CN104352629B - Traditional Chinese medicine composition for curing calculus of liver and gallbladder and application thereof - Google Patents

Traditional Chinese medicine composition for curing calculus of liver and gallbladder and application thereof Download PDF

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CN104352629B
CN104352629B CN201410587918.0A CN201410587918A CN104352629B CN 104352629 B CN104352629 B CN 104352629B CN 201410587918 A CN201410587918 A CN 201410587918A CN 104352629 B CN104352629 B CN 104352629B
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chinese medicine
medicine composition
liver
radix
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CN104352629A (en
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张红军
李侠
张梦军
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Anan Yutaka
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陈红
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Abstract

The invention belongs to the field of medicines, relates to a traditional Chinese medicine composition for curing calculus of liver and gallbladder, and aims at overcoming the defects in prior art and relieving the pain of patients suffering from the calculus of the liver and the gallbladder. The traditional Chinese medicine composition for curing the calculus of the liver and the gallbladder is prepared from the following components in parts by weight: 10-12 parts of starjasmine stem, 5-8 parts of himalayan teasel root, 6-9 parts of the root of bidentate achyranthes, 3-5 parts of rehmannia root, 10-12 parts of dandelion, 10-12 parts of kudzuvine root, 3-5 parts of plantain herb, 3-5 parts of folium ginkgo, 10-12 parts of mint, 8-10 parts of coptis, 6-9 parts of glossy privet fruit, 10-12 parts of magnolia bark, 10-12 parts of angelica root, 10-12 parts of white paeony root, 12-15 parts of setose thistle and 9-12 parts of licorice root. Based on the pharmacodynamic test, the traditional Chinese medicine composition for curing the calculus of the liver and the gallbladder, which is disclosed by the invention, has remarkable litholysis and lithecbole effects; the curative effect is remarkable; the medicine is safe and reliable, and has a wide clinical application prospect.

Description

A kind of Chinese medicine composition for the treatment of liver and bile stone and uses thereof
Technical field
The invention belongs to field of medicaments, relate to a kind of Chinese medicine composition and medical usage thereof for the treatment of liver and bile stone.
Background technology
Cholelithiasis is the commonly encountered diseases of biliary system, accounts for 20% ~ 30% of Surgical Acute Venter Diseases.In recent years, along with the raising of living standards of the people and the day by day perfect of inspection method, particularly Type B are ultrasonic, since the application clinically such as CT, to the Diagnosis and Treat means of biliary tract, all provided accurate and effective therapeutic scheme.Epidemiological study shows, dietary constituents occupies very important position to the formation of calculus and change.The report system at China's cholelithiasis end of the thirties to beginning of the sixties based on bile pigment calculus, especially in rural area.But national cholelithiasis analyzing specimen points out China's cholelithiasis type to have a very large change in recent years, and the ratio of cholesterol calculus has exceeded bile pigment calculus, and this is relevant with the change of our people's dietary structure.Meanwhile, in zoopery, also prove the fat content in keeping on a diet or the relative scale of fatty acid and protein, can have an impact to the quantity of calculus and composition.To the understanding of cholelithiasis, since oneth century of past, all concentrate on the various changes that extrahepatic biliary passages local occurs, think that extrahepatic biliary passages is the place producing calculus.But after having had " causing stone sexually transmitted disease (STD) reason bile " this concept, when especially finding that extrahepatic biliary passages pathological changes still exists sending out again of pathology bile and calculus after Surgery Treatment, people turn in liver gradually to the understanding of cholelithiasis, think that to be liver by the effect of enzyme or metabolic deficiency produce and cause stone sexually transmitted disease (STD) reason bile, thus form calculus.
Many clinical datas show that cholelithiasis is a kind of disease relevant with liver in recent years, and cholelithiasis patient has liver disease damage to a certain degree.These results of study, rule together with Chinese traditional treatment cholelithiasis liver and gall, liver spleen theory of ruling together have play the same tune on different musical instruments wonderful.Motherland's medical science thinks the gallbladder being attached to the liver, and liver and gall are the exterior and the interior each other, and gallbladder is the fu-organ that contains refined juice, built-in refined juice, and bile derives from the residual air of liver.Liver department catharsis function, dredges function of gallbladder promoting juice, and all catharsis, courage affecting liver is led to the factor of falling function and all can be caused cholestasis, decocts with the passing of time, bile deposition and form sandstone.Liver controlling conveyance and dispersion, The spleen has the function to transport and transform nutrients, and the transportation capabilities of spleen must be achieved under the catharsis effect of liver is coordinated.Upper work preventing diseases instead for the treatment of diseases, is shown in the disease of liver, knowing the liver disease will be transmitted into the spleen, in the ban tonifying the spleen.So theory that in the treatment of cholelithiasis, liver and gall of should applying in a flexible way are ruled together, liver spleen is ruled together, makes therapeutic effect more perfect.
At present, the sickness rate of liver and bile stone rises gradually, adopts operative therapy both at home and abroad to the treatment of cholelithiasis more, but the removal of Post operation retained calculus is comparatively difficult.Be used for the treatment of liver in the patent medicine of existing Chinese and Western, the medicine of gallstone disease and complication thereof has: mostly gallbladder health, JINDAN PIAN, Os Gallus domesticus blade, XIAOYAN LIDAN PIAN etc., be that the inflammation acting on body of gallbladder and biliary tract changes.Through clinical observation, the therapeutic effect of this kind of medicine is poor, and cure rate is low, can only relief of symptoms and can not curing.
Summary of the invention
In order to make up the expensive and deficiency that relapse rate is high of expenses of surgical treatment in prior art, and effectively alleviate the misery of liver and bile stone patient, the invention provides a kind of Chinese medicine composition for the treatment of liver and bile stone and preparation method thereof, this Chinese medicine composition is pure Chinese medicinal preparation, its calculus dissolving and excreting Be very effective and therapeutic process safe and reliable, can fundamentally treat liver and bile stone disease, relapse rate is low, therefore has wide potential applicability in clinical practice.
The present invention is achieved through the following technical solutions the technology of the present invention effect:
Treat a Chinese medicine composition for liver and bile stone, this Chinese medicine composition is made up of the raw material of following weight portion: Caulis Trachelospermi 10-12 part, Radix Dipsaci 5-8 part, Radix Achyranthis Bidentatae 6-9 part, Radix Rehmanniae 3-5 part, Radix Puerariae 10-12 part, Radix Puerariae 10-12 part, Herba Plantaginis 3-5 part, Folium Ginkgo 3-5 part, Herba Menthae 10-12 part, Rhizoma Coptidis 8-10 part, Fructus Ligustri Lucidi 6-9 part, Cortex Magnoliae Officinalis 10-12 part, Radix Angelicae Dahuricae 10-12 part, Radix Paeoniae Alba 10-12 part, Radix Cirsii Japonici 12-15 part, Radix Glycyrrhizae 9-12 part.
The Chinese medicine of the Chinese medicine composition for the treatment of liver and bile stone described above is all got its conventional medicinal part and is used as medicine.Applicant also to carry out further preferably Chinese medicine component for the therapeutical effect of described Chinese medicine composition for liver and bile stone, be specially Chinese medicine composition coordinate after for the litholytic effect of liver and bile stone, according to its therapeutical effect, Chinese medicine composition of the present invention is preferably made up of the raw material of following weight portion: Caulis Trachelospermi 10-12 part, Radix Dipsaci 5-8 part, Radix Achyranthis Bidentatae 6-9 part, Radix Rehmanniae 3-5 part, Radix Puerariae 10-12 part, Radix Puerariae 10-12 part, Herba Plantaginis 3-5 part, Folium Ginkgo 3-5 part, Herba Menthae 10-12 part, Rhizoma Coptidis 8-10 part, Fructus Ligustri Lucidi 6-9 part, Cortex Magnoliae Officinalis 10-12 part, Radix Angelicae Dahuricae 10-12 part, Radix Paeoniae Alba 10-12 part, Radix Cirsii Japonici 12-15 part, Radix Glycyrrhizae 9-12 part.
In order to strengthen the therapeutic effect of Chinese medicine composition for liver and bile stone, in described Chinese medicine composition, Bears Poria 5-8 part and Flos Lonicerae 12-15 part can also be contained.These two Chinese medicines can strengthen analgesic effect and the calculus dissolving and excreting effect of the above-mentioned Chinese medicine composition of the present invention further.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Present invention also offers a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get recipe quantity Chinese crude drug and be broken into coarse powder, the alcoholic solution that volumetric concentration is 35%-80% is doubly added according to the 3-6 of coarse powder gross weight, reflux, extract, three times, return time is 3-6h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment liver and bile stone medicine.The embodiment of the present invention 7 shows, mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than model group (P < 0.05) incubation period of high dose group.What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug cydiodine group (P < 0.05) and Huanglianshangqing Tablet group (1h, P < 0.05; 2h, P < 0.01) also extend the incubation period that mice adds foot reaction, there is certain analgesic activity, but its analgesic effect and model group there was no significant difference.The embodiment of the present invention 8 shows, and each treatment group of Chinese medicine composition of the present invention and positive controls have the effect significantly reducing Ca, TBIL, DBIL level in bile and the effect raising BA level.Wherein the regulating action of positive controls and low group of the present composition close.In the present composition group and high group compared with positive controls reduce Ca, TBIL, DBIL level and rising BA in bile horizontal in there is the difference of significance.Based on this, Chinese medicine composition of the present invention also has certain therapeutic effect for renal calculus.
The present invention is that inventor is through repeatedly studying, progressively improve, last successful a kind of curative effect treats the medicine of liver and bile stone preferably, for showing the therapeutic effect of medicine of the present invention to liver and bile stone, the present invention has carried out clinical observation to the liver and bile stone patient that 180 examples take this medicine, and selection has liver and bile stone patient 179 example of comparability as a control group.Treatment group patient takes medicine twice of the present invention every day, and sooner or later respectively once, once take 5 grams of medicines, matched group patient takes the oral drugs of conventional therapy liver and bile stone.Treat after one month, therapeutic outcome is in table 1.
Table 1 treatment group and treatment of control group result synopsis
Cure Effectively Cure rate Effective percentage
Treatment group 141 examples 165 examples 78.33％ 91.67％
Matched group 93 examples 117 examples 51.96％ 65.36％
Treatment group is compared matched group and is had higher cure rate and effective percentage, thinks thus, and Drug therapy liver and bile stone of the present invention has good effect, and through the Ureteral Calculus of month, takes medicine of the present invention and do not occur any toxic and side effects.
Chinese medicine composition of the present invention, in treatment liver and bile stone, compared with prior art has following advantage:
1) compared with the chemotherapeutic agent of Current therapeutic, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, and improves the quality of life of patient.
2) multi-medicament component is contained in Chinese medicine composition of the present invention, action target spot is numerous, pharmacological evaluation shows it and existing gallstone treatment medicine has significant synergism in lithodialysis, and significantly can reduce the constipation symptom that Drug therapy causes, improve patient for the acceptance of chemotherapy and compliance.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but those skilled in the art should know, described embodiment does not also limit the present invention in any way.
(1) example of formulations part
Embodiment 1 Chinese medicine composition of the present invention and preparation technology
The weight composition of Chinese medicinal components: Caulis Trachelospermi 100g, Radix Dipsaci 50g, Radix Achyranthis Bidentatae 60g, Radix Rehmanniae 30g, Herba Taraxaci 100g, Radix Puerariae 100g, Herba Plantaginis 30g, Folium Ginkgo 30g, Herba Menthae 100g, Rhizoma Coptidis 80g, Fructus Ligustri Lucidi 60g, Cortex Magnoliae Officinalis 100g, Radix Angelicae Dahuricae 100g, Radix Paeoniae Alba 100g, Radix Cirsii Japonici 120g, Radix Glycyrrhizae 90g
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, doubly add according to the 3-6 of coarse powder gross weight the alcoholic solution that volumetric concentration is 35%-80%, reflux, extract, three times, return time is 3-6h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as tablet, capsule etc. in this preparation method.
Embodiment 2 Chinese medicine composition of the present invention and preparation technology
The weight composition of Chinese medicinal components: Caulis Trachelospermi 120g, Radix Dipsaci 80g, Radix Achyranthis Bidentatae 90g, Radix Rehmanniae 50g, Radix Puerariae 120g, Herba Taraxaci 120g, Herba Plantaginis 50g, Folium Ginkgo 50g, Herba Menthae 120g, Rhizoma Coptidis 100g, Fructus Ligustri Lucidi 90g, Cortex Magnoliae Officinalis 120g, Radix Angelicae Dahuricae 120g, Radix Paeoniae Alba 120g, Radix Cirsii Japonici 150g, Radix Glycyrrhizae 120g.
Preparation method is with embodiment 1.
Embodiment 3 Chinese medicine composition of the present invention and preparation technology
The weight composition of Chinese medicinal components: Caulis Trachelospermi 110g, Radix Dipsaci 70g, Radix Achyranthis Bidentatae 70g, Radix Rehmanniae 40g, Herba Taraxaci 110g, Radix Puerariae 110g, Herba Plantaginis 40g, Folium Ginkgo 40g, Herba Menthae 110g, Rhizoma Coptidis 90g, Fructus Ligustri Lucidi 80g, Cortex Magnoliae Officinalis 110g, Radix Angelicae Dahuricae 110g, Radix Paeoniae Alba 110g, Radix Cirsii Japonici 130g, Radix Glycyrrhizae 100g.
Preparation method is with embodiment 1.
Embodiment 4 Chinese medicine composition of the present invention and preparation technology
The weight composition of Chinese medicinal components: Caulis Trachelospermi 1000g, Radix Dipsaci 500g, Radix Achyranthis Bidentatae 600g, Radix Rehmanniae 300g, Herba Taraxaci 1000g, Radix Puerariae 1000g, Herba Plantaginis 300g, Folium Ginkgo 300g, Herba Menthae 1000g, Rhizoma Coptidis 800g, Fructus Ligustri Lucidi 600g, Cortex Magnoliae Officinalis 1000g, Radix Angelicae Dahuricae 1000g, Radix Paeoniae Alba 1000g, Radix Cirsii Japonici 1200g, Radix Glycyrrhizae 900g, Bears Poria 500g, Flos Lonicerae 1300g
Preparation method is with embodiment 1.
Embodiment 5 Chinese medicine composition of the present invention and preparation technology
The weight composition of Chinese medicinal components: Caulis Trachelospermi 1200g, Radix Dipsaci 800g, Radix Achyranthis Bidentatae 900g, Radix Rehmanniae 500g, Radix Puerariae 1200g, Herba Taraxaci 1200g, Herba Plantaginis 500g, Folium Ginkgo 500g, Herba Menthae 1200g, Rhizoma Coptidis 1000g, Fructus Ligustri Lucidi 900g, Cortex Magnoliae Officinalis 1200g, Radix Angelicae Dahuricae 1200g, Radix Paeoniae Alba 1200g, Radix Cirsii Japonici 1500g, Radix Glycyrrhizae 1200g, Bears Poria 800g, Flos Lonicerae 1200g.
Preparation method is with embodiment 1.
Embodiment 6 Chinese medicine composition of the present invention and preparation technology
The weight composition of Chinese medicinal components: Caulis Trachelospermi 1100g, Radix Dipsaci 700g, Radix Achyranthis Bidentatae 700g, Radix Rehmanniae 400g, Radix Puerariae 1100g, Herba Taraxaci 1100g, Herba Plantaginis 400g, Folium Ginkgo 400g, Herba Menthae 1100g, Rhizoma Coptidis 900g, Fructus Ligustri Lucidi 800g, Cortex Magnoliae Officinalis 1100g, Radix Angelicae Dahuricae 1100g, Radix Paeoniae Alba 1100g, Radix Cirsii Japonici 1300g, Radix Glycyrrhizae 1000g, Bears Poria 600g, Flos Lonicerae 1500g.
Preparation method is with embodiment 1.
Embodiment 8 the present invention is to lithodialysis, calculus, the anti-masonry use of Cavia porcellus cholesterol calculus model
1 materials and methods
1.1 laboratory animals: healthy guinea pig is selected in the experiment of lithodialysis, anti-stone, male, body weight 200 ~ 300g, totally 100, purchased from Liaoning University of TCM's laboratory animal Breeding Center, adopt mode of raising in cages.
1.2 modeling methods: adopt bait provocation method, chow diet is provided by Liaoning University of TCM's experimental animal feeding center, become the autogamy of stone feedstuff, formula is Semen Maydis powder 15%, analysis for soybean powder 10%, flour 10%, fish flour 3%, wheat bran 10%, Sal 1%, yeast powder 1%, alfalfa meal 40%, casein 2%, Adeps Sus domestica 2%, sucrose 5%, cholesterol 1%.Normal group throws normal diet 11 weeks, and model group and treatment group of the present invention first throw into stone feedstuff 7 weeks, after throw normal diet 4 weeks.Prevention group of the present invention throws into stone feedstuff 7 weeks.Every day thrown 250g by every cage, freely drink water (tap water), and feeds appropriate Radix Dauci Sativae.
1.3 Experimental agents: the Chinese medicinal composition preparation of the present invention prepared by embodiment 1.Treatment group first throws into stone feedstuff 7 weeks, rear throwing normal diet 4 weeks gastric infusion; Medicine all uses distilled water diluting, gavage gives Chinese medicine of the present invention respectively, combination object height group, middle group and low group are respectively containing Chinese medicine composition 2g, 1g, 0.5g of the present invention, positive controls every gavage chenodeoxy cholic acid 25mg, normal group and model group gavage with same volume distilled water, once daily when every day the morning 8.
1.4 methods of sample collection animal fasting (can't help water) 24h, lethal from eye socket injection air, cut rapidly breast abdomen open, expose heart, get cardiac blood with syringe and be about 3ml, then expose gallbladder, cystic duct is blocked by vascular forceps, take off gallbladder, first perusal becomes stone situation, and with the whole bile of syringe sucking-off.Bile and blood place 40min at normal temperatures, and then the centrifugal 10min of 2000r/pm, gets bile supernatant and serum, be positioned over preserve in-20 DEG C of refrigerators to be measured.
1.5 testing index methods: various index test all adopts clinical assay reagent box, buy in chemical reagents corporation of Beijing.Wherein T-CHOL and bile acid are enzymic colorimetric; Total bilirubin and bilirubin direct are chemical colorimetry; Calcium ion is sodium ethylene diamine tetracetate method.
1.6 statistical method: this experiment the data obtained utilizes SPSS8.0 statistical software to process, statistical method adopts chi-square analysis and t inspection.
1.7 experimental result
Modelling result: in model group 10 Cavia porcelluss, 8 form calculus, and this calculus profile is irregular, not of uniform size, taupe flake, quality is soft, frangible.Model group gallstone formation rate has highly significant difference (P < 0.01) compared with normal group.The impact of Chinese medicine composition of the present invention on composition every in bile is as shown in table 2.
Table 2 Chinese medicine composition of the present invention is on the impact of composition every in bile
Group n BA Ca TBIL DBIL
Normal group 10 574.21±110.24 2.28±0.59 1.24±0.15 0.65±0.21
Model group 10 254.61±62.74 ▲▲ 4.78±1.28 ▲▲ 2.51±0.26 ▲▲ 1.02±0.35 ▲▲
Positive control 10 386.65±67.48 ＊ 4.16±1.24 ＊ 1.78±0.21 ＊ 0.98±0.32
Low group of compositions 10 380.53±75.21 ＊＊ 3.86±0.98 ＊＊ 1.80±0.16 ＊ 0.76±0.21 ＊
Group in compositions 10 452.15±76.85 ＊＊△ 3.52±0.76 ＊＊△ 1.45±0.13 ＊＊△ 0.70±0.12 ＊＊△
Combination object height group 10 534.16±53.29 ＊＊△ 2.85±0.46 ＊＊△ 1.30±0.18 ＊＊△ 0.68±0.14 ＊＊△
Compare with normal group, ▲ ▲p < 0.01; Compare with model group *p < 0.05, *p < 0.01; Compare with positive controls, △ P < 0.05.
As can be seen from Table 2, each treatment group of Chinese medicine composition of the present invention and positive controls have the effect significantly reducing Ca, TBIL, DBIL level in bile and the effect raising BA level.Wherein the regulating action of positive controls and low group of the present composition close.In the present composition group and high group compared with positive controls reduce Ca, TBIL, DBIL level and rising BA in bile horizontal in there is the difference of significance.

Claims (5)

1. treat the Chinese medicine composition of liver and bile stone for one kind, it is characterized in that, it is made up of the raw material of following weight portion: Caulis Trachelospermi 10-12 part, Radix Dipsaci 5-8 part, Radix Achyranthis Bidentatae 6-9 part, Radix Rehmanniae 3-5 part, Herba Taraxaci 10-12 part, Radix Puerariae 10-12 part, Herba Plantaginis 3-5 part, Folium Ginkgo 3-5 part, Herba Menthae 10-12 part, Rhizoma Coptidis 8-10 part, Fructus Ligustri Lucidi 6-9 part, Cortex Magnoliae Officinalis 10-12 part, Radix Angelicae Dahuricae 10-12 part, Radix Paeoniae Alba 10-12 part, Radix Cirsii Japonici 12-15 part, Radix Glycyrrhizae 9-12 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, described Chinese medicine composition is also containing Bears Poria 5-8 part and Flos Lonicerae 12-15 part.
3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that described Chinese medicine composition is powder, water preparation, tablet or capsule.
4. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that the preparation method of described Chinese medicine composition comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 35%-80% is doubly added according to the 3-6 of coarse powder gross weight, reflux, extract, three times, return time is 3-6h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method.
5. the purposes of the Chinese medicine composition described in claim 1 or 2 in preparation treatment liver and bile stone medicine.
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091026A (en) * 1993-02-16 1994-08-24 苏经国 Danshixiao medicine for treating cholelithiasis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091026A (en) * 1993-02-16 1994-08-24 苏经国 Danshixiao medicine for treating cholelithiasis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
加味四逆散治疗胆结石;陈顺泉;《新中医》;19940915(第09期);43 *

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