CN104324414B - Medical implant - Google Patents
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- CN104324414B CN104324414B CN201410706108.2A CN201410706108A CN104324414B CN 104324414 B CN104324414 B CN 104324414B CN 201410706108 A CN201410706108 A CN 201410706108A CN 104324414 B CN104324414 B CN 104324414B
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- medical
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- embedded material
- biodegradable
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- 239000007943 implant Substances 0.000 title claims abstract description 38
- 239000000463 material Substances 0.000 claims abstract description 177
- 238000006065 biodegradation reaction Methods 0.000 claims abstract description 17
- 238000010276 construction Methods 0.000 claims description 13
- 239000002131 composite material Substances 0.000 claims description 12
- 238000003780 insertion Methods 0.000 claims description 7
- 230000037431 insertion Effects 0.000 claims description 7
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 claims description 5
- 239000004952 Polyamide Substances 0.000 claims description 5
- -1 condensing model Polymers 0.000 claims description 5
- 229920002647 polyamide Polymers 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 5
- 238000009826 distribution Methods 0.000 claims description 4
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 229910010293 ceramic material Inorganic materials 0.000 claims description 2
- 230000012010 growth Effects 0.000 abstract description 8
- 230000035876 healing Effects 0.000 abstract description 6
- 150000001875 compounds Chemical group 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000011084 recovery Methods 0.000 abstract 1
- 238000002513 implantation Methods 0.000 description 21
- 229910052751 metal Inorganic materials 0.000 description 20
- 239000002184 metal Substances 0.000 description 20
- 210000000988 bone and bone Anatomy 0.000 description 12
- 241000196324 Embryophyta Species 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000001771 impaired effect Effects 0.000 description 6
- 150000002739 metals Chemical class 0.000 description 6
- 229910052758 niobium Inorganic materials 0.000 description 6
- 239000010955 niobium Substances 0.000 description 6
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 6
- 229910052715 tantalum Inorganic materials 0.000 description 6
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 6
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 239000010936 titanium Substances 0.000 description 5
- 229910052719 titanium Inorganic materials 0.000 description 5
- 239000000919 ceramic Substances 0.000 description 4
- 238000007711 solidification Methods 0.000 description 4
- 230000008023 solidification Effects 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229910017053 inorganic salt Inorganic materials 0.000 description 3
- 238000007747 plating Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000000280 densification Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- PGTXKIZLOWULDJ-UHFFFAOYSA-N [Mg].[Zn] Chemical compound [Mg].[Zn] PGTXKIZLOWULDJ-UHFFFAOYSA-N 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011536 re-plating Methods 0.000 description 1
- 239000003870 refractory metal Substances 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a medical implant with a compound structure. The medical implant is compounded by two medical implant materials. The medical implant is characterized in that the biodegradation speeds of two medical implant materials are different; the two medical implant materials are jogged with each other, and is of an interwoven compound structure to form a dense body; any medical implant material still keeps respective biological performance and physical and mechanical properties, and is a continuous structure body. The medical implant with the structure characteristics can provide a multi-level recovery space for restoration of the implanted part, and provides relatively long growth time for normal tissue; gradually allowed implant space is biodegraded by the medical implant material in fact to exchange relatively long growth time for the normal tissue; and the medical implant is beneficial to being suitable for the natural healing process of a damaged host implant part.
Description
The present patent application is application number 2011104403934,26 days December 2011 applying date, a kind of denomination of invention " doctor
With implantation piece " divisional application.
Technical field
The present invention relates to a kind of medical embedded material, particularly a kind of Medical implant with composite construction.
Background technology
Medical embedded material refers to plant, buries, the impaired or diseased region that is fixed on host, supports, repairs, substituting its work(
Can the special medical disposable materials of a class, be that a class has property and function, reproduce for artificial organ, surgery is repaiied
Again, physiotherapy and rehabilitation, medical diagnosis on disease and treatment, the material that tissue, blood are had no adverse effects.
Medical embedded material can be classified by materials application position, the such as hard tissue material such as bone, cartilage, tooth, wherein uses
It is a critically important class medical embedded material in the hard tissue material of orthopaedics.
Medical embedded material can also be classified by the biodegradability of material, such as biodegradable medical embedded material with
Not biodegradable medical embedded material；And different biodegradable medical embedded materials, they are in the host of implantation
Interior biodegradation rate is generally also different, faster or slower.
Medical embedded material substantially can be divided into several classes such as metal, pottery and polymer by material classification itself.As knee joint
The displacement material of the bearing type sclerous tissueses such as joint, marrow joint, fracture fixation and artificial bone, metal, pottery and polymer respectively have it
Advantage and deficiency；So far, for the consideration of intensity and safety, skeleton derivant of bioceramic and humans and animals etc.
As mutually give the certain biocompatibility of metal and biological activity as coating or second, and because metal material has other materials
High mechanical properties and excellent fatigue behaviour that material can not be compared, are still now the biological material of clinically most widely used load
Material.
With science and technology and the developing rapidly of medical science, at present, metal medical embedded material is made porous metals medical embedded
Material comes true, and this kind of material has the important and special purposes for the treatment of osseous tissue wound and bone formation necrosis etc..As
Porous metals rustless steel, porous metals titanium, porous metals tantalum, porous metals niobium, porous magnesium zinc etc., they are as osseous tissue wound
The porous embedded material using with bone formation necrosis therapeutic, its porosity should reach 30～80%, and hole all connects and uniform
Distribution, is allowed to i.e. consistent with body bone tissue growth, and the weight of lightening material of should trying one's best itself, and is made with being suitable for human body implantation
With.At present, refractory metals tantalum, niobium can have been made to have and higher be uniformly distributed interconnected pore and be adapted with human body
Physical and mechanical propertiess, are increasingly becoming and ensure that the important of freshman bone tissue's normal growth connects and composes material pieces.
Emphasize as front, as the hard tissue implanting material of orthopaedics, except possessing certain biocompatibility and biology
Activity, it also needs to the physical and mechanical propertiess adaptable with human body, has corresponding connection supporting by force to reach in implantation human body
Degree；More importantly it need to have higher be uniformly distributed interconnected pore, with ensure freshman bone tissue have normal grow empty
Between and repair time.As medical implant, these demands are conflicting, are intended to more normal to freshman bone tissue's offer
Growing space, embedded material just should have more interconnected pores；And when being continuously increased with the porosity of embedded material, it
Other again often up to required less than human body implantation correlated performances of the physical and mechanical propertiess such as bearing strength.And the usual impaired portion of human body
The implantation space of position is very limited, and implantation piece will meet the porosity of physical and mechanical propertiess and Geng Gao simultaneously, and this porous is medical
Embedded material normal growth space to freshman bone tissue's offer in limited implantation space is substantially by embedded material
Porosity is determined.
Also have in prior art and support strength is solved as basal layer using a kind of biological and medicinal implant material, more thereon
Another kind of biological and medicinal implant material of coating gives certain biocompatibility and biological activity, and their binding sites each other are only
It is that a kind of face combines, the normal healing process phase that the Medical implant of this composite construction still can not well with impaired host
Coupling, is unfavorable for that host is impaired or the reparation of diseased region.
Content of the invention
It is an object of the invention to provide a kind of have the medical plant being suitable for that repairing supports and normal healing process matches
Enter part.
The object of the present invention is achieved like this：A kind of Medical implant, it is by two or more medical embedded materials
Compound constitute it is characterised in that：The biodegradation rate of various medical embedded materials is different；Various medical embedded materials are each other
Chimeric and in intertexture shape composite construction constitutes DB；Any of which medical embedded material still keeps its property biology alone
Energy and physical and mechanical propertiess, and respectively one continuous structure body.
The present invention of this construction featuress why from the medical embedded material that biodegradation rate is different, be in order to
The reparation of implant site provides multi-level healing space, to the longer growth time of normal structure, actually with medical plant
Enter the implantation space that material biodegradation progressively reserves and exchange the longer growth time of normal structure for, more conducively plant with impaired host
The normal healing process entering position is mutually suitable.
Preferred embodiments of the present invention are to constitute corresponding cause using two kinds of different medical embedded materials of biodegradation rate
Dense body, that is, described DB is to be interweaved with negative and positive mode structure each other by two kinds of medical embedded materials with being fitted together to, and every kind of medical embedded
Material is to continuous the external boundary maximum space being limited and the DB external boundary institute being made up of them extending of its stereo directional
The maximum space limiting is identical or substantially suitable.Negative and positive mode structure described herein can visually be interpreted as both from Cheng Lian
The medical embedded material of continuous structure is a kind of " chiral structure " each other, and they are not to be in simply the matched molds knot that one side combines
Structure, but complexly crisscross intertexture chimeric surface, the DB of the supporter of other side each other, this construction featuress
The present invention one is easily to be obtained, and two is that the DB constituting from two kinds of medical embedded materials for continuum is also easier to reach plant
Enter the requirement of the support strength at position, and two healings can be provided due to the difference of degradation speed in identical implantation space again
Space, is more beneficial for the reparation of impaired host.
So-called biodegradation rate refers to medical embedded material biodegradable speed in host's body of implantation；Biological
The different medical embedded material of degradation speed, may refer to the medical embedded material biodegradation in host's body of implantation adopting
But it is also possible to be a kind of extreme case, one of which is not biodegradable medical embedded material, another for speed faster or slower
Planting is biodegradable medical embedded material.Currently preferred two kinds of medical embedded materials are it is simply that a kind of is can not be biological
The porous medical embedded material of degraded, another kind of is biodegradable medical embedded material；Such not biodegradable many
It is easy to get in the medical embedded material prior art of hole, on this material, the hole of equally distributed continuous insertion adopts existing skill simultaneously
The conventional meanses of art are also easily filled up completely with, by biodegradable medical embedded material, the composite construction constituting DB.Obviously,
Both medical embedded materials all keep its biology performance alone and physical and mechanical propertiess, also respectively one continuous structure
Body；It is obvious that the hole of porous medical embedded material is filled by another kind of medical embedded material, and in fine and close internal another kind
The space reserving in continuous structure body medical embedded material is equally to be filled by the porous medical embedded material of continuous structure body,
It is that both holes are mutually continuously filled by other side, so that every kind of medical embedded material is outer to the continuous extension of its stereo directional
The maximum space that border is limited is identical with the maximum space that the DB external boundary that they are constituted is limited or substantially quite
Become easily to realize.
The further preferred scheme of the present invention is described not biodegradable porous medical embedded material is that porous is medical
Metal implant material or porous medical ceramic embedded material；Described biodegradable medical embedded material is biodegradable medical
Macromolecular material or methylol inorganic salt materials.
Wherein the preferred scheme of porous medical metal implanted material is using as porous tantalum, porous niobium, POROUS TITANIUM or porous
Rustless steel etc..Biodegradable medical macromolecular materials be polyester, poe, condensing model, polyamide, poly- alpha-cyanoacrylate or
Poly phosphazene.
The Medical implant that the present invention provides, can also be complete by three kinds of different medical embedded materials of biodegradation rate
Entirely it is fitted together to and constitutes DB in intertexture shape composite construction, three kinds of internal medical embedded materials of described densification are complementary structure
Interweave chimeric, and the maximum space that limited to the continuous external boundary extending of its stereo directional of every kind of medical embedded material and three
The maximum space that the complementary DB external boundary constituting is limited is identical or substantially suitable.
Three kinds of medical embedded materials are combined the DB of composition, preferably by a kind of medical plant of not biodegradable porous
Enter material and other two kinds of biodegradable medical embedded materials are constituted；Wherein on porous medical embedded material, distribution continuously passes through
Logical hole is respectively adopted depositional mode by other Biodegradable materials or/and plating mode is filled with, until being formed
DB.Certainly, when a kind of porous medical embedded material is as " the porous body support " of Medical implant, it is distributed thereon
The hole of continuous insertion using first depositing or can also electroplate a kind of biodegradable medical embedded material layer, more solid using grouting
Change and fill another kind of biodegradable medical embedded material layer, until forming DB.The gradation no matter this section refers to deposits not
Same medical embedded material layer；Or electroplate different medical embedded material layers by several times；Or first deposit re-plating；Or first electroplate and sink again
Long-pending；Or first deposit solidification of being in the milk again；Or first electroplate solidification of being in the milk again, it is provided to form a kind of DB, more importantly
Meet the maximum space that in described DB, every kind of medical embedded material is limited to the continuous external boundary extending of its stereo directional
The maximum space that the DB external boundary that constitute complementary with three is limited is identical or substantially suitable.It is known that working as these three
After medical embedded material forms DB, each of which continuous structure body must become " the porous body of other medical embedded materials
Support ".
Similarly, it is preferably the medical embedded material of not biodegradable porous with regard to three kinds of medical embedded material one of which
Expect for porous medical metal implanted material or porous medical ceramic embedded material；Described biodegradable medical embedded material is can
Biodegradation medical macromolecular materials or methylol inorganic salt materials.
The preferred scheme of porous medical metal implanted material is using as porous tantalum, porous niobium, POROUS TITANIUM or porous stainless
Steel etc..Biodegradable medical macromolecular materials are polyester, poe, condensing model, polyamide, poly- alpha-cyanoacrylate or poly- phosphine
Nitrile.
The not biodegradable porous metals medical embedded material reported in the market or on document or porous doctor
Can be the selection of Medical implant of the present invention with ceramic material, these porous medical embedded materials have the hole of continuous insertion
The implantation that gap meets human body requires, and biodegradable medical macromolecular materials is made molten by prior art and is irrigated filling out
Fill to re-sinter and make；Or the depositional mode by prior art or/and plating mode filling make that described implantation piece becomes can
OK.
In sum, beneficial effects of the present invention are as follows：
Due to selected not biodegradable porous medical embedded material in above-mentioned Medical implant and another
Or multiple biodegradable medical embedded material, they all keep biology performance and the physical and mechanical propertiess of itself, all accord with
Cooperate as the medical embedded related request of human body.Because they are fitted together to the DB in the composite construction constituting with interweaving each other,
Its mechanical strength is higher than the intensity of simple porous medical embedded material；In the case of mechanical strength identical, again can will be many
The porosity of hole medical embedded material improves once again, and the intensity that led to due to the increase of porosity is reduced, can be by being filled in
Other biodegradable medical embedded material reinforcement therein or raising.Such Medical implant, in identical implantation
The growing space of the bigger freshman bone tissue of host in space, can be supplied to than the embedded material of prior art, with can give birth to
The biodegradation of the medical embedded material of thing degraded, provides the growth gradually expanding empty to the normal growth of freshman bone tissue
Between, and the freshman bone tissue constantly growing then substitutes biodegradable medical embedded material and occupies in not biodegradable porous
In the hole of medical embedded material, to supplement the support strength of Medical implant, to meet the normal use of host's damaged part
Require.
Medical implant of the present invention, that is simple with existing coating for metal surfaces or two kinds of medical embedded materials
The compound composite implantation material constituting is compared, and the time and space being supplied to host's reparation in identical implantation space is longer more
Greatly.If using the composite construction being simply fitted together to or being superimposed two or more medical embedded materials, their mutual independence
The implantation volume determining this implantation piece be volume sum that the extraneous end that various medical embedded materials extend is limited although
This implantation piece is different due to their biodegradation rate, also pre- leaves a blank to what host provided that normal structure at two grows into
Between, but, it but needs bigger implantation space, the described product identical with the present invention could be provided to repair to normal structure
Time.
Brief description
The invention will be further described with reference to the accompanying drawings and examples
Fig. 1 is the structural representation of the embodiment of the present invention 1；
Fig. 2 is the structural representation of the embodiment of the present invention 2；
Fig. 3 is A portion enlarged drawing in Fig. 2.
Specific embodiment
Embodiment 1：Referring to Fig. 1, a kind of Medical implant, it is combined by two kinds of medical embedded materials and constitute, both
The biodegradation rate of medical embedded material is different, and they are fitted together to each other and the composite construction in intertexture shape constitutes a DB；
Any of which medical embedded material still keeps its biology performance alone and physical and mechanical propertiess, and respectively one continuous structure
Body.
With further reference to Fig. 1, medical embedded material 1 is with medical embedded material 2 each other with the negative and positive mode structure chimeric structure of intertexture
Become DB, and the maximum space that limited to the continuous external boundary extending of its stereo directional of every kind of medical embedded material and they
The maximum space that the DB external boundary constituting is limited is identical.
Two kinds of medical embedded materials of this example are respectively not biodegradable porous medical embedded material（As porous is medical
Metal implant material, porous medical ceramic embedded material）With biodegradable medical macromolecular materials（Polyester, poe, poly-
Anhydride, polyamide, poly- alpha-cyanoacrylate or poly phosphazene）；Wherein medical embedded material 1 is porous medical embedded material, medical plant
Entering material 2 is biodegradable medical macromolecular materials, and the hole quilt of the continuous insertion of distribution on porous medical embedded material can
Biodegradation medical macromolecular materials are filled up completely with the composite construction constituting described DB.
The porous medical metal implanted material of the present invention can be porous tantalum well known in the prior art, porous niobium, porous
Titanium or porous stainless steel etc..Using porous medical metal implanted material as Medical implant of the present invention " porous body support "
When, molten made by biodegradable medical macromolecular materials in addition, and the grouting solidification using prior art is filled.
Embodiment 2：Referring to Fig. 2, a kind of Medical implant, it is by three kinds of different medical embedded materials of biodegradation rate
It is completely fitted the DB in intertexture shape of composition；Any of which medical embedded material still keep its biology performance alone and
Physical and mechanical propertiess, and certainly for a continuous structure body.
The internal medical embedded material of described densification 1 is interweaved with medical embedded material 2 and medical embedded material 3 complementary structure
Chimeric, and the maximum space that every kind of medical embedded material is limited to the continuous external boundary extending of its stereo directional is complementary with three
The maximum space that the DB external boundary constituting is limited is identical.
Wherein medical embedded material 1 is not biodegradable porous medical embedded material, medical embedded material 2 and medical
Embedded material 3 is biodegradable medical embedded material, and the biodegradable medical embedded material in this example is biology to drop
Solution medical macromolecular materials, these three medical embedded materials constitute Medical implant of the present invention；Wherein porous is medical embedded
On material 1, the hole of the continuous insertion of distribution is respectively adopted depositional mode by other biodegradable medical macromolecular materials
Or/and plating mode is filled with, until forming DB.
Certainly, when a kind of porous medical embedded material is as " the porous body support " of Medical implant, it is distributed thereon
Continuous insertion hole can also using first deposit or electroplate a kind of biodegradable medical embedded material layer, then using grouting
Another kind of biodegradable medical embedded material layer is filled in solidification, until forming DB.
Porous medical embedded material is porous medical metal implanted material or porous medical ceramic embedded material；Described give birth to
Thing degraded medical embedded material is biodegradable medical macromolecular materials or methylol inorganic salt materials.
Wherein the preferred scheme of porous medical metal implanted material is using as porous tantalum, porous niobium, POROUS TITANIUM or porous
Rustless steel etc..Biodegradable medical macromolecular materials be polyester, poe, condensing model, polyamide, poly- alpha-cyanoacrylate or
Poly phosphazene.
Claims (2)
1. a kind of Medical implant, be combined by two kinds of medical embedded materials constituting it is characterised in that：Both is medical embedded
The biodegradation rate of material is different, and they are fitted together to each other and the composite construction in intertexture shape constitutes a DB；Any of which
Medical embedded material still keeps its biology performance alone and physical and mechanical propertiess, and respectively one continuous structure body；Described
Medical embedded material is constituted DB so that negative and positive mode structure intertexture is chimeric each other with medical embedded material, and every kind of medical embedded material
Expect that the DB external boundary that the maximum space being limited to the continuous external boundary extending of its stereo directional is constituted with them is limited
Maximum space identical；Two kinds of described medical embedded materials are respectively not biodegradable porous medical embedded material and can
Biodegradation medical macromolecular materials, described not biodegradable porous medical embedded material implants material for porous medical ceramic
Material；Described biodegradable medical macromolecular materials are made molten it is irrigated filling and re-sinter, the medical plant of described porous
The hole entering the continuous insertion of distribution on material is filled up completely with the described DB of composition by biodegradable medical macromolecular materials
Composite construction.
2. the Medical implant as described in claim 1 it is characterised in that：Described biodegradable medical macromolecular materials are
Polyester, condensing model, polyamide, poly- alpha-cyanoacrylate or poly phosphazene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410706108.2A CN104324414B (en) | 2011-12-26 | 2011-12-26 | Medical implant |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110440393.4A CN103170013B (en) | 2011-12-26 | 2011-12-26 | Medical implant |
| CN201410706108.2A CN104324414B (en) | 2011-12-26 | 2011-12-26 | Medical implant |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110440393.4A Division CN103170013B (en) | 2011-12-26 | 2011-12-26 | Medical implant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104324414A CN104324414A (en) | 2015-02-04 |
| CN104324414B true CN104324414B (en) | 2017-02-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410706108.2A Active CN104324414B (en) | 2011-12-26 | 2011-12-26 | Medical implant |
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| CN (1) | CN104324414B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007183A (en) * | 2006-12-01 | 2007-08-01 | 华南理工大学 | Preparation method of an in situ pore-forming self-setting calcium phosphate composite tissue engineering scaffold |
| CN101474428A (en) * | 2009-01-16 | 2009-07-08 | 浙江普洛医药科技有限公司 | Polyester reinforced degradable porous gastrosil compound stent material, preparation and use |
| CN101983728A (en) * | 2010-11-09 | 2011-03-09 | 厦门大学 | Shell porous hydroxyapatite basal bone repair material and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017170A1 (en) * | 2006-08-10 | 2008-02-14 | Ao Technology Ag | Biomedical polymer material for tissue repair and engineering |
-
2011
- 2011-12-26 CN CN201410706108.2A patent/CN104324414B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007183A (en) * | 2006-12-01 | 2007-08-01 | 华南理工大学 | Preparation method of an in situ pore-forming self-setting calcium phosphate composite tissue engineering scaffold |
| CN101474428A (en) * | 2009-01-16 | 2009-07-08 | 浙江普洛医药科技有限公司 | Polyester reinforced degradable porous gastrosil compound stent material, preparation and use |
| CN101983728A (en) * | 2010-11-09 | 2011-03-09 | 厦门大学 | Shell porous hydroxyapatite basal bone repair material and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104324414A (en) | 2015-02-04 |
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