CN104274712A - Antipyretic and analgesic pharmaceutical composition for department of pediatrics - Google Patents
Antipyretic and analgesic pharmaceutical composition for department of pediatrics Download PDFInfo
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- CN104274712A CN104274712A CN201410514347.8A CN201410514347A CN104274712A CN 104274712 A CN104274712 A CN 104274712A CN 201410514347 A CN201410514347 A CN 201410514347A CN 104274712 A CN104274712 A CN 104274712A
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- benorylate
- vitamin
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- antipyretic
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
- 230000001754 anti-pyretic effect Effects 0.000 title abstract description 4
- 239000002221 antipyretic Substances 0.000 title abstract description 4
- 230000000202 analgesic effect Effects 0.000 title abstract 3
- 229960004277 benorilate Drugs 0.000 claims abstract description 19
- FEJKLNWAOXSSNR-UHFFFAOYSA-N benorilate Chemical compound C1=CC(NC(=O)C)=CC=C1OC(=O)C1=CC=CC=C1OC(C)=O FEJKLNWAOXSSNR-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229930003451 Vitamin B1 Natural products 0.000 claims abstract description 16
- 229960003495 thiamine Drugs 0.000 claims abstract description 16
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 16
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 16
- 235000010374 vitamin B1 Nutrition 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 16
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 206010037660 Pyrexia Diseases 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 3
- 206010019233 Headaches Diseases 0.000 abstract description 2
- 231100000869 headache Toxicity 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 241000758794 Asarum Species 0.000 abstract 1
- 244000189799 Asimina triloba Species 0.000 abstract 1
- 235000006264 Asimina triloba Nutrition 0.000 abstract 1
- 235000009467 Carica papaya Nutrition 0.000 abstract 1
- 241000931705 Cicada Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 241001071795 Gentiana Species 0.000 abstract 1
- 241000270295 Serpentes Species 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940085771 feverall Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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Abstract
The invention discloses an antipyretic and analgesic pharmaceutical composition for department of pediatrics. The composition is composed of the following medicinal components: 4-8 parts of radix bupleuri, 6-10 parts of asarum, 4-8 parts of large-leaved gentian, 2-6 parts of rhizoma gastrodiae, 1-3 parts of snake gall, 0.4-0.8 part of bear gall powder, 0.2-0.4 part of ephedra, 4-8 parts of cassia twig, 0.2-0.4 part of periostracum cicada, 6-10 parts of radix angelicae pubescentis, 10-14 parts of pawpaw, 120-180g of benorilate and 4-6g of vitamin B1. The pharmaceutical composition disclosed by the invention is prepared by mixing and processing a series of natural antipyretic and analgesic traditional Chinese medicines, and has a significant effect on such symptoms as headache caused by fever; and the pharmaceutical composition is free from any side effect.
Description
Technical field
The present invention relates to a kind of medicine of antipyretic-antalgic, particularly relate to a kind of pharmaceutical composition for department of pediatrics antipyretic-antalgic.
Background technology
Heating is a kind of symptom comparatively common during department of pediatrics is gone to a doctor, if the too high meeting of temperature has a strong impact on child health even threaten life, therefore needs to take effective measures reply.The at present conventional mode of bringing down a fever of bringing down a fever is to child administration aspirin or takes Merrill Lynch's (i.e. ibuprofen), and in both, the first can stimulate to the intestinal of children's's fragility and liver, kidney.And long-term taking Merrill Lynch, comparatively large to the side effect of kidney, therefore, need a kind of for medicine safely and effectively during infantile fever.
Summary of the invention
The present invention is exactly for the problems referred to above, and develop a kind of pharmaceutical composition for department of pediatrics antipyretic-antalgic, said composition is without any side effects to children's, and Be very effective.
For reaching above-mentioned technical purpose, present invention employs a kind of pharmaceutical composition for department of pediatrics antipyretic-antalgic, being made up of following medicine components: Radix Bupleuri 4-8 part, Herba Asari 6-10 part, Radix Gentianae Macrophyllae 4-8 part, Rhizoma Gastrodiae 2-6 part, Fel Serpentis 1-3 part, Fel Ursi powder 0.4-0.8 part, Herba Ephedrae 0.2-0.4 part, Ramulus Cinnamomi 4-8 part, Periostracum Cicadae 0.2-0.4 part, Radix Angelicae Pubescentis 6-10 part, Fructus Chaenomelis 10-14 part, benorylate 120g-180g, vitamin B1 4g-6g.
The best number of Chinese medicine component of the present invention is as follows: Radix Bupleuri 6 parts, Herba Asari 8 parts, Radix Gentianae Macrophyllae 6 parts, 4 parts, Rhizoma Gastrodiae, Fel Serpentis 2 parts, Fel Ursi powder 0.6 part, 0.3 part, Herba Ephedrae, Ramulus Cinnamomi 6 parts, Periostracum Cicadae 0.3 part, Radix Angelicae Pubescentis 8 parts, Fructus Chaenomelis 12 parts, benorylate 150g, VITAMIN B15 g, the above-mentioned medicine except benorylate and vitamin B1 is cleaned, dry, be crushed to 160 orders, be then mixed into benorylate and vitamin B1, finally incapsulate; Or the above-mentioned medicine except benorylate and vitamin B1 is cleaned, big fire decocts three times extracting juice, be then mixed into benorylate and vitamin B1, finally pour in bottle.
The present invention adopts a series of natural Chinese medicine for Antipyretic through being mixed and processed, and through 30 groups of immature tests on white mice results, the symptoms such as the headache caused for having a fever all have positive effect, and without any side effects.
Detailed description of the invention
Detailed description of the invention is described in more detail the present invention below.
For a pharmaceutical composition for department of pediatrics antipyretic-antalgic, be made up of following medicine components: Radix Bupleuri 4-8 part, Herba Asari 6-10 part, Radix Gentianae Macrophyllae 4-8 part, Rhizoma Gastrodiae 2-6 part, Fel Serpentis 1-3 part, Fel Ursi powder 0.4-0.8 part, Herba Ephedrae 0.2-0.4 part, Ramulus Cinnamomi 4-8 part, Periostracum Cicadae 0.2-0.4 part, Radix Angelicae Pubescentis 6-10 part, Fructus Chaenomelis 10-14 part, benorylate 120g-180g, vitamin B1 4g-6g.
In the present invention, also disclose the best number of Chinese medicine component: specific as follows: Radix Bupleuri 6 parts, Herba Asari 8 parts, Radix Gentianae Macrophyllae 6 parts, 4 parts, Rhizoma Gastrodiae, Fel Serpentis 2 parts, Fel Ursi powder 0.6 part, 0.3 part, Herba Ephedrae, Ramulus Cinnamomi 6 parts, Periostracum Cicadae 0.3 part, Radix Angelicae Pubescentis 8 parts, Fructus Chaenomelis 12 parts, benorylate 150g, vitamin B1 5g.
The present invention adopts two kinds of method pharmacy: the first is: the above-mentioned medicine except benorylate and vitamin B1 is cleaned, dry, be crushed to 160 orders, be then mixed into benorylate and vitamin B1, finally incapsulate; Capsule is applicable to larger children taking.
The second is: cleaned by the above-mentioned medicine except benorylate and vitamin B1, big fire decocts three times extracting juice, be then mixed into benorylate and vitamin B1, finally pour in bottle.Medicament is applicable to less than three years old child and takes.
Claims (2)
1. for a pharmaceutical composition for department of pediatrics antipyretic-antalgic, it is characterized in that, be made up of following medicine components: Radix Bupleuri 4-8 part, Herba Asari 6-10 part, Radix Gentianae Macrophyllae 4-8 part, Rhizoma Gastrodiae 2-6 part, Fel Serpentis 1-3 part, Fel Ursi powder 0.4-0.8 part, Herba Ephedrae 0.2-0.4 part, Ramulus Cinnamomi 4-8 part, Periostracum Cicadae 0.2-0.4 part, Radix Angelicae Pubescentis 6-10 part, Fructus Chaenomelis 10-14 part, benorylate 120g-180g, VB14 g-6g.
2. for a pharmaceutical composition for department of pediatrics antipyretic-antalgic, it is characterized in that, be made up of following medicine components: Radix Bupleuri 6 parts, Herba Asari 8 parts, Radix Gentianae Macrophyllae 6 parts, 4 parts, Rhizoma Gastrodiae, Fel Serpentis 2 parts, Fel Ursi powder 0.6 part, 0.3 part, Herba Ephedrae, Ramulus Cinnamomi 6 parts, Periostracum Cicadae 0.3 part, Radix Angelicae Pubescentis 8 parts, Fructus Chaenomelis 12 parts, benorylate 150g, VITAMIN B15 g, the above-mentioned medicine except benorylate and vitamin B1 is cleaned, dry, be crushed to 160 orders, be then mixed into benorylate and vitamin B1, finally incapsulate; Or the above-mentioned medicine except benorylate and vitamin B1 is cleaned, big fire decocts three times extracting juice, be then mixed into benorylate and vitamin B1, finally pour in bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410514347.8A CN104274712A (en) | 2014-09-30 | 2014-09-30 | Antipyretic and analgesic pharmaceutical composition for department of pediatrics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410514347.8A CN104274712A (en) | 2014-09-30 | 2014-09-30 | Antipyretic and analgesic pharmaceutical composition for department of pediatrics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104274712A true CN104274712A (en) | 2015-01-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410514347.8A Pending CN104274712A (en) | 2014-09-30 | 2014-09-30 | Antipyretic and analgesic pharmaceutical composition for department of pediatrics |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105727011A (en) * | 2015-12-23 | 2016-07-06 | 马敬斌 | Traditional Chinese medicine composition for pediatric heat releasing and pain relieving |
Citations (4)
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|---|---|---|---|---|
| CN1488352A (en) * | 2002-10-09 | 2004-04-14 | 西北合成药厂 | Medicinal composition for antipyretic analgesic for pediatrics |
| JP2006176460A (en) * | 2004-12-24 | 2006-07-06 | Kanebo Ltd | Composition compounded with galenical and pharmaceutical preparation containing the same |
| CN102600265A (en) * | 2012-04-07 | 2012-07-25 | 李承平 | Medicinal composition for relieving superficies syndrome with pungent and warm natured drugs |
| CN103230568A (en) * | 2013-04-18 | 2013-08-07 | 林凡友 | Benorilate vitamin B1 particle for children and preparation process thereof |
-
2014
- 2014-09-30 CN CN201410514347.8A patent/CN104274712A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1488352A (en) * | 2002-10-09 | 2004-04-14 | 西北合成药厂 | Medicinal composition for antipyretic analgesic for pediatrics |
| JP2006176460A (en) * | 2004-12-24 | 2006-07-06 | Kanebo Ltd | Composition compounded with galenical and pharmaceutical preparation containing the same |
| CN102600265A (en) * | 2012-04-07 | 2012-07-25 | 李承平 | Medicinal composition for relieving superficies syndrome with pungent and warm natured drugs |
| CN103230568A (en) * | 2013-04-18 | 2013-08-07 | 林凡友 | Benorilate vitamin B1 particle for children and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 陈秀琳等: "HPLC法测定小儿复方贝诺酯片中贝诺酯的含量", 《海峡药学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105727011A (en) * | 2015-12-23 | 2016-07-06 | 马敬斌 | Traditional Chinese medicine composition for pediatric heat releasing and pain relieving |
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| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
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Application publication date: 20150114 |