CN104306699A - Liquid preparation for preventing diabetic foot - Google Patents

Liquid preparation for preventing diabetic foot Download PDF

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Publication number
CN104306699A
CN104306699A CN201410523954.0A CN201410523954A CN104306699A CN 104306699 A CN104306699 A CN 104306699A CN 201410523954 A CN201410523954 A CN 201410523954A CN 104306699 A CN104306699 A CN 104306699A
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parts
liquid preparation
herba
foot
grams
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CN201410523954.0A
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徐小琳
吴红霞
张钟文
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Dermatology (AREA)
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Abstract

The invention discloses a liquid preparation for preventing diabetic foot. The liquid preparation is prepared from the following raw materials in parts by weight: 20-30 parts of safflower carthamus, 20-30 parts of Angelica sinensis, 10-20 parts of cynomorium songaricum, 20-30 parts of radix polygonati officinalis, 10-20 parts of frankincense, 5-10 parts of oroxylum indicum, 10-20 parts of Chinese wolfberry, 10-15 parts of Pleurospermum hookeri var. thomsonii, 5-15 parts of Astragalus membranaceus, 10-20 parts of dahurian patrinia herb, 20-30 parts of portulaca oleracea and 5-15 parts of Mirabilis himalaica. The liquid preparation is mixed with water in a ratio of 1 to 10, and when the temperature of the mixture reaches 38 DEG C, feet are put into the mixture and soaked for 30min. The liquid preparation is capable of improving the blood circulation of feet of diabetics, has the functions of dredging the channels, alleviating ache and numb of lower limbs and preventing foot ulcers and necrosis and the like and achieves remarkable effects.

Description

A kind of sufficient liquid preparation that prevents diabetes
Technical field
The invention belongs to technical field of medicine preparation, be specifically related to a kind of sufficient liquid preparation that prevents diabetes.
Background technology
Diabetic foot (diabetic foot) is one of modal chronic complicating diseases of diabetics, and a lot of foot complication of diabetics rise from sensualness neuropathy and slight autonomous and nervus motorius pathological changes.Wherein sensory nerve pathological changes merges too high mechanical stress, is the main initiating agent causing foot ulcers and infection.Inflammation and histologic lesion are the results that alternate stress to a certain degree acts on the region that specifically loses sensibility.Cause ulcer from the pressure of ground, shoes or other contiguous toes or shearing force, owing to lacking normal Neuroprotective Mechanisms, ulcer often increases the weight of because of the existence of apophysis.Autonomic pathological changes causes the normal perspire regulatory function of skin, skin temperature regulatory function and blood to transport regulating power forfeiture, causes local organization pliability to reduce, and forms thick callus and easier broken and cracking.In addition, the forfeiture of normal perspire ability has blocked the rehydration of local organization, causes tissue to destroy further, makes deep tissue be easier to bacteria planting.Nervus motorius pathological changes also serves certain effect in the morbidity of diabetic foot, and the contracture of the inherent flesh of foot causes typical claw toe deformity.The hyperextension of metatarsophalangeal joints is also proved to be able to directly increase head of metatarsal bone downforce, makes this position more easily form ulcer.Nearly interphalangeal joint flexing causes the ulcerated risk of the interphalangeal joint dorsal part of projection and toe point sole of the foot side to increase, and vascular lesion makes the tissue destroyed be difficult to healing.
The physical and mental health of diabetics in diabetic foot serious threat, and therefore, the prevention of diabetic foot is significant.Clinically, the onset risk of diabetic foot is fundamentally reduced by actively controlling blood glucose.In addition, patient needs to check foot and shoes every day, to find that the mechanical stress in disorganization and the shoes hidden increases, by pad in transformation shoes, die type or shoes intensification, can effectively cushion foot stress and the protection that provides support.In addition, medicine cleaning foot is adopted also to be one of important measures to reach the sufficient object that prevents diabetes.
Summary of the invention
The present invention is intended to provide a kind of pharmaceutical composition that is sufficient, determined curative effect that prevents diabetes, and this medicine composite for curing diabetic foot is with strong points, and curative effect is better, and side effect is little, and safety is good.
The present invention is achieved through the following technical solutions:
Prevent diabetes a sufficient liquid preparation, is made up of the crude drug of following weight portion: 20 ~ 30 parts, Flos Carthami, Radix Angelicae Sinensis 20 ~ 30 parts, Herba Cynomorii 10 ~ 20 parts, Rhizoma Polygonati Odorati 20 ~ 30 parts, Olibanum 10 ~ 20 parts, Semen Oroxyli 5 ~ 10 parts, Fructus Lycii 10 ~ 20 parts, Herba pleurospermi thomsonii 10 ~ 15 parts, the Radix Astragali 5 ~ 15 parts, Herba Patriniae 10 ~ 20 parts, Herba Portulacae 20 ~ 30 parts, Radix Mirabilis himalaicae 5 ~ 15 parts.
Preferably, by weight, following component is comprised: 25 parts, Flos Carthami, Radix Angelicae Sinensis 25 parts, Herba Cynomorii 15 parts, Rhizoma Polygonati Odorati 25 parts, Olibanum 15 parts, Semen Oroxyli 8 parts, Fructus Lycii 15 parts, Herba pleurospermi thomsonii 13 parts, the Radix Astragali 10 parts, Herba Patriniae 15 parts, Herba Portulacae 25 parts, Radix Mirabilis himalaicae 10 parts.
The preparation method of liquid preparation of the present invention is: be added to the water by each crude drug, the consumption of water is 8 ~ 12 times of crude drug gross mass, decoct 30 ~ 40 minutes, filter to get filtrate and filtering residue, in filtering residue, add the water of filtering residue quality 8 ~ 12 times again, decoct 30 ~ 40 minutes, filter to get filtrate, merge the filtrate of twice, be the sufficient liquid preparation that prevents diabetes.
Liquid preparation embody rule mode of the present invention is: for the foot of diabetics, every afternoon or before sleeping foot bath is once, it within 30 days, is a course for the treatment of, serious symptom person foot bath every day 2 times, before foot bath, emptying defecation, first use the dirt on warm water cleaning patient foot, the sufficient liquid preparation that prevents diabetes of the present invention is placed with in the foot bath of thermostat, then adds the water of 10 times amount (volume multiple), be heated to 38 DEG C, both feet are put into foot bath liquid to soak 30 minutes, in foot bath process, both legs position coordinates part massage, can increase comfort level.
Beneficial effect of the present invention is: the sufficient liquid preparation that prevents diabetes of the present invention, for the foot that prevents diabetes, significantly can improve the blood circulation of diabetic foot, dredging the meridian, improve the symptoms such as patient's lower limb pain, numbness, prevent patient from foot ulcers, necrosis etc. occurring, Be very effective.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, according to technical spirit of the present invention to any simple modification made for any of the above embodiments or equivalent variations, all drop in protection scope of the present invention.
Application Example one
Embodiment 1
Formula is: 25 grams, Flos Carthami, Radix Angelicae Sinensis 25 grams, Herba Cynomorii 15 grams, Rhizoma Polygonati Odorati 25 grams, Olibanum 15 grams, Semen Oroxyli 8 grams, Fructus Lycii 15 grams, Herba pleurospermi thomsonii 13 grams, the Radix Astragali 10 grams, Herba Patriniae 15 grams, Herba Portulacae 25 grams, Radix Mirabilis himalaicae 10 grams.
Preparation method is: be added to the water by each crude drug, the consumption of water is 10 times of crude drug gross mass, decoct 35 minutes, filter to get filtrate and filtering residue, in filtering residue, add the water of filtering residue quality 10 times again, decoct 30 minutes, filter to get filtrate, merge the filtrate of twice, be the sufficient liquid preparation that prevents diabetes.
During embody rule, for the foot of diabetics, application mode is: every afternoon or before sleeping foot bath once, within 30 days, be a course for the treatment of, serious symptom person foot bath every day 2 times.Before foot bath, advise the emptying defecation of patient, first use the dirt on warm water cleaning patient foot, the sufficient liquid preparation that prevents diabetes of the present invention is placed with in the foot bath of thermostat, then adds the water of 10 times amount (volume multiple), be heated to 38 DEG C, both feet are put into foot bath liquid to soak 30 minutes, in foot bath process, both legs position coordinates part massage, can increase comfort level.
Embodiment 2
Formula is: 20 grams, Flos Carthami, Radix Angelicae Sinensis 30 grams, Herba Cynomorii 10 grams, Rhizoma Polygonati Odorati 20 grams, Olibanum 10 grams, Semen Oroxyli 10 grams, Fructus Lycii 20 grams, Herba pleurospermi thomsonii 10 grams, the Radix Astragali 5 grams, Herba Patriniae 20 grams, Herba Portulacae 30 grams, Radix Mirabilis himalaicae 15 grams.
Preparation method and using method thereof are with embodiment 1.
Embodiment 3
Formula is: 30 grams, Flos Carthami, Radix Angelicae Sinensis 20 grams, Herba Cynomorii 20 grams, Rhizoma Polygonati Odorati 30 grams, Olibanum 20 grams, Semen Oroxyli 5 grams, Fructus Lycii 10 grams, Herba pleurospermi thomsonii 15 grams, the Radix Astragali 15 grams, Herba Patriniae 10 grams, Herba Portulacae 20 grams, Radix Mirabilis himalaicae 5 grams.
Preparation method and using method thereof are with embodiment 1.
Application Example two
Embodiment 4 clinical trial
Patient data: 108 routine patients are the diabetics at certain hospital between year March in March, 2012 to 2014, wherein, man 68 example, female 40 example, at 65 ± 5 years old age, diabetes medical history 15 ± 2 years, patient all meets the diagnostic criteria that WHO diabetologist committee formulates for 1999. test through 10g nylon yarn, wherein 66 routine patient's monopodias or the biped positive, account for 61.1%.52 examples have intermittent claudication in various degree, account for the fluctuation of 48.1%. dorsal artery of foot and subtract weak person 42 example, disappearance person 17 example.Patients feet all has skin temperature drop in various degree low, has 57 routine patient's readme lower limb pains, numbness.
Both feet are put into foot bath liquid and are soaked 30 minutes by foot bath method: the sufficient liquid preparation that prevents diabetes embodiment 1 prepared is placed with in the foot bath of thermostat, then adds the water of 10 times amount (volume multiple), is heated to 38 DEG C.Every afternoon or before sleeping foot bath once, within 30 days, be a course for the treatment of, serious symptom person foot bath every day 2 times.Advise patient first to use the dirt on warm water cleaning foot before foot bath and emptying defecation, in foot bath process, coordinate massaging leg position.Statistics curative effect is observed after treating a course for the treatment of.
Therapeutic evaluation:
Invalid: the state of an illness has no improvement.
Effective: patients feet's skin is warm, dorsal artery of foot fluctuation recovers normal, 10g nylon yarn negative, and patient's intermittent claudication symptom is improved, without the generation of foot ulcers.
Result: 108 routine diabeticss, effective 102 examples, invalid 6 examples, there is foot ulcers without 1 example in effective percentage 94.4%.Illustrate that liquid preparation of the present invention improves the blood circulation of patients feet, dredging the meridian, effective prevention and cure diabetic foot, Be very effective, has very big popularizing value.

Claims (4)

1. prevent diabetes a sufficient liquid preparation, it is characterized in that, comprises following component by weight: 20 ~ 30 parts, Flos Carthami, Radix Angelicae Sinensis 20 ~ 30 parts, Herba Cynomorii 10 ~ 20 parts, Rhizoma Polygonati Odorati 20 ~ 30 parts, Olibanum 10 ~ 20 parts, Semen Oroxyli 5 ~ 10 parts, Fructus Lycii 10 ~ 20 parts, Herba pleurospermi thomsonii 10 ~ 15 parts, the Radix Astragali 5 ~ 15 parts, Herba Patriniae 10 ~ 20 parts, Herba Portulacae 20 ~ 30 parts, Radix Mirabilis himalaicae 5 ~ 15 parts.
2. liquid preparation according to claim 1, is characterized in that, comprises following component by weight: 25 parts, Flos Carthami, Radix Angelicae Sinensis 25 parts, Herba Cynomorii 15 parts, Rhizoma Polygonati Odorati 25 parts, Olibanum 15 parts, Semen Oroxyli 8 parts, Fructus Lycii 15 parts, Herba pleurospermi thomsonii 13 parts, the Radix Astragali 10 parts, Herba Patriniae 15 parts, Herba Portulacae 25 parts, Radix Mirabilis himalaicae 10 parts.
3. liquid preparation according to claim 1 and 2, it is characterized in that, this liquid preparation is prepared by the following method: be added to the water by each crude drug, and the consumption of water is 8 ~ 12 times of crude drug gross mass, decocts 30 ~ 40 minutes, filter to get filtrate and filtering residue, in filtering residue, add the water of filtering residue quality 8 ~ 12 times again, decoct 30 ~ 40 minutes, filter to get filtrate, merge the filtrate of twice, be the sufficient liquid preparation that prevents diabetes.
4. liquid preparation according to claim 1, is characterized in that: during use, the volume ratio of said preparation and water is 1: 10, and temperature controls at 38 DEG C.
CN201410523954.0A 2014-10-09 2014-10-09 Liquid preparation for preventing diabetic foot Pending CN104306699A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102697939A (en) * 2012-07-03 2012-10-03 山东省千佛山医院 Traditional Chinese medicine foot bath solution for preventing diabetic foot and preparation method thereof
CN103610770A (en) * 2013-11-29 2014-03-05 武长虹 Foot-soaking traditional Chinese medicine composition for treating diabetic feet
CN103610769A (en) * 2013-09-24 2014-03-05 陆群英 Diabetic peripheral neuropathy treatment traditional Chinese medicine composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102697939A (en) * 2012-07-03 2012-10-03 山东省千佛山医院 Traditional Chinese medicine foot bath solution for preventing diabetic foot and preparation method thereof
CN103610769A (en) * 2013-09-24 2014-03-05 陆群英 Diabetic peripheral neuropathy treatment traditional Chinese medicine composition
CN103610770A (en) * 2013-11-29 2014-03-05 武长虹 Foot-soaking traditional Chinese medicine composition for treating diabetic feet

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
刘希德: "糖尿病足中药外用方整理研究", 《中国中医药现代远程教育》 *
姚沛雨等: "刘学勤主任医师治疗糖尿病足临床10法", 《陕西中医》 *
徐进等: "中西医结合治疗糖尿病足38例", 《实用中医内科杂志》 *
良石等: "《巧招妙治糖尿病》", 30 June 2008, 黑龙江科学技术出版社 *

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