CN104352939A - 一种治疗消化性溃疡及抗幽门螺杆菌的胶囊 - Google Patents

一种治疗消化性溃疡及抗幽门螺杆菌的胶囊 Download PDF

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CN104352939A
CN104352939A CN201410664937.9A CN201410664937A CN104352939A CN 104352939 A CN104352939 A CN 104352939A CN 201410664937 A CN201410664937 A CN 201410664937A CN 104352939 A CN104352939 A CN 104352939A
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peptic ulcer
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严纯
曾朝辉
郭高举
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LICHUAN ETHNIC HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Abstract

本发明提供了一种治疗消化性溃疡及抗幽门螺杆菌的胶囊。其特征在于由以下药物组成：白术20g、鸡内金12g、枯矾2.4g、瓦楞子12g、海螵蛸16g、象皮12g、田七4g、白芷8g、白芨16g、元胡12g、贝母9.6g、石斛12g、甘草4.8g、砂仁4g。中药复方治疗幽门螺旋杆菌感染同样具有较好的疗效，通过正确的中医辨证配方，不仅起到显著的抗HP作用，同时能够治疗HP感染相关疾病。

Description

一种治疗消化性溃疡及抗幽门螺杆菌的胶囊
技术领域
本发明涉及一种治疗消化性溃疡及抗幽门螺杆菌的胶囊。
背景技术
消化性溃疡是常见的消化道疾病，主要病因与幽门螺旋杆菌感染有关。研究表明，幽门螺旋杆菌是胃癌、慢性胃炎、消化性溃疡、胃MALT淋巴瘤等疾病的重要因素。目前采用PPI+两种抗生素的三联疗法最为常用，随着西药抗HP根除率逐步降低、复发率增高，抗生素耐药性增强及毒副作用大等问题日益突出，研究证实许多单味中药及复方制剂具有较显著的抗HP作用。
中药复方治疗幽门螺旋杆菌感染同样具有较好的疗效，通过正确的中医辨证配方，不仅起到显著的抗HP作用，同时能够治疗HP感染相关疾病。有关中药联合三联疗法治疗幽门螺旋杆菌相关性消化性溃疡的研究报道较多。分析对比所检文献：所检文献均为中药联合三联疗法治疗幽门螺旋杆菌相关性消化性溃疡的相关研究，但本发明提出中药药物组成与上述文献的研究处方有区别：特别是其中的中药枯矾、象皮、白芷、石斛、鸡内金在所检文献中未见有应用研究。
发明内容
本发明提供了一种治疗消化性溃疡及抗幽门螺杆菌的胶囊。
本发明一种治疗消化性溃疡及抗幽门螺杆菌的胶囊，其特征在于由以下药物组成：白术20g、鸡内金12g、枯矾2.4g、瓦楞子12g、海螵蛸16g、象皮12g、田七4g、白芷8g、白芨16g、元胡12g、贝母9.6g、石斛12g、甘草4.8g、砂仁4g。
所述的治疗消化性溃疡及抗幽门螺杆菌的胶囊加工方法为：取白术20g、鸡内金12g、瓦楞子12g、海螵蛸16g、白芷8g、白芨16g、元胡12g、石斛12g、甘草4.8g、砂仁4g加水500ml小火水煎2.5-3小时，过滤取汁150ml，继续小火浓缩至比重为1.1；取枯矾2.4g、贝母9.6g、田七4g、象皮12g研磨为粉剂加入上浓缩液混匀，放入烤箱在60-70℃温度烘干；粉碎至120目，筛分后装58粒胶囊。
根据幽门螺旋杆菌相关性消化性溃疡的病因病理，脾虚是溃疡发病和转归、愈合和复发的关键,脾虚则气血生化乏源,机体抗病能力下降而易患病,局部防御因子减弱,胃黏膜屏障功能低下,易招致外邪入侵而形成溃疡。故健脾益气实际上就是提高机体免疫功能,保护胃黏膜屏障,以抵御各种损伤因素的侵袭。该药以益气健脾为主、对各脏器全面调节，辩清虚实，做到补气生肌，收敛生肌，活血止血，和胃止痛。
本发明一种治疗消化性溃疡及抗幽门螺杆菌的胶囊不仅对消化性溃疡彻底根治，而且能全面调整人体各器官，特别是脾胃虚弱所致消化性溃疡疗效更佳。胶囊是用10多种中草药精制而成。该药物的制备方法：采用白术、瓦楞子、海螵蛸、白芷，枯矾、象皮、白芨、田七、元胡、贝母、石斛经过清洗，烘干等工艺，在无菌、无尘的条件下，经浓煎、取汁、浓缩、干燥，用中药粉碎机蘑碎，用120目筛进行筛分后装胶囊，每粒胶囊相当生药2.5g。该中药使用方便，疗效稳定，治疗彻底，无任何毒副作用。
对消化性溃疡的治疗不仅是越快越好，而是一个对消化系统整体调节过程。一种治疗消化性溃疡及抗幽门螺杆菌的胶囊是对消化性溃疡及各脏腑全面调节，通过健脾益气使人体各消化器官趋于正常的过程，特别是对脾胃功能改善更加明显。胶囊是调整人体消化系统功能的理想药物，是治疗消化性溃疡难得的一种的好药。消化性溃疡患者服用胶囊2-3个疗程后(1个疗程为1个月)，药物中的有效活性分子进入血液，直达病变部位，在治疗消化性溃疡过程中，以健脾益气为主，逐步控制溃疡的发病机制，调节人体消化系统，促进脾胃的运化，在和胃止痛中起到协调与综合治疗作用，从根本上彻底逆转溃疡发病机制，使身体达到康复的目的。胶囊是从消化性溃疡的发病根源入手，起到止痛与恢复人体消化机能正常化和整体调治并发症等多重功效。胶囊具有以下特点：标本兼治。它突破传统的治疗局限，该药在治疗溃疡的同时，能最大限度的保护肠道益生菌，整体调整胃肠功能。健脾益气打破传统的为止痛而止痛，它能调整各脏腑的失调，脾胃虚弱所致的胃溃疡。众药综治打破常规战术，它是用多种药物，全面出击，提高机体免疫功能,保护胃黏膜屏障,以抵御各种损伤因素的侵袭。止血止痛.增强豁膜屏障,修复溃疡,改善黏膜微循环。彻底根治。不需长期服药，当药物中的活性分子进入人体后，激活并调节紊乱的消化系统，使其趋于正常。宏观调节脾胃功能,有效防治消化性溃疡,故而临床应用可以明显改善患者的临床症状和体征,促进创面的愈合和胃黏膜的恢复。
本发明一种治疗消化性溃疡及抗幽门螺杆菌的胶囊的效果独特，处表现在以下方面：从消化性溃疡发病根源入手，用众多的药对人体消化系统全面调理，从去积消食，到益气健脾，活血生肌止痛。增强胃肠的功能，清除消化系统幽门螺旋杆菌，使消化道的功能恢复。提高机体免疫力，提高机体免疫功能,保护胃黏膜屏障。配伍从简、用药精当、法度严谨，胶囊制剂服用方便，价格低廉，便于临床推广应用，为患者减轻经济负担。提出脾虚是幽门螺旋杆菌相关性消化性溃疡的关键因素，治以益气健脾法，胶囊联合西药三联疗法治疗幽门螺旋杆菌相关性溃疡深入体现了“异病同治”的辩证思想，再次论证了“脾胃为后天之本”的学术思想。
本发明一种治疗消化性溃疡及抗幽门螺杆菌的胶囊中白术甘温补中，入脾胃经，能健脾和胃，益气燥湿，用于脾虚食少，腹胀泄泻，鸡内金甘平无毒，可生发胃气，养胃生津，消食化积，二药合用，白术偏于补，内金善于消。补消兼施，健脾开胃消食化积之力更甚，共为君药，臣以元胡、砂仁、田七以燥湿行气、化瘀止痛，象皮、枯矾、白芷、白芨共奏消痈排毒、敛疮生肌之效，瓦楞子、海螵蛸、贝母、石斛以清热养阴生津、制酸止痛，用于反胃吐酸，胃脘刺痛等。甘草既能补中益气，又能调和诸药。诸药相伍，则健脾、消食、收敛、生肌。适用于脾胃虚弱、络脉阻滞所致胃脘疼痛诸症。因本方具有健脾和胃，收敛生肌之功效。
本发明一种治疗消化性溃疡及抗幽门螺杆菌的胶囊所用药为：
象皮(Elephant Hide)：止血敛疮；祛腐生肌。主外伤出血；溃疡久不收口；褥疮等
白术(Atractylodes macrocephala Koidz.)：健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，泄泻便溏，胎动不安。
枯矾：入肺、脾、胃、大肠经，主治：胃，十二指肠溃疡，喉痹，肝炎，黄疸，口舌生疮等。
白芷(Fisch.ex Hoffm.)：祛风，燥湿，消肿，止痛。治头痛，眉棱骨痛，齿痛，鼻渊，寒湿腹痛，肠风痔漏等。
白芨(Bletilla striata)：收敛止血，消肿生肌。用于咳血吐血，外伤出血，疮疡肿毒，皮肤皲裂；肺结核咳血，溃疡病出血。
玄胡(Corydalis Tuber)：活血，利气，止痛。用于气血瘀滞之痛证。
瓦楞子(Arca subcrenata Lischke)：消痰化瘀；软坚散结；制酸止痛。用于瘰疬，瘿瘤，顽痰久咳，胃痛吐酸，牙疳，外伤出血等。
海螵蛸：除湿，制酸，止血，敛疮。治胃痛吞酸，吐、衄、呕血，便血，崩漏带下，血枯经闭，腹痛症瘕，虚疟泻痢，阴蚀烂疮。
田七(Panax pseudoginseng)：活血定痛、止血化瘀主治跌扑瘀肿、胸痹绞痛、血瘀经闭。
贝母(fritillary)：味苦，性微寒，归肺经具有清热化痰、润肺止咳、开郁散结
石斛(Dendrobium)：阴伤津亏、口干烦渴、食少干呕等
鸡内金：消食健胃助消化，涩精止遗。可以促进胃液分泌，提高胃酸度及消化力，使胃运动功能明显增强，胃排空加快。
甘草(Glycyrrhiza uralensis Fisch.)：补脾益气、润肺止咳、缓急止痛、缓和药性、清热解毒应用：用于脾胃虚弱，中气不足，气短乏力，食少便溏、食物或药物中毒、脘腹或四肢挛急作痛。
具体实施方式
下面结合实施例对本发明进一步说明。
实施例1：
一种治疗消化性溃疡及抗幽门螺杆菌的胶囊，由以下药物组成：白术20g、鸡内金12g、枯矾2.4g、瓦楞子12g、海螵蛸16g、象皮12g、田七4g、白芷8g、白芨16g、元胡12g、贝母9.6g、石斛12g、甘草4.8g、砂仁4g。
治疗消化性溃疡及抗幽门螺杆菌的胶囊加工方法为：取白术20g、鸡内金12g、瓦楞子12g、海螵蛸16g、白芷8g、白芨16g、元胡12g、石斛12g、甘草4.8g、砂仁4g加水500ml小火水煎2.5-3小时，过滤取汁150ml，继续小火浓缩至比重为1.1；取枯矾2.4g、贝母9.6g、田七4g、象皮12g研磨为粉剂加入上浓缩液混匀，放入烤箱在60-70℃温度烘干；粉碎至120目，筛分后装58粒胶囊。
消化性溃疡患者服用胶囊2-3个疗程后(1个疗程为1个月，1个疗程为360粒胶囊)，药物中的有效活性分子进入血液，直达病变部位，在治疗消化性溃疡过程中，以健脾益气为主，逐步控制溃疡的发病机制，调节人体消化系统，促进脾胃的运化，在和胃止痛中起到协调与综合治疗作用，从根本上彻底逆转溃疡发病机制，使身体达到康复的目的。
实施例2：
一种治疗消化性溃疡及抗幽门螺杆菌的胶囊，由以下药物组成：白术20kg、鸡内金12kg、枯矾2.4kg、瓦楞子12kg、海螵蛸16kg、象皮12kg、田七4kg、白芷8kg、白芨16kg、元胡12kg、贝母9.6kg、石斛12kg、甘草4.8kg、砂仁4kg。
治疗消化性溃疡及抗幽门螺杆菌的胶囊加工方法为：取白术20kg、鸡内金12kg、瓦楞子12kg、海螵蛸16kg、白芷8kg、白芨16kg、元胡12kg、石斛12kg、甘草4.8kg、砂仁4kg加水500l小火水煎2.5-3小时，过滤取汁150l，继续小火浓缩至比重为1.1；取枯矾2.4kg、贝母9.6kg、田七4kg、象皮12kg研磨为120目粉剂加入上浓缩液混匀，放入烤箱在60-70℃温度烘干；粉碎至120目，筛分后装58000粒胶囊。

Claims (2)

1.一种治疗消化性溃疡及抗幽门螺杆菌的胶囊，其特征在于由以下药物组成：白术20g、鸡内金12g、枯矾2.4g、瓦楞子12g、海螵蛸16g、象皮12g、田七4g、白芷8g、白芨16g、元胡12g、贝母9.6g、石斛12g、甘草4.8g、砂仁4g。
2.按照权利要求1所述的一种治疗消化性溃疡及抗幽门螺杆菌的胶囊，其特征在于所述的加工方法为：取白术20g、鸡内金12g、瓦楞子12g、海螵蛸16g、白芷8g、白芨16g、元胡12g、石斛12g、甘草4.8g、砂仁4g加水500ml小火水煎2.5-3小时，过滤取汁150ml，继续小火浓缩至比重为1.1；取枯矾2.4g、贝母9.6g、田七4g、象皮12g研磨为粉剂加入上浓缩液混匀，放入烤箱在60-70℃温度烘干；粉碎至120目，筛分后装58粒胶囊。
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