CN104352546A - Traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, preparation method and combined package - Google Patents
Traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, preparation method and combined package Download PDFInfo
- Publication number
- CN104352546A CN104352546A CN201410540069.3A CN201410540069A CN104352546A CN 104352546 A CN104352546 A CN 104352546A CN 201410540069 A CN201410540069 A CN 201410540069A CN 104352546 A CN104352546 A CN 104352546A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- superfine powder
- crude drugs
- chinese crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 96
- 238000002360 preparation method Methods 0.000 title claims abstract description 65
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 230000003116 impacting effect Effects 0.000 claims description 68
- 229940079593 drug Drugs 0.000 claims description 66
- 239000000843 powder Substances 0.000 claims description 66
- 240000002853 Nelumbo nucifera Species 0.000 claims description 61
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 61
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 61
- 210000000988 bone and bone Anatomy 0.000 claims description 61
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 42
- 230000001954 sterilising effect Effects 0.000 claims description 42
- 238000004659 sterilization and disinfection Methods 0.000 claims description 42
- 238000001035 drying Methods 0.000 claims description 41
- 238000000227 grinding Methods 0.000 claims description 41
- 238000010008 shearing Methods 0.000 claims description 41
- 238000002791 soaking Methods 0.000 claims description 34
- 241001533947 Psammosilene Species 0.000 claims description 30
- 238000004806 packaging method and process Methods 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 26
- 241000628997 Flos Species 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 19
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical group CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 abstract description 19
- 230000036407 pain Effects 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 15
- 230000008961 swelling Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 241000759271 Alangium Species 0.000 abstract 1
- 244000014908 Gaultheria leucocarpa var. yunnanensis Species 0.000 abstract 1
- 241001534096 Psammosilene tunicoides Species 0.000 abstract 1
- 241001386821 Schefflera leucantha Species 0.000 abstract 1
- 208000010392 Bone Fractures Diseases 0.000 description 42
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 15
- 239000010931 gold Substances 0.000 description 15
- 229910052737 gold Inorganic materials 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 241000699670 Mus sp. Species 0.000 description 12
- 230000003110 anti-inflammatory effect Effects 0.000 description 10
- 230000006378 damage Effects 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 208000006820 Arthralgia Diseases 0.000 description 8
- 206010061218 Inflammation Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000002316 fumigant Substances 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- 208000014674 injury Diseases 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 239000007921 spray Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 230000000202 analgesic effect Effects 0.000 description 7
- 230000017531 blood circulation Effects 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 6
- 230000036592 analgesia Effects 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 201000003068 rheumatic fever Diseases 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 231100000252 nontoxic Toxicity 0.000 description 5
- 230000003000 nontoxic effect Effects 0.000 description 5
- 230000008439 repair process Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 230000001506 immunosuppresive effect Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000008736 traumatic injury Effects 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 201000005569 Gout Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000007799 cork Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- WLYGSPLCNKYESI-RSUQVHIMSA-N Carthamin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@]1(O)C(O)=C(C(=O)\C=C\C=2C=CC(O)=CC=2)C(=O)C(\C=C\2C([C@](O)([C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(O)=C(C(=O)\C=C\C=3C=CC(O)=CC=3)C/2=O)=O)=C1O WLYGSPLCNKYESI-RSUQVHIMSA-N 0.000 description 2
- 241000208809 Carthamus Species 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 241000545405 Tripterygium Species 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000003356 anti-rheumatic effect Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000003435 antirheumatic agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000019636 bitter flavor Nutrition 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 239000012645 endogenous antigen Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- -1 golden preparation Chemical compound 0.000 description 2
- 210000002149 gonad Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 210000002997 osteoclast Anatomy 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 241001164374 Calyx Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010058112 Chondrolysis Diseases 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 1
- 208000007875 Femur Head Necrosis Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 description 1
- 108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 206010034464 Periarthritis Diseases 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 241000501113 Sargentodoxa cuneata Species 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000019667 acute articular rheumatism Diseases 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 229960002170 azathioprine Drugs 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 229960003677 chloroquine Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000006028 immune-suppresssive effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 208000018934 joint symptom Diseases 0.000 description 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 1
- 229960000681 leflunomide Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- NCYVXEGFNDZQCU-UHFFFAOYSA-N nikethamide Chemical compound CCN(CC)C(=O)C1=CC=CN=C1 NCYVXEGFNDZQCU-UHFFFAOYSA-N 0.000 description 1
- 229960003226 nikethamide Drugs 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930194301 safflor yellow Natural products 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000002356 skeleton Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 239000009270 zilongjin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, a preparation method and a combined package. The traditional Chinese medicine decoction piece combined preparation containing the Jin Gu Lian Pian comprises raw materials in parts by weight as follows: 343 parts of gaultheria yunnanensis, 400 parts of schefflera kwangsiensis, 370 parts of caulis sargentodoxae, 50 parts of Chinese alangium root and 50 parts of psammosilene tunicoides. The traditional Chinese medicine decoction piece combined preparation containing the Jin Gu Lian Pian has functions of dispelling wind, eliminating dampness and relieving swelling and pain, is used for treating joint gall, difficulty in flexion and extension and the like caused by rheumatism blockage stasis, is good in curative effect and free of toxic and side effects, and takes effect quickly.
Description
Technical field
The present invention relates to a kind of preparation of the prepared slices of Chinese crude drugs, specifically relate to golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, preparation method and assembly packaging.
Background technology
The needs of modern healthy, in field of traditional Chinese in succession, revive and develop middle formation numerous Chinese medicine old established firm brand, as Tongrentang (1669), Hu Qingyu Pharmaceutical Workshop (1874), large life auspicious (1885), Han Xingtang (1901), Fu Tong (1644), Fructus Pruni and hall (1600), public good is large, Chen Zhi father-in-law, bosom moral crane (1948), old man and Tai, father-in-law Changchun (1699), Fu Jichun, refined vegetarian (between bright year in Wanli year), first-class and the Chinese medicine health-care tea old established firm brand of Lei Yun is as ten thousand safe units (1860), Zhu Qiansheng, roc red sun, universe Thailand is poly-, wherein ten thousand safe first tea No. win ten thousand state's World's Fair gold medals in 1915 especially, the first-class Grand Prix of nineteen twenty-six U.S. Philadelphia World's Fair and nineteen twenty-nine first West Lake Exposition gold medal.
Rheumatism is one group, and to invade joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue be the disease led, and wherein majority is autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer, and mostly has genetic predisposition.Treatment and diagnosis all acquires a certain degree of difficulty; How different autoantibodys can be checked out in blood, may be relevant from different HLA hypotype.
Rheumatismal pathogeny is: body exogenous or endogenous antigen material are directly or the stimulation of being presented by macrophage, make corresponding T-cell activation, some T-cell produces a large amount of multiple inflammation cytokines and causes the damage in various degree of various organization organ or destruction; Some T-cell reactivation B-cell, produces lot of antibodies, directly or be combined with antigen and form immune complex, makes tissue or organ sustain damage or destroy.In addition the monocyte chemoattractant protein (as MCP-1) etc. produced by mononuclear cell, also can participate in inflammatory reaction.Major part rheumatism, or owing to infecting the exogenous antigen material produced, or the endogenous antigen material owing to producing in body, can start or aggravate this autoimmune response, in serum, can Multiple Antibodies be occurred.
Wind-damp numbness is that with the passing of time rheumatism does not heal, and blood stasis becomes, or the heresy that affection of exogenous wind-cold is wet, strongly fragrant and heat-transformation, a kind of symptom that heat in blood is tied mutually.
Rheumatism is the autoimmune disease that a class invades Various Tissues multisystem and internal organs.The immune inflammation reaction that degree is different, can cause into various tissue and organ injury, have a strong impact on its normal function.Mortality is even caused to damage.In addition, most of rheumatism has joint symptoms; Each patient, same disease, the different course of disease has its particularity.Should carefully evaluate, to work up the treatment plan of its people.Therapeutic goal should comprise relief of symptoms, improves the state of an illness, and restore funcitons is improved the quality of living, as far as possible the life of continued patient.Because most of rheumatism can't effect a radical cure at present, therefore to strive for the cooperation of patient, adhere to treatment for a long time.The method for the treatment of comprises medicine, physical therapy, has a rest and exercise, orthopedic and operation.Educate the state of an illness that patient understands oneself, partner treatment.Below the medicine only with regard to treating rheumatism is simply introduced:
1. nonsteroidal anti-inflammatory agent (NSAIDs): the effect of this type of medicine, is mainly antipyretic, antiinflammatory and analgesia, and reach reduce inflammation reaction and object.Be that aspirin (aspirin) is so far still for treating the active drug of acute rheumatic fever and rheumatic arthritis the earliest.Produced various Salicylates afterwards, conventional has ibuprofen, diclofenac, indomethacin, piroxicam, naproxen etc., but the pharmacokinetics of various medicine and untoward reaction different, main to gastrointestinal, kidney, liver and blood system, must note dosage during use, usage, side effect etc.
2. adrenocortical hormone: mainly refer to glucocorticoid, because this kind of medicine has antiinflammatory and immunosuppressive action, has more by force and diminishes inflammation fast and various symptoms that inflammatory reaction brings, as heating, and arthroncus and pain.So to various rheumatism, be often used as First Line medicine.Having of applying clinically is fugitive, middle effect and the preparation such as long-acting.Usage has oral, muscle or intraarticular injection, intravenous injection, can according to disease kind, and the state of an illness does different selections.But because it not effects a radical cure medicine, long-term a large amount of use can bring out infection, osteoporosis, femur head necrosis, diabetes, peptic ulcer, hypertension, psychological problem etc.; And easy generation state of an illness rebound phenomenon as too fast in drug withdrawal, therefore should note according to disease kind and the state of an illness, regulate the kind and dosage that use medicine.Except patient with severe symptoms, in principle with low dose, Low doses is advisable.
3. the antirheumatic (DMARDs) improving the state of an illness is also called and acts on antirheumatic slowly.It is different that this type of medicine comprises numerous species structure, acts on different medicine.Their general character is that onset is slow, has certain cumulative action, therefore after drug withdrawal, event resolves is also comparatively slow, still can maintain a period of time.They there is no direct anti-inflammatory analgetic effect, but can play antiinflammatory and immune or immunosuppressive action by different mechanism.Thus, also can improve arthroncus, pain, stiff and mitigation system symptom, reduce acute phase reactive protein, erythrocyte sedimentation rate.As service time is longer, also other immune indexes can be improved, as RF, ANA etc.The irradiation image that still can make had improves.The medicine of DMARDs class includes antimalarial-chloroquine, oxychloroquine, sulfasalazine, methotrexate, azathioprine, cyclophosphamide, penicillamine, golden preparation, ciclosporin A and leflunomide.
The internal organs (liver, kidney, bladder, lung, gastrointestinal, gonad) wanted body weight for humans of various medicine and tissue (bone marrow) toxic action of having nothing in common with each other, should note the selection of indication above.
4. other: other treatment comprises Tripterygium glycosides, Pa Fulin, Yun Ke etc.
(1) Yun Ke: suppress prostaglandin synthesis, suppress the activity of collagenase, prevent chondrolysis and destruction, suppress osteoclast.Can antiinflammatory, analgesia.
(2) tripterygium glycosides: suppress T, B cell proliferation, suppresses T-cell to produce IL-2 and B-cell and produces immunoglobulin.Prostaglandin is suppressed to produce.There are stronger antiinflammatory and immunosuppressive action.
For the problems referred to above, develop some in prior art and treat rheumatismal Chinese medicine composition, to can rheumatism be cured.But between pharmaceutical compositions and content thereof, relation is comparatively complicated, even if identical Chinese medicine ingredients, its monarch relation of different content is not identical yet, and the reduction of drug effect may be caused even to occur contrary curative effect.In prior art, the therapeutic effect of Chinese medicine composition is often bad.Therefore, for the research of the Chinese medicine composition for the treatment of rheumatism, there is reality and meaning remote.
In addition, in the prescription clinical practice of Traditional Chinese Medicine, general adopt formula system, namely after the good prescription of doctor prescribed, and grab the process of joining and completed by pharmacy room, such flow process makes the proportioning of medicine accurate, does not often reach best curative effect.
Summary of the invention
Main purpose of the present invention is to overcome internal organs (liver, kidney, the bladder that prior art Chinese medicine is wanted body weight for humans, lung, gastrointestinal, gonad) and the toxic action of tissue (bone marrow), a kind of golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, preparation method and assembly packaging are provided.
An object of the present invention is, provides a kind of golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation.
In order to realize foregoing invention object, the present invention solves the problems of the technologies described above by the following technical programs:
A kind of golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts.
Preferably, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation also comprises each composition of following weight portion: Radix Saposhnikoviae 30-50 part, Herba Schizonepetae 20-30 part, Rhizoma Et Radix Notopterygii 20-30 part, Radix Angelicae Pubescentis 10-20 part, Flos Carthami 10-20 part.
Preferably, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation also comprises each composition of following weight portion: Radix Saposhnikoviae 35-40 part, Herba Schizonepetae 20-25 part, Rhizoma Et Radix Notopterygii 25-30 part, Radix Angelicae Pubescentis 15-20 part, Flos Carthami 10-20 part.
Preferably, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation also comprises each composition of following weight portion: Radix Saposhnikoviae 35 parts, Herba Schizonepetae 23 parts, Rhizoma Et Radix Notopterygii 26 parts, Radix Angelicae Pubescentis 16 parts, 15 parts, Flos Carthami.
Do for mentioned component and character thereof below and further illustrate as follows:
In the present invention, described Caulis et folium gaultheriae yunnanensis is Herb or the root of ericad Caulis et folium gaultheriae yunnanensis.The whole year all can adopt. and root is cut into slices, and Herb is shredded, and dries.Be distributed in various places on the south Shaanxi and the Yangtze river basin.Cure mainly: expelling wind and removing dampness; Dispersing cold for relieving pain; Promoting blood circulation to remove obstruction in the collateral; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Cold syndrome of the stomach pain; Traumatic injury; Cough ant phlegm.
In the present invention, described Radix Schefflerae Arboricolae, main product, in Guangxi China, has another name called Radix Schfflerae kwangisensis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), more than seven.The effective ingredient that stem and leaf contain analgesia and treatment convulsions is organic acid, uses as Chinese crude drug.Character identification: stem branch is cylindrical, is often mitered into sheet or section, long 1 ~ 3cm, diameter 0.4 ~ 3cm.Appearance canescence is to fallow, and tool indulges wrinkle and point-like hole skin, sometimes visible annular leaf trace, the normal flaking of cork.Mildly bitter flavor is puckery, and temperature, has wind-expelling pain-stopping, relaxing muscles and tendons and activating QI and blood in the collateral function.For the disease such as trigeminal neuralgia, nervous headache, sciatica, rheumatic arthritis and stomach, intestinal, biliary tract pain.The whole year can adopt, and cutting is dried or dried.
In the present invention, described Caulis Sargentodoxae (Classification system: Sargentodoxa cuneata (Oliv.) Rehd. et Wils.), practises and claims Caulis Sargentodoxae, have another name called Caulis seu Radix Schisandrae Henryi, Folium Styracis Suberifoliae rattan etc., and Caulis Sargentodoxae is fallen leaves, bejuco; Stem bronzing; Compound leaf three goes out, alternate; The different strain of flower unisexuality, radiation symmetric, petal 6, minimum, calyx 6, petal-shaped; Fruit is aggregate fruit, is made up of multiple meat small berries.Be born in hillside sparse woods, small stream limit; There is cultivation.Main product Hubei, Sichuan, Jiangxi, Henan, Jiangsu; Anhui, Zhejiang are also produced.Nature and flavor are bitter, flat.There is the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide.Control acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down.
In the present invention, described Radix Alangii, heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.Root and skin drug effect best, root name Radix Alangii, stem name Bai Long bar.Energy expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, eliminating stasis to stop pain, for rheumatic arthralgia, numb limbs and tense tendons, traumatic injury; Leaf is used for injury and bone fracture, and outer knife injury is hemorrhage; Flower is used for wind syndrome of head pain and distension and fullness of the chest and abdomen.
In the present invention, described Radix Psammosilenes, dry root conico-acuminate, is about 8 ~ 15 centimetres, diameter about 0.5 ~ 1.5 centimetre, cork yellowish-brown, has most vertical wrinkle; The person that removes cork, in yellow-white, visible cross-drilled hole stricture of vagina.Frangibility, section opaque shape, vascular bundle is obviously arranged in yellow intensive radial texture.Gas without, acrid in the mouth is peppery, the stimulation mouthpiece tasted.Be good with Zhi great Zhe.Except rheumatism, analgesic therapy, hemostasis, blood stasis dispelling.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, wound hemorrhage, traumatic injury.
In the present invention, described Radix Saposhnikoviae acrid-sweet flavor is warm in nature nontoxic, pungent walk the agent of lung therefore the logical knot treating all pathogenic wind, the trouble of pain person's wind.Described Herba Schizonepetae acrid in the mouth bitterness tepor, nontoxic enter the promoting the circulation of blood of lung liver treat all wind of wind diaphoresis peeling hair.Herba Schizonepetae in vitro tests has weak anticancer effect.Herba Schizonepetae decoct has obviously suppression mice auricle swelling effect, and the inflammation that Dichlorodiphenyl Acetate causes also has obvious antiinflammatory action.Described Rhizoma Et Radix Notopterygii sweet in the mouth slightly warm in nature enters lung kidney two through curing mainly new and old all rheumatism numbness, enters the few cloudy kidney of lunar lung to manage floating wind.Rhizoma Et Radix Notopterygii volatile oil has antiinflammatory and anti-allergic effects.After gastric infusion, xylol dropsy of ear, carrageenin and dextran foot swelling have inhibitory action.There is certain inhibitory action to the delayed hypersensitivity caused by 2,4-dinitrochlorobenzene, and vitamin C content in adrenal gland can be made to have reduction trend. its antiinflammatory action may be relevant with hypophysis-interrenal system.Described Radix Angelicae Pubescentis bitter but sweet flavor slightly warm in nature nontoxic enter small intestinal urinary bladder channel spill into table ailment said due to cold or exposure, sharp Zhousheng arthralgia, the disease except new and old rheumatism enters sun small intestinal, bladder meridian to manage the mutual the exterior and the interior of urticaria.Book on Chinese herbal medicine converges to be sayed: Radix Angelicae Pubescentis, benefaction blood system, and the medicine of the wet cold expelling of the row that dispels the wind also.The card of all sick wind, as head term can not pitching, waist knee joint can not bend and stretch, or arthralgia pain is difficult to walk, numbness need not, all wind with cold caused by, summer-heat is hindered also with wet institute; Must be warm by the toil of Radix Angelicae Pubescentis, activity QI and blood, cold expelling heresy of dispelling, the beriberi therefore " book on Chinese herbal medicine " speech can fall apart, change renal mass, treatment hernia abdominal mass, subduing inflammation, controls harmful wind hundred joint and attacks bitterly, surely lack the strongly fragrant headache of YIN-cold, be intended to this.Flos Carthami acrid in the mouth warm in nature nontoxic enter conscience two warp, treat the swelling of traumatic injury sore.Carthamus yellow has calmness, analgesia and anticonvulsant action.Hot plate method in mice and acetic acid twisting experiment prove: Carthamus yellow has analgesic activity, and can strengthen the central inhibitory action of barbital and chloral hydrate, reduce response rate and the mortality rate of nikethamide convulsions.Extract can suppress carrageenin
Caused foot swelling, points out it to have antiinflammatory action.Safflor yellow also has immunosuppressive action, can reduce the leukocytic phagocytic function of serum lysozyme content, peritoneal macrophage and whole blood.
Two of object of the present invention is, the present invention also provides a kind of preparation method of golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, and the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 1 ~ 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 1 ~ 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Caulis Sargentodoxae superfine powder of nanoscale 1 ~ 40nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Alangii superfine powder of nanoscale 1 ~ 45nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 5 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Psammosilenes superfine powder of nanoscale 1 ~ 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again.
Described Caulis et folium gaultheriae yunnanensis superfine powder is the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 25nm; Described Radix Schefflerae Arboricolae superfine powder is the Radix Schefflerae Arboricolae superfine powder of nanoscale 25nm; Described Caulis Sargentodoxae superfine powder is the Caulis Sargentodoxae superfine powder of nanoscale 30nm; Described Radix Alangii superfine powder is the Radix Alangii superfine powder of nanoscale 30nm; Described Radix Psammosilenes superfine powder is the Radix Psammosilenes superfine powder of nanoscale 25nm.
After described step (1) Fracture completes, also carry out ozone sterilization; After described step (2) Fracture completes, also carry out ozone sterilization; After described step (3) Fracture completes, also carry out ozone sterilization; After described step (4) Fracture completes, also carry out ozone sterilization; After described step (5) Fracture completes, also carry out ozone sterilization; After described step (6) Fracture completes, also carry out ozone sterilization.
The present invention also provides a kind of assembly packaging of golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, comprises Caulis et folium gaultheriae yunnanensis, Radix Schefflerae Arboricolae, Caulis Sargentodoxae, Radix Alangii, Radix Psammosilenes, Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami.
Preferably, also comprise adjuvant in described packaging, wherein the total amount of Caulis et folium gaultheriae yunnanensis, Radix Schefflerae Arboricolae, Caulis Sargentodoxae, Radix Alangii, Radix Psammosilenes, Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami and the proportioning of adjuvant are 1:1.
Preferably, described adjuvant is HP-β-CD.
Beneficial effect of the present invention is: golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation of the present invention can be Film coated tablets, and after removing film-coat, aobvious brownish red is to reddish brown brown; Feeble QI is mildly bitter flavor, puckery.
Golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation expelling wind and removing dampness of the present invention, reducing swelling and alleviating pain.For the arthralgia caused by wind-damp numbness, joint stuffiness etc.
Treatment rheumatism of the present invention, rheumatoid golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, can make rheumatoid fumigant, rheumatoid repairs spray two kinds of preparations, good effect, instant effect, has no side effect.Two kinds of preparations can configure separately, are used alone.Rheumatoid fumigant is mainly used in rheumatoid, rheumatism, gout etc. and uses in gassing machine; Solving rheumatism, rheumatoid, gout etc. causes arthroncus to cross reparation and the rehabilitative action of arthralgia, and energy pain-relieving rheumatism-dispelling heat rapidly, control activeness rheumatoid and rheumatism, reach local or hydrosarca alleviates until disappear.From the immune disorder of external adjustment human body and deficiency, shorten treatment rheumatism, rheumatoid time and the course for the treatment of, compare with chemicals than traditional oral drugs, this composition of medicine need not be oral, do not injure human body, regulate the blood circulation of human body and immune system thus reach therapeutic purposes.Rheumatoid is repaired spray and is mainly used in rheumatoid, rheumatism, gout, scapulohumeral periarthritis, intervertebral disk hernia or bulging, cervical vertebra pain, sprain, magnet therapeutic apparatus or infrared therapy apparatus carry out ion get involved and soak penetrate diseased region topical therapeutic, through thermion, effective ingredient Transdermal absorption is entered blood circulation and arrives each tissue by photoion or magnetic wave, higher in diseased region concentration, the metabolite harmful to pathological tissues decomposes, kill the rheumatoid factor in blood, the osteoclast of pathological changes joint part, abnormal proliferation cell, allergy cell, decompose destroyed histiocyte and immune complex, get rid of external through blood circulation, recover the microcirculqtory system of diseased region, set up normal blood circulation passage, allow the automatic and passive reparation pathological tissues of human body, thus reach therapeutic purposes.The defect that infrared ray and magnet therapeutic apparatus do not have soak and hot compress can be solved, promote local lesion's rehabilitation Shorten the Treatment Process.According to clinical trial, rheumatoid fumigant can control rheumatic fever that activeness rheumatoid causes and rheumatalgia, migratory rheumatism pain for 3-4 days, mild rheumatic arthritis can be cured for 7 days substantially, recovery from illness in 25 days, rheumatoid fumigant and rheumatoid are repaired spray and are used 10 days can control violent arthralgia simultaneously, within 3 months to 6 months, rheumatoid returns to one's perfect health and reaches 97%, and common knee joint rheumatic arthritis returns to one's perfect health 78% in 25 days.
Detailed description of the invention
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.
Agents useful for same of the present invention and raw material are all commercially.
embodiment 1 gold medal bone lotus sheet prepared slices of Chinese crude drugs combination preparation and assembly packaging
The raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts, Radix Saposhnikoviae 35 parts, Herba Schizonepetae 23 parts, Rhizoma Et Radix Notopterygii 26 parts, Radix Angelicae Pubescentis 16 parts, 15 parts, Flos Carthami.
The preparation method of gold bone lotus sheet prepared slices of Chinese crude drugs combination preparation, the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 25nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 25nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis Sargentodoxae superfine powder of nanoscale 30nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Alangii superfine powder of nanoscale 30nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 8MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Psammosilenes superfine powder of nanoscale 25nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again;
(6) Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami are carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the superfine powder of nanoscale 25nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again.
By above-mentioned obtained superfine powder mixing, mix with the ratio of HP-β-CD in 1:1.Obtain golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging.
embodiment 2 gold medal bone lotus sheet prepared slices of Chinese crude drugs combination preparation and assembly packaging
The raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts, Radix Saposhnikoviae 40 parts, Herba Schizonepetae 25 parts, Rhizoma Et Radix Notopterygii 25 parts, Radix Angelicae Pubescentis 20 parts, 20 parts, Flos Carthami.
The preparation method of gold bone lotus sheet prepared slices of Chinese crude drugs combination preparation, the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis Sargentodoxae superfine powder of nanoscale 20nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Alangii superfine powder of nanoscale 40nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 8MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Psammosilenes superfine powder of nanoscale 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again;
(6) Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami are carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again.
By above-mentioned obtained superfine powder mixing, mix with the ratio of HP-β-CD in 1:1.Obtain golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging.
embodiment 3 gold medal bone lotus sheet prepared slices of Chinese crude drugs combination preparation and assembly packaging
The raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts, Radix Saposhnikoviae 30 parts, Herba Schizonepetae 20 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Angelicae Pubescentis 20 parts, 10 parts, Flos Carthami.
The preparation method of gold bone lotus sheet prepared slices of Chinese crude drugs combination preparation, the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis Sargentodoxae superfine powder of nanoscale 20nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Alangii superfine powder of nanoscale 40nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 8MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Psammosilenes superfine powder of nanoscale 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again;
(6) Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami are carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again.
By above-mentioned obtained superfine powder mixing, mix with the ratio of HP-β-CD in 1:1.Obtain golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging.
embodiment 4 gold medal bone lotus sheet prepared slices of Chinese crude drugs combination preparation and assembly packaging
The raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts, Radix Saposhnikoviae 40 parts, Herba Schizonepetae 25 parts, Rhizoma Et Radix Notopterygii 30 parts, Radix Angelicae Pubescentis 15 parts, 15 parts, Flos Carthami.
The preparation method of gold bone lotus sheet prepared slices of Chinese crude drugs combination preparation, the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis Sargentodoxae superfine powder of nanoscale 20nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Alangii superfine powder of nanoscale 40nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 8MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Psammosilenes superfine powder of nanoscale 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again;
(6) Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami are carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again.
By above-mentioned obtained superfine powder mixing, mix with the ratio of HP-β-CD in 1:1.Obtain golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging.
embodiment 5 gold medal bone lotus sheet prepared slices of Chinese crude drugs combination preparation and assembly packaging
The raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts, Radix Saposhnikoviae 35 parts, Herba Schizonepetae 25 parts, Rhizoma Et Radix Notopterygii 30 parts, Radix Angelicae Pubescentis 10 parts, 10 parts, Flos Carthami.
The preparation method of gold bone lotus sheet prepared slices of Chinese crude drugs combination preparation, the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 25nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Caulis Sargentodoxae superfine powder of nanoscale 30nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Alangii superfine powder of nanoscale 30nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the Radix Psammosilenes superfine powder of nanoscale 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 10MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again;
(6) Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami are carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, ozone sterilization, make the superfine powder of nanoscale 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again.
By above-mentioned obtained superfine powder mixing, mix with the ratio of HP-β-CD in 1:1.Obtain golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging.
With ventilative non-toxic material, the golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging package of above embodiment is made fumigant.Using method is: fumigant is put into gassing machine and fumigates, and temperature controls, between 39-60 degree Celsius, to be advisable with Human Tolerance, between time 30-40 minute, and can not more than 40 minutes.
The golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging obtained by said method can also add water, the ratio mixing of 2000ml water is added according to every 53 grams of golden bone lotus sheet prepared slices of Chinese crude drugs assembly packagings, heat 20 minutes to 95-100 degree Celsius, extract effective liquid by high pressure extract method and make rheumatism, rheumatoid repair liquid spray, be sprayed at lesion for nebulizer when infrared ray and magnet therapeutic apparatus treatment.
Treatment rheumatism of the present invention, rheumatoid golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging, allergic constitution is forbidden, and significant heart disease people avoids use.
The fumigant that the present invention treats rheumatism, rheumatoid golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging obtains and rheumatoid repair liquid spray jointly can be arranged in pairs or groups to use and be treated rheumatism, rheumatoid.
the test of pesticide effectiveness of test example 1 gold medal bone lotus sheet prepared slices of Chinese crude drugs combination preparation
rheumatism, rheumatoid golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging analgesic activity:
1, on the impact of the mice threshold of pain:
Adopt hot plate method to measure the threshold of pain, its condition is hot plate temperature is 55 ± 0.5 DEG C.Get body weight 18g-20g female mice, select the mice 20 that its response latency is no more than 30 hours after the response latency, divide equally two groups, smear affected part with water decoction for one group; Another group is matched group, non-drug.First group of golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging water decoction by embodiment 1 (golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging 40g/kg of the present invention and the mixing of 40ml water) is applied in affected part, measure the mice response latency before and after administration, the response latency of result rheumatism, rheumatoid Chinese medicine composition group mice all obviously extends after the tablet has been ingested for 60 hours and 90 hours, demonstrates rheumatism, rheumatoid Chinese medicine composition has good analgesic effect.
2, electricity irritation Mus tail method:
Electricity irritation Mus tail method measures analgesic effect, and its condition is that the unidirectional current used time 1-2 of 180v wounds mouse tail second, surveys the pain reaction number of times of mice, gets the mice 10 of 16 grams of-20 grams of body weight, be divided into two groups, often organizes 5, is divided into matched group and reference group.White mice and spray are that every kg body weight white mice 20g treats rheumatism according to weight ratio, rheumatoid Chinese medicine composition, and every kg body weight 42g treats rheumatism, rheumatoid golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging, golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging is added again the obtained rheumatism of ratio mixing of 2000ml water according to every 53 grams of Chinese medicine compositions, rheumatoid repair liquid spray, be sprayed on white mice affected part to observe, after administration, 10 minutes analgesia rates are respectively 71% and 86%, analgesia rate after 60 minutes then distinguishes 89% and 97%, can find out all there is certain analgesic activity.
the anxious poison experiment of gold bone lotus sheet prepared slices of Chinese crude drugs assembly packaging:
Give 20 Healthy Peoples with the fumigant that 2-3 rheumatism doubly, rheumatoid golden bone lotus sheet prepared slices of Chinese crude drugs assembly packaging obtain to fumigate, do not find toxic reaction, continue and be sprayed on joint part to rheumatism, rheumatoid repair liquid spray 200ml, irradiate with infrared ray and magnet therapeutic apparatus simultaneously, observe 1-48 hour without toxic reaction, local nothing is red and swollen, without anaphylaxis.
The above; be only preferred embodiment of the present invention; not to any formal and substantial restriction of the present invention; should be understood that; for those skilled in the art; under the prerequisite not departing from the inventive method, also can make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.All those skilled in the art, without departing from the spirit and scope of the present invention, a little change made when utilizing disclosed above technology contents, the equivalent variations of modifying and developing, be Equivalent embodiments of the present invention; Meanwhile, all according to substantial technological of the present invention to the change of any equivalent variations that above-described embodiment is done, modify and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (10)
1. a golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, it is characterized in that, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation comprises each composition of following weight portion: Caulis et folium gaultheriae yunnanensis 343 parts, Radix Schefflerae Arboricolae 400 parts, Caulis Sargentodoxae 370 parts, Radix Alangii 50 parts, Radix Psammosilenes 50 parts.
2. golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 1, it is characterized in that, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation also comprises each composition of following weight portion: Radix Saposhnikoviae 30-50 part, Herba Schizonepetae 20-30 part, Rhizoma Et Radix Notopterygii 20-30 part, Radix Angelicae Pubescentis 10-20 part, Flos Carthami 10-20 part.
3. golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 1, it is characterized in that, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation also comprises each composition of following weight portion: Radix Saposhnikoviae 35-40 part, Herba Schizonepetae 20-25 part, Rhizoma Et Radix Notopterygii 25-30 part, Radix Angelicae Pubescentis 15-20 part, Flos Carthami 10-20 part.
4. golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 1, it is characterized in that, the raw material of described golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation also comprises each composition of following weight portion: Radix Saposhnikoviae 35 parts, Herba Schizonepetae 23 parts, Rhizoma Et Radix Notopterygii 26 parts, Radix Angelicae Pubescentis 16 parts, 15 parts, Flos Carthami.
5. a preparation method for golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, it is characterized in that, the method comprises the steps:
(1) Caulis et folium gaultheriae yunnanensis is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 1 ~ 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-15 DEG C before impacting;
(2) Radix Schefflerae Arboricolae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Schefflerae Arboricolae superfine powder of nanoscale 1 ~ 45nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first brittle at temperature-22 DEG C before impacting;
(3) Caulis Sargentodoxae is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Caulis Sargentodoxae superfine powder of nanoscale 1 ~ 40nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out after embrittlement impacting before impacting at temperature-22 DEG C again;
(4) Radix Alangii is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Alangii superfine powder of nanoscale 1 ~ 45nm, the time that wherein Radix Alangii is soaked is 35-40 minute, the hydraulic pressure rinsed is 5 ~ 12MPa, first carries out impacting before impacting after temperature less than-12 DEG C embrittlement again;
(5) Radix Psammosilenes is carried out soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the Radix Psammosilenes superfine powder of nanoscale 1 ~ 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-11 DEG C embrittlement again.
6. golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 5, it is characterized in that, also comprise the steps: Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami to carry out to soak, rinsing, drying, impact, collision, friction, shearing, grinding and fracture, make the superfine powder of nanoscale 1 ~ 35nm, the time of wherein soaking is 35-40 minute, the hydraulic pressure rinsed is 2 ~ 12MPa, first carries out impacting before impacting after temperature less than-15 DEG C embrittlement again.
7. the golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 5 or 6, it is characterized in that, described Caulis et folium gaultheriae yunnanensis superfine powder is the Caulis et folium gaultheriae yunnanensis superfine powder of nanoscale 25nm; Described Radix Schefflerae Arboricolae superfine powder is the Radix Schefflerae Arboricolae superfine powder of nanoscale 25nm; Described Caulis Sargentodoxae superfine powder is the Caulis Sargentodoxae superfine powder of nanoscale 30nm; Described Radix Alangii superfine powder is the Radix Alangii superfine powder of nanoscale 30nm; Described Radix Psammosilenes superfine powder is the Radix Psammosilenes superfine powder of nanoscale 25nm.
8. the golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 5 or 6, is characterized in that, after described step (1) Fracture completes, also carry out ozone sterilization; After described step (2) Fracture completes, also carry out ozone sterilization; After described step (3) Fracture completes, also carry out ozone sterilization; After described step (4) Fracture completes, also carry out ozone sterilization; After described step (5) Fracture completes, also carry out ozone sterilization; After described step (6) Fracture completes, also carry out ozone sterilization.
9. the assembly packaging of a golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation, it is characterized in that, described assembly packaging comprises Caulis et folium gaultheriae yunnanensis, Radix Schefflerae Arboricolae, Caulis Sargentodoxae, Radix Alangii, Radix Psammosilenes, Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami and pharmaceutically acceptable adjuvant, and wherein the total amount of Caulis et folium gaultheriae yunnanensis, Radix Schefflerae Arboricolae, Caulis Sargentodoxae, Radix Alangii, Radix Psammosilenes, Radix Saposhnikoviae, Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Flos Carthami and the proportioning of adjuvant are 1:1.
10. the assembly packaging of golden bone lotus sheet prepared slices of Chinese crude drugs combination preparation according to claim 9, it is characterized in that, described adjuvant is HP-β-CD.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410540069.3A CN104352546A (en) | 2014-10-14 | 2014-10-14 | Traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, preparation method and combined package |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410540069.3A CN104352546A (en) | 2014-10-14 | 2014-10-14 | Traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, preparation method and combined package |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104352546A true CN104352546A (en) | 2015-02-18 |
Family
ID=52519919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410540069.3A Pending CN104352546A (en) | 2014-10-14 | 2014-10-14 | Traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, preparation method and combined package |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104352546A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873708A (en) * | 2015-05-11 | 2015-09-02 | 杭州美誉医药有限公司 | Traditional Chinese medicine preparation for treating soreness of waist as well as preparation method and application thereof |
| CN112107609A (en) * | 2020-11-10 | 2020-12-22 | 贵州益佰制药股份有限公司 | Application of Jingu lotus preparation in preparing medicine for treating chalazion |
| CN112924600A (en) * | 2021-03-23 | 2021-06-08 | 贵州益佰制药股份有限公司 | Fingerprint spectrum establishment method of preparation for treating joint swelling and pain caused by rheumatic obstruction |
| CN112986458A (en) * | 2021-03-23 | 2021-06-18 | 贵州益佰制药股份有限公司 | Content determination method of Jingu lotus preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449802A (en) * | 2003-01-07 | 2003-10-22 | 贵州民族制药厂 | Traditional Chinese medicine for treating arthralgia and preparation process thereof |
| CN101708208A (en) * | 2009-12-23 | 2010-05-19 | 贵州民族药业股份有限公司 | Quality control method of capsule preparation for treating a painful swollen joint |
-
2014
- 2014-10-14 CN CN201410540069.3A patent/CN104352546A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449802A (en) * | 2003-01-07 | 2003-10-22 | 贵州民族制药厂 | Traditional Chinese medicine for treating arthralgia and preparation process thereof |
| CN101708208A (en) * | 2009-12-23 | 2010-05-19 | 贵州民族药业股份有限公司 | Quality control method of capsule preparation for treating a painful swollen joint |
Non-Patent Citations (1)
| Title |
|---|
| 罗刚等: "超微粉碎技术在中药研究中的应用", 《现代药物与临床》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873708A (en) * | 2015-05-11 | 2015-09-02 | 杭州美誉医药有限公司 | Traditional Chinese medicine preparation for treating soreness of waist as well as preparation method and application thereof |
| CN112107609A (en) * | 2020-11-10 | 2020-12-22 | 贵州益佰制药股份有限公司 | Application of Jingu lotus preparation in preparing medicine for treating chalazion |
| CN112924600A (en) * | 2021-03-23 | 2021-06-08 | 贵州益佰制药股份有限公司 | Fingerprint spectrum establishment method of preparation for treating joint swelling and pain caused by rheumatic obstruction |
| CN112986458A (en) * | 2021-03-23 | 2021-06-18 | 贵州益佰制药股份有限公司 | Content determination method of Jingu lotus preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104352546A (en) | Traditional Chinese medicine decoction piece combined preparation containing Jin Gu Lian Pian, preparation method and combined package | |
| CN101601796A (en) | The herbal fumigation compositions and the priming thereof of treatment arthromyodynia | |
| CN105169017A (en) | Traditional Chinese medicine for treating kidney stone and preparation method of traditional Chinese medicine | |
| CN104491220B (en) | A kind of traditional Chinese medicine composition for herpes | |
| CN103565969A (en) | Traditional Chinese medicine composition for treating soft tissue injury and fracture | |
| CN106389881A (en) | Ointment capable of invigorating blood circulation and dissipating blood stasis | |
| CN106806399A (en) | Golden bone lotus piece prepared slices of Chinese crude drugs combination preparation, preparation method and assembly packaging | |
| CN104173978A (en) | Heat clearing and cold dispelling traditional Chinese medicine composition for treating winter cold fever and preparation method thereof | |
| CN102258602B (en) | Chinese medicinal composition for treating rheumatism and rheumatoid and preparation method thereof | |
| CN104984122A (en) | Chinese herbal medicament for treating tetanus and preparation method thereof | |
| CN104771637A (en) | Cholagogic and lithagogue agent for treating gallstone and preparation method thereof | |
| CN104940811A (en) | External Chinese herba preparation for treating traumatic injury and relieving pain, and preparation method thereof | |
| CN104800524A (en) | Traditional Chinese medicine ointment for relieving muscular pain caused by anesthesia dissipation | |
| CN104645081A (en) | Traditional Chinese medicine capsules for treating trigeminal neuralgia and preparation method thereof | |
| CN104096103A (en) | Traditional Chinese medicine agent for treating uroschesis | |
| CN104474049B (en) | A kind of Traditional Chinese medicinal spray and preparation method thereof | |
| CN107320560A (en) | A kind of pain, which is scalded, treats agent and preparation method thereof | |
| CN106913751A (en) | A kind of Chinese medicine preparation for treating stomach trouble, medicament and preparation method thereof and instructions of taking | |
| CN103006770A (en) | Chinese medicinal composition for treating rheumatism and rheumatoid | |
| CN102988481A (en) | Traditional Chinese medicine composition for treating rheumatism and rheumatoid | |
| CN105596849A (en) | Traditional Chinese medicine fuming and washing solution for treating external piles and preparing method of traditional Chinese medicine fuming and washing solution | |
| CN103861062A (en) | Traditional Chinese medicine composition for treating rheumatoid diseases and preparation method thereof | |
| CN104324252A (en) | Traditional Chinese medicine preparation for treating sudden dizziness | |
| CN103861063A (en) | Traditional Chinese medicine composition for treating rheumatism and rheumatoid diseases and preparation method thereof | |
| CN103861064A (en) | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150218 |
|
| RJ01 | Rejection of invention patent application after publication |