CN104415316A - Production method of capsules for clearing away heart-fire and tonifying spleen - Google Patents

Production method of capsules for clearing away heart-fire and tonifying spleen Download PDF

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Publication number
CN104415316A
CN104415316A CN201310397720.1A CN201310397720A CN104415316A CN 104415316 A CN104415316 A CN 104415316A CN 201310397720 A CN201310397720 A CN 201310397720A CN 104415316 A CN104415316 A CN 104415316A
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China
Prior art keywords
spleen
fire
away heart
capsules
rhizoma
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Pending
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CN201310397720.1A
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Chinese (zh)
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陈培林
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Individual
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Individual
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Priority to CN201310397720.1A priority Critical patent/CN104415316A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a production method of capsules for clearing away heart-fire and tonifying spleen. The capsules disclosed by the invention are obtained by uniformly mixing the dry medicine powder prepared after finely processing eight medicinal materials of angelica sinensis, pericarpium citri reticulatae, rhizoma zingiberis, radix paeoniae alba, gastrodia elata, eucommia ulmoides, elecampane and Chinese yam with magnesium stearate in a ratio, using ethyl alcohol as a wetting agent for preparing wet grains, drying, and capsulating. The capsules disclosed by the invention are simple and exact in medicine composition, advanced in process, high in technical content, good in taste and good in stability and is conveniently taken by patients, and quality is easy to control and moisture is not liable to adsorption. The preparation is reasonable in design and convenient to take and carry, and has a unique healthcare curative effect on heart and spleen.

Description

A kind of manufacture method of the medical capsule for invigorating function of spleen that clears away heart-fire
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of manufacture method of the medical capsule for invigorating function of spleen that clears away heart-fire.
 
Background technology
The Chinese patent medicine for the treatment of the spleen and stomach illness conventional clinically at present has a lot, and they differ from one another, and all have goodish effect; But based on Western medicine, Western medicine effect is normal too single again.Someone once designed and the Chinese crude drug such as the Cortex Eucommiae, Rhizoma Smilacis Glabrae was made into tablet, and adjuvant is soluble starch, Pulvis Talci, magnesium stearate, but this product stability is poor, the easy moisture absorption goes bad, and in tablet, additive is many, and active substance content is lower, and dose is large, does not meet actual demand.
Summary of the invention
Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, the Radix Paeoniae Alba, Rhizoma Gastrodiae, the Cortex Eucommiae, the Radix Aucklandiae, Rhizoma Dioscoreae eight taste Chinese crude drug is the object of the invention is to be made into a kind of capsule after extracting effective ingredient, this capsule can overcome the deficiency that existing product exists, and has unique curative effect for taste health care.
The present invention is achieved in that
Herbal raw material selected by the present invention is eight tastes, and it is made up of the proportioning of following parts by weight: Radix Angelicae Sinensis 2 parts, Pericarpium Citri Reticulatae 2 parts, Rhizoma Zingiberis 1 part, the Radix Paeoniae Alba 1 part, 1 part, Rhizoma Gastrodiae, the Cortex Eucommiae 1 part, the Radix Aucklandiae 1 part, Rhizoma Dioscoreae 1 part.
The manufacture method of benefitting qi, nourishing blood, nourishing capsule: Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, the Radix Paeoniae Alba, Rhizoma Gastrodiae, the Cortex Eucommiae, the Radix Aucklandiae, Rhizoma Dioscoreae are ground into fine powder respectively, crosses 100 mesh sieves; Decoct with water secondary, first time adds the soak by water 1.5 hours of 8 times, and second time adds the soak by water 1.5 hours of 8 times amount, merging filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (70 DEG C), and spraying dry, makes dried cream powder, mix with above-mentioned fine powder, must medicated powder be done, calculate with composition by weight: get dry medicated powder, magnesium stearate mixes in 1: 0.05 ~ 0.1 ratio, make wet granular with the ethanol of simmer down to 70% ~ 90% as wetting agent.Drying, makes dry granule, encapsulated, to obtain final product.
The present invention clear away heart-fire medical capsule for invigorating function of spleen be the medicine made by the preparation method of advanced person for raw material with Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, the Radix Paeoniae Alba, Rhizoma Gastrodiae, the Cortex Eucommiae, the Radix Aucklandiae, Rhizoma Dioscoreae eight taste Chinese crude drug its formed simply, clear and definite, quality is easy to control, the capsule made is sugarless type formulations, applicable crowd can be increased, capsule is the dosage form of Chinese medicine advanced person, with high content of technology, patient's taking convenience, mouthfeel is good, the not easily moisture absorption, good stability; This product has dose few compared with tablet, and curative effect has the feature of equivalence with it.This capsule has definite curative effect to taste, and its volume is little, easy to carry, the standing medication being applicable to family and travelling away from home.
Embodiment 1:
Get Radix Angelicae Sinensis 2 kilograms, Pericarpium Citri Reticulatae 2 kilograms, Rhizoma Zingiberis 1 kilogram, the Radix Paeoniae Alba 1 kilogram, 1 kilogram, Rhizoma Gastrodiae, the Cortex Eucommiae 1 kilogram, the Radix Aucklandiae 1 kilogram, Rhizoma Dioscoreae 1 kilogram, be ground into fine powder, cross 100 mesh sieves.Amount to 10 kilograms of medical materials, decoct with water secondary, first time adds the soak by water 1.5 hours of 80kg, and second time adds the soak by water 1.5 hours of 80kg, merging filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (70 DEG C), spraying dry, baking temperature is about 120 DEG C, make dried cream powder, mix with above-mentioned fine powder, obtain dry medicated powder.In one, two components calculate: the ratio in 1: 0.05 takes dry medicated powder 500g, magnesium stearate 25g mixing, makes wet granular with the edible ethanol 40ml of simmer down to 70% as wetting agent, dry at about 50 DEG C, make capsule, be up to the standards, powdery, must be applicable to the medical capsule for invigorating function of spleen finished product that clears away heart-fire.
 
Embodiment 2:
Get Radix Angelicae Sinensis 200 grams, Pericarpium Citri Reticulatae 200 grams, Rhizoma Zingiberis 100 grams, the Radix Paeoniae Alba 100 grams, 100 grams, Rhizoma Gastrodiae, the Cortex Eucommiae 100 grams, the Radix Aucklandiae 100 grams, Rhizoma Dioscoreae 100 grams, be ground into fine powder, cross 100 mesh sieves.Amount to 1 kilogram of medical material, decoct with water secondary, first time adds the soak by water 1.5 hours of 8kg, and second time adds the soak by water 1.5 hours of 8kg, merging filtrate, filter, filtrate is concentrated into the clear paste that relative density is 1.10 (70 DEG C), spraying dry, baking temperature is about 120 DEG C, make dried cream powder, mix with above-mentioned fine powder, obtain dry medicated powder.Namely making particl method obtains with embodiment 1 and is applicable to the medical capsule for invigorating function of spleen finished product that clears away heart-fire.

Claims (3)

1. clear away heart-fire the manufacture method of medical capsule for invigorating function of spleen, it is characterized in that it has the raw material of following parts by weight to make: Radix Angelicae Sinensis 2 parts, Pericarpium Citri Reticulatae 2 parts, Rhizoma Zingiberis 1 part, the Radix Paeoniae Alba 1 part, 1 part, Rhizoma Gastrodiae, the Cortex Eucommiae 1 part, the Radix Aucklandiae 1 part, Rhizoma Dioscoreae 1 part.
2. the manufacture method of a kind of medical capsule for invigorating function of spleen that clears away heart-fire according to claim 1, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, the Radix Paeoniae Alba, Rhizoma Gastrodiae, the Cortex Eucommiae, the Radix Aucklandiae, Rhizoma Dioscoreae are ground into fine powder by its feature request respectively, cross 100 mesh sieves.
3. the manufacture method of a kind of medical capsule for invigorating function of spleen that clears away heart-fire according to claim 2, is characterized in that: the temperature of spray drying chamber is 100 DEG C ~ 120 DEG C.
CN201310397720.1A 2013-09-05 2013-09-05 Production method of capsules for clearing away heart-fire and tonifying spleen Pending CN104415316A (en)

Priority Applications (1)

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CN201310397720.1A CN104415316A (en) 2013-09-05 2013-09-05 Production method of capsules for clearing away heart-fire and tonifying spleen

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Application Number Priority Date Filing Date Title
CN201310397720.1A CN104415316A (en) 2013-09-05 2013-09-05 Production method of capsules for clearing away heart-fire and tonifying spleen

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CN104415316A true CN104415316A (en) 2015-03-18

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106361965A (en) * 2016-08-25 2017-02-01 广西慧投互联网金融服务有限公司 Composition for clearing heart and tonifying spleen and kidney

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106361965A (en) * 2016-08-25 2017-02-01 广西慧投互联网金融服务有限公司 Composition for clearing heart and tonifying spleen and kidney

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Application publication date: 20150318