CN104434013A - Multimodal colposcope system and method for acquiring multimodal images - Google Patents
Multimodal colposcope system and method for acquiring multimodal images Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/303—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the vagina, i.e. vaginoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
- A61B1/00096—Optical elements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/045—Control thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
- A61B1/051—Details of CCD assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0676—Endoscope light sources at distal tip of an endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0684—Endoscope light sources using light emitting diodes [LED]
Abstract
The invention discloses a multimodal colposcope system and a method for acquiring multimodal images. According to the multimodal colposcope system and the method for acquiring multimodal images, opening and closing of all channels of a light source and the intensity of the light source are controlled independently through the ultra-bright LED light source and an imaging module which are selected through the special arrangement design and the wavelength, and several sorts of different medical imaging modalities are fused organically. Substance compositions can be effectively classified by multispectral imaging, normal tissue and lesion tissue can be distinguished according to fluorescence intensity by cervix uteri autofluorescence imaging, a doctor can be guided to judge the development degree of a nidus from the aspect of forms, colors and the like by conventional RGB color imaging, and therefore a more comprehensive, accurate and quantitative diagnosis basis can be provided for the doctor.
Description
Technical field
The present invention relates to technical field of medical equipment, particularly relate to a kind of method of multi-modal vaginoscope system and acquisition multi-modality images.
Background technology
In global range, cervical cancer pathogenesis rate occupies second in female malignant, is only second to breast carcinoma.And in developing country, due to the imperfection of cervix uteri screening, cervical cancer incidence rate is 6 times of developed country, mortality rate occupies first of female cancer.Traditional cervix uteri inspection method mainly contains conventional smear and colposcopy.
But the former misdiagnosis rate is high, person under inspection is painful, proof cycle is long, the latter can realize the RGB colour imaging of cervical tissue, but can only judge intuitively from the color of tissue surface and form, cannot distinguishing benign epithelial tissue change and malignant tumor.
Summary of the invention
The object of this invention is to provide a kind of method of multi-modal vaginoscope system and acquisition multi-modality images, plurality of medical image technology organically can be merged, realize the acquisition to same focal area different aspect (structure, function, molecule) information, doctor greatly can be helped to grasp comprehensive pathological information, improve the accuracy of diagnosis.
The object of the invention is to be achieved through the following technical solutions:
A kind of multi-modal vaginoscope system, this system comprises: image module, light source module, control module and construction module;
Described image module comprises: sensor devices, camera lens, optical filter and computer; Described sensor devices is connected with computer, and described camera lens is fixedly mounted on sensor devices, and described optical filter is placed on camera lens front;
Described light source module is placed on optical filter front, and it comprises: the SMD superbright LED lamp bead of several different wave lengths, is evenly distributed on the shadow surface of annular, respectively as fluorescence excitation light source, RGB colour imaging light source and multispectral imaging light source;
Control module one end and described light source module are connected to light source module provides power supply, and the other end is connected with computer, controls light source module according to the instruction that computer sends;
Construction module comprises: gripper shoe, be arranged on support below this gripper shoe, and arranges switching device of optical fiber on the supporting plate; Wherein, described optical filter is placed on switching device of optical fiber, and sensor devices and light source module are all placed in described gripper shoe.
Further, described light source module comprises:
Each eight of the SMD superbright LED lamp bead of 365nm, 475nm, 530nm, 545nmm, 560nm, 575nm, 590nm and 635nm; According to the division of shadow surface centrage, the LED lamp bead arrangement between each quadrant is consistent; In each quadrant, often the lamp pearl quantity of kind of wavelength has two, is parallel relationship each other;
Wherein, the SMD superbright LED lamp bead of 365nm is as fluorescence excitation light source, the SMD superbright LED lamp bead of 635nm, 545nm and 475nm is as RGB colour imaging light source, and the SMD superbright LED lamp bead of 530nm, 545nm, 560nm, 575nm and 590nm is as multispectral imaging light source.
Further, described control module comprises: multiple independently for controlling the passage of LED lamp bead switch and brightness.
Utilize aforementioned system to obtain a method for multi-modality images, the method comprises:
Adjustment sensor devices and camera lens, make cervical tissue to be seen meet visual field size;
Recycling computer controls control module and regulates light source module, carries out multispectral imaging, auto-fluorescence imaging and RGB colour imaging successively, thus obtains multi-modality images;
Wherein, when carrying out multispectral imaging, after pre-exposure is carried out on the cervical tissue surface utilizing standard reflection block to be placed on observation, take off this standard reflection block, then multispectral imaging is carried out to the cervical tissue observed; And by the position of switching device of optical fiber adjustment optical filter when carrying out multispectral imaging, make optical filter not block imaging optical path;
When carrying out auto-fluorescence imaging, by the position of switching device of optical fiber adjustment optical filter, optical filter is made to shelter from imaging optical path;
When carrying out RGB colour imaging, by the position of switching device of optical fiber adjustment optical filter, optical filter is made not block imaging optical path.
Further, described standard reflection block is a politef blank being placed in ring-shaped shell, through surface finish process, and as the label of focusing on the scraps of paper of adhesion one band "+" shape labelling.
Further, described light source module comprises: each eight of the SMD superbright LED lamp bead of 365nm, 475nm, 530nm, 545nmm, 560nm, 575nm, 590nm and 635nm; According to the division of shadow surface centrage, the LED lamp bead arrangement between each quadrant is consistent; In each quadrant, often the lamp pearl quantity of kind of wavelength has two, is parallel relationship each other;
Wherein, the SMD superbright LED lamp bead of 365nm is as fluorescence excitation light source, the SMD superbright LED lamp bead of 635nm, 545nm and 475nm is as RGB colour imaging light source, and the SMD superbright LED lamp bead of 530nm, 545nm, 560nm, 575nm and 590nm is as multispectral imaging light source.
Further, described control module comprises: multiple independently for controlling the passage of LED lamp bead switch and brightness.
As seen from the above technical solution provided by the invention, the super-bright LED light source selected by specific configuration design and wavelength and image-forming module, control cut-offfing and intensity of each passage of light source independently, organically several different medical imaging modalities is merged: multispectral imaging can be classified to material composition effectively, cervix uteri auto-fluorescence imaging can distinguish normal and pathological tissues according to fluorescence intensity, conventional RGB colour imaging can from form, the aspects such as color instruct doctor to judge the development degree of focus, thus provide more comprehensive for doctor, accurate and quantitative diagnosis basis.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme of the embodiment of the present invention, below the accompanying drawing used required in describing embodiment is briefly described, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawings can also be obtained according to these accompanying drawings.
The schematic diagram of a kind of multi-modal vaginoscope system that Fig. 1 provides for the embodiment of the present invention one;
The schematic diagram of the light source module that Fig. 2 provides for the embodiment of the present invention one;
The operating procedure flow chart of the multi-modal vaginoscope system that Fig. 3 provides for the embodiment of the present invention two.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on embodiments of the invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to protection scope of the present invention.
Component distributing figure, provides information more accurately for analyzing, detecting.Multi-optical spectrum imaging technology mainly there are differences as principle with the absorption of material to different wavelengths of light, utilize the one group of specific wavelength filtered out in advance, gather the Reflection intensity information of tissue surface to be detected, and by specific image classification algorithms, the constituent of sample is classified.
Containing multiple idiopathic fluorescent material in tissue, specific fluorescence can be sent under the irradiation of particular excitation light.Cervix uteri autofluorescence diagnostic techniques utilizes cervix uteri normal structure and the difference of cancerous issue in primary fluorescence characteristic, under the irradiation of specific wavelength exciting light, gathers fluoroscopic image, distinguish fluorescence intensity to normal and cancerous issue in certain wave strong point.
Multi-modal medical imaging technology is organically merged by two or more Medical Imaging Technologies, realize the acquisition to same focal area different aspect (structure, function, molecule) information, doctor greatly can be helped to grasp comprehensive pathological information, improve the accuracy of diagnosis.Therefore, if existing cervical tissue RGB colour imaging, multispectral imaging and auto-fluorescence imaging can be combined, new visual angle and means are provided by the preliminary examination for cervical cancer.
Embodiment one
The schematic diagram of a kind of multi-modal vaginoscope system that Fig. 1 provides for the embodiment of the present invention, as shown in Figure 1, this system mainly comprises: image module, light source module, control module and construction module;
Described image module comprises: sensor devices 6, camera lens 5, optical filter 4 and computer 8; Described sensor devices 6 is connected with computer 8, and described camera lens 5 is fixedly mounted on sensor devices 6, and described optical filter 4 is placed on camera lens 5 front.
Exemplary, sensor devices can be CCD industrial camera, the monochrome image of 12 can be gathered, its CCD spectral response curve at the efficiency >80% of 470-600nm wave band, to multispectral image and fluoroscopic image by good collection efficiency.CCD industrial camera is connected with the data collecting card on computer 8 by 1394A live wire, realizes image acquisition and data transmission.Camera lens 5 is arranged on industrial camera 6 by C bayonet socket, can manual adjustments aperture size and focusing, and collects the cervical tissue image meeting visual field size under suitable operating distance, and compared to zoom lens, tight shot has higher imaging quality.Optical filter 4 can be 420-480nm bandpass filter, diameter 25.4mm, and for collecting the histofluorescence image of 420-480nm wave band, under 365nm exciting light, the fluorescence spectrum of normal structure and non-normal tissue has notable difference at this wave band.
Described light source module 3 is placed on optical filter 4 front, and it comprises: the SMD superbright LED lamp bead of several different wave lengths, is evenly distributed on the shadow surface of annular, respectively as fluorescence excitation light source, RGB colour imaging light source and multispectral imaging light source; According to the division of shadow surface centrage, the LED lamp bead arrangement between each quadrant is consistent; In each quadrant, the lamp pearl quantity of often kind of wavelength is identical, is parallel relationship each other.
Exemplary, be illustrated in figure 2 the schematic diagram of light source module.Light source module shown in Fig. 2 comprises: each eight of the SMD superbright LED lamp bead of 365nm (9), 475nm (10), 530nm (12), 545nmm (13), 560nm (14), 575nm (15), 590nm (16), 635nm (11), be evenly distributed on the shadow surface of annular, respectively as fluorescence excitation light source (365nm), RGB colour imaging light source (635nm, 545nm, 475nm) and multispectral imaging light source (530nm, 545nm, 560nm, 575nm, 590nm); In each quadrant, the lamp pearl quantity of often kind of wavelength has each two.
Control module 7 one end and described light source module are connected to light source module provides power supply, and the other end is connected with computer, controls light source module according to the instruction that computer sends.
Further, control module 7 comprises: multiple independently for controlling the passage of LED lamp bead switch and brightness.Such as, have eight passages, each passage can independently gauge tap and brightness, and output voltage 24V, can detect load maximum current automatically.
Construction module comprises: gripper shoe 17, be arranged on support 1 below this gripper shoe, and arranges switching device of optical fiber 2 on the supporting plate; Wherein, described optical filter 4 is placed on switching device of optical fiber 2, and sensor devices 6 and light source module 3 are all placed in described gripper shoe.On support 1, be free to regulate and locking height, left and right directions and the angle of pitch.Switching device of optical fiber is for adjusting working light path during different modalities: when gathering multispectral image and RGB color image, and adjustment optical filter 4 does not block imaging optical path; When gathering cervical tissue autofluorescence, adjustment optical filter 4, before camera lens 5, blocks light path, and screws down fixing, only collects the fluoroscopic image of 420-480nm wave band.
The embodiment of the present invention is by specific configuration design and the super-bright LED light source selected of wavelength and image-forming module, control cut-offfing and intensity of each passage of light source independently, organically several different medical imaging modalities is merged: multispectral imaging can be classified to material composition effectively, cervix uteri auto-fluorescence imaging can distinguish normal and pathological tissues according to fluorescence intensity, conventional RGB colour imaging can instruct doctor to judge the development degree of focus from the aspect such as form, color, thus provides more comprehensive, accurate and quantitative diagnosis basis for doctor.
Embodiment two
The embodiment of the present invention provides a kind of method obtaining multi-modality images, and the method is that the multi-modal vaginoscope system provided based on previous embodiment realizes, and the method mainly comprises:
Adjustment sensor devices and camera lens, make cervical tissue to be seen meet visual field size;
Recycling computer controls control module and regulates light source module, carries out multispectral imaging, auto-fluorescence imaging and RGB colour imaging successively, thus obtains multi-modality images;
Wherein, when carrying out multispectral imaging, after pre-exposure is carried out on the cervical tissue surface utilizing standard reflection block to be placed on observation, take off this standard reflection block, then multispectral imaging is carried out to the cervical tissue observed; And by the position of switching device of optical fiber adjustment optical filter when carrying out multispectral imaging, make optical filter not block imaging optical path;
When carrying out auto-fluorescence imaging, by the position of switching device of optical fiber adjustment optical filter, optical filter is made to shelter from imaging optical path;
When carrying out RGB colour imaging, by the position of switching device of optical fiber adjustment optical filter, optical filter is made not block imaging optical path.
Described standard reflection block is a politef blank being placed in ring-shaped shell, through surface finish process, and as the label of focusing on the scraps of paper of adhesion one band "+" shape labelling.
Described light source module comprises: each eight of the SMD superbright LED lamp bead of 365nm, 475nm, 530nm, 545nmm, 560nm, 575nm, 590nm and 635nm; According to the division of shadow surface centrage, the LED lamp bead arrangement between each quadrant is consistent; In each quadrant, often the lamp pearl quantity of kind of wavelength has two, is parallel relationship each other;
Wherein, the SMD superbright LED lamp bead of 365nm is as fluorescence excitation light source, the SMD superbright LED lamp bead of 635nm, 545nm and 475nm is as RGB colour imaging light source, and the SMD superbright LED lamp bead of 530nm, 545nm, 560nm, 575nm and 590nm is as multispectral imaging light source.
Described control module comprises: multiple independently for controlling the passage of LED lamp bead switch and brightness.
For the ease of understanding, the step below in conjunction with accompanying drawing 3 pairs of the method is described in detail.
In multi-modal image collection process, need the standard reflection block preparing to be used for reflectivity correction in advance.Standard reflection block is politef (Teflon) blank being placed in ring-shaped shell, through surface finish process, and at the label that the scraps of paper of adhesion one band "+" shape labelling are focused as camera.Because politef has comparatively average reflectance at 200-1000nm wave band, can be used to carry out the correction of intensity of light source difference to each wavelength in multispectral imaging.Before the use, need to carry out disinfection, and must not reuse.
Its step as shown in Figure 3, comprising:
1) examine person is in place, opens imager power supply, opens imager operation interface.
2) on software, patient name and storing path is registered.
3) adjust imager position, make cervical tissue to be seen meet visual field size.
4) multispectral imaging.
A) with tweezers, sterile standard reflection block is placed on tissue surface, camera lens is accurately focused;
B) pre-exposure: light 530nm successively, 545nm, 560nm, 575nm, 590nm wavelength LED lamp bead, carries out an automatic exposure and regulates, and ensures that image data exposure parameter is suitable, and records the exposure parameter under each wavelength;
C) be with the collection of standard reflection block: again light above-mentioned lamp pearl successively, while each lamp pearl is lighted, trigger camera, gather the image under current wavelength;
D) take off the collection of standard reflection block: repeating above said collection process, multispectral imaging terminates;
E) through feature extraction sorting algorithm, obtain and preserve multispectral classification chart.
5) cervix uteri auto-fluorescence imaging.
A) 365nm fluorescent exciting is lighted;
B) manually adjust fluorescent optical filter, shelter from light path and lock;
C) adjust proper exposure parameter, obtain and preserve fluoroscopic image;
D) fluorescent optical filter resets, and fluorescence imaging terminates.
6) RGB colour imaging.
A) red (635nm), green (545nm), blue (475nm) LED lamp bead are lighted successively;
B) each lamp pearl is lighted simultaneously, triggers camera, gathers the image under current wavelength;
C) the Images uniting RGB color image under three wavelength;
D) preserve RGB color image, RGB colour imaging terminates.
7) multi-modal view data is obtained.
The above; be only the present invention's preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (7)
1. a multi-modal vaginoscope system, is characterized in that, this system comprises: image module, light source module, control module and construction module;
Described image module comprises: sensor devices, camera lens, optical filter and computer; Described sensor devices is connected with computer, and described camera lens is fixedly mounted on sensor devices, and described optical filter is placed on camera lens front;
Described light source module is placed on optical filter front, and it comprises: the SMD superbright LED lamp bead of several different wave lengths, is evenly distributed on the shadow surface of annular, respectively as fluorescence excitation light source, RGB colour imaging light source and multispectral imaging light source;
Control module one end and described light source module are connected to light source module provides power supply, and the other end is connected with computer, controls light source module according to the instruction that computer sends;
Construction module comprises: gripper shoe, be arranged on support below this gripper shoe, and arranges switching device of optical fiber on the supporting plate; Wherein, described optical filter is placed on switching device of optical fiber, and sensor devices and light source module are all placed in described gripper shoe.
2. system according to claim 1, is characterized in that, described light source module comprises:
Each eight of the SMD superbright LED lamp bead of 365nm, 475nm, 530nm, 545nmm, 560nm, 575nm, 590nm and 635nm; According to the division of shadow surface centrage, the LED lamp bead arrangement between each quadrant is consistent; In each quadrant, often the lamp pearl quantity of kind of wavelength has two, is parallel relationship each other;
Wherein, the SMD superbright LED lamp bead of 365nm is as fluorescence excitation light source, the SMD superbright LED lamp bead of 635nm, 545nm and 475nm is as RGB colour imaging light source, and the SMD superbright LED lamp bead of 530nm, 545nm, 560nm, 575nm and 590nm is as multispectral imaging light source.
3. system according to claim 1, is characterized in that, described control module comprises: multiple independently for controlling the passage of LED lamp bead switch and brightness.
4. utilize system described in any one of claim 1-3 to obtain a method for multi-modality images, to it is characterized in that, the method comprises:
Adjustment sensor devices and camera lens, make cervical tissue to be seen meet visual field size;
Recycling computer controls control module and regulates light source module, carries out multispectral imaging, auto-fluorescence imaging and RGB colour imaging successively, thus obtains multi-modality images;
Wherein, when carrying out multispectral imaging, after pre-exposure is carried out on the cervical tissue surface utilizing standard reflection block to be placed on observation, take off this standard reflection block, then multispectral imaging is carried out to the cervical tissue observed; And by the position of switching device of optical fiber adjustment optical filter when carrying out multispectral imaging, make optical filter not block imaging optical path;
When carrying out auto-fluorescence imaging, by the position of switching device of optical fiber adjustment optical filter, optical filter is made to shelter from imaging optical path;
When carrying out RGB colour imaging, by the position of switching device of optical fiber adjustment optical filter, optical filter is made not block imaging optical path.
5. method according to claim 4, is characterized in that, described standard reflection block is a politef blank being placed in ring-shaped shell, through surface finish process, and as the label of focusing on the scraps of paper of adhesion one band "+" shape labelling.
6. method according to claim 4, is characterized in that, described light source module comprises: each eight of the SMD superbright LED lamp bead of 365nm, 475nm, 530nm, 545nmm, 560nm, 575nm, 590nm and 635nm; According to the division of shadow surface centrage, the LED lamp bead arrangement between each quadrant is consistent; In each quadrant, often the lamp pearl quantity of kind of wavelength has two, is parallel relationship each other;
Wherein, the SMD superbright LED lamp bead of 365nm is as fluorescence excitation light source, the SMD superbright LED lamp bead of 635nm, 545nm and 475nm is as RGB colour imaging light source, and the SMD superbright LED lamp bead of 530nm, 545nm, 560nm, 575nm and 590nm is as multispectral imaging light source.
7. method according to claim 4, is characterized in that, described control module comprises: multiple independently for controlling the passage of LED lamp bead switch and brightness.
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