CN104383201A - Six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation, preparation method, application and packaging - Google Patents
Six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation, preparation method, application and packaging Download PDFInfo
- Publication number
- CN104383201A CN104383201A CN201410557109.5A CN201410557109A CN104383201A CN 104383201 A CN104383201 A CN 104383201A CN 201410557109 A CN201410557109 A CN 201410557109A CN 104383201 A CN104383201 A CN 104383201A
- Authority
- CN
- China
- Prior art keywords
- superfine powder
- preparation
- rhizoma
- nanoscale
- fructus corni
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation which is a compound traditional Chinese medicine decoction piece composition preparation and is characterized by being prepared from the following ingredients in percentage by weight: 30-35% of prepared rehmannia root, 10-18% of fructus corni bark, 10-14% of moutan bark, 10-14% of Chinese yam, 12-14% of poria cocos and 12-14% of rhizoma alismatis. The invention further discloses a preparation method of the six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation as well as application and packaging of the six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation. According to the invention, the compatibility of the complex prescription of six-ingredient radices rehmanniae can effectively inhibit cancers, is stable and uniform in quality, and is obviously higher than patent six-ingredient radices rehmanniae preparation in curative effect.
Description
Technical field
The present invention relates to a kind of six drugs containing rehmanniae prescription, be specifically related to a kind of Liuwei Dihuang prepared slices of Chinese crude drugs combination preparation, preparation method and application packages.
Background technology
LIUWEI DIHUANG WAN stems from the JINGUI SHENQI WAN in the large physician's Zhang Zhongjing " Medical Treasures of the Golden Chamber " of the Eastern Han Dynasty, also be " shenqi pill ", " Rehmanniae Bolus of Eight Ingredients ", be originally eight taste Chinese crude drugs, afterwards to the Northern Song Dynasty, by national imperial physician assistant officer Qian Yi, former side is deducted Cortex Cinnamomi, Radix Aconiti Lateralis Preparata two taste Chinese medicine, defines by Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae (three taste tonics), Poria, Rhizoma Alismatis, the LIUWEI DIHUANG WAN of Cortex Moutan (three taste cathartics) ingenious compatibility; Three mend and three to rush down, and mend and not dry.LIUWEI DIHUANG WAN is the famous medicine of enriching yin and nourishing kidney, and for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and quenches one's thirst.LIUWEI DIHUANG WAN is usually used in treatment sub-health state, improves immunity, slow down aging, and a lot of people is used as it as health care medicine at long-term taking.Meanwhile, as treatment medicine, in the treatment and auxiliary treatment of the diseases such as hypertension, good effect is also achieved.
Six drugs containing rehmanniae is from Song dynasty Cheng Fang, continue more than 1000 year till now always, lasting through successive dynasties doctor and undergoing of patient, can be described as " volt cattle prescription changes; within thousand, medicine does not wane ", define numerous Dihuang Wan series brand, as Tongrentang, Zhong Jing board, Fo Ci, large raw auspicious, Cai Tongtai, Han Xingtang, Fu Jichun, Zuo Kaitai, Jiu Zhitang, Hu Qingyu Pharmaceutical Workshop, Sheng kind moral hall etc. simultaneously.Common Dihuang Wan plus-minus derivation prescription has Shenmai-dihuang side (Rhizoma Zingiberis Recens Six-element side), Maiwei-dihuang side (Eight Immortals longevity side), ZHIBAIDIHUANG side, Mingmu-Dihuang side, Lycium-rehmannia sides etc., include big honeyed pills, water-honeyed pill, concentrated pill, tablet, capsule, oral liquid etc.
In recent years, the research of Liuwei Dihuang in treating diabetes field also achieves a series of progress, and in its side, each medicine has the report of function of reducing blood sugar, and the research of its full side becomes the focus of research especially, in clinical, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, plus-minus change, determined curative effect; The present inventor finds also there is certain inhibitory action by the combination of six drugs containing rehmanniae plus-minus side for cancer simultaneously, but due to six drugs containing rehmanniae Chinese patent medicine preparation cannot to the effective ingredient in prescription complete patent medicine, and the Liuwei Dihuang preparation after patent medicine also cannot distinguish the quality standard of medical material and control; Simultaneously in six drugs containing rehmanniae Chinese patent medicine preparation quality standard also only to paeonol (C9H10O3) and ursolic acid (C20H48O3) assay, to cause in six drugs containing rehmanniae Chinese patent medicine preparation that quality is irregular to differ, thus have impact on the curative effect of its prescription in plus-minus side.
In addition, in the prescription clinical practice of Traditional Chinese Medicine, general adopt formula system, namely after the good prescription of doctor prescribed, and grab the process of joining and completed by pharmacy room, such flow process makes the proportioning of medicine accurate, does not often reach best curative effect.
Summary of the invention
The object of the invention is to, provide a kind of prepared slices of Chinese crude drugs of six drugs containing rehmanniae patent medicine preparation to combine, its technical problem solved effectively can suppress the compatibility of the six drugs containing rehmanniae plus-minus side of cancer and steady quality, homogeneous, and drug effect is significantly higher than six drugs containing rehmanniae patent medicine preparation.
The object of the invention is to, additionally provide a kind of manufacture method of six drugs containing rehmanniae prescription, adopt the matching method of the six drugs containing rehmanniae prescription in the present invention, Chinese crude drug is after micronizing process, due to its granularity fine and even, specific surface area increases, porosity increases, adsorptivity strengthens, dissolubility improves, affinity becomes large, reaction rate increases, medicine can preferably dispersing and dissolving in gastro-intestinal Fluid, and with gastrointestinal mucosa bump contact, can tightly be attached on again on the mucosa of gastrointestinal inwall simultaneously, it is made to extend at gastrointestinal residence time, absorb more abundant, absorbtivity also can increase, thus greatly improve its bioavailability, the absorbance of this medicament composing prescription is improved, more be conducive to the effect playing six drugs containing rehmanniae prescription.
The object of the invention is to, additionally provide a kind of Combination application packaging of six drugs containing rehmanniae prescription, wherein Fructus Corni: Cortex Moutan: Rhizoma Dioscoreae: Poria: Rhizoma Alismatis is combined and packaged as bag by 8:4:3:3:3:3, combinations thereof application packages also comprises lytic agent.
The Combination application of above-mentioned six drugs containing rehmanniae prescription is adopted to pack
For solving the problems of the technologies described above, the invention provides following technical scheme:
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, wherein the weight proportion of each component is Radix Rehmanniae Preparata 30%-35%, Fructus Corni skin 10%-18%, Cortex Moutan 10%-14%, Rhizoma Dioscoreae 10%-14%, Poria 12%-14%, Rhizoma Alismatis 12%-14%.
Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis are primary herbal mixture decoction pieces preparation processed, and aforementioned primary prepared slices of Chinese crude drugs preparation processed is decoction pieces processed or directly oral medicinal slice or ultramicro decoction piece only.
Wherein the weight proportion of each component is Radix Rehmanniae Preparata 33%, Fructus Corni 17%, Cortex Moutan 12.5%, Rhizoma Dioscoreae 12.5%, Poria 12.5%, Rhizoma Alismatis 12.5%.
Also comprise Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi.
Wherein Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi weight proportion are Radix Asparagi 2%-3%, CHUANSHAO 1%-2%, Rhizoma Curcumae 0.5-1%, Caulis Spatholobi 5%-8%.
Wherein Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi weight proportion are Radix Asparagi 3%, CHUANSHAO 1.5%, Rhizoma Curcumae 0.7%, Caulis Spatholobi 7%.
A preparation method for six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, comprises the steps:
(1) Radix Rehmanniae Preparata is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Rehmanniae Preparata superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-19 DEG C before impacting;
(2) Fructus Corni is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Fructus Corni superfine powder of nanoscale 1 ~ 75nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-21 DEG C before impacting;
(3) Cortex Moutan is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Cortex Moutan superfine powder of nanoscale 1 ~ 70nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out after embrittlement impacting before impacting at temperature-21 DEG C again;
(4) Rhizoma Dioscoreae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 75nm, the time that wherein Rhizoma Dioscoreae is soaked is 35-40 minute, the hydraulic pressure rinsed is 5 ~ 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again;
(5) Poria is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(6) Rhizoma Alismatis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again.
Described Radix Rehmanniae Preparata superfine powder is the Radix Rehmanniae Preparata superfine powder of nanoscale 55nm; Described Fructus Corni superfine powder is the Fructus Corni superfine powder of nanoscale 55nm; Described Cortex Moutan superfine powder is the Fructus Corni superfine powder of nanoscale 60nm; Described Rhizoma Dioscoreae superfine powder is the Fructus Corni superfine powder of nanoscale 60nm; Described Poria superfine powder is the Fructus Corni superfine powder of nanoscale 65nm; Described Rhizoma Alismatis superfine powder is the Fructus Corni superfine powder of nanoscale 55nm.
After described step (1) Fracture completes, also carry out ozone sterilization; After described step (2) Fracture completes, also carry out ozone sterilization; After described step (3) Fracture completes, also carry out ozone sterilization; After described step (4) Fracture completes, also carry out ozone sterilization; After described step (5) Fracture completes, also carry out ozone sterilization; After described step (6) Fracture completes, also carry out ozone sterilization.
Described Radix Rehmanniae Preparata superfine powder, Fructus Corni superfine powder, Cortex Moutan superfine powder, Rhizoma Dioscoreae superfine powder, Poria superfine powder, Rhizoma Alismatis superfine powder are packaged into bag in proportion.
Comprise Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis be packaged into bag in proportion.
Also comprise adjuvant in described packaging, wherein the total amount of Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis and the proportioning of adjuvant are 1:1.
Described adjuvant is HP-β-CD.
The present invention has the following advantages:
Effectively can suppress the compatibility of the six drugs containing rehmanniae plus-minus side of cancer and steady quality, homogeneous, drug effect is significantly higher than six drugs containing rehmanniae patent medicine preparation.
Detailed description of the invention
Below in conjunction with detailed description of the invention, embodiment of the present invention are described in detail.
Embodiment 1
With six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation to immune function of mice.Aged Mice macrophage FC and C3b mono-receptor active all has increasing action.LIUWEI DIHUANG TANG basis is added Radix Asparagi, CHUANSHAO, Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi composition Six-element, can Phagocytosis By The Peritoneal Macrophages In Mice be promoted.Increase hemolytic antibody growing amount, improve lymhocyte transformation rate, promote the generation figure of interleukin in splenocyte, further demonstrate the party and there is obvious immune increasing action.The micronucleus of mice and on finding in spontaneous tumor impact experiment that LIUWEI DIHUANG TANG can reduce animal bone marrow polychromatocyte Rate of Appearance Micronuclei that is normal and chemomorphosis, after offeing medicine 60 weeks continuously, the spontaneous rate of animal tumor reduces with dosage increase.The incidence rate of tumor significantly lower than matched group (P<0.01), illustrate the party's medicine to sudden change and canceration all have certain protective action.Show with the pharmacology of Liuweidihuang Oral Liquid anti-kinds of tumors chemotherapeutic toxic and side effects and clinical study results: this medicine can significantly extend during chemotherapeutics medication survival rate; and establish ten powerful tonics oral liquid and chemotherapy matched group; with 10 objective indicator observe the curative effect; discovery takes Liuweidihuang Oral Liquid at chemotherapeutic period to hemopoietic function; immunologic function; the heart, liver, kidney organ function have good protective effect and improve effect of clinical symptoms, and total effective rate is 84.4%.Curative effect is obviously better than medicinal piece of shiquan dabu liquid group and chemotherapy group, be respectively P<0.05 to this, P<0.01 pavilion this description of test the party has the poisonous side effect of medicine that significant anti-six drugs containing rehmanniae prescription has anticancer to grow and produces in treatment neoplastic process or in treatment other diseases.Take mice oxter inoculated tumour cell to observe the antitumor action of six drugs containing rehmanniae fermentation liquid, result shows, the growth of this liquid to rat liver cancer H22 has remarkable inhibitory action (P<0. 05), the mouse bone marrow cells that cyclophosphamide causes is suppressed, has the effect (P< 0. 01) raising peripheral blood leucocyte.Show that six drugs containing rehmanniae fermentation liquid has antitumor and lowers haematological toxicity effect caused by chemotherapy.
Embodiment 2
Add taste treatment malignant tumor chemotherapy with six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation and cause leukopenia 31 example, after taking 6 ~ 8 doses, leukocyte rises to normal value, only has 2 routine severe patients, recovers normal after taking 15 doses.
Embodiment 3
Six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation does clinical trial; the patient 200 examples being met hyperthyroidism diagnostic criteria is divided into treatment group and matched group; treatment group, on the basis that application antithyroid drug and VB4 are treated, adds with Six-element six Radix Rehmanniae prescription 6g, every day 2 times; Matched group is only with antithyroid drug and VB4 treatment.Result shows, and leukopenia appears in none example for the treatment of group, and matched group then has 15 examples to occur leukopenia.Show that compatibility application Six-element six Radix Rehmanniae prescriptions can prevent and treat peripheral blood leucocyte minimizing effectively while treatment hyperthyroidism.
Be more than the description of this invention and non-limiting, based on other embodiment of inventive concept, all among protection scope of the present invention.
Embodiment 4
Improve drug bioavailability, strengthen drug effect Chinese crude drug after micronizing process, due to its granularity fine and even, specific surface area increases, porosity increases, adsorptivity strengthens, dissolubility improves, affinity becomes large, reaction rate increases, medicine can preferably dispersing and dissolving in gastro-intestinal Fluid, and with gastrointestinal mucosa bump contact, can tightly be attached on again on the mucosa of gastrointestinal inwall simultaneously, it is made to extend at gastrointestinal residence time, absorb more abundant, absorbtivity also can increase, thus greatly improves its bioavailability.Find that Rhizoma Gastrodiae common flour and superfine powder all have the effect of anti-cerebral ischemia reperfusion injury neuronal apoptosis, and this effect of superfine powder is more obvious.Employing In vivo antibacterial experiment studies the antibacterial action that a kind of reed mentioned in ancient books connects superfine powder capsule, and find that drug dose can reduce microbiological contamination mouse death rate when 10 g/kg, the capsule that conventional size reduction method is made and tablet are then.
Embodiment 5
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, wherein the weight proportion of each component is Radix Rehmanniae Preparata 30%, Fructus Corni skin 10%, Cortex Moutan 10%, Rhizoma Dioscoreae 10%, Poria 12%, Rhizoma Alismatis 12%.
Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis are primary herbal mixture decoction pieces preparation processed, and aforementioned primary prepared slices of Chinese crude drugs preparation processed is decoction pieces processed or directly oral medicinal slice or ultramicro decoction piece only.
Embodiment 6
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, wherein the weight proportion of each component is Radix Rehmanniae Preparata 35%, Fructus Corni skin 18%, Cortex Moutan 14%, Rhizoma Dioscoreae 14%, Poria 14%, Rhizoma Alismatis 14%.
Embodiment 7
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, and wherein the weight proportion of each component is Radix Rehmanniae Preparata 33%, Fructus Corni 17%, Cortex Moutan 12.5%, Rhizoma Dioscoreae 12.5%, Poria 12.5%, Rhizoma Alismatis 12.5%.
Embodiment 8
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi, wherein the weight proportion of each component is Radix Rehmanniae Preparata 30%, Fructus Corni skin 10%, Cortex Moutan 10%, Rhizoma Dioscoreae 10% Poria 12%, Rhizoma Alismatis 12%, Radix Asparagi 2%, CHUANSHAO 1%, Rhizoma Curcumae 0.5%, Caulis Spatholobi 5%.
Embodiment 9
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Radix Asparagi, CHUANSHAO, Rhizoma Curcumae and Caulis Spatholobi, wherein the weight proportion of each component is Radix Rehmanniae Preparata 35%, Fructus Corni skin 18%, Cortex Moutan 14%, Rhizoma Dioscoreae 14%, Poria 14%, Rhizoma Alismatis 14%, Radix Asparagi 3%, CHUANSHAO 2%, Rhizoma Curcumae 1%, Caulis Spatholobi 8%.
Embodiment 10
A kind of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Radix Asparagi, CHUANSHAO, Rhizoma Curcumae and Caulis Spatholobi, and wherein the weight proportion of each component is Radix Rehmanniae Preparata 33%, Fructus Corni 17%, Cortex Moutan 12.5%, Rhizoma Dioscoreae 12.5%, Poria 12.5%, Rhizoma Alismatis 12.5%, Radix Asparagi 3%, CHUANSHAO 1.5%, Rhizoma Curcumae 0.7% and Caulis Spatholobi 7%.
Embodiment 11
A kind of application packages of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, comprise Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis in proportion 8:4:3:3:3:3 be combined and packaged as bag, wherein also comprise adjuvant, wherein the total amount of Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis and the weight proportion of adjuvant are 1:1.In the present embodiment, adjuvant is HP-β-CD.
The invention also discloses a kind of preparation method of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, comprise the steps:
(7) Radix Rehmanniae Preparata is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Rehmanniae Preparata superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-19 DEG C before impacting;
(8) Fructus Corni is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Fructus Corni superfine powder of nanoscale 1 ~ 75nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-21 DEG C before impacting;
(9) Cortex Moutan is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Cortex Moutan superfine powder of nanoscale 1 ~ 70nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out after embrittlement impacting before impacting at temperature-21 DEG C again;
(10) Rhizoma Dioscoreae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 75nm, the time that wherein Rhizoma Dioscoreae is soaked is 35-40 minute, the hydraulic pressure rinsed is 5 ~ 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again;
(11) Poria is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(12) Rhizoma Alismatis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again.
Described Radix Rehmanniae Preparata superfine powder is the Radix Rehmanniae Preparata superfine powder of nanoscale 55nm; Described Fructus Corni superfine powder is the Fructus Corni superfine powder of nanoscale 55nm; Described Cortex Moutan superfine powder is the Fructus Corni superfine powder of nanoscale 60nm; Described Rhizoma Dioscoreae superfine powder is the Fructus Corni superfine powder of nanoscale 60nm; Described Poria superfine powder is the Fructus Corni superfine powder of nanoscale 65nm; Described Rhizoma Alismatis superfine powder is the Fructus Corni superfine powder of nanoscale 55nm.
After described step (1) Fracture completes, also carry out ozone sterilization; After described step (2) Fracture completes, also carry out ozone sterilization; After described step (3) Fracture completes, also carry out ozone sterilization; After described step (4) Fracture completes, also carry out ozone sterilization; After described step (5) Fracture completes, also carry out ozone sterilization; After described step (6) Fracture completes, also carry out ozone sterilization.
Described Radix Rehmanniae Preparata superfine powder, Fructus Corni superfine powder, Cortex Moutan superfine powder, Rhizoma Dioscoreae superfine powder, Poria superfine powder, Rhizoma Alismatis superfine powder are packaged into bag in proportion respectively.
Claims (13)
1. a six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation, said preparation is herbal mixture decoction pieces preparation, it comprises Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, it is characterized in that: wherein the weight proportion of each component is Radix Rehmanniae Preparata 30%-35%, Fructus Corni skin 10%-18%, Cortex Moutan 10%-14%, Rhizoma Dioscoreae 10%-14%, Poria 12%-14%, Rhizoma Alismatis 12%-14%.
2. six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as claimed in claim 1, it is characterized in that: Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis are primary herbal mixture decoction pieces preparation processed, aforementioned primary prepared slices of Chinese crude drugs preparation processed is decoction pieces processed or directly oral medicinal slice or ultramicro decoction piece only.
3. six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as claimed in claim 1, is characterized in that: wherein the weight proportion of each component is Radix Rehmanniae Preparata 33%, Fructus Corni 17%, Cortex Moutan 12.5%, Rhizoma Dioscoreae 12.5%, Poria 12.5%, Rhizoma Alismatis 12.5%.
4. the six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as described in any one of claim 1-3, is characterized in that: also comprise Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi.
5. six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as claimed in claim 4, is characterized in that: wherein Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi weight proportion are Radix Asparagi 2%-3%, CHUANSHAO 1%-2%, Rhizoma Curcumae 0.5-1%, Caulis Spatholobi 5%-8%.
6. six drugs containing rehmanniae prescription as claimed in claim 5, is characterized in that: wherein Radix Asparagi, CHUANSHAO, Rhizoma Curcumae, Caulis Spatholobi weight proportion are Radix Asparagi 3%, CHUANSHAO 1.5%, Rhizoma Curcumae 0.7%, Caulis Spatholobi 7%.
7. the preparation method of the six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as described in any one of claim 1-6, is characterized in that: comprise the steps:
(1) Radix Rehmanniae Preparata is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Rehmanniae Preparata superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-19 DEG C before impacting;
(2) Fructus Corni is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Fructus Corni superfine powder of nanoscale 1 ~ 75nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-21 DEG C before impacting;
(3) Cortex Moutan is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Cortex Moutan superfine powder of nanoscale 1 ~ 70nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out after embrittlement impacting before impacting at temperature-21 DEG C again;
(4) Rhizoma Dioscoreae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 75nm, the time that wherein Rhizoma Dioscoreae is soaked is 35-40 minute, the hydraulic pressure rinsed is 5 ~ 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again;
(5) Poria is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(6) Rhizoma Alismatis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Rhizoma Dioscoreae superfine powder of nanoscale 1 ~ 65nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again.
8. the preparation method of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as claimed in claim 7, is characterized in that: described Radix Rehmanniae Preparata superfine powder is the Radix Rehmanniae Preparata superfine powder of nanoscale 55nm; Described Fructus Corni superfine powder is the Fructus Corni superfine powder of nanoscale 55nm; Described Cortex Moutan superfine powder is the Cortex Moutan superfine powder of nanoscale 60nm; Described Rhizoma Dioscoreae superfine powder is the Rhizoma Dioscoreae superfine powder of nanoscale 60nm; Described Poria superfine powder is the Poria superfine powder of nanoscale 65nm; Described Rhizoma Alismatis superfine powder is the Rhizoma Alismatis superfine powder of nanoscale 55nm.
9. the preparation method of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as claimed in claim 8, is characterized in that: after described step (1) Fracture completes, also carry out ozone sterilization; After described step (2) Fracture completes, also carry out ozone sterilization; After described step (3) Fracture completes, also carry out ozone sterilization; After described step (4) Fracture completes, also carry out ozone sterilization; After described step (5) Fracture completes, also carry out ozone sterilization; After described step (6) Fracture completes, also carry out ozone sterilization.
10. the preparation method of six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparation as claimed in claim 8, is characterized in that: described Radix Rehmanniae Preparata superfine powder, Fructus Corni superfine powder, Cortex Moutan superfine powder, Rhizoma Dioscoreae superfine powder, Poria superfine powder, Rhizoma Alismatis superfine powder are packaged into bag in proportion.
The application packages of 11. six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparations as described in any one of claim 1-6, is characterized in that: comprise Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis be packaged into bag in proportion.
The application packages of 12. six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparations as claimed in claim 11, is characterized in that: also comprise adjuvant in described packaging, wherein the total amount of Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis and the proportioning of adjuvant are 1:1.
The application packages of 13. six drugs containing rehmanniae prepared slices of Chinese crude drugs combination preparations as claimed in claim 11, is characterized in that: described adjuvant is HP-β-CD.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410557109.5A CN104383201A (en) | 2014-10-20 | 2014-10-20 | Six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation, preparation method, application and packaging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410557109.5A CN104383201A (en) | 2014-10-20 | 2014-10-20 | Six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation, preparation method, application and packaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104383201A true CN104383201A (en) | 2015-03-04 |
Family
ID=52601225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410557109.5A Pending CN104383201A (en) | 2014-10-20 | 2014-10-20 | Six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation, preparation method, application and packaging |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104383201A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090053339A1 (en) * | 2005-04-01 | 2009-02-26 | Bionovo, Inc. | Composition for treatment of menopause |
-
2014
- 2014-10-20 CN CN201410557109.5A patent/CN104383201A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090053339A1 (en) * | 2005-04-01 | 2009-02-26 | Bionovo, Inc. | Composition for treatment of menopause |
Non-Patent Citations (4)
| Title |
|---|
| 刘坚: "《古传中医名方新用》", 30 November 1989, 广西民族出版社 * |
| 张晋榕: "六味地黄方剂的药理研究与临床新用", 《海峡药学》 * |
| 罗刚: "超微粉碎技术在中药研究中的应用", 《现代药物与临床》 * |
| 郭泉: "六味地黄制剂的研究现状与中药制剂质量标准的构建", 《现代中药研究与实践》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105920085B (en) | Composition with attenuation effect and preparation method and application thereof | |
| CN102988821B (en) | Chinese medicine composition for treating carcinomatosis postoperation, postchemotherapy and postradiotherapy and preparation method of Chinese medicine composition | |
| CN112972547A (en) | Traditional Chinese medicine composition for treating qi-blood deficiency syndrome and preparation method and application thereof | |
| CN103768534A (en) | Traditional Chinese medicinal composition with anti-tumor activity | |
| CN103800661A (en) | Composition for improving immunity and relieving physical fatigue and preparation thereof | |
| CN102008650B (en) | Compound traditional Chinese medicine preparation for treating tumors and preparation method thereof | |
| CN105031301A (en) | Anti-tumor traditional Chinese medicine composition and preparation method thereof | |
| CN102861193B (en) | Traditional Chinese medicine composition for treating gastric cancer | |
| CN103432421B (en) | Medicine composition for improving immunity | |
| CN102028924B (en) | Medicinal composition for late gastric cancer | |
| CN100464759C (en) | Anticancer Chinese traditional extracts and preparation process and application thereof | |
| CN104069194B (en) | A kind of Chinese medicine composition with antitumaous effect and its production and use | |
| CN107854565B (en) | Anti-radiation traditional Chinese medicine composition | |
| CN104547523A (en) | Medicine for enhancing immunity and preparation method thereof | |
| CN105213822B (en) | A kind of Chinese medicine composition and its application treated phlegm wet and stop up Sheng type essential hypertension | |
| CN101293081A (en) | Medicament for treating hyperlipemia and preparation method thereof | |
| CN102805799A (en) | Traditional Chinese medicine composition with antitumous effect | |
| CN104383201A (en) | Six-ingredient radices rehmanniae traditional Chinese medicine decoction piece composition preparation, preparation method, application and packaging | |
| KR20070006830A (en) | Pharmaceutics of traditional chinese medicine of treating aids and preparation method thereof | |
| CN105125616A (en) | Traditional Chinese medicine composition having function of improving anoxia endurance | |
| CN102836315A (en) | Chinese medicinal composition for preventing and conditioning prognosis tumors and preparation method thereof | |
| CN105267793B (en) | A kind of new application of Chinese medicine composition | |
| CN103191267A (en) | Traditional Chinese medicine composition for treating liver cancers | |
| CN116270873B (en) | Traditional Chinese medicine composition for treating dermatophyte infection | |
| CN102423384A (en) | Traditional Chinese drug preparation for treating lung cancer, and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150304 |
|
| RJ01 | Rejection of invention patent application after publication |