CN104312021A - Halogenated butyl rubber pad capable of replacing medical synthesized isoprene pad - Google Patents
Halogenated butyl rubber pad capable of replacing medical synthesized isoprene pad Download PDFInfo
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- CN104312021A CN104312021A CN201410522065.2A CN201410522065A CN104312021A CN 104312021 A CN104312021 A CN 104312021A CN 201410522065 A CN201410522065 A CN 201410522065A CN 104312021 A CN104312021 A CN 104312021A
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- Prior art keywords
- pad
- butyl rubber
- film
- extracting
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2312/00—Crosslinking
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- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Sealing Material Composition (AREA)
Abstract
The invention discloses a halogenated butyl rubber pad capable of replacing a medical synthesized isoprene pad, relating to the technical field of preparation methods of medical rubber pads. The halogenated butyl rubber pad is prepared from brominated butyl rubber, brominated butyl rubber, zinc oxide, a silica gel sulfurizing reagent, titanium dioxide and carbon black. The preparation method comprises the steps of preparing raw materials, proportioning, mixing, preforming the pad, vacuum mould pressing sulfur, trimming, acid-base extracting, washing and silicifying, packaging and storing. The halogenated butyl rubber pad capable of replacing the medical synthesized isoprene pad, which is prepared by the method and the components, can be directly contacted with the medicine, can save the inner cap of a combined cap, lowers the puncture force and exfoliation probability, and furthermore lowers the cost of the combined cap for pharmaceutical factories.
Description
Technical field:
The present invention relates to medicinal rubber pad manufacture method technical field, be specifically related to a kind of halobutyl glue gasket replacing medicinal synthesis isoprene pad.
Background technology:
Medical grade rubber pad is the heat-resistant powder filler goods with definite shape, size, for the sealing of the medicinal ampuliform vessel port such as glass, plastics.Harmful solvends such as the requirement of this pad sizing material is not leaded, mercury, arsenic, barium, bottle stopper itself can not have ejecta.Generally make of sizing material, produce by compression molding.Be widely used in pharmacy and medical industry.But normal pad is all medicinal synthesis isoprene pad, and conventional gaskets aftertreatment all needs to carry out silication in the process that medicinal synthesis isoprene pad is produced, the object of silication is coated with last layer silicon fiml at gasket surface, so that the packing of pad and gland, prevent from being clamminess in medicine storage process simultaneously, surface friction is reduced in transport handling process, avoid because friction causes buffings particulate, and medicinal synthesis isoprene pad needs and plastic combination cover assembling uses, medicinal isoprene pad directly can not contact medicine, plastic combination cover must have inner cap, which adds cost and bring trouble to use.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of directly to contact medicine, can save the inner cap of combination cover, reduce puncture force and exfoliation probability and can to the halobutyl glue gasket replacing medicinal synthesis isoprene pad of pharmaceutical factory's reduction group lid cost.
Technical problem to be solved by this invention adopts following technical scheme to realize:
Replace a halobutyl glue gasket for medicinal synthesis isoprene pad, be made up of following component:
| The name of an article | Proportion (mass ratio) |
| Brominated butyl rubber | 60％ |
| Calcined kaolin | 33～40％ |
| Zinc oxide | 4％ |
| Silica gel vulcanizing agent | 0.1～0.2％ |
| Titanium dioxide | 1～2％ |
| Carbon black | 0.1～0.2％ |
Replace a halobutyl glue gasket for medicinal synthesis isoprene pad, its preparation method mainly comprises the following steps:
1, brominated butyl rubber, calcined kaolin, zinc oxide, silica gel vulcanizing agent, titanium dioxide and carbon black are weighed up with electronic scale respectively in proportion, by part proportioning, stand-by;
2, the sizing material prepared is carried out kneading according in the number input milling machine of component successively, the order of input is thrown in by as many as less successively according to component, and sizing material is made in kneading after half an hour;
3, the sizing material after kneading is put in mill begin to pratise, by mill, sizing material is pressed into rectangular film;
4, the rectangular film be pressed into after beginning to pratise is put into the size being tailored into by film in fixed length slitter and meeting processing requirement;
5, the film after having tailored is put in vacuum vulcanization machine carry out sulfidizing, and utilize mould film to be pressed into the specification set in advance;
6, the film of sulfuration out aftershaping to be rendered to pad on plug pad deflasher except limit of removing photoresist, plug is shaped in external form;
7, the pad after sizing is put in extracting tank and is carried out soda acid extracting, can guarantee after extracting the high clarity of butyl rubber pad, aseptic, without bacterial endotoxin, noresidue moisture content;
8, the product of extracting is put in medical rubber stopper special cleaning machine again clean, after cleaning, carry out drying and processing;
9, packed by processing requirement by the qualified product of cleaning after having processed, packaging will aseptically operate, and in point, bag and outsourcing two procedures are carried out;
10, packaged qualified product are carried out point specifications and models and enter stockyard.
In this processing method, its key is extraction process, because the butyl rubber pad after extracting has better clarity and ensure that sterility and inside are without bacteriotoxin and noresidue moisture, cleaning in addition after extracting can make the clarity of product, particulate and silicone oil reach processing requirement, such halobutyl glue gasket directly can contact medicine, and can save combination cover inner cap, reduce puncture force and exfoliation probability, on the other hand reduce group lid cost to pharmaceutical factory; And medicinal synthesis isoprene pad needs and plastic combination cover assembling uses, medicinal isoprene pad directly can not contact medicine, and plastic combination cover must have inner cap, uses and also relatively bothers.
Below producing and manufacturing technique, flow process are summarized as follows:
Starting material-proportioning-mixing-film premolding-vacuum molding sulphur-trimming-soda acid extracting-cleaning silication-packaging-warehouse-in.
Common method silication is the aftertreatment technology that pad is produced, conventional gaskets aftertreatment all needs to carry out silication, the object of silication is coated with last layer silicon fiml at gasket surface, so that the packing of pad and gland, prevent from being clamminess in medicine storage process simultaneously, in transport handling process, reduce surface friction, avoid because friction causes buffings particulate.But silicone oil can produce following problem:
1. infusion products is at the high-temperature sterilization through 120 DEG C (1 ~ 3h), after being cooled to normal temperature, can find bottle has " hanging pearl " phenomenon, because the molecular thermalmotion aggravation when high temperature of the silicone oil of gasket surface, invest bottle wall after the silicone oil of gasket surface comes off and cause.
2. in the process of silication, the true consumption of silicone oil cannot accurately be controlled, and the coating homogeneity of silicone oil is also difficult to ensure, thus causes cannot effectively controlling silication effect, can only making for judging by pad.In use silication amount is little, can have influence on the problems referred to above, and the conference of silication amount causes film dancing, particulate matter to increase, and also can affect and the consistency of medicine (as liquid is muddy) simultaneously.Under the prerequisite ensureing point packing quality, the remaining silicone oil of butyl rubber gasket surface is the smaller the better, and general control is suitable for 5 ~ 10 micro-grams/cm of scopes.
The invention has the beneficial effects as follows: halobutyl glue gasket directly can contact medicine, and the inner cap of combination cover can be saved, reduce puncture force and exfoliation probability, reduce group lid cost to pharmaceutical factory on the other hand.
Embodiment:
The technique means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with concrete example, setting forth the present invention further.
Replace a halobutyl glue gasket for medicinal synthesis isoprene pad, be made up of following component:
| The name of an article | Proportion (mass ratio) |
| Brominated butyl rubber | 60％ |
| Calcined kaolin | 34.7％ |
| Zinc oxide | 4％ |
| Silica gel vulcanizing agent | 0.1％ |
| Titanium dioxide | 1％ |
| Carbon black | 0.2％ |
Replace a halobutyl glue gasket for medicinal synthesis isoprene pad, its preparation method mainly comprises the following steps:
1, brominated butyl rubber, calcined kaolin, zinc oxide, silica gel vulcanizing agent, titanium dioxide and carbon black are weighed up with electronic scale respectively in proportion, by part proportioning, stand-by;
2, the sizing material prepared is carried out kneading according in the number input milling machine of component successively, the order of input is thrown in by as many as less successively according to component, and sizing material is made in kneading after half an hour;
3, the sizing material after kneading is put in mill begin to pratise, by mill, sizing material is pressed into rectangular film;
4, the rectangular film be pressed into after beginning to pratise is put into the size being tailored into by film in fixed length slitter and meeting processing requirement;
5, put in vacuum vulcanization machine by the film after having tailored and carry out sulfidizing, the time of sulfidizing at 1-2 hour, and utilizes mould film to be pressed into the specification set in advance;
6, the film of sulfuration out aftershaping to be rendered to pad on plug pad deflasher except limit of removing photoresist, plug is shaped in external form;
7, the pad after sizing is put in extracting tank and is carried out soda acid extracting, extracting 3-4 hour, can guarantee after extracting the high clarity of butyl rubber pad, aseptic, without bacterial endotoxin, noresidue moisture content;
8, the product of extracting is put in medical rubber stopper special cleaning machine again carry out cleaning half an hour or repeatedly clean three times, carry out drying and processing after cleaning;
9, packed by processing requirement by the qualified product of cleaning after having processed, packaging will aseptically operate, and in point, bag and outsourcing two procedures are carried out;
10, packaged qualified product are carried out point specifications and models and enter stockyard.
In this processing method, its key is extraction process, because the butyl rubber pad after extracting has better clarity and ensure that sterility and inside are without bacteriotoxin and noresidue moisture, cleaning in addition after extracting can make the clarity of product, particulate and silicone oil reach processing requirement, such halobutyl glue gasket directly can contact medicine, and can save combination cover inner cap, reduce puncture force and exfoliation probability, on the other hand reduce group lid cost to pharmaceutical factory; And medicinal synthesis isoprene pad needs and plastic combination cover assembling uses, medicinal isoprene pad directly can not contact medicine, and plastic combination cover must have inner cap, uses and also relatively bothers.
Below producing and manufacturing technique, flow process are summarized as follows:
Starting material-proportioning-mixing-film premolding-vacuum molding sulphur-trimming-soda acid extracting-cleaning silication-packaging-warehouse-in.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and specification sheets just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (2)
1. can replace a halobutyl glue gasket for medicinal synthesis isoprene pad, it is characterized in that: be made up of following component in mass ratio:
2. can replace a halobutyl glue gasket for medicinal synthesis isoprene pad, it is characterized in that: preparation method comprises the following steps:
(1), by brominated butyl rubber, calcined kaolin, zinc oxide, silica gel vulcanizing agent, titanium dioxide and carbon black weigh up with electronic scale in proportion respectively, by part proportioning, stand-by;
(2), by the sizing material prepared carry out kneading according in the number input milling machine of component successively, the order of input is thrown in by as many as less successively according to component, and sizing material is made in kneading after half an hour;
(3), by the sizing material after kneading put in mill and begin to pratise, by mill, sizing material is pressed into rectangular film;
(4), the rectangular film be pressed into after beginning to pratise is put into the size being tailored into by film in fixed length slitter and meeting processing requirement;
(5), by the film after having tailored put in vacuum vulcanization machine and carry out sulfidizing, and utilize mould film to be pressed into the specification set in advance;
(6), by the film of sulfuration out aftershaping to render to pad on plug pad deflasher except limit of removing photoresist, plug is shaped in external form;
(7), by the pad after sizing put in extracting tank and carry out soda acid extracting, can guarantee after extracting the high clarity of butyl rubber pad, aseptic, without bacterial endotoxin, noresidue moisture content;
(8), by the product of extracting put into again in medical rubber stopper special cleaning machine and clean, after cleaning, carry out drying and processing;
(9), processed after by cleaning qualified product pack by processing requirement, packaging will aseptically operate, point in bag and outsourcing two procedures carry out;
(10), packaged qualified product are carried out point specifications and models and enter stockyard.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410522065.2A CN104312021A (en) | 2014-09-30 | 2014-09-30 | Halogenated butyl rubber pad capable of replacing medical synthesized isoprene pad |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410522065.2A CN104312021A (en) | 2014-09-30 | 2014-09-30 | Halogenated butyl rubber pad capable of replacing medical synthesized isoprene pad |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104312021A true CN104312021A (en) | 2015-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410522065.2A Pending CN104312021A (en) | 2014-09-30 | 2014-09-30 | Halogenated butyl rubber pad capable of replacing medical synthesized isoprene pad |
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| CN (1) | CN104312021A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104985783A (en) * | 2015-07-24 | 2015-10-21 | 李兴吉 | Medicinal thermoplastic elastomer gasket |
| CN105153560A (en) * | 2015-10-20 | 2015-12-16 | 河北橡一医药科技股份有限公司 | Halogenated butyl rubber gasket for medicinal aerosol valve systems |
| CN105295393A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Halogenated butyl rubber membrane covering rubber plug for injection |
| CN105295391A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Medicinal compound polyisoprene and epoxy resin copolymerization gasket |
| CN105295395A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Novel film-coated butyl rubber plug |
| CN105295390A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Medicinal compound polyisoprene and hide glue copolymerization gasket |
| CN107474406A (en) * | 2017-07-18 | 2017-12-15 | 应城市恒天药业包装有限公司 | A kind of medicinal halogenated butyl rubber pad |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101427981A (en) * | 2007-11-06 | 2009-05-13 | 江苏博生橡塑有限公司 | Chlorinated butyl rubber bung for injection and method of producing the same |
| CN101759936A (en) * | 2008-12-02 | 2010-06-30 | 山东省药用玻璃股份有限公司 | Halogenated butyl rubber plug |
| CN101759937A (en) * | 2008-12-02 | 2010-06-30 | 山东省药用玻璃股份有限公司 | Brominated butyl rubber plug for sterile powder for injection |
| CN102702587A (en) * | 2012-06-01 | 2012-10-03 | 青岛华仁塑胶医药用品有限公司 | Synthetic polyisoprene rubber plug for injection and preparation method thereof |
| CN102977476A (en) * | 2012-08-22 | 2013-03-20 | 安徽中马橡塑制品有限公司 | Infusion combination cover gasket butylation |
| CN103112168A (en) * | 2012-12-31 | 2013-05-22 | 山东省药用玻璃股份有限公司 | Method for manufacturing piston for refilling injection syringe |
-
2014
- 2014-09-30 CN CN201410522065.2A patent/CN104312021A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101427981A (en) * | 2007-11-06 | 2009-05-13 | 江苏博生橡塑有限公司 | Chlorinated butyl rubber bung for injection and method of producing the same |
| CN101759936A (en) * | 2008-12-02 | 2010-06-30 | 山东省药用玻璃股份有限公司 | Halogenated butyl rubber plug |
| CN101759937A (en) * | 2008-12-02 | 2010-06-30 | 山东省药用玻璃股份有限公司 | Brominated butyl rubber plug for sterile powder for injection |
| CN102702587A (en) * | 2012-06-01 | 2012-10-03 | 青岛华仁塑胶医药用品有限公司 | Synthetic polyisoprene rubber plug for injection and preparation method thereof |
| CN102977476A (en) * | 2012-08-22 | 2013-03-20 | 安徽中马橡塑制品有限公司 | Infusion combination cover gasket butylation |
| CN103112168A (en) * | 2012-12-31 | 2013-05-22 | 山东省药用玻璃股份有限公司 | Method for manufacturing piston for refilling injection syringe |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104985783A (en) * | 2015-07-24 | 2015-10-21 | 李兴吉 | Medicinal thermoplastic elastomer gasket |
| CN105153560A (en) * | 2015-10-20 | 2015-12-16 | 河北橡一医药科技股份有限公司 | Halogenated butyl rubber gasket for medicinal aerosol valve systems |
| CN105295393A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Halogenated butyl rubber membrane covering rubber plug for injection |
| CN105295391A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Medicinal compound polyisoprene and epoxy resin copolymerization gasket |
| CN105295395A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Novel film-coated butyl rubber plug |
| CN105295390A (en) * | 2015-10-22 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Medicinal compound polyisoprene and hide glue copolymerization gasket |
| CN107474406A (en) * | 2017-07-18 | 2017-12-15 | 应城市恒天药业包装有限公司 | A kind of medicinal halogenated butyl rubber pad |
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Application publication date: 20150128 |