CN104306606A - 一种治疗骨关节炎的中药制剂及其制备方法 - Google Patents
一种治疗骨关节炎的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗骨关节炎的中药制剂及其制备方法。该中药制剂由以下重量份配比的原料制成:骨碎补、忍冬藤、半夏、川穹、防风、红花、郁李仁、枳壳、车前子、山茱萸、羌活、火麻仁、番木瓜、蜂房、黄芪、当归、丹参和五加皮。本发明的一种治疗骨关节炎的中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,对治疗骨关节炎引起的各种症状具有显著的效果,疗程短,见效快,疗效可靠,无任何毒副作用,能够达到标本兼治的目的。
Description
技术领域
本发明涉及一种中药,尤其涉及一种治疗骨关节炎的中药制剂及其制备方法。
背景技术
骨关节炎为一种退行性病变,系由于增龄、肥胖、劳损、创伤、关节先天性异常、关节畸形等诸多因素引起的关节软骨退化损伤、关节边缘和软骨下骨反应性增生,又称骨关节病、退行性关节炎、老年性关节炎、肥大性关节炎等。临床表现为缓慢发展的关节疼痛、压痛、僵硬、关节肿胀、活动受限和关节畸形等。主要症状为关节疼痛,常发生于晨间,活动后疼痛反而减轻,但如活动过多,疼痛又可加重。另一症状是关节僵硬,常出现在早晨起床时或白天关节长时间保持一定体位后。检查受累关节可见关节肿胀、压痛,活动时有摩擦感或“咔嗒”声,病情严重者可有肌肉萎缩及关节畸形。目前,在骨关节炎的治疗中,主要以西医和中医治疗为主,西医主要采取理疗、使用非抗炎药物等对症治疗以及关节置换等外科手术治疗,但存在药物副作用大、手术利弊及远期效果难以权衡、价格昂贵等缺点。目前中医主要用药物内服和推拿按摩,针灸,拔罐等疗法,但这些疗法较为繁琐,疗程长,费用高,疗效缓慢,也可能存在副作用或风险。
中药用于治疗骨关节炎,在我国具有较为悠久的历史,由于中医治疗疗效稳定,不易复发,大多数患者都选择中药来治疗。目前市场已有的中药制剂,要么是使用大量使用激素和生物制剂,其治疗成本高,药毒副作用多,不利于人体健康;要么就是难吸收,药效低。例如CN201410158753.5一种治疗骨关节炎的药物及制备方法和CN201410316648.X一种治疗骨关节炎的中药制剂及其制备方法,该两件专利中记载的中药制剂组方简单,效果单一,且使用过程中,服用量大、疗效不明显。而因此,迫切需要寻找一种易吸收、药效好、无毒无副作用的治疗慢性支气管炎的中药制剂。
发明内容
本发明的目的在于提供一种治疗骨关节炎的中药制剂及其制备方法,本发明药物所选药材配伍相宜,符合中医药学和现代医药学理论,对治疗骨关节炎引起的各种症状具有显著的效果,疗程短,见效快,疗效可靠,无任何毒副作用,能够达到标本兼治的目的。
为了实现上述目的,本发明提供了一种治疗骨关节炎的中药制剂,该中药制剂由以下重量份配比的原料制成 :骨碎补15-20份、忍冬藤15-20份、半夏14-16份、川穹10-15份、防风8-19份、红花9-17份、郁李仁15-19份、枳壳11-16份、车前子12-17份、山茱萸10-16份、羌活12-15份、火麻仁15-18份、番木瓜15-19份、蜂房15-19份、黄芪10-20份、当归11-15份、丹参15-20份和五加皮25-30份。
该中药制剂由以下重量份配比的原料制成 :骨碎补15份、忍冬藤15份、半夏14份、川穹10份、防风8份、红花9份、郁李仁15份、枳壳11份、车前子12份、山茱萸10份、羌活12份、火麻仁15份、番木瓜15份、蜂房15份、黄芪10份、当归11份、丹参15份和五加皮25份。
该中药制剂由以下重量份配比的原料制成 :骨碎补20份、忍冬藤20份、半夏16份、川穹15份、防风19份、红花17份、郁李仁19份、枳壳16份、车前子17份、山茱萸16份、羌活15份、火麻仁18份、番木瓜19份、蜂房19份、黄芪20份、当归15份、丹参20份和五加皮30份。
该中药制剂由以下重量份配比的原料制成 :骨碎补18份、忍冬藤18份、半夏15份、川穹12份、防风14份、红花13份、郁李仁17份、枳壳14份、车前子15份、山茱萸13份、羌活13份、火麻仁16份、番木瓜17份、蜂房17份、黄芪15份、当归13份、丹参17份和五加皮28份。
所述中药制剂制成药剂学上的水剂。
一种治疗骨关节炎的中药制剂的制备方法,包括以下步骤 :
(1)将组方中各组分药物研磨粉碎制成药粉;
(2)将步骤(1)中所得药粉混合均匀,用温度为25-35℃的清水浸泡12小时,用水量为所述药粉重量的3-6倍;
(3)先用武火熬炼10-15分钟,然后文火加热,沸腾持续0.5-3h后,过滤药渣,得药液; (4)将步骤(3)所得药液无菌灌装,即可得水剂。
步骤(1)中药粉的细度为80-120目。
步骤(3)中文火加热,沸腾持续0.5-1.5h。
本发明具有以下有益效果 :
本发明是经过临床实践经验中优选出的治疗骨关节炎的中药中药制剂,因此本组合物具有补肾益精,气血双补,活血化瘀,通络强筋,祛风除湿,止痛祛痹功效,对OA或骨痹具有标本同治的作用。同时本发明进行了临床实验,观察其活血、镇痛、抗炎、抗氧化作用。临床实验表明,患者用药后,关节活动程度明显改善,血液流变学指标明显改善,从而对骨关节炎患者的行动不利、关节肿痛等缓解效果明显。因此本发明所得中药的疗效得到了临床的充分验证。 本制备方法工艺独到,方法简单,成本低,节能环保,同时能显著缩短生产周期,降低生产成本及能耗,具有显著的竞争优势和广泛的应用前景,推广应用后将会取得显著的社会经济效益。
具体实施方式
实施例1
一种治疗骨关节炎的中药制剂,该中药制剂由以下重量份配比的原料制成 :骨碎补15-20份、忍冬藤15-20份、半夏14-16份、川穹10-15份、防风8-19份、红花9-17份、郁李仁15-19份、枳壳11-16份、车前子12-17份、山茱萸10-16份、羌活12-15份、火麻仁15-18份、番木瓜15-19份、蜂房15-19份、黄芪10-20份、当归11-15份、丹参15-20份和五加皮25-30份。
其制备方法如下:
(1)将组方中各组分药物研磨粉碎制成细度为80-120目的药粉;
(2)将步骤(1)中所得药粉混合均匀,用温度为25-35℃的清水浸泡12小时,用水量为所述药粉重量的3-6倍;
(3)先用武火熬炼10-15分钟,然后文火加热,沸腾持续0.5-3h后,过滤药渣,得药液; (4)将步骤(3)所得药液无菌灌装,即可得中药制剂(水剂)。
实施例2
一种治疗骨关节炎的中药制剂,该中药制剂由以下重量份配比的原料制成 :骨碎补15份、忍冬藤15份、半夏14份、川穹10份、防风8份、红花9份、郁李仁15份、枳壳11份、车前子12份、山茱萸10份、羌活12份、火麻仁15份、番木瓜15份、蜂房15份、黄芪10份、当归11份、丹参15份和五加皮25份。
其制备方法如下:
(1)将组方中各组分药物研磨粉碎制成细度为80目的药粉;
(2)将步骤(1)中所得药粉混合均匀,用温度为25℃的清水浸泡12小时,用水量为所述药粉重量的3倍;
(3)先用武火熬炼10分钟,然后文火加热,沸腾持续0.5h后,过滤药渣,得药液; (4)将步骤(3)所得药液无菌灌装,即可得中药制剂(水剂)。
实施例3
一种治疗骨关节炎的中药制剂,该中药制剂由以下重量份配比的原料制成 :骨碎补20份、忍冬藤20份、半夏16份、川穹15份、防风19份、红花17份、郁李仁19份、枳壳16份、车前子17份、山茱萸16份、羌活15份、火麻仁18份、番木瓜19份、蜂房19份、黄芪20份、当归15份、丹参20份和五加皮30份。
其制备方法如下:
(1)将组方中各组分药物研磨粉碎制成细度为120目的药粉;
(2)将步骤(1)中所得药粉混合均匀,用温度为35℃的清水浸泡12小时,用水量为所述药粉重量的6倍;
(3)先用武火熬炼15分钟,然后文火加热,沸腾持续3h后,过滤药渣,得药液;
(4)将步骤(3)所得药液无菌灌装,即可得中药制剂(水剂)。
实施例4
一种治疗骨关节炎的中药制剂,该中药制剂由以下重量份配比的原料制成 :骨碎补18份、忍冬藤18份、半夏15份、川穹12份、防风14份、红花13份、郁李仁17份、枳壳14份、车前子15份、山茱萸13份、羌活13份、火麻仁16份、番木瓜17份、蜂房17份、黄芪15份、当归13份、丹参17份和五加皮28份。
其制备方法如下:
(1)将组方中各组分药物研磨粉碎制成细度为100目的药粉;
(2)将步骤(1)中所得药粉混合均匀,用温度为30℃的清水浸泡12小时,用水量为所述药粉重量的4.5倍;
(3)先用武火熬炼12分钟,然后文火加热,沸腾持续1.5h后,过滤药渣,得药液; (4)将步骤(3)所得药液无菌灌装,即可得中药制剂(水剂)。
实施例5
本临床试验100例,选择确诊的骨关节炎患者,均来源于门诊病历,其中男性60例女性40例;年龄25-40岁50例,年龄41-62岁50例;
治疗方法:
口服本发明中药制剂(水剂)每次10毫升,每日2次,半月为一疗程,共2-3个疗程。
疗效判定标准:以症状改变程度为疗效判定标准。
观察结果:
用本发明药物,治疗骨关节炎患者100例,取得了较好的临床疗效,治愈87例,显效11例,无效2例,有效率达到98%,所有病历均无不良反应。对临床治愈人员随机抽查20人,随访2年未见复发。 用药期间未发现局部及全身过敏现象,用药安全。
本发明可用其他的不违背本发明的精神或主要特征的具体形式来概述。因此,无论从哪一点来看,本发明的上述实施方案都只能认为是对本发明的说明而不能限制发明,权利要求书指出了本发明的范围,而上述的说明并未指出本发明的范围,因此,在与本发明的权利要求书相当的含义和范围内的任何变化,都应认为是包括在权利要求书的范围内。
Claims (8)
1.一种治疗骨关节炎的中药制剂、其特征在于该中药制剂由以下重量份配比的原料制成 :骨碎补15-20份、忍冬藤15-20份、半夏14-16份、川穹10-15份、防风8-19份、红花9-17份、郁李仁15-19份、枳壳11-16份、车前子12-17份、山茱萸10-16份、羌活12-15份、火麻仁15-18份、番木瓜15-19份、蜂房15-19份、黄芪10-20份、当归11-15份、丹参15-20份和五加皮25-30份。
2.根据权利要求 1 所述的治疗骨关节炎的中药制剂、其特征在于该中药制剂由以下重量份配比的原料制成 :骨碎补15份、忍冬藤15份、半夏14份、川穹10份、防风8份、红花9份、郁李仁15份、枳壳11份、车前子12份、山茱萸10份、羌活12份、火麻仁15份、番木瓜15份、蜂房15份、黄芪10份、当归11份、丹参15份和五加皮25份。
3.根据权利要求 1 所述的治疗骨关节炎的中药制剂、其特征在于该中药制剂由以下重量份配比的原料制成 :骨碎补20份、忍冬藤20份、半夏16份、川穹15份、防风19份、红花17份、郁李仁19份、枳壳16份、车前子17份、山茱萸16份、羌活15份、火麻仁18份、番木瓜19份、蜂房19份、黄芪20份、当归15份、丹参20份和五加皮30份。
4.根据权利要求 1 所述的治疗骨关节炎的中药制剂、其特征在于该中药制剂由以下重量份配比的原料制成 :骨碎补18份、忍冬藤18份、半夏15份、川穹12份、防风14份、红花13份、郁李仁17份、枳壳14份、车前子15份、山茱萸13份、羌活13份、火麻仁16份、番木瓜17份、蜂房17份、黄芪15份、当归13份、丹参17份和五加皮28份。
5.根据权利要求 1-4中任一项所述的治疗骨关节炎的中药制剂,其特征在于 :所述中药制剂制成药剂学上的水剂。
6.一种权利要求 5所述的治疗骨关节炎的中药制剂的制备方法,其特征在于 ,包括以下步骤 : (1)将组方中各组分药物研磨粉碎制成药粉; (2)将步骤(1)中所得药粉混合均匀,用温度为25-35℃的清水浸泡12小时,用水量为所述药粉重量的3-6倍; (3)先用武火熬炼10-15分钟,然后文火加热,沸腾持续0.5-3h后,过滤药渣,得药液; (4)将步骤(3)所得药液无菌灌装,即可得水剂。
7.根据权利要求6所述的治疗骨关节炎的中药制剂的制备方法,其特征在于 :步骤(1)中药粉的细度为80-120目。
8.根据权利要求6所述的治疗骨关节炎的中药制剂的制备方法,其特征在于 :步骤(3)中文火加热,沸腾持续0.5-1.5h。
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