CN104306956A - Oral liquid for preventing and treating diarrhea of bred pigs and preparation method of oral liquid - Google Patents
Oral liquid for preventing and treating diarrhea of bred pigs and preparation method of oral liquid Download PDFInfo
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- CN104306956A CN104306956A CN201410530952.4A CN201410530952A CN104306956A CN 104306956 A CN104306956 A CN 104306956A CN 201410530952 A CN201410530952 A CN 201410530952A CN 104306956 A CN104306956 A CN 104306956A
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Abstract
The invention relates to an oral liquid for preventing and treating diarrhea of bred pigs. The oral liquid comprises the following components in parts by weight: 2-6 parts of colistin sulfate, 1-5 parts of gentamicin sulfate, 2-6 parts of discolor cinquefoil herb, 1-5 parts of wrinkled gianthyssop herb, 3-7 parts of yerbadetajo herb, 1-5 parts of tree-of-heaven ailanthus bark, 4-8 parts of alpine yarrow herb, 4-8 parts of asiatic pennywort herb, 4-8 parts of common andrographis herb, 1-5 parts of bitter wood, 1-5 parts of green tangerine peel and 1-5 parts of Indian buead. The oral liquid has the advantages of scientific and reasonable formula composition, simple process, convenient use and relatively low cost, and the oral liquid can treat diseases of an intestinal system by sterilizing, stopping diarrhea and repairing intestinal mucosa. The oral liquid has great effects for preventing and treating epidemic diarrheal diseases, infectious gastroenteritis, diarrhea caused by rotavirus and other reasons and the like of the bred pigs.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of oral liquid and preparation method thereof preventing and treating bred pigs diarrhoea.
Background technology
China's pig industry is in the various causes of disease causing diarrhea of pigs disease, and the harm of viral diarrhea is the most serious, and it can cause the death of piglet, become losing flesh of pig, the reduction of the price of deed, increases the harm such as the spending of labour cost and expenses for medicine, is the Important Infectious Diseases of harm pig industry.The main viral transmissible gastroenteritis of swine of viral diarrhea, porcine epizootic diarrhea, porcine rotavirus is caused to be the main pathogen of China's epidemic virus diarrhea, simultaneously other viruses such as enterovirus infection, porcine adenovirus infection, Astrovirus, Calicivirus, norwalk virus, parvovirus, Pseudorabies virus, swine fever virus also can cause the diarrhoea of pig, can say, the cause of disease of viral diarrhea is very complicated, should cause enough attention.But lose flesh, reduce the price of deed, the economic loss that increase medicine and manpower etc. cause is very serious.This disease is one of global disease.
Summary of the invention
The object of the present invention is to provide a kind of oral liquid preventing and treating bred pigs diarrhoea, said composition formula composition is scientific and reasonable, and technique is simple, easy to use, cost is lower, this oral liquid by sterilization, antidiarrheal, reparation intestinal mucosa, reach treatment intestinal tract disease.The diarrhoea etc. that oral liquid causes for control bred pigs epidemic diarrhea disease, transmissible gastroenteritis, rotavirus reason has good effect.
Another object of the present invention is to provide a kind of preparation method of preventing and treating the oral liquid of bred pigs diarrhoea.
The present invention is achieved through the following technical solutions:
Prevent and treat an oral liquid for bred pigs diarrhoea, component and the ratio of weight and number thereof of its oral liquid are respectively:
And component and the optimum ratio of weight and number thereof of this oral liquid are respectively:
Prevent and treat a preparation method for the oral liquid of bred pigs diarrhoea, its preparation methods steps is:
(1) Herba Potentillae Discoloris, Herba Pogostemonis, Herba Ecliptae, Cortex Ailanthi, achillea millefolium, Herba Centellae, Herba Andrographis, Ramulus Et Folium Picrasmae, Pericarpium Citri Reticulatae Viride, Poria is taken by proportioning weight, drop in Chinese medicine extracting tank through cleaning after demulcen is dried, add the purified water of 1:1 inventory, at room temperature soak after 24 hours, continue again to be heated to water boiling decoction 10 hours, after being filtered by extracting solution 0.45um, suck Agitation Tank inner storage tank;
(2) add the purified water of 1 times of inventory in Chinese medicine extracting tank again, be heated to boiling decoction and will suck Agitation Tank inner storage tank after extracting liquid filtering in 2 hours, and first time extracting solution merging;
(3) concentrated by extracting solution, by Agitation Tank heating with steam pressure 0.09Mpa, vaporizer 15 minutes discharge condensed waters once, every two hours discharge the condensation vapour of heater once;
(4) extracting solution is concentrated into crude drug in whole 1ml and sucks in Alcohol-settling tank by extracting solution, and Indoor Natural cools, for subsequent use;
(5) suck alcohol Alcohol-settling tank by after the extracting liquid filtering in supernatant storage tank, natural precipitate with ethanol collects supernatant in 36 hours, discards residue, until crude drug in whole 1ml;
(6) sodium benzoate of 0.3% merthiolate and 5% is added, with 0.22um polyether sulfone filter element filtering;
(7) colistine sulfate, gentamycin sulfate is taken in weighing district, colistine sulfate, gentamycin sulfate is slowly added in Agitation Tank, add the injection water of 80 DEG C again, add to 200L, regulate liquid PH value: 4.5-6.5, stir more than 15 minutes, with 0.22um polyether sulfone filter element filtering, medicinal liquid directly enters filling machine by pipeline;
(8) open filling machine and carry out fill, be filled in medical vials, a kind of oral liquid preventing and treating bred pigs diarrhoea can be obtained.
Advantage of the present invention and beneficial effect are:
1. oral liquid by sterilization, antidiarrheal, reparation intestinal mucosa, get rid of toxin prevent botulism, regulating intestinal canal environment, recover intestinal normal creepage of gastrointestinal functions rhythm and pace of moving things liter reach treatment intestinal diarrhoea disease.
2. Chinese medicine ingredients toxic and side effects is little, can not produce drug resistance, emphasizes to regulate allomeric function during application, and improve the resistance against diseases of human body self, prolonged application is safe and reliable.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Prevent and treat an oral liquid for bred pigs diarrhoea, the weight of this oral liquid component is respectively: colistine sulfate 4kg, gentamycin sulfate 3kg, Herba Potentillae Discoloris 4kg, Herba Pogostemonis 3kg, ink non-irrigated careless 5kg, Cortex Ailanthi 3kg, achillea millefolium 6kg, Herba Centellae 6kg, Herba Andrographis 6kg, Ramulus Et Folium Picrasmae 3kg, Pericarpium Citri Reticulatae Viride 3kg, Poria 3kg.
Prevent and treat a preparation method for the oral liquid of bred pigs diarrhoea, this oral liquid step of preparation process is as follows:
(1) Anguo City Wan Lian prepared slices of Chinese crude drugs company limited purchases the clean medical material of screening, Herba Potentillae Discoloris, Herba Pogostemonis, Herba Ecliptae, Cortex Ailanthi, achillea millefolium, Herba Centellae, Herba Andrographis, Ramulus Et Folium Picrasmae, Pericarpium Citri Reticulatae Viride, Poria is taken by proportioning weight at Weighing Area, drop in Chinese medicine extracting tank through cleaning after demulcen is dried, add the purified water of 1:1 inventory, at room temperature soak after 24 hours, continue again to be heated to water boiling decoction 10 hours, after being filtered by extracting solution 0.45um, suck Agitation Tank inner storage tank.
(2) add the purified water of 1 times of inventory in Chinese medicine extracting tank again, be heated to boiling decoction and will suck Agitation Tank inner storage tank after extracting liquid filtering in 2 hours, and first time extracting solution merging.
(3) concentrated by extracting solution, Agitation Tank heating be advisable with steam pressure 0.09Mpa, vaporizer 15 minutes discharge condensed waters once, every two hours discharge the condensation vapour of heater once.
(4) extracting solution is concentrated into crude drug in whole 1ml and is equivalent to crude drug in whole 2g and sucks in Alcohol-settling tank by extracting solution, and Indoor Natural cools, for subsequent use.
(5) suck alcohol Alcohol-settling tank by after the extracting liquid filtering in supernatant storage tank, natural precipitate with ethanol collects supernatant in 36 hours, discards residue, until crude drug in whole 1ml is equivalent to crude drug in whole 2g.
(6) sodium benzoate of 0.3% merthiolate and 5% is added, with 0.22um polyether sulfone filter element filtering.
(7) colistine sulfate, gentamycin sulfate is taken in weighing district, colistine sulfate, gentamycin sulfate is slowly added in Agitation Tank, add the injection water of 80 DEG C again, add to 200L, regulate liquid PH value: 4.5-6.5, stir more than 15 minutes, with 0.22um polyether sulfone filter element filtering, medicinal liquid directly enters filling machine by pipeline.
(8) open filling machine and carry out fill, be filled in medical vials, clean medical vials by purified water, fill, a kind of oral liquid preventing and treating bred pigs diarrhoea can be obtained.
Embodiment 2
Prevent and treat an oral liquid for bred pigs diarrhoea, the weight of this oral liquid component is respectively: colistine sulfate 2kg, gentamycin sulfate 1kg, Herba Potentillae Discoloris 2kg, Herba Pogostemonis 1kg, ink non-irrigated careless 3kg, Cortex Ailanthi 1kg, achillea millefolium 4kg, Herba Centellae 4kg, Herba Andrographis 4kg, Ramulus Et Folium Picrasmae 1kg, Testa Tritici 1kg, Poria 1kg.
The step of its preparation technology is with embodiment 1.
Embodiment 3
Prevent and treat an oral liquid for bred pigs diarrhoea, the weight of this oral liquid component is respectively: colistine sulfate 3kg, gentamycin sulfate 2kg, Herba Potentillae Discoloris 3kg, Herba Pogostemonis 2kg, ink non-irrigated careless 4kg, Cortex Ailanthi 2kg, achillea millefolium 5kg, Herba Centellae 5kg, Herba Andrographis 5kg, Ramulus Et Folium Picrasmae 2kg, Testa Tritici 2kg, Poria 2kg.
The step of its preparation technology is with embodiment 1.
Embodiment 4
Prevent and treat an oral liquid for bred pigs diarrhoea, the weight of this oral liquid component is respectively: colistine sulfate 5kg, gentamycin sulfate 4kg, Herba Potentillae Discoloris 5kg, Herba Pogostemonis 4kg, ink non-irrigated careless 6kg, Cortex Ailanthi 4kg, achillea millefolium 7kg, Herba Centellae 7kg, Herba Andrographis 7kg, Ramulus Et Folium Picrasmae 4kg, Testa Tritici 4kg, Poria 4kg.
The step of its preparation technology is with embodiment 1.
Embodiment 5
Prevent and treat an oral liquid for bred pigs diarrhoea, the weight of this oral liquid component is respectively: colistine sulfate 6kg, gentamycin sulfate 5kg, Herba Potentillae Discoloris 6kg, Herba Pogostemonis 5kg, ink non-irrigated careless 7kg, Cortex Ailanthi 5kg, achillea millefolium 8kg, Herba Centellae 8kg, Herba Andrographis 8kg, Ramulus Et Folium Picrasmae 5kg, Testa Tritici 5kg, Poria 5kg.
The step of its preparation technology is with embodiment 1.
Clinical trial
1. the clinical trial of oral liquid on bred pigs, performance is vomitted, suffer from diarrhoea, dewater, the symptom such as stiff of moving.Affected pig, anorexia depressed with spirit while vomiting, diarrhoea, to become thin and exhaustion.The weight of symptom is relevant with age size, and the age is less, and symptom is heavier, and often after diarrhoea, endogenous cause of ill dehydration in 2 ~ 4 days is dead, case fatality rate about 50%.Bred pigs sickness rate is very high, almost reaches 100%, but symptom is comparatively light, and performance spirit is depressed, is sometimes off one's feed, suffers from diarrhoea, sustainable 4 ~ 7 days, recovers normal gradually.
2. test period: 2014.02.16 day, test swinery, certain cultivation factory bred pigs, is divided into 4 groups by 100, matched group, test group, conventional therapy I group, conventional therapy II group often organizes 15, usage and dosage: treat the every 1kg body weight of an oral secondary amounts, pig 5ml, once-a-day, only uses once.
Matched group: be blank group, do not use any Drug therapy.
Experimental group of the present invention: be oral medication group.1kg body weight 2ml
Conventional therapy I group: be marketed drugs treatment group, neomycin sulphate solution 20%, 1kg body weight 5ml.
Conventional therapy II group: for marketed drugs treatment group four taste Herba Andrographis falls apart, 1kg body weight 2g.
Result of the test is as follows:
Test shows:
In sum, oral liquid of the present invention to be suffered from diarrhoea instant effect to bred pigs, good effect.
Claims (3)
1. prevent and treat an oral liquid for bred pigs diarrhoea, it is characterized in that: component and the ratio of weight and number thereof of this oral liquid are respectively:
2. the oral liquid of control bred pigs diarrhoea according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this oral liquid are respectively:
3. a preparation method for the oral liquid of control bred pigs diarrhoea as claimed in claim 1, is characterized in that: this preparation method step is:
(1) Herba Potentillae Discoloris, Herba Pogostemonis, Herba Ecliptae, Cortex Ailanthi, achillea millefolium, Herba Centellae, Herba Andrographis, Ramulus Et Folium Picrasmae, Pericarpium Citri Reticulatae Viride, Poria is taken by proportioning weight, drop in Chinese medicine extracting tank through cleaning after demulcen is dried, add the purified water of 1:1 inventory, at room temperature soak after 24 hours, continue again to be heated to water boiling decoction 10 hours, after being filtered by extracting solution 0.45um, suck Agitation Tank inner storage tank;
(2) add the purified water of 1 times of inventory in Chinese medicine extracting tank again, be heated to boiling decoction and will suck Agitation Tank inner storage tank after extracting liquid filtering in 2 hours, and first time extracting solution merging;
(3) concentrated by extracting solution, by Agitation Tank heating with steam pressure 0.09Mpa, vaporizer 15 minutes discharge condensed waters once, every two hours discharge the condensation vapour of heater once;
(4) extracting solution is concentrated into crude drug in whole 1ml and sucks in Alcohol-settling tank by extracting solution, and Indoor Natural cools, for subsequent use;
(5) suck alcohol Alcohol-settling tank by after the extracting liquid filtering in supernatant storage tank, natural precipitate with ethanol collects supernatant in 36 hours, discards residue, until crude drug in whole 1ml;
(6) sodium benzoate of 0.3% merthiolate and 5% is added, with 0.22um polyether sulfone filter element filtering;
(7) colistine sulfate, gentamycin sulfate is taken in weighing district, colistine sulfate, gentamycin sulfate is slowly added in Agitation Tank, add the injection water of 80 DEG C again, add to 200L, regulate liquid PH value: 4.5-6.5, stir more than 15 minutes, with 0.22um polyether sulfone filter element filtering, medicinal liquid directly enters filling machine by pipeline;
(8) open filling machine and carry out fill, be filled in medical vials, a kind of oral liquid preventing and treating bred pigs diarrhoea can be obtained.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410530952.4A CN104306956A (en) | 2014-10-10 | 2014-10-10 | Oral liquid for preventing and treating diarrhea of bred pigs and preparation method of oral liquid |
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| CN201410530952.4A CN104306956A (en) | 2014-10-10 | 2014-10-10 | Oral liquid for preventing and treating diarrhea of bred pigs and preparation method of oral liquid |
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|---|---|---|---|---|
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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Application publication date: 20150128 |