CN104256652A - Oral multi-vitamin nano liposome - Google Patents

Oral multi-vitamin nano liposome Download PDF

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Publication number
CN104256652A
CN104256652A CN201410520174.0A CN201410520174A CN104256652A CN 104256652 A CN104256652 A CN 104256652A CN 201410520174 A CN201410520174 A CN 201410520174A CN 104256652 A CN104256652 A CN 104256652A
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vitamin
cobastab
nano liposome
liposome
oral
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李明刚
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to an oral multi-vitamin nano liposome, belonging to the technical field of nutrient supplements. In multi-vitamin nano liposome oral liquid, nano liposome prepared from lecithin, cholesterol and tween-80 is used as an embedding agent, and the liposome contains vitamin A1, vitamin D3, vitamin E, vitamin K, vitamin C, vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid) and vitamin B12 (cyanocobalamin). The oral multi-vitamin nano liposome can be directly absorbed and utilized by small intestines, so that the absorption rate and the bioavailability of the oral multi-vitamin nano liposome are improved; and the oral multi-vitamin nano liposome can be widely applied to the industries of health-care food, functional beverage, cosmetics, medicine and the like, and is suitable for large-scale production.

Description

A kind of oral B B-complex nano liposomes
Technical field
The invention provides a kind of oral B B-complex nano liposomes, belong to nutrient prime replenisher technical field.
Background technology
Vitamin maintains the required type organic matter of human life activity, is also the important active substances keeping health.Vitamin content is in vivo little, but plays an important role in growth in humans, metabolism, growth course, can cause dysbolism, and cause various diseases during shortage.When body can not meet its vital movement needs from external world's picked-up vitamin, metabolic function will be caused disorderly, cause various disease.
Because vitamin kind is a lot, distinct, in the majority with separate constituent of the vitamin preparation of therefore at present domestic production, Cernevit-12 is less, and formulation is main mainly with tablet or capsule, and liquid oral vitamin is then main mainly with B family vitamin.For fat-soluble A, D, E, K, because it is water-soluble poor, bioavilability is low.Find after deliberation, the absorptivity in the liposoluble vitamin in tablet or capsule is 20% ~ 25%, and bioavailability is 30%; The absorptivity of the liposoluble vitamin in emulsification B B-complex is 40% ~ 45%, and bioavailability is 55%.The biological value of visible tablet or capsule B B-complex is 6% ~ 7.5%; The biological value of general emulsification B B-complex is 22% ~ 25%.
Summary of the invention
For overcoming the shortcoming that prior art exists, goal of the invention of the present invention is to provide a kind of B B-complex nano liposomes oral liquid, and it directly can be absorbed by small intestine, improves its absorptivity and bioavilability.
For realizing described goal of the invention, the invention provides a kind of B B-complex nano liposomes oral liquid, it is characterized in that, with the nano liposomes prepared by lecithin, cholesterol and Tween 80 for embedding medium, containing vitamin A in its liposome 1, vitamin D 3, vitamin E, vitamin K, vitamin C, Cobastab 1(thiamine), Cobastab 2(riboflavin), Cobastab 3(nicotinic acid), Cobastab 5(pantothenic acid), Cobastab 6(pyridoxol), Cobastab 7(biotin), Cobastab 9(folic acid), Cobastab 12(cyanocobalamin).
Preferably, described B B-complex nano liposomes oral liquid, containing 0.01 ~ 2mg vitamin A in every 10mL nano liposomes oral liquid 1, 1 ~ 50 μ g vitamin D 3, 0.5 ~ 300mg vitamin E, 2 ~ 500 μ g vitamin Ks 1, 10 ~ 300mg vitamin C, 0.2 ~ 10mg Cobastab 1(thiamine), 0.2 ~ 10mg Cobastab 2(riboflavin), 5 ~ 50mg Cobastab 3(nicotinic acid), 1 ~ 50mg Cobastab 5(pantothenic acid), 0.5 ~ 10mg Cobastab 6(pyridoxol), 10 ~ 1000 μ g Cobastabs 7(biotin), 50 ~ 1000 μ g Cobastabs 9(folic acid), 0.1 ~ 20 μ g Cobastab 12(cyanocobalamin).
Compared with prior art, B B-complex nano liposomes oral liquid provided by the invention, with lecithin, cholesterol and Tween 80 for embedding medium, emulsion-dynamic high-pressure micro jetting technology (D HPM) is adopted to prepare B B-complex nano liposomes, acquisition appearance transparent, average grain diameter are about 50nm, the B B-complex nano liposomes that envelop rate is greater than 90%, and ensure that the stability of vitamin in preparation process.Lipidization vitamin directly can be absorbed by small intestine, improves its absorptivity and bioavilability, and this product can be widely used in the industries such as health food, drinks, cosmetics, medicine, is applicable to large-scale production.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail.
B B-complex nano liposomes oral liquid provided by the invention, containing 0.01 ~ 2mg vitamin A in every 10mL nano liposomes oral liquid 1, 1 ~ 50 μ g vitamin D 3, 0.5 ~ 300mg vitamin E, 2 ~ 500 μ g vitamin Ks 1, 10 ~ 300mg vitamin C, 0.2 ~ 10mg vitamin B1 (thiamine), 0.2 ~ 10mg Cobastab 2(riboflavin), 5 ~ 50mg Cobastab 3(nicotinic acid), 1 ~ 50mg Cobastab 5(pantothenic acid), 0.5 ~ 10mg Cobastab 6(pyridoxol), 10 ~ 1000 μ g Cobastabs 7(biotin), 50 ~ 1000 μ g Cobastabs 9(folic acid), 0.1 ~ 20 μ g Cobastab 12(cyanocobalamin).
Embodiment 1:
The concrete preparation method of the B B-complex nano liposomes oral liquid that the embodiment of the present invention 1 provides is as follows:
S01: take soybean lecithin 5g, cholesterol 1g, Tween 80 1g, add 30ml in absolute ethyl alcohol (or chloroform, methyl alcohol or carrene etc.), then put into eggplant-shape bottle, on water-bath evaporimeter (bath temperature 40 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution a;
S02: get 5ml olive oil and put into container, and add 50mg vitamin A wherein 1, 0.5mg vitamin D 3, 1g vitamin E, 5mg vitamin K 1, mix, obtain liposoluble vitamin solution b;
S03: above-mentioned liposoluble vitamin solution b is joined in the solution a of step (1), stirs and evenly mixs, obtain solution c
S04: by 10g vitamin C, 0.1g thiamine, 0.1g Cobastab 2, 1.2g niacinamide, 0.5g pantothenic acid, 0.1g Cobastab 6, 30mg biotin, 40mg folic acid, 0.3mg Cobastab 12be dissolved in 10mL distilled water, obtain water soluble vitamin solution d;
The water soluble vitamin solution d of step (4) joins in step (3) solution c by S05, stirs and obtains solution e;
S06: evaporation under reduced pressure removed solvent is carried out to solution e;
S07: use spy formula Ultrasound Instrument to make the abundant aquation of lipid membrane 80 minutes under ice-water bath condition, until become transparent to emulsion;
S08: use Microfluidizer under 100MPa pressure to emulsion breast even 2 times;
S09: add distilled water to 1000ml, stir, then filter packing, obtains B B-complex nano liposomes oral liquid, and described B B-complex nano liposomes appearance transparent, average grain diameter are about 50.2nm, and envelop rate is 91%.
Embodiment 2:
The concrete preparation method of the B B-complex nano liposomes oral liquid that the embodiment of the present invention 2 provides is as follows:
S01: take soybean lecithin 5g, cholesterol 1g, Tween 80 1g, add 30ml in absolute ethyl alcohol (or chloroform, methyl alcohol or carrene etc.), then put into eggplant-shape bottle, on water-bath evaporimeter (bath temperature 50 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution a;
S02: get 5ml olive oil and put into container, and add 1mg vitamin A wherein 1, 0.1mg vitamin D 3, 50mg vitamin E, 0.2mg vitamin K 1, mix, obtain liposoluble vitamin solution b;
S03: above-mentioned liposoluble vitamin solution b is joined in the solution a of step (1), stirs and evenly mixs, obtain solution c;
S04: by 10g vitamin C, 0.1g thiamine, 0.1g Cobastab 2, 1.2g niacinamide, 0.5g pantothenic acid, 1g Cobastab 6, 3g biotin, 4g folic acid, 30mg Cobastab 12be dissolved in 10mL distilled water, obtain water soluble vitamin solution d;
S05: the water soluble vitamin solution d of step (4) is joined in step (3) solution c, stirs and obtain solution e;
S06: evaporation under reduced pressure removed solvent is carried out to solution e;
S07: use spy formula Ultrasound Instrument to make the abundant aquation of lipid membrane 40 minutes under ice-water bath condition, until become transparent to emulsion;
S08: use Microfluidizer under 100MPa pressure to emulsion breast even 6 times;
S09: add distilled water to 1000ml, stir, then filter packing, obtains B B-complex nano liposomes oral liquid, and described B B-complex nano liposomes appearance transparent, average grain diameter are about 49.8nm, and envelop rate is 91.2%.
Embodiment 3:
The concrete preparation method of the B B-complex nano liposomes oral liquid that the embodiment of the present invention 3 provides is as follows:
S01: take soybean lecithin 5g, cholesterol 1g, Tween 80 1g, add 30ml in absolute ethyl alcohol (or chloroform, methyl alcohol or carrene etc.), then put into eggplant-shape bottle, on water-bath evaporimeter (bath temperature 55 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution a;
S02: get 5ml olive oil and put into container, and add 40mg vitamin A wherein 1, 1mg vitamin D 3, 2g vitamin E, 4mg vitamin K 1, mix, obtain liposoluble vitamin solution b;
S03: above-mentioned liposoluble vitamin solution b is joined in the solution a of step (1), stirs and evenly mixs, obtain solution c;
S04: by 30g vitamin C, 1g thiamine, 1g Cobastab 2, 5g niacinamide, 0.5g pantothenic acid, 0.1g Cobastab 6, 30mg biotin, 40mg folic acid, 0.3mg Cobastab 12be dissolved in 10mL distilled water, obtain water soluble vitamin solution d;
S05: the water soluble vitamin solution d of step (4) is joined in step (3) solution c, stirs and obtain solution e;
S06: evaporation under reduced pressure removed solvent is carried out to solution e;
S07: use spy formula Ultrasound Instrument to make the abundant aquation of lipid membrane 40 minutes under ice-water bath condition, until become transparent to emulsion;
S08: use Microfluidizer under 100MPa pressure to emulsion breast even 10 times;
S09: add distilled water to 1000ml, stir, then filter packing, obtains B B-complex nano liposomes oral liquid, and described B B-complex nano liposomes appearance transparent, average grain diameter are about 50nm, and envelop rate is 90.8%.
B B-complex nano liposomes nutrient solution oral liquid prepared by the method utilizing the embodiment of the present invention 1 to provide is tested:
One, materials and methods
1. test specimen
B B-complex nano liposomes nutrient solution is obtained by formula provided by the invention and method.
2. animal used as test, grouping and hello oxygen method
2-1 experimental animal:
Screech owl white rabbit 6,2-3kg, is provided by Peking University's experimental animal center.
2-2 tests grouping: experimental rabbit is after laboratory adapts to 5 days, be divided into 3 groups at random, that is: water group (control group A) is fed in normal diet+filling, B B-complex (control group B) is fed in normal diet+filling and B B-complex nano liposomes nutrient solution (experimental group C) is fed in normal diet+filling, and described B B-complex has the vitamin with the equal proportioning of liposome provided by the invention;
2-3 experimental technique:
A treated animal is normally fed, and B treated animal gives to fill with hello B B-complex oral liquid 5ml every day.C treated animal gives B B-complex nano liposomes nutrient solution oral liquid 5ml every day.5 days experimental periods.Feed after 5 days, get blood, separation of serum, measure vitamine concentration in animal blood.METHOD FOR CONTINUOUS DETERMINATION 5 times, is averaged.
3. test index and method
By pharmacopeia annex (VID), adopt ultraviolet-visible spectrophotometer method.
Two, experimental result
Vitamin A in serum between three treated animals 1content results sees the following form:
Experimental result shows, liposomal encapsulated vitamin A 1absorbability is apparently higher than non-encapsulated, and the two has compared significant difference.The absorbability of other vitamin same is also apparently higher than non-encapsulated.
The structure of liposome (Liposome) take bimolecular film as the closed vesica of interlayer cyst wall.Various lipid and lipid mixture all can be used for preparing liposome, and phosphatide is the most frequently used.The main component of phosphatide is phosphatid ylcholine, phosphatidyl-ethanolamine, phosphatidylserine, phosphatidyl glycerol, phosphatidic acid etc.Phosphatide is the main component of cell membrane, and therefore liposome is in similar in human body cell, human body cell is had to the compatibility of height.Phosphatide is amphipathic molecule, containing hydrophilic radical (phosphate group and nitrogenous base) in its structure, and hydrophobic grouping (two longer hydrocarbon chain).Under a certain certain concentration condition, polar group is towards both sides aqueous phase, and the hydrocarbon chain of non-polar group faces each other and associates into a stable bilayer structure.Utilize the design feature of liposome can load lipophilic ingredients in the middle of bilayer molecules, and at centre of sphere place sealing embedding hydrophilic composition.Forming the another kind of material of lipid is cholesterol, and comparatively hydrophily is strong for its hydrophobicity, and be embedded in the middle of bilayer that phosphatide formed, mainly play a part to change pure phospholipid layer character, it plays a part adjustment membrane structure " mobility " as " buffer ".
B B-complex nano liposomes oral liquid of the present invention, its average grain diameter is at about 50nm, and except lipid adventitia, its main component is vitamin A 1, vitamin D 3, vitamin E, vitamin K 1, vitamin C, vitamin B complex.Product clear, thermodynamic stability are good, system is compatible good, and have high absorptivity and bioavilability.
Below the effect describing component of the present invention, preparation method in detail in conjunction with the embodiments and reach, but embodiment is only, for demonstration, the present invention is described.Description is only for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.

Claims (2)

1. a B B-complex nano liposomes oral liquid, is characterized in that, with the nano liposomes prepared by lecithin, cholesterol and Tween 80 for embedding medium, containing vitamin A in its liposome 1, vitamin D 3, vitamin E, vitamin K, vitamin C, Cobastab 1(thiamine), Cobastab 2(riboflavin), Cobastab 3(nicotinic acid), Cobastab 5(pantothenic acid), Cobastab 6(pyridoxol), Cobastab 7(biotin), Cobastab 9(folic acid), Cobastab 12(cyanocobalamin).
2. B B-complex nano liposomes oral liquid according to claim 1, is characterized in that, containing 0.01 ~ 2mg vitamin A in every 10mL nano liposomes oral liquid 1, 1 ~ 50 μ g vitamin D 3, 0.5 ~ 300mg vitamin E, 2 ~ 500 μ g vitamin Ks 1, 10 ~ 300mg vitamin C, 0.2 ~ 10mg vitamin B1 (thiamine), 0.2 ~ 10mg Cobastab 2(riboflavin), 5 ~ 50mg Cobastab 3(nicotinic acid), 1 ~ 50mg Cobastab 5(pantothenic acid), 0.5 ~ 10mg Cobastab 6(pyridoxol), 10 ~ 1000 μ g Cobastabs 7(biotin), 50 ~ 1000 μ g Cobastabs 9(folic acid), 0.1 ~ 20 μ g Cobastab 12(cyanocobalamin).
CN201410520174.0A 2014-10-08 2014-10-08 Oral multi-vitamin nano liposome Pending CN104256652A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016197889A1 (en) * 2015-06-12 2016-12-15 上海泽生科技开发股份有限公司 Use of composition of vitamin complex in preparing drug for stimulating gastrointestinal system motility
CN106667793A (en) * 2017-01-17 2017-05-17 上海应用技术大学 D-panthenol microcapsules and preparation method thereof
CN107348514A (en) * 2017-06-29 2017-11-17 安徽康博特保健食品有限公司 A kind of preparation method of low-sugar type iron Couteat of Folic Acid
CN113768057A (en) * 2021-08-04 2021-12-10 深圳市红瑞生物科技股份有限公司 Hair removing cream for cats
US11351171B2 (en) 2016-11-23 2022-06-07 Zensun (Shanghai) Science & Technology, Co., Ltd. Composite vitamin composition promoting gastrointestinal system motility
CN114796119A (en) * 2022-02-21 2022-07-29 重庆医科大学 Composite antioxidant co-carried liposome and preparation method thereof
US11464797B2 (en) 2017-03-07 2022-10-11 Zensun (Shanghai) Science & Technology, Co., Ltd. Use of vitamin composition in preparing drug for preventing, treating, or delaying Alzheimer's disease

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CN101953830A (en) * 2010-08-06 2011-01-26 南昌大学 Method for preparing medium chain fatty acid-vitamin C compounded liposome by multi-emulsion-high-pressure microjet

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016197889A1 (en) * 2015-06-12 2016-12-15 上海泽生科技开发股份有限公司 Use of composition of vitamin complex in preparing drug for stimulating gastrointestinal system motility
US10881639B2 (en) 2015-06-12 2021-01-05 Zensun (Shanghai) Science & Technology, Co., Ltd. Use of composition of multivitamin in preparing drug for stimulating gastrointestinal system motility
US11351171B2 (en) 2016-11-23 2022-06-07 Zensun (Shanghai) Science & Technology, Co., Ltd. Composite vitamin composition promoting gastrointestinal system motility
US11759463B2 (en) 2016-11-23 2023-09-19 Zensun (Shanghai) Science & Technology, Co., Ltd. Composite vitamin composition promoting gastrointestinal system motility
CN106667793A (en) * 2017-01-17 2017-05-17 上海应用技术大学 D-panthenol microcapsules and preparation method thereof
US11464797B2 (en) 2017-03-07 2022-10-11 Zensun (Shanghai) Science & Technology, Co., Ltd. Use of vitamin composition in preparing drug for preventing, treating, or delaying Alzheimer's disease
CN107348514A (en) * 2017-06-29 2017-11-17 安徽康博特保健食品有限公司 A kind of preparation method of low-sugar type iron Couteat of Folic Acid
CN113768057A (en) * 2021-08-04 2021-12-10 深圳市红瑞生物科技股份有限公司 Hair removing cream for cats
CN114796119A (en) * 2022-02-21 2022-07-29 重庆医科大学 Composite antioxidant co-carried liposome and preparation method thereof

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Application publication date: 20150107