CN104306759A - Chinese herbal preparation for treating uremia and preparation method of Chinese herbal preparation - Google Patents

Chinese herbal preparation for treating uremia and preparation method of Chinese herbal preparation Download PDF

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CN104306759A
CN104306759A CN201410515714.6A CN201410515714A CN104306759A CN 104306759 A CN104306759 A CN 104306759A CN 201410515714 A CN201410515714 A CN 201410515714A CN 104306759 A CN104306759 A CN 104306759A
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匡玉华
宋秀香
赵庆沛
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Abstract

The invention belongs to the field of traditional Chinese medicine, in particular relates to a Chinese herbal preparation for treating uremia and a preparation method of the Chinese herbal preparation. The Chinese herbal preparation for treating the uremia is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 10 to 25 parts of canescent wikstroemia, 10 to 25 parts of lalang grass rhizome, 10 to 15 parts of pogonatherum crinitum, 3 to 8 parts of the root of red-rooted salvia, 2 to 3 parts of ligusticum wallichii, 3 to 5 parts of wolfiporia extensa, 5 to 10 parts of teasel root, 3 to 5 parts of astragalus membranaceus, 1 to 2 parts of centella asiatica, 10 to 15 parts of eucommia ulmoides, 3 to 5 parts of ash bark, 2 to 3 parts of stem of moupin dutchmanspipe, 3 to 5 parts of root of rehmannia and 1 to 2 parts of ginkgo leaves. The Chinese herbal preparation has the advantages that the used traditional Chinese herbs conform to the stipulation of Chinese pharmacopoeia, and the medicine is safe and reliable. The Chinese herbal preparation has a combined action for dispelling the wind, clearing away the internal heat, cooling the blood, detoxifying and the like and has the characteristics of accurate curative effect, fast effectiveness, high curative rate, no side effect and the like when used for treating the uremia.

Description

One treats uremic Chinese medicine preparation and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to one and treat uremic Chinese medicine preparation and preparation method thereof.
Background technology
Body all to carry out complicated biological metabolism every day, takes in foreign substance, carries out decomposing, anabolism is for needed for body.The various metabolites that simultaneously body must be produced in metabolism again excrete, and the excretion of these metabolites and toxicant is mainly completed by kidney.The physiological function of kidney mainly comprises following 3 aspects:
1. the generation of urine
The plasma volume that the 1/4--1/5. unit interval internal glomerulus that the blood flow of normal person both sides kidney accounts for systemic blood flow filters is called that the rate of glomerule is filtered, and the glomerule rate of adult normal is filtered and is per minutely about 120ml.The total plasma volume that both sides kidney was considered from glomerule every day reaches 150--180L.This part blood plasma filtered is referred to as crude urine.When crude urine flows through renal tubules and collecting tubule, wherein about 99% is heavily absorbed.Therefore get rid of external crude urine and only have about 1500ml.Glucose, aminoacid, vitamin, polypeptides matter and a small amount of protein, almost all absorbed at proximal convoluted tubule, renal tubules still can directly get rid of some drugs and poisonous substance in addition.
2. regulate electrolyte and acid-base balance
First a large amount of acidic materials that human body produces in sugar, fat and protein metabolism process in food digestion process and in body and a small amount of alkaline matter are released into blood, then excrete.Wherein with acidic materials for mainly to get rid of material.Containing multiple electrolyte in Glomerular filtrate, after entering renal tubules, most of sodium, potassium, calcium, magnesium, bicarbonate, chlorine and phosphate anion etc. are heavily absorbed.Press the needs of human body, by neuroendocrine and humoral factor actuator absorbtivity.Kidney regulates the flat very sluggish of soda acid, but fully can regulate the change of blood plasma PH.
3. endocrine function
1. vaso-active substance: comprise feritin, Kallidin I release enzyme, kinin system and prostaglandin etc.The feritin of 95% is from juxtaglomerular apparatus, and the latter is the place of synthesis, storage, release feritin.Feritin can be converted into angiotensin I, II, III.From promixal tubular cell, also there is kallikrein in kidney in 90% kallikrein, can make kassinin kinin inactivation, and therefore kassinin kinin is the tissue hormone of a kind of local action.Prostaglandin (PG) has very strong vasorelaxation, plays an important role to the adjustment of blood pressure and body fluid, diuresis can be caused simultaneously to arrange sodium, arterial pressure is declined.
2. erythropoietin (EPO): the EPO of 90% is produced by kidney, about 10% produces at the internal organs such as liver, spleen.EPO is a kind of glycoprotein, and its orientation is combined with the specific receptor of CFU-E, accelerates Bone marrow erythroblast maturation, release, and impels bone marrow reticulocyte to enter circulation, erythropoiesis is increased.
3. 1-25-(OH)2-D3: its major physiological act as: promote that intestinal is to the absorption of calcium phosphorus; Promote Calcium and phosphorous absorption and bone mineralization in bone.Kidney can deactivation gastrin, insulin, parathyroid hormone etc. simultaneously.Renal insufficiency, gastrin fire extinguishing reduces, and gastrin raises, and can bring out peptic ulcer.
Chronic renal failure refers to that various nephropathy causes the gradual irreversibility of renal function to go down, until the clinical syndrome that the series of symptoms that occurs of afunction and metabolism disorder form, is called for short chronic kidney hypofunction.Be the uremia that it has often been said the whole latter stage of chronic kidney hypofunction.Uremia is not an independently disease, but the clinical syndrome that the nephropathy in various late period is total, is the syndrome that series of clinical manifestations that chronic renal failure occurs when entering end stage eventually forms.Some patient of frequent meeting, enters Uremic, but delays always, is unwilling to accept dialysis treatment, total worry dialysis side effect, expense etc.A lot of patient also can place hope on traditional Chinese medical herbal treatment energy " healing " uremia, breaks away from dialysis.Dialysis is exactly replace kidney work in fact, when patient enters Uremic, kidneys of patients should damage more than more than 90%, if at this moment delay and do not take replacement therapy always, so toxin retains in body, also irreversible infringement can be brought, as heart, digestive system, skeleton, blood system etc. to other internal organs of health.And uremia be Drug therapy can not curable disease, do not exist and so-calledly can cure uremic " miraculous cure ".Therefore uremic patient should take renal replacement therapies without hesitation in time, i.e. dialysis treatment, and dialysis treatment is expensive, and average family cannot bear.Just not saying its kidney source of kidney transfer operation is few, it is more difficult to mate, and there is certain risk in operation, and post-operative recovery also will bear suitable risk.In addition, in also adopting, Western medicine eliminates the inflammation of kidney, and nephrectasia amasss urinary catheter.At present, treat uremic in, Western medicine kind is more, but toxic and side effects is comparatively strong mostly, and treatment time is long, and price is high, has more increased the weight of the financial burden of patient.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides one and treat uremic Chinese medicine preparation and preparation method thereof, it is evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
One of the present invention treats uremic Chinese medicine preparation, according to weight parts, formulated by following raw material of Chinese medicine: Flos Wikstroemiae Dolichanthae 10 ~ 25 parts, Rhizoma Imperatae 10 ~ 25 parts, Herba Melicae Scabrosae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 3 ~ 8 parts, Rhizoma Chuanxiong 2 ~ 3 parts, 3 ~ 5 parts, Poria, Radix Dipsaci 5 ~ 10 parts, the Radix Astragali 3 ~ 5 parts, Herba Centellae 1 ~ 2 part, the Cortex Eucommiae 10 ~ 15 parts, Cortex Fraxini 3 ~ 5 parts, Caulis aristolochiae moupinensis 2 ~ 3 parts, 3 ~ 5 parts, the Radix Rehmanniae and Folium Ginkgo 1 ~ 2 part.
Wherein, preferred version is as follows:
According to weight parts, formulated by following raw material of Chinese medicine: Flos Wikstroemiae Dolichanthae 15 parts, Rhizoma Imperatae 25 parts, Herba Melicae Scabrosae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 2 parts, 3 parts, Poria, Radix Dipsaci 10 parts, the Radix Astragali 5 parts, Herba Centellae 1 part, the Cortex Eucommiae 10 parts, Cortex Fraxini 3 parts, Caulis aristolochiae moupinensis 2 parts, 3 parts, the Radix Rehmanniae and Folium Ginkgo 1 part.
A kind of preparation method for the treatment of uremic Chinese medicine preparation of the present invention, prepare in accordance with the following methods: take raw material of Chinese medicine according to formula and join in container, add water and cover powder immersion 10 ~ 20 minutes, add water again and do not have powder 3 ~ 5 centimetres, decoct with high heat and use slow fire boiling again instead 20 ~ 30 minutes to boiling, get filtrate; And then add water and do not have powder 3 ~ 5 centimetres, decoct with high heat and uses slow fire boiling again instead 15 ~ 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.
During use, each 200 ~ 300ml, sooner or later respectively once.
Pharmacology analysis:
Flos Wikstroemiae Dolichanthae: removing water retention by purgation is drunk, removing mass gathers.Control prolonged fluid-retention, cough with dyspnea, edema, lump in the abdomen mass beside the umbilicus." herbal classic ": main typhoid fever pyrexial malaria, lower 12 water, removing mass is poly-, large hard lump in the abdomen, cleanses in the intestines and stomach and stays addiction, diet, cold and heat pathogen, dredging water passages.
Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.
Herba Melicae Scabrosae: heat clearing away, expelling summer-heat, diuresis.For high heat of catching a cold, heatstroke, urinary tract infection, oedema due to nephritis, icterohepatitis, diabetes, children's's heat of a specified duration is not moved back.Heat-clearing and toxic substances removing; Cooling blood for hemostasis; Dampness removing.Main calentura excessive thirst; Spit blood; Epistaxis; Hemoptysis; Hematuria; Metrorrhagia; Jaundice; Edema; Stranguria with turbid discharge leukorrhagia, dysentery; Children's's infantile malnutrition with fever; Furuncle carbuncle.
Radix Salviae Miltiorrhizae: bitter in the mouth.Cold nature, enters the heart, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, pain relieving, nourishing blood to tranquillize the mind.Radix Salviae Miltiorrhizae can be apt to control blood system, removes stagnant tissue regeneration promoting, has regulating menstruation along arteries and veins drug effect.Radix Salviae Miltiorrhizae can improve the symptoms of uremia of inductivity renal failure rat, obviously can reduce blood urea nitrogen, creatinine, methylguanidine, and the serum-concentration of guanidine radicals succinic acid, namely improves hyperphosphatemia, changes again the crystal formation of blood Free Amino Acids, can promote graft function.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, enter liver, gallbladder meridian.Effect: activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness.Promoting blood circulation and stopping pain.Effective ingredient in Rhizoma Chuanxiong: ligustrazine, expansible glomerule small artery, reduces albuminuria, suppresses diffuse crescent formation base fibrosis to have certain effect.
Poria: sweet in the mouth, light, property is put down, and enters the heart, spleen, lung meridian.Effect: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Poria has obvious inducing diuresis to remove edema effect, and to affect renal tubules relevant to receiving the heavily absorption of ion with it.
Radix Dipsaci: bitter in the mouth, pungent, slightly warm in nature, enters liver, kidney channel.Function: invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.Its bitter can hard kidney, pungently can moisten kidney, can frequent micturition be treated, the sliding nocturnal emission of essence, back ache, the kidney channel diseases such as the foot and knee being feeble.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Return spleen, lung meridian.Enter edema caused by disorder of QI, can rise and can fall.Function: tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, line water detumescence, promoting pus discharge and tissue regeneration strengthening.Astragalus membranaceus powder Oral Administration in Rats exempts to injection the nephrolytic sera nephritis that against murine kidney serum causes obvious therapeutical effect, and significantly can reduce the amount of albumen in urine, nephropathy also alleviates.In addition, to light, moderate renal failure Mus that Part Nephrectomy causes, the Radix Astragali is improved the effect of renal function.
Herba Centellae: nature and flavor bitter, acrid, cold.Return liver,spleen,kidney warp.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema, beneficial brain is refreshed oneself, and is the long-lived medicine of Asians.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.
The Cortex Eucommiae: sweet in the mouth, warm in nature.Return liver, kidney, stomach warp.Effect liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.The lumbago and skelalgia or aching and limp unable that treatment insufficiency of kidney-YANG causes.Born of the same parents' tire that deficiency of liver-QI causes is not solid, the diseases such as scrotum pruritus due to damp pathogen.
Cortex Fraxini: nature and flavor are bitter, cold.Heat clearing and damp drying Chinese medicine.Cure mainly: heat clearing and damp drying, liver heat removing and eyesight improving, antiasthmatic-antitussive.For pyretic toxicity dysentery, conjunctival congestion and swelling pain, the raw cataracta of order.
Caulis aristolochiae moupinensis: clearing away heat-damp and promoting diuresis, row is breast under water, evacuation of pus pain relieving.For dysuria, edema, urinary tract infection, trichomonas vaginitis, rheumatic arthritis, eczema, urticaria, carbuncle.
The Radix Rehmanniae: cold in nature, bitter in the mouth.Removing heat from blood is enriched blood, the kidney invigorating water kidney-YIN being deficient, controls few cloudy heat in the heart interior.This medicine Great Cold, should consider with it, probably damage gastric qi." curing mainly secret formula " cloud: cold in nature, bitter in the mouth, gas is thin rich, and sink and fall, the moon also.It is with having three: removing heat from blood, and one also; Except skin is dry, two also; Go all wet puckery, three also.Cloud again: micro-sun in the moon, steeping in wine is up.
Folium Ginkgo: mildly bitter flavor, property is put down.There is the beneficial heart, promoting blood circulation and stopping pain, astringe the lung relieving asthma, effect of removing dampness antidiarrheal.
The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases and have the effect such as wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body, treatment uremia has that determined curative effect, instant effect, cure rate are high, the feature such as have no side effect.
Outcome measure:
1, case selection:
As the uremic Chinese medicine preparation for the treatment of, select uremic patient 100 clinical observation of making a definite diagnosis, wherein male 52 example, women 48 example, 25 ~ 75 years old age, 48.3 years old mean age, the shortest person of the course of disease 3 months, most elder 9 years, average 4.9 years.Take Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 300ml; Seven days 1 courses for the treatment of.
2, diagnostic criteria:
1) blood routine examination: during uremia, hemoglobin is generally under 80g/L, and majority only has 40 ~ 60g/L, is positive cell normochromic anemia, when patient merges chronic blood loss, malnutrition, also can shows as microcytic hypochromic anemia.Leukocyte changes less, leukocyte count can be made to increase when acidosis and infection.Platelet count is on the low side or normal, but function reduces, and erythrocyte sedimentation rate is often accelerated because of anemia and hypoproteinemia.
2) routine urianlysis: the urine of uraemic patients changes, has larger difference with protopathy difference.Its common ground is: 1. osmotic pressure of urine reduces, and most urina sanguinis is at below 450mOsm/kg, and proportion is lower, how below 1.018, is fixed between 1.010 ~ 1.012 time serious.When doing concentrationdilution test, nocturnal urine output is greater than a day urine volume, and each time specific gravity of urine is all no more than 1.020, and the highest and minimum specific gravity of urine difference is less than 0.008.2. hypourocrinia, how below 1000ml/ days, when being down to below 1.0 ~ 2.0ml/ second to creatinine clearance rate in late period, then can anuria.3. urine protein be+~ +++, late period damages because of the glomerule overwhelming majority, and urine protein reduces on the contrary.4. uropsammus examination can promising number do not wait erythrocyte, leukocyte, epithelial cell and granular cast, if find thick and short, the fatiscent waxy cast in homogeneity, edge, meaningful to diagnosis.
3) kidney function test: at compensatory stage of renal insufficiency, though creatinine renal clearance declines, serum creatinine does not raise; At azotemia phase, though serum creatinine raises, patient without uremia's clinical symptoms, also without metabolic acidosis; At Uremic, as creatinine renal clearance <25ml/min, serum creatinine can obviously raise, and with metabolic acidosis.
4) blood bio-chemistry checking: plasma protein reduces, total protein concentration is everlasting below 60g/L, and wherein albuminous minimizing is normal comparatively obvious, how lower than 30g/L.Blood calcium is on the low side, and be everlasting about 2mmol/L, and serium inorganic phosphorus is many higher than 1.7mmol/L.Blood potassium, blood sodium are fixed with the state of an illness.
3, criterion of therapeutical effect:
(1) cure: above-mentioned symptom disappears, every mechanism recovers normal
(2) effective: above-mentioned symptom is alleviated to some extent.
(3) invalid: by treating rear symptom without being clearly better.
4, result: cure 23 examples, take a turn for the better 72 examples, invalid 5 examples, cure rate 23%, total effective rate 95%.
Below enumerate a model case:
Zhang, man, 45 years old.Suffer from nephropathy 5 years, decline with appetite, oral ulcer, halitosis, has blood in stool, yellowing of the skin, coarse, hair jaundice, come off serious, anemia, dyspnea, the diseases such as walking disorder.Within 2013, remove hospital admission: creatinine 5.1mg%, uremic nitrogen 38mg%, hematochrome 4.7g; Ultrasound diagnosis result is that two kidney chronic lesion changes.This patient took Chinese medicine preparation of the present invention after 45 days, and disease disappears completely, and walking freely.Go to hospital to check subsequently: creatinine 0.72mg%, uremic nitrogen 20.15mg%, hematochrome 7.8g, indices is tending towards normal.
Detailed description of the invention
The present invention will be further described by the following examples.
Embodiment 1:
One treats uremic Chinese medicine preparation, according to weight parts, formulated by following raw material of Chinese medicine: Flos Wikstroemiae Dolichanthae 15 parts, Rhizoma Imperatae 25 parts, Herba Melicae Scabrosae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 2 parts, 3 parts, Poria, Radix Dipsaci 10 parts, the Radix Astragali 5 parts, Herba Centellae 1 part, the Cortex Eucommiae 10 parts, Cortex Fraxini 3 parts, Caulis aristolochiae moupinensis 2 parts, 3 parts, the Radix Rehmanniae and Folium Ginkgo 1 part.
Embodiment 2:
Embodiment 1 is according to the uremic Chinese medicine preparation of following steps preparation treatment: take raw material of Chinese medicine according to formula and join in container, add water and cover powder and soak 15 minutes, add water again and do not have powder 3 centimetres, decoct with high heat and use slow fire boiling again instead 30 minutes to boiling, get filtrate; And then add water and do not have powder 3 centimetres, decoct with high heat and uses slow fire boiling again instead 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.

Claims (3)

1. the uremic Chinese medicine preparation for the treatment of, it is characterized in that according to weight parts, formulated by following raw material of Chinese medicine: Flos Wikstroemiae Dolichanthae 10 ~ 25 parts, Rhizoma Imperatae 10 ~ 25 parts, Herba Melicae Scabrosae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 3 ~ 8 parts, Rhizoma Chuanxiong 2 ~ 3 parts, 3 ~ 5 parts, Poria, Radix Dipsaci 5 ~ 10 parts, the Radix Astragali 3 ~ 5 parts, Herba Centellae 1 ~ 2 part, the Cortex Eucommiae 10 ~ 15 parts, Cortex Fraxini 3 ~ 5 parts, Caulis aristolochiae moupinensis 2 ~ 3 parts, 3 ~ 5 parts, the Radix Rehmanniae and Folium Ginkgo 1 ~ 2 part.
2. one according to claim 1 treats uremic Chinese medicine preparation, it is characterized in that according to weight parts, formulated by following raw material of Chinese medicine: Flos Wikstroemiae Dolichanthae 15 parts, Rhizoma Imperatae 25 parts, Herba Melicae Scabrosae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 2 parts, 3 parts, Poria, Radix Dipsaci 10 parts, the Radix Astragali 5 parts, Herba Centellae 1 part, the Cortex Eucommiae 10 parts, Cortex Fraxini 3 parts, Caulis aristolochiae moupinensis 2 parts, 3 parts, the Radix Rehmanniae and Folium Ginkgo 1 part.
3. the preparation method of the uremic Chinese medicine preparation for the treatment of according to claim 1, it is characterized in that preparing in accordance with the following methods: take raw material of Chinese medicine according to formula and join in container, add water and cover powder immersion 10 ~ 20 minutes, add water again and do not have powder 3 ~ 5 centimetres, decoct with high heat and use slow fire boiling again instead 20 ~ 30 minutes to boiling, get filtrate; And then add water and do not have powder 3 ~ 5 centimetres, decoct with high heat and uses slow fire boiling again instead 15 ~ 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.
CN201410515714.6A 2014-09-29 2014-09-29 Chinese herbal preparation for treating uremia and preparation method of Chinese herbal preparation Pending CN104306759A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101444598A (en) * 2007-11-27 2009-06-03 陈金宗 Traditional Chinese medicine composition for treating uremia and preparation method and use thereof
CN102895543A (en) * 2012-10-11 2013-01-30 唐启裕 Traditional Chinese medicine detoxifying decoction for treating uremia
CN103417641A (en) * 2013-08-13 2013-12-04 吴中区胥口精益生物医药研究所 Traditional Chinese medicine essence for treating uremia and extraction process thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101444598A (en) * 2007-11-27 2009-06-03 陈金宗 Traditional Chinese medicine composition for treating uremia and preparation method and use thereof
CN102895543A (en) * 2012-10-11 2013-01-30 唐启裕 Traditional Chinese medicine detoxifying decoction for treating uremia
CN103417641A (en) * 2013-08-13 2013-12-04 吴中区胥口精益生物医药研究所 Traditional Chinese medicine essence for treating uremia and extraction process thereof

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Application publication date: 20150128