CN104257847A - Preparation method and application of Chinese magnolcavine fruit volatile oil microcapsule - Google Patents
Preparation method and application of Chinese magnolcavine fruit volatile oil microcapsule Download PDFInfo
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- CN104257847A CN104257847A CN201410445630.XA CN201410445630A CN104257847A CN 104257847 A CN104257847 A CN 104257847A CN 201410445630 A CN201410445630 A CN 201410445630A CN 104257847 A CN104257847 A CN 104257847A
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- volatile oil
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- schisandrae chinensis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
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Abstract
The invention discloses a preparation method and application of a Chinese magnolcavine fruit volatile oil microcapsule. The preparation method comprises the following steps: taking Chinese magnolcavine fruit volatile oil as a core material, preparing a wall material solution by taking maltodextrin and whey protein as raw materials, then adding a mixed emulsifying agent of monoglyceride and sucrose ester, further adding the core material, emulsifying, homogenizing and performing spray drying to obtain microcapsule particles. According to the preparation method disclosed by the invention, the Chinese magnolcavine fruit volatile oil is wrapped by the polymer material to form the microcapsule, so that the obtained product has relatively good water solubility and stability; pharmacodynamic evaluation proves that the microcapsule has an effect on relieving cough, and the efficacy is above 70% of that of codeine, so that the microcapsule can provide a preferred medicament for treating acute and chronic cough.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of preparation method and application thereof of Fructus Schisandrae Chinensis volatile oil microcapsule.
Background technology
Fructus Schisandrae Chinensis is commonly called as Fructus Zanthoxyli Plansipini, sliding weight of steelyard, medicine Fructus Schisandrae Chinensis, face rattan, five Fructus Armeniacae Mumes etc., is the dry mature fruit of magnoliaceae schisandra.Medical value is high, to human body, there is QI invigorating, nourishing kidney, astringe the lung, arresting seminal emission, promote the production of body fluid, quench the thirst, Fructus Alpiniae Oxyphyllae, the effect of calming the nerves.Be rich in volatile oil in Fructus Schisandrae Chinensis medicinal part sarcocarp and seed, especially seed content is the highest, can reach 1.6 ~ 2.9%.Volatile ingredient mainly contains
α-pinene, copaene, farnesene,
β-pinene,
β-myrcene,
α-the materials such as terpineol, borneol acetate, Ylangene.Pharmaceutical research shows, Fructus Schisandrae Chinensis volatile oil tool antitussive effect, its effect is 75% of codeine.Fructus Schisandrae Chinensis volatile oil, as the bioactive ingredients of Chinese medicine, has good development prospect, but domestic and international less to Fructus Schisandrae Chinensis volatile oil research at present, development and utilization not yet in addition.
Due to the high volatility of volatile oil, easily oxidized, cause it to preserve and use all being very restricted.Utilize microcapsule technology that Fructus Schisandrae Chinensis volatile oil is carried out micro encapsulation, greatly can improve the stable of product, be convenient to storage and utilize.
Microcapsule technology is a kind of a kind of resist technology adopting filmogen some to be had reactivity, sensitivity or volatile liquid or solid encapsulating formation fine particle; the process of encapsulating is micro encapsulation; the fine particle formed is called microcapsule; size is generally at 1 ~ 1000 μm, and the thickness of cyst wall is at 0.2 ~ 10 μm.The advantage of technology be can protective core materials/substances from the impact of environmental condition, reduce oxidation, passivation heliosensitivity and thermal sensitivity, reduce core volatility.
By literature search, identical with the present invention open source literature report is had no.
Summary of the invention
The object of the present invention is to provide a kind of preparation method and application of Fructus Schisandrae Chinensis volatile oil microcapsule, this microcapsule has extraordinary curative effect for antitussive.
The present invention completes by following technical solution, and particular content comprises: the preparation method of Fructus Schisandrae Chinensis volatile oil microcapsule and the application in the acute and chronic cough medicine of preparation treatment.
1. the preparation method of a Fructus Schisandrae Chinensis volatile oil microcapsule, the method comprises the Fructus Schisandrae Chinensis volatile oil microcapsule based on 100 weight portions: be first 1:1 ~ 3 maltodextrin and lactalbumin with the mass ratio of 36 ~ 60 weight portions be wall material, be dissolved in the hot water of 60 ~ 80 DEG C of described wall material weight 1 ~ 3 times, do not stop to stir, make it fully dissolve, obtain wall material solution; The mass ratio adding 1 ~ 4 weight portion is again the monoglyceride of 1:1 and the blended emulsifier of sucrose ester, mix homogeneously, finally the core Fructus Schisandrae Chinensis volatile oil of 39 ~ 60 weight portions is joined in above-mentioned solution, high pressure homogenizer is passed into after 10000 ~ 15000r/min high-speed stirred 10min, homogenizing three times under 70 ~ 80 DEG C and pressure 30 ~ 50MPa, form the emulsion of uniform particle diameter, in inlet temperature be 150 ~ 200 DEG C, outlet temperature is 80 ~ 120 DEG C, atomizing pressure be the condition of 0.2 ~ 0.5MPa under spraying dry, obtain Fructus Schisandrae Chinensis volatile oil microcapsule.
2. the application of Fructus Schisandrae Chinensis volatile oil microcapsule in the acute and chronic cough medicine of preparation treatment.
Microscapsule powder prepared by the present invention, even particle size, is rich in fragrance, and microencapsulated oil powder reaches more than 90%, and product has good heat stability and dissolution dispersity.Experiment proves, the microcapsule prepared by the present invention has significant antitussive effect, and action intensity is more than 70% of codeine, abundant raw material source, and preparation cost is low, for the acute and chronic cough symptom of clinical treatment provides preferred agents.
Further illustrate the present invention below in conjunction with detailed description of the invention, but the scope of protection of present invention is not limited to following embodiments.
detailed description of the invention:
Embodiment 1:
First with the mass ratio of 36g for 1:2 maltodextrin and lactalbumin are for wall material, be dissolved in the hot water of 60 DEG C of 72ml, do not stop stir, make it fully dissolve, obtain wall material solution; The mass ratio adding 4g is again the monoglyceride of 1:1 and the blended emulsifier of sucrose ester, mix homogeneously, finally the core Fructus Schisandrae Chinensis volatile oil of 60g is joined in above-mentioned solution, high pressure homogenizer is passed into after 10000r/min high-speed stirred 10min, homogenizing three times under 70 DEG C and pressure 30MPa, form the emulsion of uniform particle diameter, in inlet temperature be 150 DEG C, outlet temperature is 80 DEG C, atomizing pressure be the condition of 0.2MPa under spraying dry, obtain Fructus Schisandrae Chinensis volatile oil microcapsule, embedding rate is 92.6%.
Embodiment 2:
First with the mass ratio of 60g for 1:1 maltodextrin and lactalbumin are for wall material, be dissolved in the hot water of 80 DEG C of 180ml, do not stop stir, make it fully dissolve, obtain wall material solution; The mass ratio adding 1g is again the monoglyceride of 1:1 and the blended emulsifier of sucrose ester, mix homogeneously, finally the core Fructus Schisandrae Chinensis volatile oil of 39g is joined in above-mentioned solution, high pressure homogenizer is passed into after 12000r/min high-speed stirred 10min, homogenizing three times under 80 DEG C and pressure 50MPa, form the emulsion of uniform particle diameter, in inlet temperature be 200 DEG C, outlet temperature is 120 DEG C, atomizing pressure be the condition of 0.5MPa under spraying dry, obtain Fructus Schisandrae Chinensis volatile oil microcapsule, embedding rate is 95.3%.
Embodiment 3:
First with the mass ratio of 48g for 1:3 maltodextrin and lactalbumin are for wall material, be dissolved in the hot water of 60 DEG C of 48ml, do not stop stir, make it fully dissolve, obtain wall material solution; The mass ratio adding 2g is again the monoglyceride of 1:1 and the blended emulsifier of sucrose ester, mix homogeneously, finally the core Fructus Schisandrae Chinensis volatile oil of 50g is joined in above-mentioned solution, high pressure homogenizer is passed into after 15000r/min high-speed stirred 10min, homogenizing three times under 75 DEG C and pressure 40MPa, form the emulsion of uniform particle diameter, in inlet temperature be 180 DEG C, outlet temperature is 100 DEG C, atomizing pressure be the condition of 0.3MPa under spraying dry, obtain Fructus Schisandrae Chinensis volatile oil microcapsule, embedding rate is 94.5%.
The application of Fructus Schisandrae Chinensis volatile oil microcapsule in the acute and chronic cough medicine of preparation treatment.
Grouping: be divided into 4 groups, often organizes 10 Cavia porcelluss, male and female.Specifically be grouped as follows:
A: saline control group, with normal saline gastric infusion
B: Fructus Schisandrae Chinensis volatile oil microcapsule 10mg/kg
C: Fructus Schisandrae Chinensis volatile oil microcapsule 20mg/kg
D: codeine 10mg/kg
Adopt strong aqua ammonia to draw the method for coughing by table 1 dosage gastric infusion, blank group is to the normal saline of same dose
Experimental procedure: all experimental guinea pigs all strong aqua ammonia draw cough before 1h administration 1 time.With the container internal spraying strong aqua ammonia of glass atomizer in diameter 8cm, high 15cm, mice is taken out immediately after 1min, be placed in 20 × 10 × 10 plethysmography boxes, with highly sensitive pressure transducer by Cavia porcellus respiratory frequency and plethysmogram signal input microcomputer Pclab Biological Signal Collecting System, record guinea pig cough's number of times in mice incubation period and 3min.Cough is each time all to hear the obvious cough record binding analysis that guinea pig cough's sound and microcomputer Pclab see.Adopt Stata7.0 software to carry out statistical analysis to experimental result, data with
± S represents, compare between group and adopt t inspection, P < 0.05 is as the standard of significant difference.
Experimental result is as following table:
Inhibitory action that table 1 Fructus Schisandrae Chinensis volatile oil microcapsule causes guinea pig cough to react to strong aqua ammonia (n=10,
± S)
| Group | Dosage | Administering mode | Cough latent period (s) | Cough number of times in 3min | Suppression ratio (%) |
| A | 10ml/kg | ig | 39.94±6.73 | 160.14±10.38 | ? |
| B | 10mg/kg | ig | 74.86±7.45 ** | 98.84±8.22 * | 38.28 |
| C | 20mg/kg | ig | 80.18±5.76 ** | 79.60±5.17 ** | 50.29 |
| D | 10mg/kg | ig | 91.52±10.33 ** | 74.65±8.31 ** | 54.38 |
Note:
*experimental group compares P < 0.01 with blank group,
*experimental group compares P < 0.05 with blank group
Experiment shows, B, C two groups and blank group more all have the antitussive effect of highly significant, and suppression ratio reaches more than 70% of codeine.
Claims (2)
1. the preparation method of a Fructus Schisandrae Chinensis volatile oil microcapsule, it is characterized in that, the method comprises the Fructus Schisandrae Chinensis volatile oil microcapsule based on 100 weight portions: be first 1:1 ~ 3 maltodextrin and lactalbumin with the mass ratio of 36 ~ 60 weight portions be wall material, be dissolved in the hot water of 60 ~ 80 DEG C of described wall material weight 1 ~ 3 times, do not stop to stir, make it fully dissolve, obtain wall material solution; The mass ratio adding 1 ~ 4 weight portion is again the monoglyceride of 1:1 and the blended emulsifier of sucrose ester, mix homogeneously, finally the core Fructus Schisandrae Chinensis volatile oil of 39 ~ 60 weight portions is joined in above-mentioned solution, high pressure homogenizer is passed into after 10000 ~ 15000r/min high-speed stirred 10min, homogenizing three times under 70 ~ 80 DEG C and pressure 30 ~ 50MPa, form the emulsion of uniform particle diameter, in inlet temperature be 150 ~ 200 DEG C, outlet temperature is 80 ~ 120 DEG C, atomizing pressure be the condition of 0.2 ~ 0.5MPa under spraying dry, obtain Fructus Schisandrae Chinensis volatile oil microcapsule.
2. the application of a kind of Fructus Schisandrae Chinensis volatile oil microcapsule as described in claim 1 in the acute and chronic cough medicine of preparation treatment.
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| CN201410445630.XA CN104257847A (en) | 2014-09-04 | 2014-09-04 | Preparation method and application of Chinese magnolcavine fruit volatile oil microcapsule |
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| CN201410445630.XA CN104257847A (en) | 2014-09-04 | 2014-09-04 | Preparation method and application of Chinese magnolcavine fruit volatile oil microcapsule |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578222A (en) * | 2016-11-08 | 2017-04-26 | 云南爱尔康生物技术有限公司 | Fucoxanthin solid beverage and preparation method thereof |
| CN109157424A (en) * | 2018-10-12 | 2019-01-08 | 赵孔发 | A kind of preparation method and applications of Japan pepper essential oil microcapsules |
| CN109497551A (en) * | 2017-09-14 | 2019-03-22 | 无限极（中国）有限公司 | A kind of magnolia vine fruit oil powdered oil and its preparation method and application |
| CN109497552A (en) * | 2017-09-14 | 2019-03-22 | 无限极（中国）有限公司 | A kind of magnolia vine fruit oil powdered oil and its preparation method and application |
| CN112057500A (en) * | 2020-10-16 | 2020-12-11 | 陕西嘉禾药业有限公司 | Method for extracting polysaccharide, volatile oil, flavone and lignan from schisandra chinensis |
| CN113826898A (en) * | 2021-08-26 | 2021-12-24 | 闽江学院 | Sparassis crispa beta-glucan microcapsule and preparation method thereof |
-
2014
- 2014-09-04 CN CN201410445630.XA patent/CN104257847A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578222A (en) * | 2016-11-08 | 2017-04-26 | 云南爱尔康生物技术有限公司 | Fucoxanthin solid beverage and preparation method thereof |
| CN109497551A (en) * | 2017-09-14 | 2019-03-22 | 无限极（中国）有限公司 | A kind of magnolia vine fruit oil powdered oil and its preparation method and application |
| CN109497552A (en) * | 2017-09-14 | 2019-03-22 | 无限极（中国）有限公司 | A kind of magnolia vine fruit oil powdered oil and its preparation method and application |
| CN109157424A (en) * | 2018-10-12 | 2019-01-08 | 赵孔发 | A kind of preparation method and applications of Japan pepper essential oil microcapsules |
| CN112057500A (en) * | 2020-10-16 | 2020-12-11 | 陕西嘉禾药业有限公司 | Method for extracting polysaccharide, volatile oil, flavone and lignan from schisandra chinensis |
| CN113826898A (en) * | 2021-08-26 | 2021-12-24 | 闽江学院 | Sparassis crispa beta-glucan microcapsule and preparation method thereof |
| CN113826898B (en) * | 2021-08-26 | 2023-11-03 | 闽江学院 | Sparassis crispa beta-glucan microcapsule and preparation method thereof |
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Application publication date: 20150107 |
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