CN104398544A - Strigose-hydrangea-leaf antiallergic tablet and preparation method thereof - Google Patents
Strigose-hydrangea-leaf antiallergic tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a strigose-hydrangea-leaf antiallergic tablet and a preparation method thereof. By comprehensively using a strigose hydrangea leaf extractive, mint, borneol, maltodextrin, calcium lactate, citric acid, mannitol and magnesium stearate, the buccal tablet is extremely excellent in antiallergic effect, mild in medicine property and small in side effect. The tablet prepared by the method is good in disintegration degree, good in release rate and high in bioavailability, and also is good in mouthfeel and easy to accept by patients.
Description
Technical field
The present invention relates to a kind of Folium hydrangeae strigosae antiallergic sheet and preparation method thereof, belong to the technical field of medicine.
Background technology
Anaphylaxis refers to the reaction of the tissue injury that immunifacient body occurs when again accepting same antigen and stimulating or dysfunction.Be characterized in outbreak rapidly, strong reaction, disappear very fast; Generally can not disorganize cell, also can not cause tissue injury, have obvious genetic predisposition and individual variation.Conventional antiallergic agent is mainly chemicals, thus inevitably produces very large side effect.Contrast chemical drugs, natural drug has the property of medicine gentle, the feature that side effect is little.Folium hydrangeae strigosae is containing, for example many effective ingredient such as Folium hydrangeae strigosae element, flavone, polyphenol.Its major function has blood fat reducing, blood sugar lowering, cough-relieving etc., and especially its antiallergic effect is splendid.Therefore invent a kind of antiallergic sheet be made up of Folium hydrangeae strigosae to have great importance.
Summary of the invention
The object of this invention is to provide a kind of Folium hydrangeae strigosae antiallergic sheet and preparation method thereof, Folium hydrangeae strigosae antiallergic sheet antiallergic effect of the present invention is splendid, and the property of medicine is gentle, and side effect is little; The tablet disintegration that described method is made is good, and release is good, and bioavailability is high; And mouthfeel is good, patient is easy to accept.
The present invention is achieved in that a kind of Folium hydrangeae strigosae antiallergic sheet, calculate according to composition by weight, be prepared from by following compositions: sweet tea extract 40 ~ 60 parts, maltodextrin 10 ~ 30 parts, Herba Menthae 0.5 ~ 2 part, calcium lactate 10 ~ 20 parts, citric acid 0.5 ~ 2 part, 5 ~ 15 parts, mannitol, 0.5 ~ 2 part, Borneolum Syntheticum and magnesium stearate 1 ~ 3 part.
More preferably, in aforementioned Folium hydrangeae strigosae antiallergic sheet, calculate according to composition by weight, be prepared from by following compositions: sweet tea extract 50 parts, maltodextrin 20 parts, Herba Menthae 1 part, calcium lactate 15 parts, citric acid 1 part, 10 parts, mannitol, 1 part, Borneolum Syntheticum, magnesium stearate 2 parts.
The preparation method of aforementioned Folium hydrangeae strigosae antiallergic sheet is, get sweet tea extract, Herba Menthae, Borneolum Syntheticum, maltodextrin, calcium lactate, citric acid, mannitol and magnesium stearate mixing, conveniently technique makes tablet.
Described tablet is buccal tablet.
The preparation method of described buccal tablet is:
A. get the sweet tea extract of 100 ~ 220 mesh sieves, citric acid, Herba Menthae, Borneolum Syntheticum to drop in mixer with the magnesium stearate of calcium lactate, mannitol and 1/2 amount and fully mix homogeneously, obtain A product;
B. soft material processed: the ethanol slowly adding maltodextrin and 65%-85% in A product, makes soft material, and soft material humidity agglomeratingly unclamps namely loose being as the criterion to pinch with hands, obtains B product;
C. granulate: B product are crossed 10 ~ 18 mesh sieves and makes granule, obtain C product;
D. dry: the dry 2 ~ 3h of air dry oven C product being placed in 50 DEG C, obtains D product;
E. granulate: D product are crossed 15 ~ 20 mesh sieves, obtains E product;
F. tabletting: the magnesium stearate adding surplus in E product, uses tablet machine tabletted, coating after mixing, gets product.
Particularly, the preparation method of described buccal tablet is:
A. get the sweet tea extract of 200 mesh sieves, citric acid, Herba Menthae, Borneolum Syntheticum to drop in mixer with the magnesium stearate of calcium lactate, mannitol and 1/2 amount and fully mix homogeneously, obtain A product;
B. soft material processed: the ethanol slowly adding maltodextrin and 75% in A product, makes soft material, and adjustment soft material humidity agglomeratingly unclamps namely loose being as the criterion to pinch with hands, obtains B product;
C. granulate: B product are crossed 14 mesh sieves and makes granule, obtain C product;
D. dry: the dry 2.5h of air dry oven C product being placed in 50 DEG C, obtains D product;
E. granulate: D product are crossed 18 mesh sieves, obtains E product;
F. tabletting: the magnesium stearate adding surplus in E product, uses tablet machine tabletted, coating after mixing, gets product.
Folium hydrangeae strigosae antiallergic sheet of the present invention is made up of sweet tea extract, Herba Menthae, Borneolum Syntheticum, maltodextrin, calcium lactate, citric acid, mannitol and magnesium stearate.Wherein, sweet tea extract is extracted by Folium hydrangeae strigosae and obtains.Folium hydrangeae strigosae is containing abundant nutrient substance and the necessary trace element of human body, research shows to be rich in 18 seed amino acids in Wild sweet tea, every 100 grams of dry products are containing total amino acid content 331.54 milligrams, particularly be rich in Folium hydrangeae strigosae human body necessary, human body can not generate, 8 seed amino acids that can only absorb from food in addition, Folium hydrangeae strigosae is also containing zinc 105.5mg/kg, germanium 5.5 μ g/kg, selenium 17.94 μ g/kg, and the multiple element such as potassium, magnesium, phosphorus, ferrum, sodium, copper, chromium, strontium, lithium.It is not containing the noxious substance such as arsenic aluminum, containing dizziness can be produced, palpitate quickly, cardiopalmus, anxiety irritability, Psychological inadaptability, interference sleep, etc. the caffeine of side effect; Wherein contained germanium, selenium etc., be all better than general green tea and Folium Ilicis.Except above-mentioned contained trace element, it is also rich in vitamin C, B1, B2, B3, superoxide dismutase, and in fresh and sweet tea, ascorbic content is up to 115mg/100g; Particularly also be rich in the bioflavonoids of most valuable 4.1%, the tea polyphenols of 18.04% and 5% Folium hydrangeae strigosae element.Record according to related documents, Wild sweet tea has " resolving heat and reducing pathogenic fire, lung moistening, eliminate the phlegm, effect of cough-relieving ", is described as " refreshing tea ", and its medical and consumption are for local medical and among the peoplely to be confirmed.It also contains the Folium hydrangeae strigosae element of the flavone of more than 3.2%, the sweet tea polyphenols of 8.94% and 4-5%.Sweet tea polyphenols has obvious antioxidation, mutation, anti-cancer, reduction cholesterol, the effect that reduces low density lipoprotein, LDL in blood, suppress blood pressure to rise, suppress blood glucose to rise, suppress platelet aggregation, antibacterial, anti-food anaphylaxis, improve gastrointestinal microbiological environment, smelly eliminating, be find optimal natural antioxidant at present, purposes is very extensive.Moreover, adopt models of passive skin irritability of rats and mouse ear xenogenesis models of passive skin irritability, cause Cavia porcellus to draw and breathe heavily, DCH caused by dinitrochlorobenzene and histamine bring out Cavia porcellus pedal swelling method, observe the anti-allergic effects of sweet tea extract, result shows the inflammatory seep that sweet tea extract obviously can suppress models of passive skin irritability of rats and mouse ear xenogenesis models of passive skin irritability and causes, prolonged guinea pig bronchospasm causes the incubation period of asthma attack, reduce DCH mice auricle weight caused by dinitrochlorobenzene, and Cavia porcellus pedal swelling is brought out to histamine have certain antagonism.This shows that sweet tea extract has significant anti-allergic effects.Therefore Wild sweet tea is a kind of nontoxic natural sweet taste plant with having health care, and having good auxiliary curative effect to diseases such as hypertension, diabetes, cardiovascular diseases, kidneys, is a kind of natural plants having Development volue.
Herba Menthae has medical and edible dual-use function, and main Leaf-feeding insects is stem and leaf, clothes of also can squeezing the juice.On edible, Herba Menthae both can be used as flavoring agent, can make spice again, also can join wine, make tea.In every 100 grams of dried peppermints, moisture content 9.6 grams, 6.8 grams, protein and fiber 31.1 grams, can provide the heat of 870.7 kilojoules.On edible function, Herba Menthae can be made multiple food and be selected for people, and variety classes has different benefits to human body, as: Herba Menthae medicated porridge can pure and freshly be soothed the spirit, wind-dispelling heat-dissipating, and appetite stimulator helps digest; Herba Menthae bean curd can treat the diseases such as cold nasal obstruction, sneeze, rhinorrhea; Herba Menthae shredded chicken can quench expelling summer-heat; Pepper mint patty can be refrigerant, wind-dispelling heat-dissipating, pharynx-clearing throat-benefiting; Fresh Herba Menthae gold carp soup can control chronic cough in children; Herba Menthae soup can detoxify and relieve inflammation or internal heat; It is comfortable that Herba Menthae herbal tea drinks rear entire body, and energy doubles.In addition, peppermint stem and leaf has peat-reek, can be used for making chewing gum, toothpaste etc., plays effect of refreshing, pathogenic fire purging.On medical function, Herba Menthae is Chinese conventional Chinese medicine, and young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption.In addition also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.
Borneolum Syntheticum, has another name called Borneolum Syntheticum, is the crisp crystallization of lamellar of water white transparency or white translucent; Gas delicate fragrance, acrid in the mouth, cool, have refreshment of having one's ideas straightened out, the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, and heat-damp in summer hoodwinks key clearly, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.
Maltodextrin, be the starch hydrolysate that DE value is less than 20, it is between starch and starch sugar, be a kind of cheap, mouthfeel is satiny, without any the trophism polysaccharide of taste.The maltodextrin of different DE value has different functions and character: as thickening, gelling, reduction product sweetness, change system freezing point, suppress ice-crystal growth, replace fat, reduce heat energy, improve matter structure and as spray or dry support etc.
Calcium lactate is a kind of white to creamy white crystals or powder, basic odorless, tasteless.Have the advantages that dissolubility is high, dissolution velocity soon, is easily absorbed by the body.The main hardening agent being used as food additive, child nutrition food.In addition, he can also be used as the calcium preparation of nutrition enhancer, makes the buffer agent of bread, cake etc., bulking agent.Medicine aspect, calcium lactate can prevent and treat calcium deficiency, as rickets, tetany, and forepart pregnant women, the supplementing of calcium needed for age of sucking.
Citric acid, has another name called citric acid, clear crystal, and normal containing a part water of crystallization, odorless, has very strong tart flavour, soluble in water, and at medicine, grocery trade, cosmetic industry etc. has extremely many purposes.At pharmaceutical sector, in the formation of thrombokinase and later coagulation process, calcium ion must be had to participate in.Citric acid radical ion and calcium ion can form a kind of soluble complexes being difficult to dissociate, and thus reduce calcium ion concentration in blood, blood coagulation is obstructed.Citric acid transfuse blood or laboratory blood sample anticoagulant time, as external anticoagulation.At grocery trade, because citric acid has gentle frank tart flavour, be commonly used to the manufacture of the food such as various beverage, soda pop, wine, confection, dessert, cookies, canned fruit juice, milk product.In all organic acid market, citric acid market share more than 70%, it can be used as flavoring agent, improves the sensory properties of food, appetite strengthening and promote digesting and assimilating of calcium in body, phosphorus substance.Simultaneously.Anhydrous citric acid is in a large number for solid beverage.Salt such as calcium citrate and the ferric citrate of citric acid are the hardening agents needing to add calcium ion and iron ion in some food.Esters such as the triethyl citrate of citric acid can make nontoxic plasticizer, and manufacturing food packaging plastic sheeting, is the acidic flavoring agent of drink and food industry, antiseptic.In cosmetic industry, citric acid belongs to the one of fruit acid, and it is usually used in emulsion, cream, shampoo, whitening articles for use, aging resistance articles for use, Acne, object accelerates cutin to upgrade, the renewal of cutin contributes to melanic in skin peeling off, and the receipts of pore are thin, the dissolving etc. of blackhead.
Mannitol is a kind of white, needle-shaped crystals, and pharmaceutically, it can reduce intracranial pressure, intraocular pressure, is also used as the diluent of the excipient of tablet and solid, liquid.Formula mannitol injection liquid as Thief zone depressor, be clinical rescue particularly brain disorder rescue conventional a kind of medicine, have and reduce that blood pressure lowering required by intracranial pressure medicine is fast, curative effect feature accurately.As tablet excipients, mannitol no hygroscopicity, fast drying, chemical stability is good, and has the features such as tasty and refreshing, pelletize is good, for most of tablets such as anticarcinogen, antimicrobial drug, antihistaminic and vitamin.In addition, mannitol is also for chewing tablets such as fresheners in hangover medicine, mouth.In food, the water absorption of these product in sugar and sugar alcohol is minimum, and has tasty and refreshing sweet taste, antiseized for food such as maltose, chewing gum, new year cakes, and is used as the antiseized powder of general cake.It also can be used as the sweeting agent of the low heat values such as diabetics food, body-building food, low sugar.Mannitol is used for the synthesis of resin and medicine, can be made into dehydrant, diuretic.Treat cerebral edema and glaucoma, acute oliguria, prevent acute renal failure, treatment nephrotic syndrome edema.
Magnesium stearate, for white is easily without the fine powder of grittiness, micro-have off-odor, has soapy feeling with contact skin.It is mainly used as lubricant, antiplastering aid, fluidizer.The granulation of special appropriate oil, extract medicament, the granule made has good mobility and compressibility.Fluidizer is used as in direct compression.Also can be used as filter aid, clarifier and drip infusion, and the suspending agent of liquid preparation, thickening agent.
In the present invention, citric acid, Herba Menthae, Borneolum Syntheticum are as flavoring agent; Calcium lactate, mannitol as filler magnesium stearate as disintegrating agent; Maltodextrin is as binding agent; Sweet tea extract, Herba Menthae, Borneolum Syntheticum, maltodextrin, calcium lactate, citric acid, mannitol and magnesium stearate are share by the present invention, and the buccal tablet antiallergic effect made is splendid, and the property of medicine is gentle, and side effect is little; The tablet disintegration that described method is made is good, and release is good, and bioavailability is high; And mouthfeel is good, patient is easy to accept.Reach goal of the invention.
experimental example 1. contrast experiment
One, medicine
1, former technique buccal tablet
Formula: Folium hydrangeae strigosae flavone extract powder 40g, supplementary product starch 38.75g, vitamin C 5g, mannitol 14.7g, citric acid 0.4g, magnesium stearate 0.5g, Pulvis Talci 1g, Mint Essence 0.05g, Hami melon essence 0.1g
Technique: mixed by above-mentioned raw materials, conveniently technique makes buccal tablet.
2, buccal tablet of the present invention: be prepared according to the formula of the embodiment of the present invention 1 and technique.
Two, detect disintegration
1. instrument and apparatus
1.1 disintegration testers (apparatus see " Chinese Pharmacopoeia " 2010 editions two annex XA).
1.2 beaker 1000ml
1.3 thermometer scale division values 1 DEG C
2. operational approach and examination criteria
Hanging basket hangs on metal rack by the stainless steel shaft of upper end by 2.1, immerse in 1000ml beaker, and 25mm at the bottom of screen cloth distance beaker when regulating hanging basket position to make it decline, fill the water that temperature is 37 ± 1 DEG C in beaker, screen cloth 15mm place under liquid level when regulating liquid surface height makes hanging basket rise.Unless otherwise specified, get test sample 6, be set up respectively and state in hanging basket glass tubing, often manage and add 1, start disintegration tester immediately and check.
2.2 examination criterias: unless otherwise specified, the method by 2.1 checks 6, and each all should whole disintegrate in 10min, against regulation if any 1, separately should get 6 retrials, all should conform with the regulations.
Three, experimental result
1, former technique buccal tablet: get 6, detect according to the method described above, has 2 whole disintegrates in 10min.Get 6 again to detect according to the method described above, have 1 whole disintegrate in 10min.
2, buccal tablet of the present invention: get 6, detect according to the method described above, all not whole disintegrate in 10min.Get 6 again to detect according to the method described above, do not have 1 not whole disintegrate in 10min yet.
Four, conclusion: the disintegration of former technique buccal tablet is bad, can affect quality and the clinical efficacy of medicine.And the disintegration of buccal tablet of the present invention is good, human body is easier to absorb.
experimental example 2. treats example
1, imperial ××, man, 43 years old, its body constitution to alcohol intolerance, but is often treated with courtesy because of occupational relation and is drunk, and occurs playing the symptoms of allergic such as erythema, skin pruritus with it, according to dosage (1 time on the one, each 2-3 sheet) take Tablets (being prepared by the method for embodiment 1) after, anaphylaxis is alleviated immediately, and after taking medicine 1 day, symptom all disappears.
2, poplar ××, female, 27 years old, to pollen hypersensitivity, there is the symptoms such as rhinocnesmus, sneeze, snivel, nasal obstruction, according to dosage (1 time on the one, each 2-3 sheet) take Tablets (being prepared by the method for embodiment 1) after, anaphylaxis is alleviated immediately, and after taking medicine 2 days, symptom all disappears.
3, Shen ××, man, 30 years old, irritated to seafood, occur that skin plays erythema and adjoint pruritis, according to dosage (1 time on the one, each 2-3 sheet) take Tablets (being prepared by the method for embodiment 1) after, anaphylaxis is alleviated immediately, and after taking medicine 2 days, symptom all disappears.
Detailed description of the invention
Embodiment 1.A kind of Folium hydrangeae strigosae antiallergic sheet, get sweet tea extract 50kg, maltodextrin 20kg, Herba Menthae 1kg, calcium lactate 15kg, citric acid 1kg, mannitol 10 kg, Borneolum Syntheticum 1kg and magnesium stearate 2kg, prepare in the steps below:
A. get the sweet tea extract of 200 mesh sieves, citric acid, Herba Menthae, Borneolum Syntheticum to drop in mixer with the magnesium stearate of calcium lactate, mannitol and 1/2 amount and fully mix homogeneously, obtain A product;
B. soft material processed: the ethanol slowly adding maltodextrin and 65%-85% in A product, makes soft material, and soft material humidity agglomeratingly unclamps namely loose being as the criterion to pinch with hands, obtains B product;
C. granulate: B product are crossed 14 mesh sieves and makes granule, obtain C product;
D. dry: the dry 2 ~ 3h of air dry oven C product being placed in 50 DEG C, obtains D product;
E. granulate: D product are crossed 18 mesh sieves, obtains E product;
F. tabletting: the magnesium stearate adding surplus in E product, uses tablet machine tabletted, coating after mixing, gets product.
Embodiment 2.A kind of Folium hydrangeae strigosae antiallergic sheet, get sweet tea extract 45kg, maltodextrin 15kg, Herba Menthae 0.75kg, calcium lactate 12kg, citric acid 0.75kg, mannitol 8 kg, Borneolum Syntheticum 0.75kg and magnesium stearate 1.5kg, prepares by embodiment 1 step.
Claims (6)
1. a Folium hydrangeae strigosae antiallergic sheet, it is characterized in that: calculate according to composition by weight, be prepared from by following compositions: sweet tea extract 40 ~ 60 parts, maltodextrin 10 ~ 30 parts, Herba Menthae 0.5 ~ 2 part, calcium lactate 10 ~ 20 parts, citric acid 0.5 ~ 2 part, 5 ~ 15 parts, mannitol, 0.5 ~ 2 part, Borneolum Syntheticum and magnesium stearate 1 ~ 3 part.
2. Folium hydrangeae strigosae antiallergic sheet according to claim 1, it is characterized in that: calculate according to composition by weight, be prepared from by following compositions: sweet tea extract 50 parts, maltodextrin 20 parts, Herba Menthae 1 part, calcium lactate 15 parts, citric acid 1 part, 10 parts, mannitol, 1 part, Borneolum Syntheticum and magnesium stearate 2 parts.
3. prepare the method for Folium hydrangeae strigosae antiallergic sheet described in claim 1 or 2, it is characterized in that: get sweet tea extract, Herba Menthae, Borneolum Syntheticum, maltodextrin, calcium lactate, citric acid, mannitol and magnesium stearate mixing, conveniently technique makes tablet.
4. the preparation method of Folium hydrangeae strigosae antiallergic sheet according to claim 3, is characterized in that: described tablet is buccal tablet.
5. the preparation method of Folium hydrangeae strigosae antiallergic sheet according to claim 4, it is characterized in that, described buccal tablet is prepared in the steps below:
A. get the sweet tea extract of 100 ~ 220 mesh sieves, citric acid, Herba Menthae, Borneolum Syntheticum to drop in mixer with the magnesium stearate of calcium lactate, mannitol and 1/2 amount and fully mix homogeneously, obtain A product;
B. soft material processed: the ethanol slowly adding maltodextrin and 65%-85% in A product, makes soft material, and soft material humidity agglomeratingly unclamps namely loose being as the criterion to pinch with hands, obtains B product;
C. granulate: B product are crossed 10 ~ 18 mesh sieves and makes granule, obtain C product;
D. dry: the dry 2 ~ 3h of air dry oven C product being placed in 50 DEG C, obtains D product;
E. granulate: D product are crossed 15 ~ 20 mesh sieves, obtains E product;
F. tabletting: the magnesium stearate adding surplus in E product, uses tablet machine tabletted, coating after mixing, gets product.
6. the preparation method of Folium hydrangeae strigosae antiallergic sheet according to claim 5, it is characterized in that, described buccal tablet is prepared in the steps below:
A. get the sweet tea extract of 200 mesh sieves, citric acid, Herba Menthae, Borneolum Syntheticum to drop in mixer with the magnesium stearate of calcium lactate, mannitol and 1/2 amount and fully mix homogeneously, obtain A product;
B. soft material processed: the ethanol slowly adding maltodextrin and 75% in A product, makes soft material, and adjustment soft material humidity agglomeratingly unclamps namely loose being as the criterion to pinch with hands, obtains B product;
C. granulate: B product are crossed 14 mesh sieves and makes granule, obtain C product;
D. dry: the dry 2.5h of air dry oven C product being placed in 50 DEG C, obtains D product;
E. granulate: D product are crossed 18 mesh sieves, obtains E product;
F. tabletting: the magnesium stearate adding surplus in E product, uses tablet machine tabletted, coating after mixing, gets product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108902972A (en) * | 2018-07-16 | 2018-11-30 | 怀化学院 | A kind of lithocarpus litseifolius chewable tablets and preparation method thereof |
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- 2014-10-29 CN CN201410587506.7A patent/CN104398544A/en active Pending
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| CN101829209A (en) * | 2010-04-28 | 2010-09-15 | 广西大学 | Preparation method of fruit-flavored sweet tea polyphenols |
| CN103416754A (en) * | 2013-08-26 | 2013-12-04 | 贵州省健康茶科技有限公司 | Sweet-tea tooth protection lozenge |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108902972A (en) * | 2018-07-16 | 2018-11-30 | 怀化学院 | A kind of lithocarpus litseifolius chewable tablets and preparation method thereof |
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Application publication date: 20150311 |