按随机法分为2个临床疗效观察组。第一组为穴位贴敷治疗组(治疗组)，30例；第二组为西药常规治疗对照组(对照组)，30例。所选患者均为抑郁症失眠首发的中老年患者，初诊时间集中在2012年11月至2013年10月前后，经患者及家属同意予以实验治疗，并遵守与检测者达成的协议，在此期间不可接受其他治疗，历时1个月(28天)。
2.诊断标准 (1)不寐中医证候诊断标准依据(参考国家中医
药管理局《中医病证诊断疗效标准》拟定)：
①轻者入寐困难或寐而易醒，醒后不寐，重者彻夜难眠。
②常伴有头痛，头昏，心悸，健忘，多梦等症。
③经各系统和实验室检查未发现异常。
(2)郁病中医证候诊断标准依据(参考国家中医药管理局《中医病证诊断疗效标准》拟定)：
①忧郁不畅，精神不振，胸闷胁胀，善太息。或不思饮食，失眠多梦，易怒善哭等症。
②有郁怒、多虑、悲哀、忧愁等情志所伤史。
③经各系统检查和实验室检查可排除器质性疾病。
④应与癫病、狂病鉴别。
3.治疗方法
穴位贴敷治疗组：
(1)药物组成：称取草柏枝10g、梦花8g、太阳针7g、定心散20g、含羞草20g、长春花8g、石菖蒲4g、菠菜子10g、梵天花根40g、大剑叶木20g、柠条根25g、牛尾菜8g，研末，取适量加水及蜂蜜少许调成糊状，搓成一元硬币大小待用。
(2)取穴：风府、大椎、心俞穴(双)、太溪穴(双)、神阙穴、内关穴(双)、涌泉穴(双)。
(3)操作：患者常规消毒，取敷贴剂贴风府、大椎、心俞穴(双)、太溪穴(双)、神阙穴、内关穴(双)、涌泉穴(双)，医用胶布固定，每天1次，每次贴12小时，共治疗1个月(28天)。
西药对照组：西药采用盐酸阿米替林片，生产厂家：常州四药制药有限公司。国药准字H32023764，用法用量：每次1-3片，每日1次，晚上睡前服。共治疗1个月。
4.疗效标准 ①临床痊愈：睡眠时间恢复正常或夜间睡眠时间在6h以上；睡眠深沉，醒后精力充沛。证候积分减少≥95％。
②显效：睡眠明显好转，睡眠时间增加3h以上，睡眠深度增加。证候积分减少≥70％。
③有效：症状减轻，睡眠时间较前增加不到3h。证候积分减少≥30％。
④无效：治疗后失眠症状无明显改变或反而加重者。证候积分减少不足30％。
5.治疗效果 两组患者治疗一个月后观察疗效
表1 两组患者治疗效果
根据上表可知，本发明所述中药穴位敷贴剂对于治疗和改善中老年抑郁症失眠具有显著疗效，且治疗组治疗前后血常规、尿常规、大便常规、心电图、ALT、BUN、Cr等均无治疗前正常而治疗后异常，或治疗前异常而治疗后加重者。可见本发明所述中药穴位敷贴剂无毒副作用，安全可靠。
具体实施方式
实施例一：称取草柏枝10g、梦花8g、太阳针7g、定心散20g、含羞草20g、长春花8g、石菖蒲4g、菠菜子10g、梵天花根40g、大剑叶木20g、柠条根25g、牛尾菜8g，研末，取适量加水及蜂蜜少许调成糊状，搓成一元硬币大小待用。
实施例二：草柏枝12g、梦花6g、太阳针8g、定心散15g、含羞草25g、长春花6g、石菖蒲5g、菠菜子9g、梵天花根50g、大剑叶木155g、柠条根30g、牛尾菜6g。研末，取适量加水及蜂蜜少许调成糊状，搓成一元硬币大小待用。
实施例三：草柏枝8g、梦花10g、太阳针6g、定心散25g、含羞草15g、长春花10g、石菖蒲3g、菠菜子12g、梵天花根30g、大剑叶木25g、柠条根20g、牛尾菜10g。研末，取适量加水及蜂蜜少许调成糊状，搓成一元硬币大小待用。
Claims (2)
1.一种治疗中老年抑郁症失眠的中药敷贴剂，其特征在于该中药敷贴剂由以下重量份的中药制成：草柏枝8-12份、梦花6-10份、太阳针6-8份、定心散15-25份、含羞草15-25份、长春花6-10份、石菖蒲3-5份、菠菜子9-12份、梵天花根30-50份、大剑叶木15-25份、柠条根20-30份、牛尾菜6-10份。
2.根据权利要求1所述的一种治疗中老年抑郁症失眠的中药敷贴剂，其特征在于该中药敷贴剂由以下重量份的中药制成：草柏枝10份、梦花8份、太阳针7份、定心散20份、含羞草20份、长春花8份、石菖蒲4份、菠菜子10份、梵天花根40份、大剑叶木20份、柠条根25份、牛尾菜8份。
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