CN104311662A - 一种稳定性高的人源抗vegf抗体及其应用 - Google Patents
一种稳定性高的人源抗vegf抗体及其应用 Download PDFInfo
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- CN104311662A CN104311662A CN201410461126.9A CN201410461126A CN104311662A CN 104311662 A CN104311662 A CN 104311662A CN 201410461126 A CN201410461126 A CN 201410461126A CN 104311662 A CN104311662 A CN 104311662A
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突变位点 | 亲和力变化 | 热稳定性 | 突变位点 | 亲和力变化 | 热稳定性 |
A23T | 1 | ↑ | D62P | 3 | ↑ |
T28P | 0.5 | — | S63P | 1 | ↓ |
T28D | 1.5 | ↑ | T69K | 1 | ↓ |
S31D | 1.5 | ↑ | N77K | 1.5 | ↓ |
S35L | 0.5 | ↓ | N77G | 1.5 | ↓ |
T52S | 1.5 | — | Y80S | 0.7 | ↓ |
G53P | 1 | ↑ | A88P | 0.5 | ↑ |
G55D | 1 | ↓ | V93I | 1 | ↓ |
E57S | 1.5 | ↓ |
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CN201410461126.9A CN104311662B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
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CN201410461126.9A CN104311662B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
CN201310075262.XA CN103204933B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
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CN201310075262.XA Division CN103204933B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
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CN104311662A true CN104311662A (zh) | 2015-01-28 |
CN104311662B CN104311662B (zh) | 2017-06-23 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109071672A (zh) * | 2016-04-12 | 2018-12-21 | 艾克隆株式会社 | 稳定性改善的特异性地结合在人表皮生长因子受体2的抗体 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010102380A1 (en) * | 2009-03-12 | 2010-09-16 | National Research Council Of Canada | Potent vegf antagonists |
CN102167740A (zh) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | 一种全人源抗vegf单克隆抗体、其制备方法及用途 |
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- 2013-03-08 CN CN201410461126.9A patent/CN104311662B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010102380A1 (en) * | 2009-03-12 | 2010-09-16 | National Research Council Of Canada | Potent vegf antagonists |
CN102167740A (zh) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | 一种全人源抗vegf单克隆抗体、其制备方法及用途 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109071672A (zh) * | 2016-04-12 | 2018-12-21 | 艾克隆株式会社 | 稳定性改善的特异性地结合在人表皮生长因子受体2的抗体 |
CN109071672B (zh) * | 2016-04-12 | 2021-11-19 | 艾克隆株式会社 | 稳定性改善的特异性地结合在人表皮生长因子受体2的抗体 |
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Address after: Qingpu District of Shanghai city in 201707 Huaqing Road No. 1288 Applicant after: SHANGHAI SERUM BIO-TECHNOLOGY CO.,LTD. Applicant after: INSTITUTE OF BIOTECHNOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, CHINA Applicant after: Shanghai Serum Biological Technology Dafeng Co.,Ltd. Address before: Qingpu District of Shanghai city in 201707 Huaqing Road No. 1288 Applicant before: SHANGHAI SERUM BIOTECHNOLOGY Co.,Ltd. Applicant before: INSTITUTE OF BIOTECHNOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, CHINA Applicant before: Shanghai Serum Biological Technology Dafeng Co.,Ltd. |
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Effective date of registration: 20170414 Address after: Qingpu District of Shanghai city in 201707 Huaqing Road No. 1288 Applicant after: SHANGHAI SERUM BIO-TECHNOLOGY CO.,LTD. Applicant after: Shanghai Serum Biological Technology Dafeng Co.,Ltd. Address before: Qingpu District of Shanghai city in 201707 Huaqing Road No. 1288 Applicant before: SHANGHAI SERUM BIO-TECHNOLOGY CO.,LTD. Applicant before: INSTITUTE OF BIOTECHNOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, CHINA Applicant before: Shanghai Serum Biological Technology Dafeng Co.,Ltd. |
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