CN104252005A - PET detector module - Google Patents
PET detector module Download PDFInfo
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- CN104252005A CN104252005A CN201310258288.8A CN201310258288A CN104252005A CN 104252005 A CN104252005 A CN 104252005A CN 201310258288 A CN201310258288 A CN 201310258288A CN 104252005 A CN104252005 A CN 104252005A
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- ORCSMBGZHYTXOV-UHFFFAOYSA-N bismuth;germanium;dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Ge].[Ge].[Ge].[Bi].[Bi].[Bi].[Bi] ORCSMBGZHYTXOV-UHFFFAOYSA-N 0.000 description 2
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Abstract
The invention provides a PET detector module. The PET detector module comprises a BGO crystal array, an SiPM array and a processing circuit which are sequentially connected. The PET detector module can not only greatly reduce the volume of PET and reduce PET cost, moreover, as an SiPM chip replaces a traditional photomultiplier, service life of the PET is substantially prolonged; the SiPM chip works under the safety voltage, so safety of the PET is greatly improved.
Description
Technical field
The present invention relates to medical imaging technology field, be specifically related to a kind of nucleus medical image PET equipment.
Background technology
PET (positron emission tomography) scanner PET (Positron Emission Tomography) is a kind of Large-size Medical Imaging Equipments carrying out bodily fuctions's video picture on a molecular scale, represents the technical merit that nuclear medicine is the highest.The ultimate principle of PET utilizes accelerator-produced ultrashort half life period isotope, as 18F, 13N, 15O, 11C etc. inject human body as tracer agent, participates in the Physiological and Biochemical Metabolism process in body.These ultrashort half life period isotopes are essential elements of composition human body, the negatron of the positron utilizing them to launch in body is combined and discharges a pair gamma-rays, detected by the crystal of popping one's head in, formed through processing of circuit and meet example and LOR (meeting line of response), then through sorting, correction, filtering, reconstruction, heavily cut and obtain faultage image clearly.By the process to image, contribute to understanding intuitively human brain, the heart, other organ of whole body and the physiology of tumor tissues and the function of pathology and metabolic condition.Detector module is the most important parts forming detector system in PET, which determines many important performances such as the sensitivity of PET, spatial discrimination, dead time characteristic.
Summary of the invention
The object of the invention is to provide a kind of pet detector module and corresponding PET (positron emission tomography) scanner PET.Can realize the gamma-rays detecting 150KeV to 750KeV, and the information such as time, position, energy that gamma-rays can be occurred is by circuitry digitizing output.
Described pet detector module provided by the present invention comprises BGO crystal array, SiPM array and treatment circuit, and connects successively; Described BGO crystal array for detecting gamma-rays, and produces photon according to the gamma-rays detected; The photon that described SiPM array is used for by obtaining from described BGO crystal array produces electric impulse signal; Described treatment circuit is used for carrying out process to the pulse signal obtained from described SiPM array and forms digital signal output.
Described pet detector module also comprises box body, and described BGO crystal array, described SiPM array and described treatment circuit are arranged in box body.
Described BGO crystal array and described SiPM array can be coupled by silicone oil.
Described BGO crystal array is the BGO crystal array of 8*8.
The BGO crystal forming described BGO crystal array is six rectangular parallelepipeds, wherein reflector layer in four sides and a coated on bottom side, and form reflective surface, another bottom surface keeps bright and clean formation light face; The light face forming the BGO crystal of described BGO array is arranged on the same face, forms the light face of BGO crystal array.The light face of described BGO crystal array scribbles silicone oil, and is coupled with the face of SiPM chip of the described SiPM array also scribbling silicone oil.
Described treatment circuit comprises pixel generation module and array generation module; Described pixel generation module is for the treatment of the picture element signal exported from described SiPM array, and described array generation module is for the treatment of the array signal exported from described SiPM array.
Described treatment circuit also comprises process chip, the information that described process chip exports for the treatment of pixel generation module and array generation module, and produces digital signal output.
The forward position of the electric impulse signal that described SiPM array produces represents the moment that gamma-rays occurs; The amplitude of electric impulse signal represents gamma-ray intensity; The position detecting BGO crystal in gamma-ray BGO crystal array is gamma-ray generation position.
Present invention also offers a kind of method using this pet detector module to carry out acquisition of signal:
A) a BGO crystal in BGO crystal array detects the gamma-rays entering into BGO crystal array, and produces photon;
B) photon is output to the light face of described BGO crystal by described BGO crystal reflection;
C) photon exported enters into the SiPM array SiPM chip corresponding with described BGO crystal by silicone oil, and described SiPM chip produces electric impulse signal;
D) array signal in described electric impulse signal enters the array generation module for the treatment of circuit, and the picture element signal in described electric impulse signal enters into the pixel generation module of described treatment circuit;
The signal exported by pixel generation module, by by the signal rise time information exported in described array generation module and array information, is generated energy information and Pixel Information by the process chip e) in processing module;
F) temporal information of generation, array information, energy information and Pixel Information are carried out digitized processing by described process chip, generate the digital signal comprising position, time, energy information, and export.
Pet detector module provided by the invention, not only can reduce the volume of PET greatly, reduces the cost of PET.In addition, owing to instead of traditional photomultiplier with SiPM chip, make have significant prolongation the serviceable life of PET; Because SiPM chip operation is below safe voltage, considerably increase the security of PET.
Accompanying drawing explanation
Fig. 1 is the BGO crystal array schematic diagram of PET detecting module provided by the invention;
Fig. 2 is the E-E sectional view of Fig. 1;
Fig. 3 is the schematic diagram being provided with the face of Connection Block 203 of SiPM array;
Fig. 4 is the schematic diagram being provided with the face of SiPM chip 201 of SiPM array;
Fig. 5 is the side view of SiPM array;
Fig. 6 illustrates the structural representation of pet detector module;
Fig. 7 illustrates the process schematic diagram of pet detector module.
Embodiment:
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
The invention provides a kind of PET detecting module, comprise bismuth germanium oxide (Bismuth germanium oxide) crystal array (BGO crystal array), silicone oil, SiPM array and treatment circuit.Wherein, each crystal forming BGO crystal array is six rectangular parallelepipeds, and wherein four sides and a bottom surface all scribble reflector layer formation reflective surface, another one bottom surface keeps bright and clean, forms light face.When BGO Crystallization BGO crystal array, the light face of all BGO crystal is arranged on the same face, form the light face of BGO crystal array.Silicone oil is coated on the light face of BGO crystal array.The chip one side of SiPM array also scribbles silicone oil, and is coupled with the light face of BGO crystal array.Treatment circuit is connected with SiPM array.
When gamma-rays is beaten on a wherein crystal of BGO array, crystal will send blue light, and a large amount of photon produced in this crystal can reflex to light face by the reflective surface of crystal.Photon is detected by the SiPM chip of a certain correspondence in SiPM array by silicone oil, and forms electric impulse signal.The forward position of electric impulse signal represents the moment of gamma-rays generation, and the amplitude of signal represents gamma-ray intensity.Wherein, the position of the SiPM chip of this correspondence represents gamma-ray active position.This pulse signal forms digitized signal by the process of signal processing circuit and exports.
PET detecting module can also comprise shell, forms a camera bellows to avoid other light to the interference of detecting module to make detecting module inside.
Below in conjunction with accompanying drawing, PET detecting module provided by the invention is described in detail:
Fig. 1 is the BGO crystal array schematic diagram of PET detecting module provided by the invention.Fig. 2 is the E-E sectional view of Fig. 1.Wherein, BGO crystal array comprises multiple BGO crystal 101.BGO crystal 101 is six rectangular parallelepipeds.Wherein four sides of each BGO crystal 101 and a bottom surface all scribble reflector layer and form reflective surface 103, another one bottom surface keeps bright and clean, forms light face 104.The light face 104 of all BGO crystal is arranged on the same face, fixed-type by adhesive tape 102, forms the light face of BGO crystal array.
The method of concrete formation BGO crystal array is as follows:
1) BGO block is cut into the pane of 4mm*4mm*30mm, forms BGO crystal bar.Certain size can set according to the needs forming PET detecting module; In the present embodiment, BGO crystal bar is 64;
2) crystal bar is cleaned up, air-dry;
3) by reflector layer on four of crystal bar sides and one of them bottom surface, form reflective surface, another face keeps bright and clean, forms light face; Reflector layer can the potpourri of choice for use titania and latex.
4) be bonded together by 64 crystal bars and form the BGO array of 8*8, the light face of all bars is in same.
5) by all reflective surface adhesive tapes (teflon adhesive tape can the be adopted) uniform winding of BGO array, then with adhesive tape fixed-type formation BGO crystal array.
Fig. 3-5 illustrates SiPM array.Wherein Fig. 3 is the schematic diagram being provided with the face of Connection Block 203 of SiPM array, and Fig. 4 is the schematic diagram being provided with the face of SiPM chip 201 of SiPM array.Fig. 5 is the side view of SiPM array.
Fig. 6 illustrates the structural representation of pet detector module.Wherein, the light face of BGO crystal array 1 scribbles silicone oil 3, and also oiling silicone oil 3 on the face of the SiPM chip 201 of SiPM array 2, and two faces are coupled.SiPM array is connected with the socket for the treatment of circuit 4 by Connection Block 203.The process such as the pulse signal that the treatment circuit 4 pairs of SiPM arrays transmit amplifies, compare, be shaped, ADC (analog to digital conversion circuit), TDC (time interval digital conversion circuit), form digitized signal and export.Above-mentioned BGO crystal array, SiPM array and treatment circuit are all arranged in a box body.Box body is the box body with upper cover.When above-mentioned parts are located at after in box body, cover upper cover, both can form PET detecting module.
The concrete method forming pet detector module is as follows:
1) silicone oil is evenly coated in the light face of BGO crystal array, and keep light towards upper placement;
2) silicone oil is coated uniformly in the face being provided with SiPM chip 201 of SiPM array, and be coupled with the light face of BGO crystal array;
3) provide box body, open box body upper cover, the BGO crystal array be coupled and SiPM array are put into box body, and keeps gap suitable between coupling body;
4) treatment circuit is put into box body, the socket for the treatment of circuit is connected with the socket Connection Block 203 of SiPM array;
5) cover box body, form PET detecting module.
Fig. 7 illustrates the process schematic diagram of pet detector module.
Gamma-rays is produced during positron annihilation.When gamma-rays is beaten on a wherein crystal of BGO array, crystal will send blue light, and a large amount of photon produced in crystal can reflex to light face by the reflective surface of crystal.Photon is detected by the SiPM chip of a certain correspondence in SiPM array by silicone oil, and forms electric impulse signal.The forward position of electric impulse signal represents the moment of gamma-rays generation, and the amplitude of signal represents gamma-ray intensity.Wherein, the position of the SiPM chip of this correspondence represents gamma-ray active position.
The pixel generation module that picture element signal in electric impulse signal enters into treatment circuit processes, and the array generation module that the array signal in electric impulse signal enters into treatment circuit processes.Wherein, the signal exported by pixel generation module generates energy information and Pixel Information, and by the signal rise time information exported in described array generation module and array information.Energy information, Pixel Information, temporal information, array information carry out digitized processing by process chip subsequently, generate the digital signal comprising position, position, time, energy information.The digital signal produced is transferred to output port and exports.Output port can be serial port, and digital signal is by Serial output.
The course of work that pet detector module is concrete is as follows:
1) powered on by the cable that pet detector module is external, download parameters.When powering on, the output of DAC (D/A conversion circuit) module is determined by the parameter in EEPROM (EEPROM (Electrically Erasable Programmable Read Only Memo)).The output of DAC module can control permutation, the threshold value of pixel and the operating voltage of SiPM array;
2) a BGO crystal in BGO crystal array detects the gamma-rays entering into BGO crystal array, and this BGO crystal is excited generation blue light, and produces a large amount of photons;
3) photon produced is reflected onto the light face of this BGO crystal at the reflecting surface of this BGO crystal, and most of photon is exported by the light face of this BGO crystal;
4) photon exported enters SiPM chip corresponding with this BGO crystal in SiPM array by silicone oil, produces photoelectric effect, forms electric impulse signal.
5) array signal in the electric impulse signal produced is output to the array generation module in treatment circuit; Picture element signal in electric impulse signal enters into the pixel generation module for the treatment of circuit;
6) the array generation module rise time information in treatment circuit and array information; Meanwhile, pixel generation module generates energy information and Pixel Information;
7) above-mentioned temporal information, array information, energy information and the Pixel Information process chip in treatment circuit processes, and generates the signal containing position, time, energy information
8) signal of this generation by serial port by Serial output.
In the present invention, the process chip in processing module has selected FPGA.Certain process chip can select any chip that can realize above-mentioned functions as required.
Above-described embodiment is only for example of the present invention is clearly described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of amplifying out or variation be still among protection scope of the present invention.
Claims (10)
1. a pet detector module, is characterized in that: described pet detector module comprises BGO crystal array, SiPM array and treatment circuit, and connects successively; Described BGO crystal array for detecting gamma-rays, and produces photon according to the gamma-rays detected; The photon that described SiPM array is used for by obtaining from described BGO crystal array produces electric impulse signal; Described treatment circuit is used for carrying out process to the pulse signal obtained from described SiPM array and forms digital signal output.
2. pet detector module as claimed in claim 1, it is characterized in that: described pet detector module also comprises box body, described BGO crystal array, described SiPM array and described treatment circuit are arranged in box body.
3. pet detector module as claimed in claim 1, is characterized in that: described BGO crystal array and described SiPM array are coupled by silicone oil.
4. pet detector module as claimed in claim 1, is characterized in that: described BGO crystal array is the BGO crystal array of 8*8.
5. as the pet detector module that claim 4 is stated, it is characterized in that: the BGO crystal forming described BGO crystal array is six rectangular parallelepipeds, wherein reflector layer in four sides and a coated on bottom side, form reflective surface, another bottom surface keeps bright and clean formation light face; The light face forming the BGO crystal of described BGO array is arranged on the same face, forms the light face of BGO crystal array.
6. as the pet detector module that claim 5 is stated, it is characterized in that: the light face of described BGO crystal array scribbles silicone oil, and be coupled with the face of SiPM chip of the described SiPM array also scribbling silicone oil.
7. as the pet detector module that claim 1 is stated, it is characterized in that: described treatment circuit comprises pixel generation module and array generation module; Described pixel generation module is for the treatment of the picture element signal exported from described SiPM array, and described array generation module is for the treatment of the array signal exported from described SiPM array.
8. as the pet detector module that claim 7 is stated, it is characterized in that: described treatment circuit also comprises process chip, the information that described process chip exports for the treatment of pixel generation module and array generation module, and produce digital signal output.
9. pet detector module as claimed in claim 1, it is characterized in that, the forward position of the electric impulse signal that described SiPM array produces represents the moment that gamma-rays occurs; The amplitude of electric impulse signal represents gamma-ray intensity; The position detecting BGO crystal in gamma-ray BGO crystal array is gamma-ray generation position.
10. one kind is carried out the method for acquisition of signal by the arbitrary described pet detector module of claim 1-9:
A) a BGO crystal in BGO crystal array detects the gamma-rays entering into BGO crystal array, and produces photon;
B) photon is output to the light face of described BGO crystal by described BGO crystal reflection;
C) photon exported enters into the SiPM array SiPM chip corresponding with described BGO crystal by silicone oil, and described SiPM chip produces electric impulse signal;
D) array signal in described electric impulse signal enters the array generation module for the treatment of circuit, and the picture element signal in described electric impulse signal enters into the pixel generation module of described treatment circuit;
The signal exported by pixel generation module, by by the signal rise time information exported in described array generation module and array information, is generated energy information and Pixel Information by the process chip e) in processing module;
F) temporal information of generation, array information, energy information and Pixel Information are carried out digitized processing by described process chip, generate the digital signal comprising position, time, energy information, and export.
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| CN201310258288.8A CN104252005A (en) | 2013-06-26 | 2013-06-26 | PET detector module |
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| CN201310258288.8A CN104252005A (en) | 2013-06-26 | 2013-06-26 | PET detector module |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688261A (en) * | 2015-03-19 | 2015-06-10 | 明峰医疗系统股份有限公司 | Full digitalization SiPM PET data collection system based on FPGA and ADC |
| CN106361361A (en) * | 2016-08-26 | 2017-02-01 | 沈阳东软医疗系统有限公司 | Information processing method and device |
| CN107320121A (en) * | 2016-04-29 | 2017-11-07 | 上海联影医疗科技有限公司 | Positron emission tomography photon detection device |
| CN108181331A (en) * | 2017-12-20 | 2018-06-19 | 上海联影医疗科技有限公司 | A kind of signal detection circuit and detector |
| US10768315B2 (en) | 2017-07-28 | 2020-09-08 | Shanghai United Imaging Healthcare Co., Ltd. | Positron emission tomography detecting device |
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