CN104324318B - A kind of outer wiping analgesic drug product and its preparation application method - Google Patents
A kind of outer wiping analgesic drug product and its preparation application method Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses wiping analgesic drug product outside one kind and its preparing application method, belong to technical field of traditional Chinese medicines.The medicine is made up of the bulk drug of following weight percents, fevervine 21%, Stephania tetrandra 21%, Piper longum 11%, cassia twig 11%, frutus cnidii 10.5%, curcuma zedoary 10.5%, Chinese azalea 5%, vomiting nut 5%, safflower 5%.Its preparation method is that above-mentioned raw materials medicine is cut into disconnected or sheet, dries, is then placed in cylinder altar, and 1500~1800 grams 50~55 degree of soaking in Chinese liquor medicine 7~10 days is added by 100 grams of medicines, the dregs of a decoction is filtered and this decoction is made.The medicine has the beneficial effect that medicinal liquid osmosis power is strong, analgesic is rapid, detumescence effect is good, easy to use, have no side effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of outer wiping analgesic drug product and its preparation and application.
Background technology
The cervical spondylopathy of medical domain treatment for a long time, scapulohumeral periarthritis, osteoproliferation, protrusion of lumber intervertebral disc, abjection, centrum are slided
De-, centrum dislocation, the wrong deformation of pelvis torsion, sciatica, pain of the knee joint etc. are all intractable disease, the treatment that doctor trained in Western medicine is typically taken
Method have surgical operation, hormone anodyne for oral administration, the closing of pain spot hormone drug injection, outer note plaster etc., demonstrate,proved by clinical practice
Bright, these treatment methods belong to therapy of curing the symptoms, not the disease；The treatment method that the traditional Chinese medical science is typically taken has traction, acupuncture, cupping jar, pin
Knife, massage, massage, outsourcing Chinese medicine and take orally various balls, dissipate, the method such as cream, pellet, but all there is decoction and see through that power is strong, analgesic
With detumescence effect it is bad, have certain side effect the problems such as.Some analgesics being made up of Chinese herbal medicines are disclosed in the prior art
Medicament, but still there is the defects such as medicinal liquid osmosis power is not strong, administration time length, effect of drugs be not obvious.Deposited for prior art
Drawbacks described above, it is an object of the invention to provide a kind of medicinal liquid osmosis power is strong, analgesic is rapid, detumescence effect is good, easy to use,
The anodyne having no side effect.
The content of the invention
The present invention is to be achieved through the following technical solutions above-mentioned purpose, a kind of outer wiping analgesic drug product, it is characterized in that under
The bulk drug of row percentage by weight is made, fevervine 21%, Stephania tetrandra 21%, Piper longum 11%, cassia twig 11%, frutus cnidii 10.5%, curcuma zedoary
10.5%, Chinese azalea 5%, vomiting nut 5%, safflower 5%.
The preparation method of medicine of the present invention is：Above-mentioned raw materials medicine is cut into disconnected or sheet, dries, is then placed in cylinder altar,
The ratio of 1500~1800 grams of 50~55 degree of white wine is added in 100 grams of medicines, soak medicine 7~10 days filters the dregs of a decoction and this is made
Decoction.
The medicine of the present invention can extract medicament effective component with the method for prior art and paste or patch is made.
The application method of medicine of the present invention is：The decoction for taking the 10-20ml present invention made, decoction infiltration is double at one piece
After layer hospital gauze, stick on the painful area of patient, then be covered on medical husky cloth and add with double-deck 50 DEG C of medicine of a warm nature towel
Temperature, is covered on medicine of a warm nature towel with plastic foil, is kept on the plastic film 20-30 minutes with two sandbag pressures afterwards, daily to patient
Treatment 1 time, it is each 20-30 minutes.
Compared with prior art, beneficial effects of the present invention have：The present invention is prevented from Chinese azalea, fevervine, vomiting nut, the Chinese
Oneself is as main ingredient, then compatibility Piper longum, cassia twig, safflower, curcuma zedoary, frutus cnidii, as adjuvant, Chinese azalea florigen containing cuckoo, Chinese photinia are plain,
Fevervine A prime containing alkaloid, alkaloid B prime, volatile oil plus non-alkali, bitter theophylline, vomiting nut contain brucine, strychnine alkali,
Stephania tetrandra contains hanfangchin A, hanfangchin B and hanfangchin C, all with very strong narcoticness and analgesic effect, clinical many
External curing sciatica, pain in waist and lower extremities and rheumatalgia；Wherein Piper longum, cassia twig, safflower, curcuma zedoary mainly contain volatile oil, blood vessel
Expand the active ingredient such as element, with stimulating the menstrual flow, qi-regulating, the effect of close blood, analgesic, the scattered stasis of blood；Frutus cnidii, which has, mitigates cell by Spurs
The cause of Ji Hou merocrine secretions serotonin is itched effect.After the scientific compatibility of above-mentioned 9 taste Chinese medicine, medicine tool produced by the present invention
There are anxious strong ground permeability and analgesic effect, medication can reach for 20-30 minutes stimulates the menstrual flow, dissipates the stasis of blood, detumescence, the good result of analgesic, can
For treating cervical spondylolisthesis, dislocation, protrusion of lumber intervertebral disc, abjection, bulging, centrum dislocation, pelvis torsional deformation and sciatic nerve
Bitterly, the disease such as muscular paralysis.The made decoction of the present invention is effective to the patient of each different age group, body surface local application pair
Skin irritatin is small, and the allergic rate in medication region is less than 2%, and after being discontinued 24 hours, allergy Lock-out does not need to make any
Processing.
The pharmacological effect of each component of the present invention is as follows：
1st, Chinese azalea（RhododendronmolleG.Don）, also known as Rhododendron molle, Azalea pontica, Solanum lasiocarpum, beautiful branch, category Du
Juan Hua sections, Rhododendron.Chinese azalea is warm-natured, pungent, and return liver warp is poisonous, and active ingredient is andromedotoxin, cuckoo florigen, Chinese photinia
Element, the effect of with analgesia, wind dispelling, dehumidifying, can control rheumatoid arthritis stubborn, skin stubborn dermatitis, fracture is grieved, as surgery anesthesia agent.Face
Bed is used for narcotic analgesic, dispelling wind and eliminating dampness.It is used for sciatica, pain in waist and lower extremities, traumatic injury and rheumatalgia outside.The present invention is selected should
Medicine treats various pain.
2nd, fevervine（Paederia scandens (Lour.) Merr.）, the complete stool of genus rubia section plant, also known as ringdove
Meal, main arrow rattan, smelly dung rattan, Chinese Fevervine Herb etc..Fevervine is mild-natured, sweet, acid, the thoughts of returning home, liver, numbness, kidney channel, containing volatile oil plus unprovoked
Alkali, bitter theophylline etc., cure mainly dispelling wind and eliminating dampness, removing toxicity for detumescence, promoting blood circulation and stopping pain etc..Research shows that the medical instrument has functions that strong pain-relieving.
The present invention makees external application narcotic analgesic medicine from the medicine.
3rd, vomiting nut（Strychnos nux-vomica L.）, the mature seed for money scarabaeidae vomiting nut plant of being born in the year of horse.Property it is bitter
It is cold, it is poisonous.Return liver, spleen two are passed through, and contain alkaloid, predominantly brucine（Strychnine）And strychnia, cure mainly it is inducing meastruation to relieve menalgia,
Sweeling-eliminating medicine powder section, excited spinal nerve etc..Rheumatic arthralgia, pain due to blood stasis, wind-cold-dampness arthralgia, whole body are arrested tight distending pain it is numb,
Muscle weakness, facioplegia etc. have therapeutic action.The present invention treats Sciatica from the medicine.
4th, Stephania tetrandra, belongs to Menispermaceae Fourstamen Stephania Root（StephaniatetrandraS. Moore）Dry rhizome, You Mingshi
Toad, pungent, hardship is cold in nature, cures mainly expelling wind and clearing away cold, dehumidifying of purging heat, filter joint, detumescence pain.Containing hanfangchin A, Stephania tetrandra second
Element, hanfangchin C, glycosides displayed volatile oil etc., mentioned component have antipyretic, analgesia, anti-inflammatory, diuresis, antiallergy through pharmacology checking
Acted on relaxed muscle, therefore ethanol extract is for muscle relaxant when performing the operation.The present invention is from medicine treatment muscular tone type four
Limb and the sour distending pain of waist.
5th, Piper longum（Piper longum Linn）, belong to Piperaceae（Piperaceae）Piper.It is warm-natured, pungent.For head
Bitterly, trusted subordinate's crymodynia, controls general debility, cloudy sweat.Mainly contain volatile oil, formic acid.The present invention selects the formic acid and volatile oil pair of the medicine
The dilating effect of chrotoplast and capillary, reaches alleviating pain and detumescence purpose.
6th, safflower（Carthamus tinctorius L.）, category feverfew dries flower bandit, and bitter is warm-natured, effectively into
Divide containing volatile oil, safflower saponin, glycosides displayed etc., invigorate blood circulation, scattered silt analgesic are cured mainly, for dysmenorrhoea, amenorrhoea, traumatic injury and hemorrhoid
Sore is relieved pain.The present invention is matched somebody with somebody from the permeability of its volatile oil and safflower saponin to the expansion of blood vessel, to the dissolubility of stasis of blood block
Close main ingredient and release the excitant pain that creatine is produced.
7th, cassia twig（Cinnamomum cassia Presl）, the dry twig of Lauraceae aiphyllium plant Chinese cassia tree, sweet property
Temperature, containing active ingredients such as volatile oil, cassia oil, cinnaldehydrum, natrium cinnamicums, cures mainly expelling cold and relieving exterior syndrome, warming meridian, activating YANG and prormoting functioning of QI,
Eliminating cold to stop pain.The present invention makes the chrotoplast of half keratinization soften hole skin and expanded by the heat leak expansion of blood vessels of Ramulus Cinnamomi Volatile oil etc.
, promote the effective ingredients such as Chinese azalea, vomiting nut to permeate the purpose for reaching deep part muscle and reaching analgesic.
8th, curcuma zedoary（Curcuma zedoaria (Christm.) Rosc）, belong to the root-like stock of zingiberaceous plant.Puckery is pungent, property
Temperature, containing sesquiterpene alcohols, the active ingredient such as a- camphorenes and eucalyptol cures mainly promoting the circulation of qi blood-breaking, alleviate long-pending dissipating bind, solidifying for qi and blood
Stagnant, place food does not disappear.The present invention can make the characteristic that muscle cell gap is expanded using camphorene, eucalyptol under Source, plus
The intercellular serotonin backflow of speed, reduces serotonin and releases pain to the neural stimulation not slightly of muscular fascia, strengthen main ingredient
Permeability, increase analgesic activity.
9th, frutus cnidii（Cnidium monnieri（L.）Cuss.）, belong to the dry mature seed of samphire cnidium monnieri,
Bitter, it is warm-natured, it is slightly poisonous, containing active ingredients such as firpene, isovaleric acid borneol acetate, osthole, Columbianetins, cure mainly
Detoxify desinsection, eliminating dampness, wind-dispelling, antipruritic.Itching-relieving action of the invention by the effective elements of the medicine isovaleric acid borneol acetate, to subtract
Light cell by thermostimulation, itch effect by the cause of merocrine secretion's serotonin.
Embodiment
Below by embodiment, the present invention is further illustrated, but is not limited to embodiment.
Embodiment 1
Take fevervine 210g, Stephania tetrandra 210g, Piper longum 110g, cassia twig 110g, frutus cnidii 105g, curcuma zedoary 105g, Chinese azalea
50g, vomiting nut 50g, safflower 50g, above-mentioned 9 taste Chinese herbal medicine is removed after impurity, is cut into disconnected or sheet, is dried, be then placed in cylinder
In altar, the white wine of 15~18kg50~55 degree is added, soak medicine 7~10 days filters the dregs of a decoction and this decoction is made.In use, taking
The made decoction of the 10-20ml present invention, pain is sticked on by the double-deck hospital gauze that decoction is infiltrated in the cm of one piece of 15 cm × 20
On position, then it is covered on medical husky cloth and is heated with double-deck 50 DEG C of medicine of a warm nature towel, then is covered with the cm plastic foils of 30 cm × 30
On medicine towel, kept on the plastic film 20-30 minutes with 15kg two sandbag pressures of 30cmx40cm afterwards.The present invention is made
Decoction is disabled at skin injury, new open wound, oral cavity, nasal cavity.The made decoction of the present invention can be used for treatment cervical spondylolisthesis,
Dislocation, the clinic such as protrusion of lumber intervertebral disc, abjection, bulging, centrum dislocation, pelvis torsional deformation and sciatica, muscular paralysis
The neck shoulder back pain of upper general term, treatment is once, each 20-30 minutes daily, can cure within general 15-30 days, to each not the same year
Age, the patient of section was effective.The made medicine of the present invention clinically demonstrates 3098, and 2711 are cured completely, 87.5% is accounted for；It is good
Turn 234, account for 7.55%；Invalid 45, account for 1.45%；Allergic 62, account for 0.02%；The drug withdrawal 24 of agents area allergy sufferers is small
Shi Hou, red Lock-out of skin, without making any processing.Now part model case is reported as follows：
Case one：Yang Dexiang, man, 59 years old, Yunnan Province Nujiang Lan Ping county towns gardener cell people, suffer from L5-S1 centrum olisthes and
Pelvis torsional deformation 8 years, in March, 2012 is made with the present invention first with after pelvis rectifier distortion correction pelvis and L5-S1 centrums
Decoction do heat dialysis treatment, it is once a day, each 20-30 minutes, cure within 30 days, follow-up do not recur for 2 years so far.
Case two：Yang Wenzhou, man, 46 years old, Yunnan Province Lincang Feng Qingxian Lu Shi towns people from Deposit of Xiniu Village, suffer from L4-L5 centrums dislocation,
Disc herniation, companion's double lower limb sciatica 6 years, in April, 2010 is first with pelvis rectifier correction pelvis, correcting vertebral dislocation
Afterwards, waist, leg local skin heat dialysis is done to patient with the made decoction of the present invention to treat, it is once a day, each 20-30 minutes,
Cure within 26 days, follow-up is not recurred for 4 years so far.
Case three：Yang Liansheng, man, 22 years old, Dali City, yunnan Province Xi Zhousha people from villages suffered from thoracic vertebrae T7-8 section bone tuberculosis, L2-3
Compression fracture 3 years, in the decoction that the private present invention of 5 month lists in 2007 is made, to patient's the small of the back skin surface 40cmx60cm
Heat dialysis treatment is done at area, once a day, is cured within 36 days, follow-up is not recurred so far.
Case four：Zhang Changbin, man, 46 years old, prosperity cell people in Dali City, yunnan Province ShiShimonoseki town suffered from double knee joint pain, trembled with fear
Cold moist day pain is aggravated, and difficulty in walking, stair activity dysfunction 3 years is seen the doctor for treatment in December, 2012, through clinical diagnosis
For damaging arthralgia, heat dialysis treatment is done with the made decoction of the present invention, it is once a day, each 20-30 minutes, control within 14 days
More.Follow-up is not recurred so far.
Case five：Duan Ruilan, female, 82 years old, Dali City, yunnan Province ShiShimonoseki building constructor worker suffered from compression fracture of lumbar vertebra,
Many centrum osteoproliferations, double knee joint pain in neck shoulder back unknown more than 20 years of distending pain, receives the present invention made in August, 2008
Decoction make heat dialysis treatment, it is once a day, each 20-30 minutes, cure within 16 days, follow-up do not recur so far, and old man is good for so far
.
Case six：Yang Jianlan, female, 29 years old, Dali City, yunnan Province Xi Zhousha people from villages suffered from cervical facet joint dislocation, oppresses vertebra
Arteries, causes headache 5 years in cerebral blood supply insufficiency, and with the sour distending pain of the neck shoulder back of the body, Minor articulus is corrected with cervical vertebra corrector through clinic
Afterwards, heat dialysis treatment is made with the made decoction of the present invention, it is once a day, each 20-30 minutes, cure within 20 days, follow-up in 3 years is extremely
The present does not recur.
Case seven：Huang Chaojun, man, 36 years old, Dali City, yunnan Province ShiShimonoseki town the Seventh Five-Year Plan people from village suffered from pelvis deformation with sacro-iliac joints
Dislocation, causes double lower limb sciatica 2 years, receives pelvis rectifier in March, 2012 and rectifys after correction pelvis, uses institute of the present invention
The decoction of system dominates area to patient's lumbosacral region and double lower limb sciatic nerve and makees heat dialysis treatment, once a day, each 20-30 points
Clock, is cured, follow-up is not recurred so far for 28 days.
Claims (2)
1. a kind of outer wiping analgesic drug product, it is characterized in that being made up of the bulk drug of following weight percents, fevervine 21%, Stephania tetrandra
21%, Piper longum 11%, cassia twig 11%, frutus cnidii 10.5%, curcuma zedoary 10.5%, Chinese azalea 5%, vomiting nut 5%, safflower 5%.
2. a kind of outer preparation method for wiping analgesic drug product according to claim 1, it is characterised in that：Above-mentioned raw materials medicine is cut
Into section or sheet, dry, be then placed in cylinder altar, 1500~1800 grams 50~55 degree of soaking in Chinese liquor is added by 100 grams of medicines
Medicine 7~10 days, filters the dregs of a decoction and this decoction is made.
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| CN201410158718.3A CN104324318B (en) | 2014-04-21 | 2014-04-21 | A kind of outer wiping analgesic drug product and its preparation application method |
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| CN201410158718.3A CN104324318B (en) | 2014-04-21 | 2014-04-21 | A kind of outer wiping analgesic drug product and its preparation application method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1686296A (en) * | 2005-03-30 | 2005-10-26 | 何周荣 | Medicinal composition for treating soreness, its preparation method and application |
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| CN1444952A (en) * | 2002-03-16 | 2003-10-01 | 王守卷 | Wiping and spreading tincture with wide effect and its preparing method |
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| CN1686296A (en) * | 2005-03-30 | 2005-10-26 | 何周荣 | Medicinal composition for treating soreness, its preparation method and application |
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