CN104434388A - Implantable electric heating module for postoperation bacteriostasis and preparation method thereof - Google Patents
Implantable electric heating module for postoperation bacteriostasis and preparation method thereof Download PDFInfo
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- CN104434388A CN104434388A CN201410683998.XA CN201410683998A CN104434388A CN 104434388 A CN104434388 A CN 104434388A CN 201410683998 A CN201410683998 A CN 201410683998A CN 104434388 A CN104434388 A CN 104434388A
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Abstract
The invention relates to an implantable electric heating module for postoperation bacteriostasis and a preparation method thereof, and belongs to the technical field of biomedical engineering. The implantable electric heating module comprises a bioprotein flexible substrate, a heating layer and a bioprotein protective film. The preparation method of the module includes the three steps that first, bioprotein is dissolved in ultrapure water to obtain a bioprotein solution, then the solution is inverted on the substrate, a bioprotein thin film is stripped from the substrate after being dried and solidified at an indoor temperature, and accordingly the bioprotein substrate and the protective film are obtained; afterwards, a resistor, a coil and an insulating material are placed on the substrate in a thin film deposition mode, and the heating layer is prepared; at last, the bioprotein flexible substrate, the heating layer and the protective film are assembled in a hot stamping mode. The heating module not only has excellent biocompatibility but also has a series of advantages of being capable of achieving wireless controlled heating bacteriostasis, efficient, easy to prepare, capable of achieving in-vivo degradation and the like, the module can be directly applied to living bodies, and the application prospect is good.
Description
Technical field
The present invention relates to a kind of for postoperative antibacterial implantable electrons heat module and preparation method thereof, belong to biomedical engineering technology field.
Background technology
Surgical site infection has become the modal bacteriological infection of shell, not only affects surgical effect, extend the hospital stays, also add or misery and financial burden.The infection of operative site often occurs in the middle of operation process, and its antibacterial unit is main from patient itself, medical personnel and environment.Postoperative infection comprises shallow table surgery cut infection, deep operation infection of incisional wound and organ infection's three levels, and symptom comprises postoperative (through being everlasting 1 month in) in a short time and occurs purulent secretion, dense or cellulitis etc.Bacteriological infection is mainly from comprising from the endogenous microbes at position and the exogenous microbial from surgical staff, operating theater instruments and surgical material etc. such as the skin of patient own, internal organs.Cause the microbe species of postoperative infection various, common comprises staphylococcus aureus, escherichia coli, Crane negative bacillus, streptococcus etc.
Surgical site infection and type of surgery and operating time closely related.In general, sufferer traumatic condition is heavier, resistance is lower, operative incision is larger, operating time is longer, and the anti-infection ability of sufferer is lower, surgical site infection chance is more.Postoperative use antibiotic is postoperative antibacterial therapeutic modality the most conventional at present.But antibiotic excessive amount, can strengthen the drug resistance of bacterial antibiotic.In addition, antibiotic sterilization also exist administration not in time with the various problems such as not in place or excessive.Such as during oral administration, medicine needs through the organ such as the intestines and stomach, liver, and the Digestion of the intestines and stomach and the first pass effect of liver often make some drugs partial failure or all lost efficacy before arrival target.And although drug administration by injection can avoid the problem in Macrosol, need to thrust deep skin with the conventional needle of syringe and carry out administration.Syringe needle chafe deep layer neurocyte easily causes suffering to human body, and needle sizes is comparatively large in addition, can cause local wound to skin, strengthens wound infection probability.
The antibacterial technology of local heat is one and possesses high efficiency postoperative antibacterial mode.By wound local heat, the activity of enzyme in the shell of antibacterial and ingredient thereof, reduction antibacterial can be destroyed, affect its eubolism thus make it dead.Traditional local heat is antibacterial mainly to be heated wound site by external heat means, but it is not remarkable not to be delivered to position, fungistatic effect for deep operation wound and internal organs wound at interior non-skin portion infection heat.
Based on above-mentioned situation, design a kind of good biocompatibility, can implant is directly used in the antibacterial wireless electron heating module of wound location, have and important meaning in biomedical applications field.
The invention provides one and (before wound suture) the electrons heat module of wound site can be implanted after surgery.This electrons heat module is formed by a series of materials processing manufacture with good biocompatibility, and energy is wirelessly transmitted to this module by the mode that can be coupled by electromagnetic wave, and to be used for local heat antibacterial.Take with traditional or injection of antibiotics to suppress compared with postoperative infection and external pasteurization method, implantable electrons heat module have good biocompatibility, can controlled in wireless heat time heating time and stable, in a series of advantages such as wound infection position local heat, the series of problems that traditional postoperative infection exists can be solved, there is fine application and development prospect.
Summary of the invention
The shortcoming of prior art in view of the above, the object of the present invention is to provide a kind of biocompatibility, the implantable wireless electron heating module with excellence, for postoperative antibacterial, can solve existingly to improve based on bacterial drug resistance in the antibacterial technology of antibiotic, effect of drugs is not in time and based on series of problems such as external pasteurization delivered heat are not in place.
For achieving the above object, the invention provides and a kind ofly to it is characterized in that for postoperative antibacterial implantable electrons heat module, described electrons heat module is made up of bioprotein flexible substrates, zone of heating and bioprotein protecting film three part.
The described preparation method for postoperative antibacterial implantable electrons heat module, carry out according to following steps:
(1) preparation has bio-flexible substrate and the bioprotein protecting film of good biocompatibility:
A. bioprotein solution is prepared:
Be dissolved in by bioprotein in ultra-pure water, wherein optional bioprotein includes but not limited to fibroin, Cornu Cervi albumen, spider
Spider's thread protein etc.
Described bioprotein solution concentration is 1-500mg/mL.
B. bioprotein thin film is prepared:
Be upside down in substrate by bioprotein solution, drying under wait solution room temperature is also solidified, and is then peeled off by bioprotein thin film
Substrate, obtains bioprotein substrate and bioprotein protecting film respectively.
Wherein the ratio of bioprotein used and substrate is 0.01-1 mL/cm
2;
Described drying time is 1-48 hour;
Described substrate is glass, silicon chip, PDMS(poly dimethyl oxosilane), Teflon(politef, i.e. Teflon) etc.;
Described curing mode is for using firming agent or steam annealing; Firming agent is methanol, and hardening time is 1 min ~ 120 min;
Steam annealing temperature is 4 DEG C ~ 100 DEG C, and the time is 0.1 h ~ 100 h, and pressure is 0.1 Pa ~ 101.325 kPa.
Described stripping means is mechanical stripping.
(2) preparation has the zone of heating of good biocompatibility:
A. be placed in above-mentioned bioprotein flexible substrates by the mode of thin film deposition by resistance, the mode of metal deposition includes but not limited to vacuum evaporation, sputter coating etc., and the thickness of metal deposition is 20-5000nm; The material of resistance includes but not limited to magnesium, silicon, ferrum etc.
B. by the mode of thin film deposition, coil is placed in above-mentioned bioprotein flexible substrates, the two ends of coil head and the tail two ends and above-mentioned metallic resistance communicate, realize electricity to connect, the mode of metal deposition includes but not limited to vacuum evaporation, sputter coating etc., and the thickness of coil is 20-5000nm; The material of coil includes but not limited to magnesium, silicon, ferrum etc.
C. be placed on above-mentioned resistance and coil by the mode of thin film deposition by insulant, the mode of insulant deposition includes but not limited to that vacuum evaporation, sputter coating, whirl coating are smeared, and the thickness of insulant is 10-10000nm; Insulant includes but not limited to silicon dioxide, magnesium oxide, silicon nitride, fibroin etc.
(3) by bioprotein flexible substrates, processing zone of heating on a flexible substrate and the assembling of bioprotein protecting film:
Bioprotein flexible substrates containing zone of heating and bioprotein protecting film are cut into preliminary dimension, and size is 10 ~ 10000 mm
2; By hot padding mode, the bioprotein flexible substrates containing zone of heating and bioprotein protecting film edge are bonded together, hot padding temperature is 40 DEG C ~ 150 DEG C, and the time is 1 ~ 60 minute.
As mentioned above, implantable electrons heat module of the present invention, has following beneficial effect:
The present invention relates to and a kind ofly can be used for postoperative antibacterial implantable electrons heat module, can solve existingly to improve based on bacterial drug resistance in the antibacterial technology of antibiotic, effect of drugs is not in time and based on series of problems such as external pasteurization delivered heat are not in place.Directly can be used in organism, under various environmental disturbances, all there is good performance, there is good application and development prospect.
Accompanying drawing explanation
Fig. 1 is the schematic diagram for postoperative antibacterial implantable electrons heat module provided by the invention.
In Fig. 1,1 is the schematic diagram of bioprotein flexible substrates, and 2 is the schematic diagram of zone of heating, and 3 is the schematic diagram of biological protein protection film.
Fig. 2 puts into animal body lab diagram for postoperative antibacterial implantable electrons heat module, and sample size is 1cm*1cm.
Fig. 3 implants in animal body for postoperative antibacterial implantable electrons heat module, by an external coil wireless transmission energy, and local heat in animal body.
Fig. 4 be for postoperative antibacterial implantable electrons heat module receive outside teach energy after add thermal map, picture be infrared thermoviewer shooting form.
Fig. 5 implants wireless heating 10 minutes bactericidal effects in animal body, Control in figure: room temperature, High Temp:49 DEG C, Low Temp:42 DEG C for postoperative antibacterial implantable electrons heat module.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is better illustrated, but protection scope of the present invention is not limited thereto.
First perform step S1, prepare fibroin solutions, the preparation method of described fibroin solutions is:
Be that the fibroin powder of 30-400kDa is dissolved in ultra-pure water by molecular weight.The described fibroin mode be dispersed in ultra-pure water is ultrasonic disperse or magnetic agitation dispersion.The power of described ultrasonic disperse is 25 W ~ 500W, and frequency is 10kHz ~ 100 kHz, and the time is 0.1h ~ 720h; The mixing speed of described magnetic agitation dispersion is 50r/min ~ 1500r/min, and mixing time is 0.1h ~ 2400h.Described fibroin solutions concentration is 1-100mg/mL.
Then, described fibroin electrons heat module, preparation process also has following steps:
Step S2, making fibroin flexible substrates;
A) be upside down in substrate by fibroin solutions, volume used is 0.01-1 mL/cm
2.
B) dry and solidify under waiting for solution room temperature, the time used is 1-48 hour.
C) by the bottom of fibroin thin film stripping group;
D) fibroin flexible substrates is obtained.
Described curing mode is for using firming agent or steam annealing.Firming agent is methanol, and hardening time is 1 min ~ 120 min; Steam annealing temperature is 4 DEG C ~ 100 DEG C, and the time is 0.1 h ~ 100 h, and pressure is-0.1 Pa ~ 101.325 kPa.Described stripping means is mechanical stripping.
Step S3, making fibroin protecting film;
A) be upside down in substrate by fibroin solutions, volume used is 0.01-1 mL/cm
2.
B) dry and solidify under waiting for solution room temperature, the time used is 1-48 hour.
C) by the bottom of fibroin thin film stripping group;
D) fibroin protecting film is obtained.
Described curing mode is for using firming agent or steam annealing.Firming agent is methanol, and hardening time is 1 min ~ 120 min; Steam annealing temperature is 4 DEG C ~ 100 DEG C, and the time is 0.1 h ~ 100 h, and pressure is-100 KPa ~-25 KPa.Described stripping means is mechanical stripping.
Step S4, prepare zone of heating based on magnesium:
By the mode of vacuum sputtering, deposit in fibroin flexible substrates by magnesium by the mask plate prepared in advance, in zone of heating, the shape of heating module (comprising resistance and coil) is determined by the opening shape of mask plate, and the thickness of magnesium is 20-2000nm.By the mode of vacuum sputtering, be deposited on by magnesium oxide in the fibroin flexible substrates of the resistance comprising magnesium and coil, magnesian thickness is 20-2000nm.
Step S5, the fibroin flexible substrates and fibroin protecting film that comprise zone of heating are fitted together, step is as follows:
1) the fibroin flexible substrates containing zone of heating is cut into preliminary dimension, size is 2 ~ 100 mm
2;
2) fibroin protecting film is cut into preliminary dimension, general and above-mentioned bioprotein flexible substrates formed objects;
3) by hot padding mode mode, the fibroin flexible substrates containing zone of heating and fibroin protecting film edge are bonded together, hot padding temperature is 40 DEG C ~ 100 DEG C, and the time is 1 ~ 60 minute.
embodiment 1:
First, step S1 is performed: prepare fibroin solutions;
Concrete, in the present embodiment, the fibroin powder getting 20mg purchase is dissolved in 20.00 mL water, and make solution homogeneous by magnetic agitation, rotating speed is 300r/min, time 6 h.
Then be upside down in by fibroin solutions in the polydimethylsiloxane substrate of horizontal positioned, drying is also solidified.
Concrete, in the present embodiment, perform S2 and get the fibroin solutions that obtains in 1mL step S1, slowly pour 10cm into
2polydimethylsiloxane substrate on, dry 1h under 25 DEG C of normal pressures (0.1MPa), solidifies 1min in methanol.
By the mode of mechanical stripping, fibroin flexible substrates and protecting film are departed from from polydimethylsiloxane substrate.
Perform S3 and get the fibroin solutions that obtains in 0.5mL step S1, slowly pour 10cm into
2pDMS(polydimethylsiloxane) in substrate, dry 1h under 25 DEG C of normal pressures (0.1MPa), solidifies 1min in methanol.
Perform S4, the mask plate comprising resistance and coil dimension realizing preparation is close to and is placed in fibroin flexible substrates.By the mode of vacuum sputtering, the magnesium of 500nm is deposited in fibroin flexible substrates through mask plate.Remove mask plate, by the mode of vacuum sputtering, the magnesium oxide of 2000nm is deposited in the fibroin substrate of resistance and the coil comprising magnesium.
Perform S5, the fibroin flexible substrates containing zone of heating is cut into 10 * 10mm, the resistance in zone of heating and loop construction in tailoring process, can not be destroyed.Fibroin protecting film is cut into 10*10 mm; by fibroin flexible substrates and the alignment of fibroin protecting film; by hot padding mode mode; fibroin flexible substrates containing zone of heating and fibroin protecting film edge are bonded together; hot padding temperature is 40 DEG C, and the time is 5 minutes.
Under above-mentioned packaged electrons heat module is placed on the skin of surgical wound, then by the regular flow process sew up wound of hospital, by the electrons heat module of external coil alignment near implanted that a diameter is 15mm, both are about 5mm at centre distance, external coil is applied to power is 100mW, frequency is the alternating current of 120MHz, by the mode of near-field coupling, energy is wirelessly transmitted to the electronic module of implanted, heat 10 minutes, temperature is about 42 DEG C of (Low Temp, low temperature), realize localized heat sterilization.Then deenergization, removes external coil.Initial stage zoopery shows, can local bactericidal ~ 40%.
embodiment 2:
First, step S1 is performed: prepare fibroin solutions;
Concrete, in the present embodiment, the fibroin powder getting 10g purchase is dissolved in 20.00 mL water, and make solution homogeneous by magnetic agitation, rotating speed is 300r/min, time 6 h.
Then be upside down in by fibroin solutions in the Teflon substrate of horizontal positioned, drying is also solidified.
Concrete, in the present embodiment, perform S2 and get the fibroin solutions that obtains in 2mL step S1, slowly pour 30cm into
2teflon substrate on, dry 24h under 25 DEG C of normal pressures (0.1MPa), solidifies 120min in methanol.
By the mode of mechanical stripping, fibroin flexible substrates and protecting film are departed from from Teflon substrate.
Perform S4, the mask plate comprising resistance and coil dimension realizing preparation is close to and is placed in fibroin flexible substrates.By the mode of vacuum sputtering, the magnesium of 5000nm is deposited in fibroin flexible substrates through mask plate.Remove mask plate, by the mode of vacuum sputtering by the nitride deposition of 5000nm in the fibroin substrate of the resistance and coil that comprise magnesium.
Perform S5, the fibroin flexible substrates containing zone of heating is cut into 20*20 mm, the resistance in zone of heating and loop construction in tailoring process, can not be destroyed.Fibroin protecting film is cut into 20*20 mm; by fibroin flexible substrates and the alignment of fibroin protecting film; by hot padding mode mode; fibroin flexible substrates containing zone of heating and fibroin protecting film edge are bonded together; hot padding temperature is 150 DEG C, and the time is 60 minutes.
Under above-mentioned packaged electrons heat module is placed on the skin of surgical wound, then by the regular flow process sew up wound of hospital, by the electrons heat module of external coil alignment near implanted that a diameter is 25mm, both are about 5mm at centre distance, external coil is applied to power is 500mW, frequency is the alternating current of 60MHz, by the mode of near-field coupling, energy is wirelessly transmitted to the electronic module of implanted, heat 5 minutes, temperature is about 49 DEG C of (High Temp, high temperature), realize localized heat sterilization.Then deenergization, removes external coil.Initial stage zoopery shows, can kill antibacterial completely in local.
embodiment 3:
First, step S1 is performed: prepare fibroin solutions;
Concrete, in the present embodiment, the fibroin powder getting 5g purchase is dissolved in 20.00 mL water, and make solution homogeneous by magnetic agitation, rotating speed is 300r/min, time 6 h.
Then be upside down in by fibroin solutions in the polydimethylsiloxane substrate of horizontal positioned, drying is also solidified.
Concrete, in the present embodiment, perform S2 and get the fibroin solutions that obtains in 1mL step S1, slowly pour 20cm into
2polydimethylsiloxane substrate on, dry 24h under 25 DEG C of normal pressures (0.1MPa), solidifies 120min in methanol.
By the mode of mechanical stripping, fibroin flexible substrates and protecting film are departed from from polydimethylsiloxane substrate.
Perform S4, the mask plate comprising resistance and coil dimension realizing preparation is close to and is placed in fibroin flexible substrates.By the mode of vacuum sputtering, the ferrum of 100nm is deposited in fibroin flexible substrates through mask plate.Remove mask plate, by the mode of vacuum sputtering by the silica deposit of 300nm in the fibroin substrate of the resistance and coil that comprise ferrum.
Perform S5, the fibroin flexible substrates containing zone of heating is cut into 15*15 mm
2, the resistance in zone of heating and loop construction in tailoring process, can not be destroyed.Fibroin protecting film is cut into 15*15 mm
2, by fibroin flexible substrates and the alignment of fibroin protecting film, by hot padding mode mode, the fibroin flexible substrates containing zone of heating and fibroin protecting film edge are bonded together, hot padding temperature is 90 DEG C, and the time is 10 minutes.
Under above-mentioned packaged electrons heat module is placed on the skin of surgical wound, then by the regular flow process sew up wound of hospital, by the electrons heat module of external coil alignment near implanted that a diameter is 20mm, both are about 5mm at centre distance, external coil is applied to power is 300mW, frequency is the alternating current of 80MHz, by the mode of near-field coupling, energy is wirelessly transmitted to the electronic module of implanted, heat 10 minutes, temperature is about 49 DEG C of (High Temp, high temperature), realize localized heat sterilization.Then deenergization, removes external coil.Initial stage zoopery shows, can kill antibacterial completely in local.
In sum, the present invention proposes a kind of simple and effective technical scheme, provides a kind of preparation method that can be used for postoperative antibacterial implantable electrons heat module with the superior bio compatibility.Can solve existingly to improve based on bacterial drug resistance in the antibacterial technology of antibiotic, effect of drugs is not in time and based on series of problems such as external pasteurization delivered heat are not in place.Directly can be used in organism, under various environmental disturbances, all there is good performance, there is good application and development prospect.There is fine application and development prospect.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all without prejudice under spirit of the present invention and category, can modify above-described embodiment or changes.Therefore, such as have in art usually know the knowledgeable do not depart from complete under disclosed spirit and technological thought all equivalence modify or change, must be contained by claim of the present invention.
Claims (10)
1. an implantable heating module, is characterized in that, described implantable heating module comprises bioprotein flexible substrates, zone of heating and bioprotein protecting film.
2. a kind of implantable heating module according to claim 1, is characterized in that, described implantable heating module is prepared according to following steps:
(1) preparation has bio-flexible substrate and the bioprotein protecting film of good biocompatibility:
A. bioprotein solution is prepared:
Be dissolved in by bioprotein in ultra-pure water, wherein optional bioprotein comprises fibroin, Cornu Cervi albumen, spider silk fibroin
Deng;
Described bioprotein solution concentration is 1-500mg/mL;
B. bioprotein thin film is prepared:
Be upside down in substrate by bioprotein solution, drying under wait solution room temperature is also solidified, and is then peeled off by bioprotein thin film
Substrate, obtains bioprotein substrate and bioprotein protecting film respectively;
(2) preparation has the zone of heating of good biocompatibility:
Resistance and coil are placed in the bioprotein flexible substrates prepared by step (1), the two ends of coil head and the tail two ends and resistance communicate, and realize electricity and connect, and then be placed on by insulant on above-mentioned resistance and coil;
Wherein resistance, coil and insulant are all placed by the mode of thin film deposition;
(3) by bioprotein flexible substrates, processing zone of heating on a flexible substrate and the assembling of bioprotein protecting film:
Bioprotein flexible substrates containing zone of heating and bioprotein protecting film are cut into preliminary dimension respectively; By hot padding mode, the bioprotein flexible substrates containing zone of heating and bioprotein protecting film edge are bonded together.
3. the preparation method of a kind of implantable heating module according to claim 2, it is characterized in that, in step (1), the ratio of bioprotein used and substrate is 0.01-1 mL/cm2, and wherein substrate is glass, silicon chip, PDMS(polydimethylsiloxane) or Teflon.
4. the preparation method of a kind of implantable heating module according to claim 2, is characterized in that, drying time described in step (1) is 1-48 hour; Described curing mode is for using firming agent or steam annealing; Firming agent is methanol, and hardening time is 1 min ~ 120 min; Steam annealing temperature is 4 DEG C ~ 100 DEG C, and the time is 0.1 h ~ 100 h, and pressure is 0.1 Pa ~ 101.325 kPa.
5. the preparation method of a kind of implantable heating module according to claim 2, is characterized in that, described in step (1), stripping means is mechanical stripping.
6. the preparation method of a kind of implantable heating module according to claim 2, is characterized in that, described in step (2), the metal deposit thickness of resistance and coil is 20-5000nm; The material of described resistance and coil is magnesium, silicon or ferrum; The thickness of described insulant deposition is 10-10000nm; Insulant is silicon dioxide, magnesium oxide, silicon nitride or fibroin.
7. the preparation method of a kind of implantable heating module according to claim 2, is characterized in that, the depositional mode described in step (2) is that vacuum evaporation, sputter coating or whirl coating are smeared.
8. the preparation method of a kind of implantable heating module according to claim 2, is characterized in that, is 10 ~ 10000 mm containing the bioprotein flexible substrates of zone of heating and the size of bioprotein protecting film described in step (3)
2, thickness is 0.02-5mm.
9. the preparation method of a kind of implantable heating module according to claim 2, is characterized in that, hot padding temperature described in step (3) is 40 DEG C ~ 150 DEG C, and the time is 1 ~ 60 minute.
10. a kind of implantable heating module according to claim 1 and 2, is characterized in that, described implantable heating module is used for postoperative antibacterial.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106183508A (en) * | 2016-07-19 | 2016-12-07 | 南通纺织丝绸产业技术研究院 | Optical anti-counterfeiting labelling based on fibroin and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397119A (en) * | 2011-09-29 | 2012-04-04 | 微创医疗器械(上海)有限公司 | Interventional medical appliance and manufacturing method thereof |
| CN102892356A (en) * | 2010-03-17 | 2013-01-23 | 伊利诺伊大学评议会 | Implantable biomedical devices on bioresorbable substrates |
| CN103200971A (en) * | 2010-08-30 | 2013-07-10 | 哈佛大学校长及研究员协会 | A high strength chitin composite material and method of making |
| US20130240251A1 (en) * | 2010-04-12 | 2013-09-19 | Trustees Of Boston University | Silk electronic components |
| CN103328034A (en) * | 2010-09-03 | 2013-09-25 | 塔夫茨大学/塔夫茨学院信托人 | Plasmonic nanoparticle-doped silk materials |
-
2014
- 2014-11-25 CN CN201410683998.XA patent/CN104434388B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102892356A (en) * | 2010-03-17 | 2013-01-23 | 伊利诺伊大学评议会 | Implantable biomedical devices on bioresorbable substrates |
| US20130240251A1 (en) * | 2010-04-12 | 2013-09-19 | Trustees Of Boston University | Silk electronic components |
| CN103200971A (en) * | 2010-08-30 | 2013-07-10 | 哈佛大学校长及研究员协会 | A high strength chitin composite material and method of making |
| CN103328034A (en) * | 2010-09-03 | 2013-09-25 | 塔夫茨大学/塔夫茨学院信托人 | Plasmonic nanoparticle-doped silk materials |
| US20130310908A1 (en) * | 2010-09-03 | 2013-11-21 | Tufts University | Plasmonic nanoparticle-doped silk materials |
| CN102397119A (en) * | 2011-09-29 | 2012-04-04 | 微创医疗器械(上海)有限公司 | Interventional medical appliance and manufacturing method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106183508A (en) * | 2016-07-19 | 2016-12-07 | 南通纺织丝绸产业技术研究院 | Optical anti-counterfeiting labelling based on fibroin and preparation method thereof |
| CN106183508B (en) * | 2016-07-19 | 2018-11-02 | 南通纺织丝绸产业技术研究院 | Optical anti-counterfeiting label based on fibroin and preparation method thereof |
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