CN104306937A - Pig gall and earthworm asthma-relieving tablet - Google Patents

Pig gall and earthworm asthma-relieving tablet Download PDF

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Publication number
CN104306937A
CN104306937A CN201410567336.6A CN201410567336A CN104306937A CN 104306937 A CN104306937 A CN 104306937A CN 201410567336 A CN201410567336 A CN 201410567336A CN 104306937 A CN104306937 A CN 104306937A
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China
Prior art keywords
asthma
tablet
zhichuan
gallbladder
dragon
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CN201410567336.6A
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Chinese (zh)
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雷雅斌
戴天骄
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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Abstract

The invention provides a pig gall and earthworm asthma-relieving tablet, and belongs to traditional Chinese and western medicine compound preparations. The tablet has the effects of effectively relieving cough and asthma and eliminating phlegm by means of the pharmacologic action of medicinal materials, and health of patients can be recovered. The tablet is prepared from the following components in the traditional Chinese medical formula: 18-38g of pig gall powder, 70-110g of earthworm, 38-58g of radix stemonae, 9-28g of fructus mume, 19-38g of alum, 9-38g of semen brassicae and 19-38g of ginger, and the components in the western medical formula comprise 8-19g of aminophylline and 0.5-2.8g of promethazine hydrochloride. The traditional Chinese and western medicinal materials are matched with syrup and honey and respectively prepared according to different properties of the medicinal materials, and are processed into sugar coated tablets or film-coated tablets. The tablet is taken orally, and the dosage is taken according to advice of doctors. The tablet is prepared from pig gall powder and earthworm as main drugs, is capable of clearing lung, removing toxicity, eliminating phlegm, relieving cough, regulating qi and relieving asthma, can be used for treating various respiratory system diseases, such as cough, asthma, senile chronic bronchitis, asthmatic bronchitis, emphysema and the like, in clinical application.

Description

Gallbladder dragon Zhichuan sheet
Technical field
The present invention relates to a kind of Chinese medicine and western medicine compound formulation based on Chinese medicine, particularly shape is the gallbladder dragon Zhichuan sheet of tablet.
Background technology
On society, chronic tracheitis, asthmatic bronchitis and emphysema patient are a lot of, especially chronic tracheitis in elderly population, asthmatic bronchitis patient are more, treating this type of disease is an outstanding medical care problem, country's once one of disease being classified as keypoint control.At present, cough-relieving, relieving asthma, class of reducing phlegm medicament categories is many, Chinese medicine and western medicine all has, but satisfactory effect is few, is sought after a kind of not only safe without toxic side effect, but also has the medicine of definite curative effect in clinical practice.
Summary of the invention
The present invention is intended to the demand met on clinical treatment, provides that a kind of determined curative effect is reliable, safety and what have no side effect take Chinese medicine as the main gallbladder dragon Zhichuan sheet adding appropriate Western medicine, to solve the need of the treatment of this type of disease.
Technical scheme of the present invention
Gallbladder dragon Zhichuan sheet contains Chinese medicine and a small amount of Western medicine, wherein prescriptions of Chinese medicine is: Pulvis Fellis Suis 18-38g Pheretima 70-110g Radix Stemonae 38-58g Fructus Mume 9-28g Alumen 19-38g Semen Sinapis Albae 9-38g Rhizoma Zingiberis Recens 19-38g Western medicine prescription is: aminophylline 8-19g promethazine hydrochloride 0.5-2.8g, adjuvant: simple syrup 4-28g Mel 2-19g.Above-mentioned every herbal medicine all should meet the quality standard that " Chinese Pharmacopoeia " relevant money specifies.
The character of this product is coated tablet, and removing coating shows taupe brown, feeble QI perfume, bitter in the mouth, micro-pungent.
The pharmacological effect of this product: cough-relieving, relieving asthma, reduce phlegm.
The using method of this product: oral, its dosage is followed the doctor's advice.
Beneficial effect 1. gallbladder of the present invention dragon Zhichuan sheet with Pulvis Fellis Suis and Pheretima for principal agent, can lung heat clearing toxin expelling, preventing phlegm from forming and stopping coughing, pleasantly to relieving asthma, effectively can treat various cough and asthma, senile chronic tracheitis, the respiratory system diseases such as asthmatic bronchitis, emphysema, pulmonary heart disease.Through Tianshui second the People's Hospital's clinical verification, to the Ureteral Calculus of 100 routine patients, result shows that this product has good curative effect to above-mentioned disease, and total effective rate reaches 91%, high compared with other these type of medicines; 2. through clinical observation, this product has no bad obvious impact to internal organs such as hemocyte, liver, kidneys, has no anaphylactic reaction and occurs, and illustrate that gallbladder dragon Zhichuan sheet has no side effect, therefore safety in utilization is good.
Detailed description of the invention
Specific embodiment of the invention scheme is as follows: the preferred prescription of gallbladder dragon Zhichuan sheet is: Pulvis Fellis Suis 30g Pheretima 100g Radix Stemonae 48g Fructus Mume 21g Alumen 32g Semen Sinapis Albae 31g Rhizoma Zingiberis Recens 24g aminophylline 11.5g promethazine hydrochloride 1.05g simple syrup 22g Mel 15g makes 1000.
The formulation method of gallbladder dragon Zhichuan sheet is as follows: Fructus Mume add water well-done enucleation, be dried and crushed into fine powder, Rhizoma Zingiberis Recens adds 2 times of water gagings and rubs, and decocts three times, each one hour, collecting decoction, filtration extracting juice; Pheretima, the Radix Stemonae, Caulis et Folium Sinapis albee substring levigation are broken into fine powder; Alumen, promethazine hydrochloride, aminophylline are ground into fine powder respectively, then mix with Fructus Mume powder, Pulvis Fellis Suis, add Sucus Zingberis, simple syrup and Mel, make granule after mix homogeneously, dry tabletting, sugar coating.This product can also film coating.
Clinical observation situation of the present invention is as follows: work out clinical verification protocol according to " new Chinese medicine guideline of clinical investigations ", determine diagnostic criteria, select case, divide inpatient and clinic case two class, work out observation plan, specifically implemented by Tianshui second the People's Hospital Respiratory Medicine, judge by predetermined curative effect determinate standard afterwards.
Actually determined observation case 100 example, man 56 example, female 44 example, age 21-65 year, average 49.85 years old, wherein inpatient 32 example, outpatient 68 example, the course of disease is the longest 28 years, the shortest 1 week, and concrete condition is as follows:
1. method of administration: oral gallbladder dragon Zhichuan sheet, each 3, every day 3 times, viewing duration does not use other similar drugs, observes the 5-8 days course for the treatment of.
2. observation item:
(1) health giving quality is observed, main detection chronic tracheitis, bronchial asthma clinical symptoms-cough, cough up phlegm, pant, the change of wheezing sound and corresponding sign, and do related assays inspection and chest X-ray examination;
(2) security inspection project is observed: general health check-up and blood, urine, feces routine test and liver power checking.
3. observational technique: by the unified observation form worked out, fill in respectively for 5 days and 8 days before and after treatment.
4. efficacy determination: according to clinic control, effective, effective, invalid four standards, result is as follows: clinic control 16 people, accounts for 16%, and effective 45 people, account for 45%, and effective 30 people, account for 30%, and invalid 9 people, account for 9%, and always effective 91 people, account for 91%.
5. safety evaluatio: this product has no harmful effect to hemocyte, hepatic and renal function, also has no anaphylactic reaction and occurs.
Concrete case: patient xxx man, 63 years old, suffers from ictal asthma, coughs, coughs up phlegm 9 years, be hospitalized for treatment, be diagnosed as asthmatic chronic bronchitis acute attack stage, emphysema after increasing the weight of 3 with bronchial asthma attack.Treatment: oral gallbladder dragon Zhichuan sheet, each 3, every day 3 times, treat and obtain effect on 3rd, symptom alleviates, and asthma alleviates, and cough reduces, and amount of expectoration reduces.To the 5th day, symptom obviously alleviated, and asthma disappears, and amount of expectoration obviously reduces, the two lung of auscultation, wheezing sound reduces, to the 8th day, cough, cough up phlegm, pant all disappear, two pulmonary respiration sound is low, without wheezing sound, look into Liver and kidney function and urine and stool routine all normal, clinical cure is left hospital.

Claims (4)

1. a gallbladder dragon Zhichuan sheet, containing Chinese medicine and a small amount of Western medicine, it is characterized in that prescriptions of Chinese medicine: Pulvis Fellis Suis 18-38g Pheretima 70-110g Radix Stemonae 38-58g Fructus Mume 9-28g Alumen 19-38g Semen Sinapis Albae 9-38g Rhizoma Zingiberis Recens 19-38g Western medicine prescription is: aminophylline 8-19g promethazine hydrochloride 0.5-2.8g, adjuvant: simple syrup 4-28g Mel 2-19g.
2. gallbladder dragon Zhichuan sheet according to claim 1, is characterized in that its preferred prescription is: Pulvis Fellis Suis 30g Pheretima 100g Radix Stemonae 48g Fructus Mume 21g Alumen 32g Semen Sinapis Albae 31g Rhizoma Zingiberis Recens 24g aminophylline 11.5g promethazine hydrochloride 1.05g simple syrup 22g Mel 15g makes 1000.
3. the gallbladder dragon Zhichuan sheet according to claim 1 and 2, is characterized in that its formulation method is: Fructus Mume add water well-done enucleation, be dried and crushed into fine powder; Rhizoma Zingiberis Recens adds 2 times of water gagings and rubs, and decocts 3 times, each 1 hour, collecting decoction, filters extracting juice; Pheretima, the Radix Stemonae, Caulis et Folium Sinapis albee substring levigation are broken into fine powder; Alumen, salt promethazine, aminophylline are ground into fine powder respectively, then mix with Fructus Mume powder, Pulvis Fellis Suis, add Sucus Zingberis, simple syrup and Mel, make granule after mix homogeneously, dry tabletting, sugar coating.
4. according to the gallbladder dragon Zhichuan sheet that claim 1 and 2 is closely stated, can also film coating after it is characterized in that tabletting.
CN201410567336.6A 2014-10-15 2014-10-15 Pig gall and earthworm asthma-relieving tablet Pending CN104306937A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815145A (en) * 2015-04-15 2015-08-05 苏州市天灵中药饮片有限公司 Traditional Chinese medicine cough syrup and preparation method thereof
CN111419960A (en) * 2020-04-30 2020-07-17 辽宁修和药业有限公司 Compound antitussive pharmaceutical composition and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815145A (en) * 2015-04-15 2015-08-05 苏州市天灵中药饮片有限公司 Traditional Chinese medicine cough syrup and preparation method thereof
CN111419960A (en) * 2020-04-30 2020-07-17 辽宁修和药业有限公司 Compound antitussive pharmaceutical composition and preparation method thereof

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Application publication date: 20150128