CN104257404A - Cardia gullet biological sample sampling device - Google Patents

Abstract

The present invention relates to a cell collection device, in particular to a cardiac and esophageal biological sample sampler, the outer surface of the sampler is covered with an esophageal net, one end of the esophageal net extends into the sampler, and a rope is connected to the top of the sampler. The initial state of the esophageal mesh is "V" shape, and the esophageal mesh is folded and drooped after use; the sampler and the esophageal mesh are contained in a soluble capsule, and the esophageal mesh is bound by the soluble capsule and squeezed together in a "V"shape; Esophagus mesh has micro-grooves on all bristles for increased roughness. Beneficial effects of the present invention: increase the comfort of the subject, especially reduce the discomfort caused by the laryngeal reflex; the structure of some bristles of the esophageal mesh is designed to collect cells to the maximum, further improving the Acquisition volume; multi-item detection can be carried out at the same time after one sampling.

Description

Cardia esophageal biological sampler

technical field

The invention relates to a cell collection device, in particular to a cardiac and esophageal biological sample sampler. the

Background technique

In the known cell collection devices, most of them are in the shape of a mesh bag, which is inflated to make it bulge after entering the esophagus, and the abrasive material at the edge is used for cell collection. Friction occurs, causing the subject's laryngeal reflex, producing a strong sense of discomfort. On the other hand, in the process of cell collection, they cannot be placed separately, which is inconvenient for later multiple detection. the

Contents of the invention

The purpose of the present invention is to provide a cardiac and esophageal biological sample sampler that improves the comfort level of the subject and facilitates later detection.

In order to achieve the above object, the present invention adopts the following technical scheme: cardia esophageal biological sample sampler, the outer surface of the sampler 1 is covered with an esophageal net 3, and one end of the esophageal net 3 is inserted into the sampler 1, and the top of the sampler 1 is connected with The initial state of the rope 2 and the esophageal net 3 is "V", and the esophageal net 3 is folded and drooped after use.

Further, the sampler 1 and the esophageal net 3 are contained in a soluble capsule 4 , and the esophageal net 3 is constrained by the soluble capsule 4 and squeezed together in a "V" shape.

Further, the material of the esophageal mesh 3 is soft wool.

Further, the top part of the bristles of the esophagus mesh 3 has a spoon-shaped body 31 .

Further, part of the bristles of the esophagus mesh 3 are hollow, and a part of the bristles has an opening 32 on one side.

Further, all the bristles of the esophagus mesh 3 have microgrooves 33 that increase the roughness.

Further, the first sampler 11 , the second sampler 12 , and the third sampler 13 are rotatably connected through the protrusion 14 with the external thread and the groove with the external thread.

Further, the sampler 1 is divided into a first sampler 11, a second sampler 12, and a third sampler 13, and the sampler is connected by a connecting strip 14 that is easy to cut or tear, and the connecting strip 14 The material is soft; the first sampler 11, the second sampler 12, the third sampler 13 correspond to the first sample drop bottle 51, the second sample drop bottle 52, the third sample drop bottle 53 respectively, the sample drop Place DNA preservation solution or RNA preservation solution or exfoliated cell preservation solution in the bottle respectively.

Further, the top of the bottle cap of the sample dropper bottle has a drop opening 55 sealed by a breakable bar 54 , a filter layer 57 inside the bottle cap, and a friction-increasing texture 56 on the bottle cap.

Further, the rope 2 is provided with a scale 21 every 5 centimeters, wherein color markings are provided for every incremental distance of 5 centimeters, 10 centimeters and 20 centimeters.

Beneficial effects of the present invention:

1. During use, the esophageal net changes from the initial V shape to the drooping shape when it is taken out. At the beginning, it has the maximum contact with the esophagus. With the dragging during use, the esophageal net gradually gathers and Reduce contact with the esophagus, and it has been completely retracted when it is finally taken out of the mouth, increasing the comfort of the subject, especially reducing the discomfort caused by the laryngeal reflex;

2. The structure of some bristles of the esophageal net is designed to collect cells to the maximum extent, further increasing the collection amount each time it is used;

3. The sampler can be separated, so that the cells collected by the corresponding bristles are put into different sample droppers for storage, which is convenient for different types of test analysis in the later stage.

Description of drawings:

Accompanying drawing 1 is the sampler schematic diagram of the present invention;

Accompanying drawing 2 is the schematic diagram of the present invention being wrapped in soluble capsule;

Accompanying drawing 3 is the initial state development schematic diagram of the present invention;

Accompanying drawing 4 is the terminal state reference figure of the present invention;

Accompanying drawing 5 is partial sectional view of part bristle of the present invention;

Accompanying drawing 6 is a partial schematic diagram of part of the bristles of the present invention;

Accompanying drawing 7 is the sample drop bottle schematic diagram of the present invention;

Accompanying drawing 8 is the schematic diagram of the cap of the sample dropping bottle of the present invention.

Detailed ways:

The present invention is further described below in conjunction with accompanying drawing:

Referring to Figures 1 to 6, the outer surface of the sampler 1 of the present invention is covered with an esophageal net 3, one end of the esophageal net 3 extends into the sampler 1, a rope 2 is connected to the top of the sampler 1, and the initial state of the esophageal net 3 is " V" shape, the esophageal net 3 is folded in an inverted "V" shape after use, the sampler 1 and the esophageal net 3 are contained in the soluble capsule 4, and the esophageal net 3 is restrained by the soluble capsule 4 in a "V" shape. Squeeze together in a V" shape.

As shown in Figure 2, after the subject swallowed the soluble capsule 4, the other end of the rope was left outside, and when the soluble capsule 4 reached the esophagus, the soluble capsule 4 was dissolved, as shown in Figure 3, compressed in the capsule 4 The esophageal net 3 expands to its original size and contacts the esophageal cortex. At this time, the esophageal net 3 presents a "V" shape. When the sampling device is dragged by the outside, the esophageal net 3 constantly rubs against the esophagus. For liquid with cells, as shown in Figure 4, the esophageal mesh 3 will gradually gather and droop after receiving the friction force. At this time, it will basically not rub against the esophagus, and will not irritate the larynx when it is pulled out from the oral cavity. Subject's comfort.

Referring to Figures 5-6, as a preferred technical solution, the preferred material of the esophagus mesh 3 is soft wool. In order to enhance the efficiency of collecting cells by the bristles, part of the bristles of the esophagus mesh 3 has a spoon-shaped body 31 on the top, and some of the bristles are hollow. Furthermore, one side of the bristles of the esophagus mesh 3 has an opening 32. Microgrooves 33 for increasing roughness on all bristles. The spoon-shaped body 31 further increases the contact area between the esophageal mesh 3 and the esophagus, improving the efficiency of the sampling device.

For the convenience of operation, the rope 2 is provided with a scale 21 every 5 centimeters (not shown in the accompanying drawings), wherein color markings are set for every incremental distance of 5 centimeters, 10 centimeters, and 20 centimeters, such as 5 centimeters from the end of the rope A red circle is marked, a yellow circle is marked at 10 cm, a blue circle is marked at 20 cm, and so on. The operator can know which position the capsule reaches in the human body according to the scale. the

Referring to Fig. 1 to Fig. 8, described sampler 1 is divided into the first sampler 11, the second sampler 12, the 3rd sampler 13, described sampler is connected by connecting strip 14 that is easy to cut off or tear, so The samplers correspond to the first drop bottle 51, the second sample drop bottle 52, and the third sample drop bottle 53 respectively, and the DNA preservation solution, the RNA preservation solution or the exfoliated cell preservation solution are respectively placed in the sample drop bottles. The top of the bottle cap of the sample dropping bottle has a drop opening 55 sealed by a breakable bar 54 , and the inside of the bottle cap has a filter layer 57 .

When in use, cut off the connecting strip 14 of the sampler, cut the sampler into three sections, put them into the sample dropper respectively, cover the lid, and shake well. When detection is required, the strip body 54 is broken off, and the liquid with cells is dripped from the drop port 55, and the filter layer 57 filters food residues etc. before the liquid drips out. Preferably, the cap has a texture 56 to increase friction. These separately preserved cells can be used for the detection of DNA, RNA, protein, exfoliated cells, etc., and multiple detections can be realized in one sampling, which is very convenient and quick.

Further, since the connecting strip 14 is soft, the sampler 1 can be bent and discharged into the soluble capsule 4, which is conducive to filling the capsule 4. In other words, more capsules can be placed in a smaller capsule. Big sampler.

Certainly, the above are only preferred implementation modes of the present invention, and are not intended to limit the scope of application of the present invention, and any other equivalent and substituted structures are within the scope of protection thereof.

Claims (9)

1. cardia esophagus biological specimen sampler, it is characterized in that: sampler (1) outer surface covers esophagus and draws in the net (3), one end that esophagus draws in the net (3) is stretched in sampler (1), sampler (1) top is connected with rope (2), esophagus draws in the net (3), and original state is " V " shape, esophagus draws in the net (3) finish using after draw in sagging.

2. cardia esophagus biological specimen sampler according to claim 1, it is characterized in that: described sampler (1) and esophagus draw in the net (3) be included in soluble capsule (4), the constraint that esophagus draws in the net (3) is subject to soluble capsule (4) presses together in " V " shape.

3. cardia esophagus biological specimen sampler according to claim 1, is characterized in that: it is fur that described esophagus draws in the net the material of (3).

4. cardia esophagus biological specimen sampler as claimed in any of claims 1 to 3, is characterized in that: described esophagus draws in the net the top of portion bristle of (3) with spoon shape body (31).

5. cardia esophagus biological specimen sampler as claimed in any of claims 1 to 3, is characterized in that: it is hollow form that described esophagus draws in the net the portion bristle of (3), and portion bristle one side has mouth (32).

6. cardia esophagus biological specimen sampler as claimed in any of claims 1 to 3, is characterized in that: described esophagus draws in the net that (3) all bristles have the microflute (33) increasing roughness.

7. cardia esophagus biological specimen sampler as claimed in any of claims 1 to 3, it is characterized in that: described sampler (1) is divided into the first sampler (11), the second sampler (12), the 3rd sampler (13), described sampler is connected by the connection strap (14) being easy to cut off or tear, and the material of described connection strap 14 is soft; First sampler (11), the second sampler (12), the 3rd sampler (13) respectively corresponding first sample drop bottle (51), the second sample drop bottle (52), the 3rd sample drop bottle (53), place DNA conserving liquid or RNA conserving liquid or exfoliated cell preservative fluid respectively in sample drop bottle.

8. cardia esophagus biological specimen sampler according to claim 7, it is characterized in that: the Bottle cap top of described sample drop bottle has drip (55), drip (55) seals by breaking disconnected bar body (54), closure inside has filter course (57), bottle cap has the texture (56) increasing friction.

9. esophagus biological specimen sampler as claimed in any of claims 1 to 3, is characterized in that: every 5 centimetres of described rope (2) arranges a scale (21), and wherein the distance that increases progressively of every 5 centimetres, 10 centimetres, 20 centimetres arranges colour code.