A kind of Chinese medicine preparation for renal calculus postoperative care and preparation method
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation for renal calculus postoperative care and preparation method.
Background technology
Renal calculus (calculus of kidney) refers to the calculus betiding renal calices, renal pelvis and renal pelvis and ureter connecting portion.Majority is positioned at renal pelvis renal calices, and excess of the kidney matter calculus is rare.There is the fine and close shadow of single or multiple circle, oval or obtuse triangle in plain film display kidney district, high and uniform density.How smooth edge is, but also have rough in Fructus Mori shape.
It is exactly diet that renal calculus forms main cause.It is by diet can the lithogenous related component intake of shape too much, cause the phenomenons such as oxalic acid accumulates too much, purine metabolism is not normal, hyperliposis, sugar increase, protein is excessive and cause formation renal calculus.
The clinical manifestation of renal calculus is divided into the case of a physically strong patient running a high fever and simulataneous insufficiency and excessive disease two type.Burning into sand stone when case of a physically strong patient running a high fever type shows as in urine, urine is involved and abstruse, or interrupts suddenly when urinating, the poverty-stricken pain of urethra, cramp and pain in the lower abdomen, or waist angina abdominis unbearably, is with blood in urine, red tongue, yellow and thin fur, stringy pulse or band number.Simulataneous insufficiency and excessive type shows as disease sandstone of a specified duration and does not go, and can accompany and see spiritlessness and weakness, down in spirits, the few China of pallor, and light red tongue has indentation, thready and weak pulse without strength, or companion's waist abdomen has a dull ache, soreness of the waist and knees, feverish sensation in the palms and soles, hectic fever, night sweat, spiritlessness and weakness, and the few tongue of red tongue, pulse condition is counted accurately.Renal calculus is that mineral crystallization deposition in urine is in kidney, move to ureter sometimes, clinical manifestation individual difference is very large, be decided by the cause of disease of calculus, composition, size, number, position, mobility, with or without the degree of blocking infection and excess of the kidney matter pathological lesion.The lighter can not have symptom completely, serious occurred anuria, renal failure, toxic shock and death.When Incarcerated stone declines in Ureteropelvic junction or ureter, renal colic can be there is, for the paroxysmal cutting pains broken out, sharp ache unbearably, patient is toss about and feel uneasy, pain is radiated to bladder area downwards from waist or flank portion, and external genital and femoribus internus have profuse sweating, nausea and vomiting sometimes.Because calculus is heavier to mucosa injury, therefore often there is gross hematuria.Pain and hematuria be everlasting patient activity more time bring out.During calculus accompanying infection, in urine, there is pus cell, have frequent micturition, dysurea symptom.When secondary acute pyelonephritis or pyonephrosis, the General Symptoms such as can have heating, fear of cold, shiver.When bilateral upper urinary calculus or renal calculus are blocked completely, anuria can be caused.
Kidney is the lithogenous main portions of urinary system shape, and the calculus at other any positions can be primary in kidney, and ureteral calculus is almost all from kidney, and renal calculus coup injury kidney easier in other any position calculus.In the last few years, renal calculus had become high morbidity kind, and harm should not be underestimated.The broken calculus of external physics and the operative treatment mode of adopting is treated more at present.But the relapse rate of renal calculus very up to, the patient of 69% because the damage of internal organs often can with hematuria or pyuria, therefore very important during postoperative care.And Western medicine price is not only expensive, and the intestinal of many patients, stomach can produce certain stimulation, there is certain side effect, for renal calculus postoperative care medicine must safety, effectively, have no side effect, and Chinese materia medica is as the traditional medicine of China, there is the advantages such as effect is strong, instant effect, lasting medicine, and there is no dependency, drug resistance and toxic and side effects, therefore select a kind of Chinese medicine preparation for renal calculus postoperative care, for renal calculus, there is very important clinical meaning.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for renal calculus postoperative care and preparation method; Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meets Chinese medicine and modern medicine theory, has lithodialysis, calculus double effects, reach bactericidal antiphlogistic simultaneously, repair the impaired mucosa of stone location, prevent calculus pathogenic bacteria from growing, there is good effect, instant effect, cure rate is high, and the advantage such as have no side effect, through clinical verification, have fabulous alleviation and therapeutic effect to renal calculus, the clinical treatment and the nursing that are applicable to renal calculus are applied.
For achieving the above object, technical scheme of the present invention is implemented as follows:
For a Chinese medicine preparation for renal calculus postoperative care, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
For a preparation method for the Chinese medicine preparation of renal calculus postoperative care, comprise following processing step:
(1) get Rhizoma Imperatae, Herba Medicaginis, Radix Triplostegiae Grandiflorae, Herba Agerati Conyzoidis and Radix Stephaniae Gracilifoliae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 150 order fine powders, for subsequent use;
(2) Radix seu Herba Pedicularis, Herba Stachytarphetae Jamaicensis, Fructus Forsythiae and Caulis et Folium Crotalariae Assamicae are put in container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 7 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 1 ~ 3 hour, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, dries, for subsequent use;
(3) getting Radix Gomphostemmae, Folium Elaeagni delavayi, Nigella damascena L. and Cortex Eucommiae saline mixes thoroughly vexed, and with the micro-stir-fry of little fire, taking-up is dried, and is placed in mortar and grinds into powder, crosses 160 order fine powders, for subsequent use;
(4) Fructus Kochiae, Pericarpium Arecae and Jie Jie tea are stir-fried with high heat for several times, surface uniform sprays yellow wine, pulverizes, grind into powder after fried dry, crosses 170 order fine powders, for subsequent use;
(5) by the fine powder of step (1), step (3), step (4) gained, make pill with the thick paste of step (2) gained, be the Chinese medicine preparation for renal calculus postoperative care of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Rhizoma Imperatae: sweet in the mouth, cold in nature; Return lung, stomach, urinary bladder channel.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis hematuria, calentura excessive thirst, jaundice edema, the puckery pain of pyretic stranguria, acute nephritis edema." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " emesis blood, epistaxis, controls stranguria with blood, diuresis, only married woman's metrostaxis.”
Radix seu Herba Pedicularis: bitter in the mouth, property is put down.Dispel the wind, victory is wet, diuretic.For Fengshi Guanjie pain, dysuria, lithangiuria, women leucorrhea, scabies." not Lu " carries: " control five infirmity, broken stranguria caused by urinary stone, stagnation of QI in bladder, dredging water passages urine.”
Radix Gomphostemmae: bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, relieving cough and resolving phlegm, antiinflammatory diuresis.For pneumonia, tracheitis, cough with copious phlegm, urinary tract infection, cystitis, oedema due to nephritis, lithangiuria.
Herba Medicaginis: bitter in the mouth, puckery, property is put down; Return spleen, stomach, kidney channel.Stomach invigorating heat clearing away, inducing diuresis to remove edema.For urinary stone, vesical calculus, edema stranguria, nyctalopia." modern Practical Chinese medicinal ": " control uric acid vesical calculus.”
Herba Stachytarphetae Jamaicensis: sweet in the mouth, hardship, cold in nature; GUIXIN, liver, kidney channel.Heat-clearing and toxic substances removing, relieving stranguria by diuresis.For controlling urinary tract infection, lithangiuria, rheumatic arthralgia, traumatic injury congestive edema, carbuncle furuncle and phyma poison." conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, relieving stranguria by diuresis.Control lithangiuria, urinary tract infection, bones and muscles pain due to rheumatism, laryngitis, acute conjunctivitis, carbuncle furuncle and phyma pain.”
Fructus Forsythiae: bitter in the mouth, cold nature; Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle scrofula, warmly to join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention." property of medicine opinion " carries: " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat.”
The Fructus Kochiae: acrid in the mouth, hardship, cold in nature; Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella eczema, skin pruritus." herbal classic " carries: " main bladder heat, diuresis.Invigorating middle warmer, beneficial vital essence.”
Pericarpium Arecae: acrid in the mouth, slightly warm in nature; Return spleen, stomach, large intestine, small intestine meridian.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, defecates not well, edema distension, beriberi edema, dysuria." Japan hanako materia medica " carries: " all gas lower, only cholera, logical intestine and small intestine, spleen benefiting and stimulating the appetite, in tune.”
Folium Elaeagni delavayi: sour in the mouth, light, property is put down; Return lung, spleen channel.Clearing away heat-damp and promoting diuresis, Tonglin Paishi, relieving cough and asthma.For chronic nephritis, renal calculus, urinary tract infection, icterohepatitis, chronic bronchitis, bronchial asthma.
Nigella damascena L.: acrid in the mouth, sweet, warm in nature; Return lung, heart channel.The kidney invigorating is stimulated the menstrual flow, lactogenesis diuresis.For controlling calculus of urethra, renal calculus, hypogalactia, amenorrhea, white insane crazy, skin ulcer scabies.
Joint joint tea: acrid in the mouth, micro-hardship, warm in nature.Dredge the meridian passage.For flu, renal calculus, uterine prolapse, puerperal hemorrhage, traumatic injury impairment caused by overstrain, rheumatic numbness, arthritis.
Radix Triplostegiae Grandiflorae: sweet in the mouth, micro-hardship, property is put down.Tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, removing toxic substances.For lumbago due to renal deficiency, anemia is coughed, and seminal emission sexual impotence, rheumatic arthritis, menoxenia, leukorrhagia is infertile." Yunnan Chinese herbal medicine " carries: " regulating menstruation and activating blood, kidney tonifying.Control amenorrhea, menoxenia, lumbago due to renal deficiency, seminal emission, sexual impotence, infertility.”
Caulis et Folium Crotalariae Assamicae: lightly seasoned, cold in nature, poisonous; Return liver, spleen channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, inducing diuresis to remove edema.For children's's head sore, aphtha is had a toothache, traumatic injury, renal calculus, cystitis, rheumatic ostalgia." SHENGCAO medicine handbook " carries: " control heat syndrome cough to spit blood, edema, children's's color of the leather Huang is thin.”
Herba Agerati Conyzoidis: acrid in the mouth, micro-hardship, cool in nature; Return lung, pericardium channel.Expelling wind and clearing away heat, analgesic hemostatic, calculus.For tonsillitis, acute gastroenteritis, stomachache stomachache, renal calculus, vesical calculus, traumatic hemorrhage." raw Fujian traditional herbal medicine " carries: " eliminating carbuncle, removing blood stasis, removing toxic substances, parasite killing.Control lymphogranuloma inguinale inguinal bubo, muscles and bones spraining is swollen and ache, throat moth.”
Radix Stephaniae Gracilifoliae: bitter in the mouth, cold nature is poisonous; Return stomach, spleen channel.Regulating QI to relieve pain, expelling wind and removing dampness, detumescence poison.For stagnation of QI food stagnation, epigastric pain, rheumatic arthralgia, carbuncle sore tumefacting virus, venom.
The Cortex Eucommiae: sweet in the mouth, micro-pungent, warm in nature; Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, frequent fetal movement, hypertension." herbal classic " carries: " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, Qiang Zhi, wet except itching under the moon, dribbling urination.”
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meets Chinese medicine and modern medicine theory, has lithodialysis, calculus double effects, reach bactericidal antiphlogistic simultaneously, repair the impaired mucosa of stone location, prevent calculus pathogenic bacteria from growing, there is good effect, instant effect, cure rate is high, and the advantage such as have no side effect, through clinical verification, have fabulous alleviation and therapeutic effect to renal calculus, the clinical treatment and the nursing that are applicable to renal calculus are applied.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The processing step of Chinese medicine preparation preparation method of the present invention is:
(1) get Rhizoma Imperatae, Herba Medicaginis, Radix Triplostegiae Grandiflorae, Herba Agerati Conyzoidis and Radix Stephaniae Gracilifoliae decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 150 order fine powders, for subsequent use;
(2) Radix seu Herba Pedicularis, Herba Stachytarphetae Jamaicensis, Fructus Forsythiae and Caulis et Folium Crotalariae Assamicae are put in container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 7 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 1 ~ 3 hour, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, dries, for subsequent use;
(3) getting Radix Gomphostemmae, Folium Elaeagni delavayi, Nigella damascena L. and Cortex Eucommiae saline mixes thoroughly vexed, and with the micro-stir-fry of little fire, taking-up is dried, and is placed in mortar and grinds into powder, crosses 160 order fine powders, for subsequent use;
(4) Fructus Kochiae, Pericarpium Arecae and Jie Jie tea are stir-fried with high heat for several times, surface uniform sprays yellow wine, pulverizes, grind into powder after fried dry, crosses 170 order fine powders, for subsequent use;
(5) by the fine powder of step (1), step (3), step (4) gained, make pill with the thick paste of step (2) gained, be the Chinese medicine preparation for renal calculus postoperative care of the present invention.
Usage and dosage: oral, each 2 balls, every day 3 times, each 1 time of morning, noon and afternoon, warm water delivery service in 1 hour after meal 15 days is a course for the treatment of, and usual 3 ~ 4 courses for the treatment of are effective, and pertinacious disease needs 5 ~ 6 courses for the treatment of.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
The routine clinical observation of patient 400 of the renal calculus selecting my institute or outer court to make a definite diagnosis, patient is divided into two groups at random, treatment group 200 example, wherein male 100 example, women 100 example, 25 ~ 73 years old age, 45 years old mean age, the course of disease 6 months ~ 22 years, average 8 years.Matched group 200 example, wherein male 102 example, women 98 example, 30 ~ 68 years old age, 50 years old mean age, the course of disease 3 months ~ 20 years, average 6 years.
The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes medicine of the present invention, each 2 balls, every day 3 times, each 1 time of morning, noon and afternoon, and warm water delivery service in 1 hour after meal 15 days is a course for the treatment of, and usual 3 ~ 4 courses for the treatment of are effective, and pertinacious disease needs 5 ~ 6 courses for the treatment of.
Matched group takes Shilintong Granule, oral, a 15g, and 3 times on the one, boiled water is taken after mixing it with water after meal.
3, efficacy determination:
(1) cure: kidney district tenderness, lower angina abdominis, urethra pain, in urine, be with the transference cures such as blood; Graft function, urinates freely.
(2) effective: above-mentioned symptom is alleviated to some extent, health is fully recovered, and urinates freely.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 145 examples, effective 45 examples, invalid 10 examples, cure rate 72.5%, total effective rate 95%.
70 examples are cured, effective 80 examples, invalid 50 examples, cure rate 35%, total effective rate 75% in matched group.
Above result display, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Wu's ××, man, 70 years old, retired cadre, Lianyungang of Jiangsu people.Patient once suffered from renal calculus, rehabilitation after operative treatment.But nearest prominent sense lower abdomen has an intense pain, and large area is perspired, and kidney pressure pain, checks through my institute, patient's kidney portion is slight hydrops, renal calculus recurrence.Take 3 courses for the treatment of of Drug therapy of the present invention, pain symptom is obviously alleviated, and continues to take 3 courses for the treatment of, above transference cure.Follow up a case by regular visits to and do not recur so far.
2, fourth ××, female, 60 years old, peasant, Shanghai people.Patient's lumbar and back pain for many years, had strain, thought it is lumbar muscle strain disease, once took various analgesic, and effect is all not good.There is again urethra pain in the recent period, in urine, be with the phenomenons such as blood.Renal calculus is diagnosed as by my institute.Postoperative take 3 courses for the treatment of of Chinese medicine preparation of the present invention after, health is fully recovered, and activity is freely.Follow up a case by regular visits to and do not recur so far.
3, Liu's ××, female, 56 years old, retired professor, people from Guilin.Patient without the unexpected lumbago of obvious inducement, hurt like hell, for paroxysmal and to femoribus internus radiation, toss about and feel uneasy, nausea and vomiting.Renal calculus is diagnosed as by my institute.Postoperative take 2 courses for the treatment of of Chinese medicine preparation of the present invention after, health is clearly better, and continues to take 2 courses for the treatment of, health recovery from illness, activity freely, not recurrence.
4, white ××, man, 51 years old, builder, people from Shijiazhuang, Hebei.Patient once suffered from renal calculus and calculus of prostate disease, postoperatively just occurred pain in the lumbar region again soon, the cold pain of lower abdomen, with urine bifurcated anuria, and the symptom that sweaty foot is many.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom is obviously alleviated, after continuing to take 3 courses for the treatment of, and transference cure, not recurrence.
5, fourth ××, man, 45 years old, enterpriser, Jinan, Shandong Province people.Patient's obesity, face color Koushi is white, and the large matter of corpulent tongue is light, pressure kidney pain, and both hands cun close floating pulse and unable, and readme once suffered from left abdomen renal calculus, oral ulcer with constipation symptom, postoperative take Western medicine after still feel uncomfortable.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom takes a turn for the better, and after continuing to take 2 courses for the treatment of, above transference cure, laboratory indexes is normal.Follow up a case by regular visits to and do not recur so far.
6 strict ××s, female, 38 years old, salesman, people from Wuhan, Hubei.Waist and right front abdomen pain many days on the right side of patient, through my institute's checkout and diagnosis be pyelolithiasis with symptoms such as dysuria, urine calcium increase, doctor carries out operative treatment.Postoperative take 1 course for the treatment of of Chinese medicine preparation of the present invention after, symptom obviously alleviates, and after then taking 3 courses for the treatment of, physical recovery is normal, and activity is freely.Follow up a case by regular visits to and do not recur so far.