CN104398948A - Traditional Chinese drug for treating diabetes insipidus - Google Patents

Abstract

The invention relates to the field of traditional Chinese drug formulas, in particular to a traditional Chinese drug for treating diabetes insipidus. The traditional Chinese drug is characterized by being prepared from the following raw material herbs by weight percentage: 6-9% of Rhamnus aurea, 4-7% of Rosa laevigata, 6-9% of Cuscuta chinensis, 4-7% of Semen Euryales, 6-9% of allium tuberosum, 3-5% of fructus alpiniae oxyphyllae, 10-13% of Folium Sauropi, 0.1-0.2% of Lepironia articulata, 10-13% of rubus parkeri hance, 3-6% of herba epimedii, 3-5% of dendrobe, 2-5% of radix ophiopogonis, 3-6% of cortex lycii radicis, 3-6% of centella, 4-6% of cacumen biotae, 2-5% of moutan bark, 2-4% of cassia twig and 2-4% of erycibe obtusifolia benth. The raw material herbs are soaked in water and decocted, and residues are removed to obtain a filter liquor. The traditional Chinese drug is low in cost, capable of effectively treating diabetes insipidus and free of toxic and side effects.

Description

The Chinese medicine for the treatment of diabetes insipidus

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine for the treatment of diabetes insipidus.

Background technology

As everyone knows, urine volume claims urine to collapse more than 3L/d.The common disease that urine collapses is caused to claim diabetes insipidus.Diabetes insipidus refers to that vasopressin is also known as antidiuretic hormone secretion deficiency (also known as central or pituitary diabetes insipidus), or one group of disease group that kidney reacts defect (also known as nephrogenic diabetes insipidus) to vasopressin and causes, be characterized in polyuria, excessive thirst, low-gravity urine and hypotonic urine.Primary disease is common in clinical manifestation following several situation: (1) a large amount of low-gravity urine, urine volume is more than 3L/d.(2) because sellar tumour is excessive or to external expansion person, the pressurized performance of Chang You sella turcica peripheral nerve tissue, as visual deterioration, visual field disappearance.(3) there is the thirsty obstacle person that feels, dehydration, hypernatremia, hyperosmotic state, heating, tic etc. can be occurred, even cerebrovas-cularaccident.At present the effective medicine of generally recognized as safe is still lacked at present for diabetes insipidus.

Summary of the invention

The object of the invention is exactly that provide a kind of Chinese medicine for the treatment of diabetes insipidus, cost is low, effectively can treat diabetes insipidus, have no side effect in order to overcome above-mentioned existing technical deficiency.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of diabetes insipidus, it is characterized in that being made up of the crude drug of following percentage by weight, Herba lespedezae pilosae 6 ~ 9%, Fructus Rosae Laevigatae 4 ~ 7%, Semen Cuscutae 6 ~ 9%, Semen Euryales 4 ~ 7%, Semen Allii Tuberosi 6 ~ 9%, Fructus Alpiniae Oxyphyllae 3 ~ 5%, Folium Sauropi 10 ~ 13%, Medulla Junci 0.1 ~ 0.2%, Radix Rubi Parkeri 10 ~ 13%, Herba Epimedii 3 ~ 6%, Herba Dendrobii 3 ~ 5%, Radix Ophiopogonis 2 ~ 5%, Cortex Lycii 3 ~ 6%, Herba Centellae 3 ~ 6%, Cacumen Platycladi 4 ~ 6%, Cortex Moutan 2 ~ 5%, Ramulus Cinnamomi 2 ~ 4%, Caulis Erycibes 2 ~ 4%, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.

The invention has the beneficial effects as follows, cost is low, effectively can treat diabetes insipidus, have no side effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Herba lespedezae pilosae, Fructus Rosae Laevigatae, Semen Cuscutae, Semen Euryales, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Folium Sauropi, Medulla Junci, Radix Rubi Parkeri, Herba Epimedii, Herba Dendrobii, Radix Ophiopogonis, Cortex Lycii, Herba Centellae, Cacumen Platycladi, Cortex Moutan, Ramulus Cinnamomi, Caulis Erycibes is adopted to be that crude drug is prepared from.The every pair of its component (% by weight) is Herba lespedezae pilosae 8.3, Fructus Rosae Laevigatae 6.2, Semen Cuscutae 8.1, Semen Euryales 6.1, Semen Allii Tuberosi 8.1, Fructus Alpiniae Oxyphyllae 4.6, Folium Sauropi 10.8, Medulla Junci 0.2, Radix Rubi Parkeri 11.3, Herba Epimedii 4.4, Herba Dendrobii 4.6, Radix Ophiopogonis 3.9, Cortex Lycii 4.4, Herba Centellae 4.9, Cacumen Platycladi 4.3, Cortex Moutan 3.9, Ramulus Cinnamomi 3.1, Caulis Erycibes 2.8.Get above-mentioned 18 taste herbal raw materials, gross weight is 202 grams, and add water 1100 ~ 1300ml, soak 2 ~ 3 hours, then boil with high heat, slow fire decocts 60 ~ 70 minutes, and remove slag to obtain filtrate about 200ml, medicinal residues add water 300 ~ 400ml again, decoct about 30 minutes, remove slag to obtain filtrate about 100ml, is total to obtain about 300ml medicine juice, load in sterile glass vials, seal bottle cap is for subsequent use.Every day 1 dose point 2 times is oral, each (medicine) being taken before meal about 150ml.

Herba lespedezae pilosae of the present invention is controlled the empty heat for a long time of body and is not moved back, acute filthy disease abdominal part distending pain, edema, carbuncle, furuncle of finger; Fructus Alpiniae Oxyphyllae warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine; Fructus Rosae Laevigatae reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal.Control spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung is breathed with cough, spontaneous sweating, bleeding not during menses, is monarch drug altogether; Semen Cuscutae the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision; Semen Euryales reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak.Control seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, loose stool and diarrhea; Semen Allii Tuberosi liver and kidney tonifying, tonifying YANG controlling nocturnal emission with astringent drugs.Main impotence due to deficiency of the kidney, soreness of the waist and knees, seminal emission, frequent micturition, turbid urine, leukorrhagia is rare clearly, and three tastes help monarch, is ministerial drug altogether; Assistant stops phlegm-fire cough asthma with Folium Sauropi.Control internal injury pulmonary tuberculosis aphonia; The main trusted subordinate's pathogen of Medulla Junci, dysuria, stranguria with urinary obstruction, rheumatism; Radix Rubi Parkeri controls impairment caused by overstrain, spits blood, menoxenia, amenorrhea ， mass in the abdomen, metrorrhagia; Herba Epimedii kidney invigorating and YANG supporting, expelling wind and removing dampness.Control sexual impotence erectile problem, hemiplegia is unsuccessful, dribbling urination, and muscles and bones contraction is anxious, cough, optic atrohic blindness after being ill, toothache caused by fire of deficiency type, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, and extremity are meciless; Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation; Cortex Lycii main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat; Herba Centellae clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Control eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood, tells, is defeated in battle, hemoptysis; Cacumen Platycladi removing heat from blood, hemostasis, wind-damp dispelling, loose toxic swelling.Control haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia; Cortex Moutan has the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever; Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass; Caulis Erycibes is used for rheumatic arthritis, rheumatoid arthritis, sciatica, hemiplegia, treating swelling and pain by traumatic injury, altogether for making medicine.

The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize, and it decocts program, oral method is identical with embodiment 1, and its content is as shown in the table.

The clinical trial carried out below in conjunction with my institute is described in further detail the present invention:

1, physical data

Inventor collects the out-patient of 85 routine diabetes insipiduss altogether between in June ,-2014 in February, 2011, age 21-45 year, the course of disease 1-12 month.

2, diagnosis basis

2.1 thirsty polydipsia, polyorexia, urinary micturition, emaciated physique.

2.2 from the beginning of can " more than three " symptom not work.Sick Chang Bingfa is dizzy for a long time, pulmonary tuberculosis, the thoracic obstruction, apoplexy, nyctalopia, furuncle etc.The visible excessive thirst of severe patient, headache, vomiting, stomachache, short of breath, the de-crisis even stupor is fainted.

2.3 look into empty stomach, 2 hours after the meal glucoses in urine and blood glucose, specific gravity of urine, glucose tolerance test.Have urine examined ketoboidies if desired, blood urea nitrogen, creatinine, CO2 combining power, CO2 CP and blood potassium, sodium, calcium, chloride etc.

3, Therapeutic Method

The decoction that oral the present invention obtains according to embodiment 1, sooner or later respectively once, one month course for the treatment of.

4, criterion of therapeutical effect and therapeutic outcome

4.1 criterion of therapeutical effect

With reference to the industry standard " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine promulgates, for diabetes insipidus efficacy evaluation: recovery from illness: urine volume, specific gravity of urine, osmotic pressure of urine are normal, and transference cure, lab testing is repeatedly normal.Take a turn for the better: hypourocrinia, specific gravity of urine is through being everlasting more than 1.010, and osmotic pressure of urine > 300mmol/L, cardinal symptom and regarding assay room check and be improved.Invalid: symptom and lab testing unchanged.

4.2 treatment statistical results

Recovery from illness 24 example, take a turn for the better 52 examples, no effect 9, total effective rate 89.4%

Model case

Zheng, female, 21 years old, frequent micturition, thirst and drinking, skin is shrivelled simultaneously, two eyeballs all have depression, body sense is tired out breathes hard, and tongue is red, thready and rapid pulse without strength, and with slight dizziness, go to local hospital in time subsequently and be diagnosed as diabetes insipidus disease, rear hospital adopts doctor trained in Western medicine routine medication one week rear poor effect, and with exacerbation of symptoms trend.After give treatment by Chinese herbs of the present invention, after taking one week, urine volume, specific gravity of urine, osmotic pressure of urine are all tending towards normalization, and continuous with after one month, the state of an illness is clearly better and there is no recurrence so far.

Xing, man, 28 years old; clear urine in large amounts, nocturnal urine volume was relatively many, and the symptom such as trick of being afraid of cold is ice-cold; lumbago, Mian Guang Koushi is white, and light red tongue is fat; tongue is white; deep-slow pulse is unable, goes to local hospital to go to a doctor subsequently, and hospital is diagnosed as diabetes insipidus by diagnosis such as x ray examination, CT scan; hospital adopts western medical treatment immediately, loses symptom take a turn for the better to some extent through treatment in 3 days.After give treatment by Chinese herbs of the present invention, after taking 5 days, above-mentioned situation symptom takes a turn for the better to some extent, and after continuing to take one month, urine volume, specific gravity of urine, osmotic pressure of urine are normal, and so far without recurring.

General certain, man, 33 years old, excessive thirst polydipsia, urinary micturition particularly significantly increases at nocturnal urine volume, dysphoria with feverish sensation in the chest palms and soles, feels soreness of the waist and knees at ordinary times, fear of cold is weak, and with symptoms such as seminal emission sexual impotence, go to hospital admission subsequently, examination in hospital confirms as it for diabetes insipidus after being checked by urine volume, blood, osmotic pressure of urine, plasma AVP mensuration etc., adopt western medical treatment after hospital, after one week, symptom is not felt any better.Give treatment by Chinese herbs of the present invention subsequently, after taking one week, after making coherence check; urine volume is tending towards normalization, and patient's blood osmotic pressure value is between 290 ~ 310mOsm/L, and osmotic pressure of urine value is between 600 ~ 800mOsm/L; above-mentioned every symptom takes a turn for the better all to some extent, there is no recurrence so far.

Claims (1)

1. treat the Chinese medicine of diabetes insipidus for one kind, it is characterized in that: be made up of the crude drug of following percentage by weight, Herba lespedezae pilosae 6 ~ 9%, Fructus Rosae Laevigatae 4 ~ 7%, Semen Cuscutae 6 ~ 9%, Semen Euryales 4 ~ 7%, Semen Allii Tuberosi 6 ~ 9%, Fructus Alpiniae Oxyphyllae 3 ~ 5%, Folium Sauropi 10 ~ 13%, Medulla Junci 0.1 ~ 0.2%, Radix Rubi Parkeri 10 ~ 13%, Herba Epimedii 3 ~ 6%, Herba Dendrobii 3 ~ 5%, Radix Ophiopogonis 2 ~ 5%, Cortex Lycii 3 ~ 6%, Herba Centellae 3 ~ 6%, Cacumen Platycladi 4 ~ 6%, Cortex Moutan 2 ~ 5%, Ramulus Cinnamomi 2 ~ 4%, Caulis Erycibes 2 ~ 4%, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.