CN104357314A - Microinjection device based on principle of friction - Google Patents
Microinjection device based on principle of friction Download PDFInfo
- Publication number
- CN104357314A CN104357314A CN201410683173.8A CN201410683173A CN104357314A CN 104357314 A CN104357314 A CN 104357314A CN 201410683173 A CN201410683173 A CN 201410683173A CN 104357314 A CN104357314 A CN 104357314A
- Authority
- CN
- China
- Prior art keywords
- piezoelectric ceramics
- fixed via
- fixed
- microinjection device
- device based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a microinjection device based on the principle of friction. The microinjection device comprises an injector, a connecting piece and piezoelectric ceramics, wherein the injector is connected with the piezoelectric ceramics by use of the connecting piece; the connecting piece comprises a first fixing through hole and a second fixing through hole; the injector and the piezoelectric ceramics go through the first fixing through hole and the second fixing through hole, respectively, and are fixed in the connecting piece by use of frictional force; the injector comprises a clamping rod, a nylon tube and a microneedle; the piezoelectric ceramics comprise a piezoelectric ceramic crimping part, a piezoelectric ceramic main body part and a piezoelectric ceramic connecting column. The microinjection device based on the principle of friction has the advantages that the displacement of the stacked piezoelectric ceramics is transferred by use of the frictional force, the traditional threaded connection manner is abandoned and the mounting error and the threaded gap of the threaded connection are avoided, and therefore, low polarization and high positioning accuracy can be obtained without mercury, tiny polarization is obtained while guaranteeing that the microinjection device has relatively high positioning accuracy, and a relatively high success rate can be obtained during cell injection.
Description
Technical field
The present invention relates to microinjection technique field, refer more particularly to a kind of microinjection device based on tribology principle.
Background technology
Microinjector is the device that bio-science field carries out that nuclear transplantation, microinjection and transgenosis inject micrurgy indispensability, and microinjection device is then the key mechanism in fiber injection link.Existing cell infusion generally adopts the type of drive such as mechanical transmission-type, hydraulic pressure ball-and-socket hinge style to carry out microinjection, the cytomorphosis that operator causes for reducing microinjection acupuncture film, mostly can adopt the method for entry needle resorption on cytolemma, dig out a through hole, retreat for microinjection pin.This process operation is loaded down with trivial details, production efficiency is low and easy damaged cells.There is electronic micro-operation hand in up-to-date cell infusion technology, which raises microinjection pin initially to pin level of automation, but because thorn film momentary velocity is low and the not high deficiency of positioning precision, cell infusion requirement of experiment cannot have been met.
A kind of micro injecting device of the prior art, this micro injecting device comprise have mobile control knob with the mechanical arm of moving-member, the needle holder be connected with moving-member, entry needle, be threaded connection piezoelectric ceramics needle holder and entry needle are connected.Although this device can significantly improve accuracy rate, operation efficiency, reduce the damage of entry needle cell membrane, but the micro injecting device of this kind of structure needs interpolation mercury to reduce the needle point polarization produced due to the installation error be threaded, but have severe toxicity, so this device has potential safety hazard to operator due to mercury.
Therefore, be necessary to propose further solution for the problems referred to above.
Summary of the invention
In view of this, the invention provides a kind of microinjection device based on tribology principle.
For achieving the above object, a kind of microinjection device based on tribology principle of the present invention, it comprises: syringe, web member, piezoelectric ceramics, and described syringe and piezoelectric ceramics are fixed connection by described web member;
Described web member comprises the first fixed via and the second fixed via, and described syringe and piezoelectric ceramics are each passed through described first fixed via and the second fixed via, and relies on frictional force to be fixed in described web member;
Described syringe comprises supporting rod, nylon tube and micropin, and described nylon tube and micropin are individually fixed in the two ends of described supporting rod, and described supporting rod is fixed in described web member by described first fixed via;
Described piezoelectric ceramics comprises piezoelectric ceramics pressure contact portion, piezoelectric ceramics main part and piezoelectric ceramics joint pin, described piezoelectric ceramics pressure contact portion and piezoelectric ceramics joint pin are positioned at the two ends of described piezoelectric ceramics main part, and described piezoelectric ceramics joint pin is also fixed with piezoelectric ceramics fixed connecting rod and is connected.
As the improvement of the microinjection device based on tribology principle of the present invention, the sidewall of described first fixed via offers the first screw, be provided with trip bolt in described first screw, described trip bolt provides fastening force to described supporting rod.
As the improvement of the microinjection device based on tribology principle of the present invention, the sidewall of described second fixed via is formed with the opening of bar shaped, the sidewall of second fixed via at the through place of described opening, the edge of described opening extends to form the fixing feet be separated from each other, described fixing feet offers the second screw that position is relative, described second screw place is provided with adjusting bolt.
As the improvement of the microinjection device based on tribology principle of the present invention, described micropin to be fixed with described supporting rod by micropin clamping head and to be connected.
As the improvement of the microinjection device based on tribology principle of the present invention, described first fixed via and the second fixed via be arranged in parallel.
As the improvement of the microinjection device based on tribology principle of the present invention, described piezoelectric ceramics main part is cylindrical, described piezoelectric ceramics main body section is in described second fixed via, and the reactive force between the sidewall of described piezoelectric ceramics main part and described second fixed via is positive pressure.
Compared with prior art, the invention has the beneficial effects as follows: the microinjection device based on tribology principle of the present invention adopts frictional force to transmit the displacement stacking type piezoelectric ceramics, abandon traditional thread connecting mode, avoid the installation error and thread pitch that are threaded, thus less polarization and higher positioning precision can be obtained when there is no mercury, thus ensure that the microinjection device based on tribology principle has higher positioning precision simultaneously, very little polarization can be obtained, higher success ratio can be obtained when cell infusion.
Accompanying drawing explanation
Fig. 1 is the floor map of an embodiment of the microinjection device based on tribology principle of the present invention;
Fig. 2 is the three-dimensional enlarged diagram of piezoelectric ceramics in Fig. 1;
Fig. 3 is the side-view of web member in Fig. 1;
Fig. 4 is the sectional view of web member in Fig. 1.
Embodiment
Be described in detail to the technical scheme in the embodiment of the present invention below, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under the prerequisite not making creative work, all belongs to the scope of protection of the invention.
As shown in Figure 1, the microinjection device 100 based on tribology principle of the present invention comprises: syringe 10, web member 20, piezoelectric ceramics 30.
Described syringe 10 is for providing injection liquid, and syringe 10 specifically comprises: supporting rod 11, nylon tube 12, micropin 13 and micropin clamping head 14.The injection liquid entering supporting rod 11 inside from nylon tube 12 can flow out from micropin 13 under reactive force.Wherein, described nylon tube 12 and micropin 13 are individually fixed in the two ends of described supporting rod 11, and micropin 13 to be fixed with described supporting rod 11 by micropin clamping head 14 and to be connected.
As shown in Figure 2, described piezoelectric ceramics 30 exports for producing displacement under actuate signal effect, piezoelectric ceramics 30 comprises piezoelectric ceramics pressure contact portion 31, piezoelectric ceramics main part 32 and piezoelectric ceramics joint pin 33, described piezoelectric ceramics pressure contact portion 31 and piezoelectric ceramics joint pin 33 lay respectively at the two ends of described piezoelectric ceramics main part 32, and described piezoelectric ceramics joint pin 33 is also fixed with piezoelectric ceramics fixed connecting rod 40 and is connected.Wherein, piezoelectric ceramics fixed connecting rod 40 is for the fixed installation of microinjection device 100.
As shown in Figure 3,4, described web member 20 is for being fixed connection by described syringe 10 and piezoelectric ceramics 30, web member 20 comprises the first fixed via 21 and the second fixed via 22, wherein, described syringe 10 and piezoelectric ceramics 30 are each passed through described first fixed via 21 and the second fixed via 22, and rely on frictional force to be fixed in described web member 20.Preferably, described first fixed via 21 and the second fixed via 22 be arranged in parallel.
Particularly, the sidewall of described first fixed via 21 offers the first screw 211, trip bolt is provided with in described first screw 211, this trip bolt contacts with supporting rod 11 through the first screw 211, and providing fastening force to described supporting rod 11, the size of this fastening force regulates by trip bolt.
Further, the sidewall of described second fixed via 22 is formed with the opening of bar shaped, the sidewall of second fixed via 22 at the through place of described opening, thus the shape of the cross section of the radial direction of the second fixed via 22 is C font.The edge of this opening stretches out the fixing feet 221 being formed and being separated from each other, and described fixing feet 221 offers the second screw 222 that position is relative, described second screw 222 place is provided with adjusting bolt.Distance between two fixing feet 221 can be regulated by adjusting bolt, and then change the size of opening.Preferably, the quantity of the second screw 222 is two.
The piezoelectric ceramics main part 32 of piezoelectric ceramics 30 is arranged in the second fixed via 22, in present embodiment, described piezoelectric ceramics main part 32 is cylindrical, described piezoelectric ceramics main part 32 is arranged in described second fixed via 22, thus, reactive force between the sidewall of described piezoelectric ceramics main part 32 and described second fixed via 22 is positive pressure, when regulating adjusting bolt, the size of positive pressure can be changed, and then regulate the frictional force size between positive pressure lower piezoelectric ceramic main body portion 32 and the sidewall of the second fixed via 22.
Thus, the present invention proposes to transmit displacement by frictional force between piezoelectric ceramics and syringe, piezoelectric ceramics is directly positioned in the second fixed via of web member, adjusts positive pressure between web member and piezoelectric ceramics by the adjustment bolt of two on web member.Syringe is positioned in the first fixed via of web member, by holding screw, syringe and web member is linked together.When piezoelectric ceramics is given with actuate signal, because action and reaction power makes the main part of piezoelectric ceramics carry out displacement output, thus under frictional force effect, what drive syringe carries out displacement output.
In sum, microinjection device based on tribology principle of the present invention adopts frictional force to transmit the displacement stacking type piezoelectric ceramics, abandon traditional thread connecting mode, avoid the installation error and thread pitch that are threaded, thus less polarization and higher positioning precision can be obtained when there is no mercury, thus ensure that the microinjection device based on tribology principle has higher positioning precision simultaneously, very little polarization can be obtained, higher success ratio can be obtained when cell infusion.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this specification sheets is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of specification sheets is only for clarity sake, those skilled in the art should by specification sheets integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (6)
1. based on a microinjection device for tribology principle, it is characterized in that, described microinjection device comprises: syringe, web member, piezoelectric ceramics, and described syringe and piezoelectric ceramics are fixed connection by described web member;
Described web member comprises the first fixed via and the second fixed via, and described syringe and piezoelectric ceramics are each passed through described first fixed via and the second fixed via, and relies on frictional force to be fixed in described web member;
Described syringe comprises supporting rod, nylon tube and micropin, and described nylon tube and micropin are individually fixed in the two ends of described supporting rod, and described supporting rod is fixed in described web member by described first fixed via;
Described piezoelectric ceramics comprises piezoelectric ceramics pressure contact portion, piezoelectric ceramics main part and piezoelectric ceramics joint pin, described piezoelectric ceramics pressure contact portion and piezoelectric ceramics joint pin are positioned at the two ends of described piezoelectric ceramics main part, and described piezoelectric ceramics joint pin is also fixed with piezoelectric ceramics fixed connecting rod and is connected.
2. the microinjection device based on tribology principle according to claim 1, it is characterized in that, the sidewall of described first fixed via offers the first screw, and be provided with trip bolt in described first screw, described trip bolt provides fastening force to described supporting rod.
3. the microinjection device based on tribology principle according to claim 1 and 2, it is characterized in that, the sidewall of described second fixed via is formed with the opening of bar shaped, the sidewall of second fixed via at the through place of described opening, the edge of described opening extends to form the fixing feet be separated from each other, described fixing feet offers the second screw that position is relative, described second screw place is provided with adjusting bolt.
4. the microinjection device based on tribology principle according to claim 1, is characterized in that, described micropin to be fixed with described supporting rod by micropin clamping head and to be connected.
5. the microinjection device based on tribology principle according to claim 1, is characterized in that, described first fixed via and the second fixed via be arranged in parallel.
6. the microinjection device based on tribology principle according to claim 1, it is characterized in that, described piezoelectric ceramics main part is cylindrical, described piezoelectric ceramics main body section is in described second fixed via, and the reactive force between the sidewall of described piezoelectric ceramics main part and described second fixed via is positive pressure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410683173.8A CN104357314B (en) | 2014-11-24 | 2014-11-24 | Microinjection device based on principle of friction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410683173.8A CN104357314B (en) | 2014-11-24 | 2014-11-24 | Microinjection device based on principle of friction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104357314A true CN104357314A (en) | 2015-02-18 |
| CN104357314B CN104357314B (en) | 2017-01-18 |
Family
ID=52524629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410683173.8A Active CN104357314B (en) | 2014-11-24 | 2014-11-24 | Microinjection device based on principle of friction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104357314B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105018333A (en) * | 2015-08-24 | 2015-11-04 | 苏州大学张家港工业技术研究院 | Microinjection mechanism based on stick-slip driving principle |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4039260A1 (en) * | 1990-12-08 | 1992-06-11 | Hilti Ag | Pipe clamp with two brackets - has bent strip at each first end, and hole for tightening screw, two hinge halves, and collar |
| CN102268360A (en) * | 2011-04-27 | 2011-12-07 | 南开大学 | Supersonic vibration microscopic cell penetrating system based on piezoelectric ceramic driving |
| CN202188232U (en) * | 2011-07-28 | 2012-04-11 | 长城汽车股份有限公司 | Flexible pipe fixing device with high structure rigidity and high fatigue resistance |
| CN102878159A (en) * | 2012-09-28 | 2013-01-16 | 南京万德游乐设备有限公司 | Fixing fastener of upright |
| CN203272369U (en) * | 2013-04-24 | 2013-11-06 | 天津市文龙紧固件有限公司 | Tightly-hooping piece |
| US20140315282A1 (en) * | 2011-11-18 | 2014-10-23 | Hunan Changsha Ao Figure Biological Technology Co., Ltd. | Microinjector mounting module and needle-holder component |
| CN204325337U (en) * | 2014-11-24 | 2015-05-13 | 苏州大学 | Based on the microinjection device of tribology principle |
-
2014
- 2014-11-24 CN CN201410683173.8A patent/CN104357314B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4039260A1 (en) * | 1990-12-08 | 1992-06-11 | Hilti Ag | Pipe clamp with two brackets - has bent strip at each first end, and hole for tightening screw, two hinge halves, and collar |
| CN102268360A (en) * | 2011-04-27 | 2011-12-07 | 南开大学 | Supersonic vibration microscopic cell penetrating system based on piezoelectric ceramic driving |
| CN202188232U (en) * | 2011-07-28 | 2012-04-11 | 长城汽车股份有限公司 | Flexible pipe fixing device with high structure rigidity and high fatigue resistance |
| US20140315282A1 (en) * | 2011-11-18 | 2014-10-23 | Hunan Changsha Ao Figure Biological Technology Co., Ltd. | Microinjector mounting module and needle-holder component |
| CN102878159A (en) * | 2012-09-28 | 2013-01-16 | 南京万德游乐设备有限公司 | Fixing fastener of upright |
| CN203272369U (en) * | 2013-04-24 | 2013-11-06 | 天津市文龙紧固件有限公司 | Tightly-hooping piece |
| CN204325337U (en) * | 2014-11-24 | 2015-05-13 | 苏州大学 | Based on the microinjection device of tribology principle |
Non-Patent Citations (1)
| Title |
|---|
| 何思明等: "基于压电陶瓷驱动的超声振动显微穿入系统", 《第三十一届中国控制会议论文集》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105018333A (en) * | 2015-08-24 | 2015-11-04 | 苏州大学张家港工业技术研究院 | Microinjection mechanism based on stick-slip driving principle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104357314B (en) | 2017-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2011149355A (en) | FUEL INJECTOR WITH PRESSURE SENSOR | |
| CN202129497U (en) | Hydraulic control system of gate type plate shearing machine | |
| CN204325337U (en) | Based on the microinjection device of tribology principle | |
| CN105429504A (en) | Bidirectional piezoelectric stack actuator with diamond and hourglass-shaped mechanisms connected in series and actuating method thereof | |
| CN104357314A (en) | Microinjection device based on principle of friction | |
| CN102275280A (en) | Injection machine servo energy-saving control system | |
| CN102268363B (en) | Microinjection mechanism | |
| CN202398792U (en) | Hydraulic system for non-sinusoidal oscillation of crystallizer | |
| CN103213237B (en) | Injecting and metering device for supercritical carbon dioxide in extrusion foaming | |
| CN103515570B (en) | A kind of square battery liquid injection machine | |
| CN105624804A (en) | Multichannel perpendicular micro-injection device | |
| CN105018333B (en) | A kind of microinjection mechanism based on stick-slip driving principle | |
| CN203663105U (en) | Liquid discharging device for capsule production | |
| CN203272294U (en) | Flexible adjustable machine tool circuit | |
| CN201992168U (en) | Control device for fuel gas regulation valve | |
| CN202039827U (en) | Steady flow straight-through type adjustor of water injection well | |
| CN202742592U (en) | Servo control system of rubber injection molding vulcanizing machine | |
| CN202202852U (en) | Carbon dioxide ground injecting system | |
| CN201139837Y (en) | Speed regulating switch for transfusion utensil | |
| CN101899750A (en) | Feeding device for sewing machine | |
| CN202274178U (en) | Device for stabilizing steam pressure | |
| CN204281910U (en) | The vertical microinjection apparatus of a kind of multichannel | |
| CN203670841U (en) | Gel solution flow control valve | |
| CN202116544U (en) | Microinjection mechanism | |
| CN205236831U (en) | Pilot pin mechanism with adjustable mould of borduring |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211221 Address after: 215000 first floor, building 10C, Yangtze River Delta International R & D community startup area, No. 286, qinglonggang, high speed rail new town, Xiangcheng District, Suzhou City, Jiangsu Province Patentee after: JIANGSU JICUI MICRO-NANO AUTOMATION SYSTEM AND EQUIPMENT TECHNOLOGY RESEARCH INSTITUTE Co.,Ltd. Address before: No. 8, Xiangcheng District Ji Xue Road, Suzhou, Jiangsu Patentee before: SOOCHOW University |
|
| TR01 | Transfer of patent right |