CN104399047B - 一种用于调治带下异常的中药制剂 - Google Patents
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Abstract
本发明提供了一种用于调治带下异常的中药制剂，属于中药保健领域。本发明以藿香、生栀子、白扁豆、佛手、陈皮、砂仁、茯苓、干姜、生薏米、枳椇子、紫苏、香橼、生甘草、绿茶为原料进行配伍，使各药物的功效产生协同，共奏健脾和胃、运化水湿、清热解毒之功能，使由于中下焦湿热气所致诸症通过脾胃、肠道、皮肤得以消解。临床检测数据表明，本发明药物对于带下异常具有很好的调制作用，总有效率达96%。另外，本发明药物对于因中下焦湿热气所致各种疾患和亚健康问题均有很好的治疗和保健作用；本发明的中药制剂采用药食同源原料，无毒无副作用，是一种比较理想的保健品。
Description
技术领域
本发明涉及一种用于调治带下异常的中药制剂，尤其涉及一种通过祛除中下焦湿热气以调治带下异常的中药制剂，属于中药保健领域。
技术背景
带下病，西医称之为“带下异常”，是指带下量多，绵绵不断，色、质、气味异常，并伴有局部或全身症状为特征的疾病。《女科证治约旨》说：“若外感六淫，内伤七情，酝酿成病，致带脉纵弛，不能约束诸脉经，于是阴中有物，淋漓下降，绵绵不断，即所谓带下也。”中医理论认为：该病发生的病因病机主要是脏腑功能失常，湿从内生；或下阴直接感染湿毒虫邪，致使湿邪损伤任带，使任脉不固，带脉失约，带浊下注胞中，流溢于阴窍，发为带下病。因此，带下病的治疗原则以健脾、升阳、除湿为主。
发明内容
本发明的目的是提供一种通过祛除中下焦湿热气以调治带下异常的中药制剂。另外，本发明药物对于因中下焦湿热气所致各种疾患和亚健康问题均有很好的治疗和保健作用。
本发明以藿香、生栀子、白扁豆、佛手、陈皮、砂仁、茯苓、干姜、生薏米、枳椇子、紫苏、香橼、生甘草、绿茶为原料进行配伍，使各药物的功效产生协同，共奏健脾和胃、运化水湿、清热解毒之功能，使由于中下焦湿热气所致诸症通过脾胃、肠道、皮肤得以消解。
藿香，辛，微温；入肺、脾、胃经；功效：快气，和中，辟秽，祛湿。本发明以藿香为君药，坐镇中焦，力主脾胃，运化水湿。
生栀子，苦，寒；归心、肺、三焦经；功能：泻火除烦，清热利尿，凉血解毒。白扁豆，甘，微温；归脾、胃经；功能：健脾化湿，和中消暑。本发明以生栀子、白扁豆为臣药，健脾化湿、和中消暑、清热解毒，解除水湿产生的源泉。
佛手，辛、苦、酸，温；归肝、脾、肺经；功能：舒肝理气，和胃止痛。陈皮，苦、辛，温；归肺、脾经；功能：理气健脾，燥湿化痰。砂仁，辛，温；归脾、胃、肾经；功能：化湿开胃，温脾止泻，理气安胎。茯苓，甘、淡，平；归心、肺、脾、肾经；功能：利水渗湿，健脾宁心。干姜，辛、热；归脾、胃、肾、心、肺经；功能：干姜温中散寒，回阳通脉，燥湿消痰。生薏米，性凉，味甘、淡，入脾、肺、肾经，具有利水、健脾、除痹、清热排脓的功效。枳椇子，甘酸，平；入心、脾二经；功能：治酒醉，烦热，口渴，呕吐，二便不利。紫苏，性温，入心、脾、胃经；功能：发表，散寒，理气，和营。香橼，辛、苦、酸，温；归肝、脾、肺经；功能：舒肝理气，宽中，化痰。本发明以佛手、陈皮、砂仁、茯苓、干姜、生薏米、枳椇子、紫苏、香橼为佐药，健脾和胃以化湿、疏散风热以解热、温里行气以祛湿。
生甘草，性味：甘，平；归心、肺、脾、胃经 ；功能：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。绿茶，具有提神清心、清热解暑、消食化痰、清心除烦、生津止渴、降火明目、止痢除湿等药理作用。本发明以生甘草、绿茶为使药，清热解毒、通便排毒、调和诸药。
本发明全方共凑健脾和胃、运化水湿、清热解毒之功能，使中下焦湿热气通过脾胃、从肠道、皮肤祛除，从根本上解决带下异常的问题。另外，本发明药物对于因中下焦湿热气所致各种疾患和亚健康问题均有很好的治疗和保健作用。
本发明中药制剂中，各原料的重量比为：藿香35-48份，生栀子30-40份，白扁豆30-40份，佛手6-15份，陈皮6-15份，砂仁6-15份，茯苓6-15份，干姜6-15份，生薏米6-15份，枳椇子6-15份，紫苏6-15份，香橼6-15份，生甘草3-8份，绿茶3-8份。
优选比例：藿香40-45份，生栀子33-36份，白扁豆33-36份，佛手8-12份，陈皮8-12份，砂仁8-12份，茯苓8-12份，干姜8-12份，生薏米8-12份，枳椇子8-12份，紫苏8-12份，香橼8-12份，生甘草5-6份，绿茶5-6份。
最佳比例：藿香40份，生栀子34份，白扁豆34份，佛手10份，陈皮10份，砂仁10份，茯苓10份，干姜10份，生薏米10份，枳椇子10份，紫苏10份，香橼10份，生甘草6份，绿茶6份。
本发明的中药制剂可以按中药药剂学的常规工艺和辅料制备成各种内服制剂。如胶囊剂、片剂、颗粒剂、散剂、丸剂（包括水丸、蜜丸、糖衣丸、胶丸、肠溶丸或滴丸）或口服液。
下面是本发明中药制剂调治带下异常的临床试验资料。
1、观察对象：经临床诊断确定为带下病患者共50例，年龄在20-45岁之间。
2、临床表现：带下量多，绵绵不断，色白或淡黄，质粘稠、有臭气或异味。局部或全身症状：面色苍白、四肢不温、精神疲倦、纳少便溏，舌质淡，苔白腻，脉缓。
3、治疗方法：本发明颗粒剂药物（藿香扁豆茶）。规格：6g/袋，30袋/盒。用法：早晚各一袋，温开水直接冲服。疗程：1月1周期，观察3周期。
4、疗效判断标准：痊愈：带下被消除，阴道内滑液透明、滋润、舒适，无异味、无不适；上述局部或全身症状基本消失。显效：带下量明显减少，基本无异味，且上述局部或全身症状得到明显改善。有效：带下量减少，基本无异味，上述局部或全身症状得到一定程度的改善。无效：上述各种临床症状没有明显改善。
5、治疗结果：痊愈：28例，占56%；显效：11例，占22%；有效：9例，占18%；无效：2例，占4%。总有效率：96%。
具体实施方式
下面通过具体实施例对本发明药物的原料配比、制备及用法作进一步说明。
实施例1、颗粒剂药物的制备
原料配方：藿香40份，生栀子34份，白扁豆34份，佛手10份，陈皮10份，砂仁10份，茯苓10份，干姜10份，生薏米10份，枳椇子10份，紫苏10份，香橼10份，生甘草6份，绿茶6份；
制备工艺：按药剂学制备颗粒剂的常规工艺和辅料制备而成；
规格：6g/袋；
用法用量：早晚各6g，温开水直接冲服或熔化口服；1个月1周期，一般观察3周期。实施例2、胶囊剂药物的制备
原料配方：藿香40份，生栀子33份，白扁豆33份，佛手8份，陈皮8份，砂仁8份，茯苓8份，干姜8份，生薏米8份，枳椇子8份，紫苏8份，香橼8份，生甘草5份，绿茶5份；
制备工艺：按药剂学制备胶囊剂的常规工艺和辅料制备而成；
规格：每粒0.3g；
用法用量：早晚各0.9g，温开水直接冲服；1个月1周期，一般观察3周期。
实施例3、片剂药物的制备
原料配方：藿香45份，生栀子36份，白扁豆36份，佛手12份，陈皮12份，砂仁12份，茯苓12份，干姜12份，生薏米12份，枳椇子12份，紫苏12份，香橼12份，生甘草6份，绿茶6份；
制备工艺：按药剂学制备片剂的常规工艺和辅料制备而成；
规格：每片1.0g；
用法用量：早晚各3g，温开水直接冲服；1 个月1周期，一般观察3周期。
实施例4、丸剂药物的制备
原料配方：藿香35份，生栀子30份，白扁豆30份，佛手6份，陈皮6份，砂仁6份，茯苓6份，干姜6份，生薏米6份，枳椇子6份，紫苏6份，香橼6份，生甘草3份，绿茶3份；
制备工艺：按药剂学制备丸剂的常规工艺和辅料制备而成；
规格：每粒0.05g；
用法用量：早晚各6g，温开水直接冲服；1个月1周期，一般观察3周期。
实施例5、口服液的制备
原料配方：藿香48份，生栀子40份，白扁豆40份，佛手15份，陈皮15份，砂仁15份，茯苓15份，干姜15份，生薏米15份，枳椇子15份，紫苏15份，香橼15份，生甘草8份，绿茶8份；
制备工艺：按药剂学制备口服液的常规工艺和辅料制备而成；
规格：每瓶10ml；
用法用量：早晚各20ml，温开水直接冲服；1个月1周期，一般观察3周期。
上述各实施例中，各原料配比均以重量份计。
Claims (4)
1.一种用于调治带下异常的中药制剂，是以藿香、生栀子、白扁豆、佛手、陈皮、砂仁、茯苓、干姜、生薏米、枳椇子、紫苏、香橼、生甘草、绿茶为原料，按中药药剂学的常规工艺和辅料制备成各种内服制剂；所述各原料按以下重量份进行配比：藿香35-48份，生栀子30-40份，白扁豆30-40份，佛手6-15份，陈皮6-15份，砂仁6-15份，茯苓6-15份，干姜6-15份，生薏米6-15份，枳椇子6-15份，紫苏6-15份，香橼6-15份，生甘草3-8份，绿茶3-8份。
2.如权利要求1所述用于调治带下异常的中药制剂，其特征在于：所述各原料按以下重量份进行配比：藿香40-45份，生栀子33-36份，白扁豆33-36份，佛手8-12份，陈皮8-12份，砂仁8-12份，茯苓8-12份，干姜8-12份，生薏米8-12份，枳椇子8-12份，紫苏8-12份，香橼8-12份，生甘草5-6份，绿茶5-6份。
3.如权利要求1所述用于调治带下异常的中药制剂，其特征在于：所述各原料按以下重量份进行配比：藿香40份，生栀子34份，白扁豆34份，佛手10份，陈皮10份，砂仁10份，茯苓10份，干姜10份，生薏米10份，枳椇子10份，紫苏10份，香橼10份，生甘草6份，绿茶6份。
4.如权利要求1所述用于调治带下异常的中药制剂，其特征在于：所述内服制剂为胶囊剂、片剂、颗粒剂、丸剂或口服液。
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