CN104225772A - Visual minimally-invasive intracranial dosing device - Google Patents
Visual minimally-invasive intracranial dosing device Download PDFInfo
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- CN104225772A CN104225772A CN201410495649.5A CN201410495649A CN104225772A CN 104225772 A CN104225772 A CN 104225772A CN 201410495649 A CN201410495649 A CN 201410495649A CN 104225772 A CN104225772 A CN 104225772A
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Abstract
The invention belongs to the technical field of medical equipment, and particularly relates to a visual minimally-invasive intracranial dosing device. The visual minimally-invasive intracranial dosing device mainly aims to solve the problems of easiness in infection, damage to brains, non-visuality and non-intuition of liquor and inaccuracy in dosage of traditional dosing. The invention adopts the technical scheme that the visual minimally-invasive intracranial dosing device comprises a U-shaped base and a liquid guide tube, wherein two ear rods are respectively arranged on two sides of the open end of the U-shaped base, an adapter is arranged on the close end of the U-shaped base, a fore-tooth clamp is arranged on the front end of the adapter, an X arm, a Y arm and a Z arm are arranged on the side wall of the U-shaped base, a clamper is arranged on the X arm, a micro-injection pump is installed on one end of the liquid guide tube, a fixed pin is installed on the other end of the liquid guide tube, a capillary quartz tube is installed on the fixed pin, and scales are marked on the outer surface of the capillary quartz tube. The visual minimally-invasive intracranial dosing device has the advantages of accuracy in positioning, precision in quantifying, intuition, visuality, microtrauma, convenience and simplicity.
Description
Technical field
The invention belongs to technical field of medical equipment, be specifically related to a kind of visual minimal removed of intracranial doser.
Background technology
The administration of intracranial core group is the important means of research brain core group function, targeted therapy disease of brain.There is not the problem of blood brain barrier and first pass effect in this administering mode, is convenient to observe medicine to the direct effect of central nervous system.Traditional administering mode comprises pipe laying administration and direct administration.Though pipe laying administration can repeated multiple times intracranial drug injection, to infect and problem that pipe laying comes off unavoidably.The administration of micro-injection pin is commonly used in direct administration.It is all comparatively thick that these dosers enter cranium part, when giving intracranial deep core group drug administration by injection, can penetrate the cerebral tissue that core group is outside, causing inevitable damage.In addition, convenient administration mode injecting fluid is all not visible, not intuitively, cannot judge whether medicine affects because of needle point blocking the problem that medicine enters cranium.
Summary of the invention
There is easy infection, damaged brain and medicinal liquid is not visible, the directly perceived and inaccurate problem of dose mainly for convenient administration in the present invention, provide a kind of accurate positioning, quantitatively accurately, directly perceived visible, damage slight, convenient and simple visual minimal removed of intracranial doser.
The present invention is the technical scheme taked that solves the problem:
A kind of visual minimal removed of intracranial doser, comprise U-shaped base, in the both sides of U-shaped base openings end, an ear bar is respectively set, adapter is provided with at the closed end of U-shaped base, front tooth folder is provided with at adapter front end, the sidewall of U-shaped base is provided with X arm, Y arm and Z arm, X arm is provided with clamper, wherein: also comprise catheter, in one end of catheter, micro-injection pump is installed, at the other end of catheter, locking pin is installed, locking pin installs a capillary quartz ampoule, and be marked with scale at the outer surface subscript of capillary quartz ampoule, on the outer surface of catheter, also mark has scale, described catheter, locking pin and capillary quartz ampoule communicate.
Further, the internal diameter of capillary quartz ampoule of the present invention is 0.35mm, and external diameter is 0.5mm.
The present invention adopts technique scheme, and during use, the locking pin of administration needle of the present invention is contained in the stiff end of visual minimal removed of intracranial doser, the other end of catheter of the present invention is connected with micro-injection pump, to facilitate to the intracranial administration of large mice.Catheter of the present invention is connected with doser, capillary quartz ampoule is thinner, very little to the damage of brain when performing the operation, and has scale on capillary quartz ampoule and catheter, and the volume of locking pin is fixing, so just the fluency of medicinal liquid and the dosage of medicinal liquid can be observed very intuitively.Therefore, the present invention have accurate positioning, quantitatively accurately, intuitively visual, damage slight, convenient and simple advantage.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is the structural representation of capillary quartz ampoule of the present invention;
Fig. 3 is estrangement injection slice map inside the embodiment of the present invention 2 rat;
Fig. 4 is the embodiment of the present invention 3 rat hippocampus injection slice map.
Detailed description of the invention
Embodiment 1
As Fig. 1, shown in Fig. 2, a kind of visual minimal removed of intracranial doser, comprise U-shaped base 1, in the both sides of U-shaped base 1 opening, an ear bar 2 is respectively set, adapter 3 is provided with at the closed end of U-shaped base 1, front tooth folder 4 is provided with in adapter 3 front end, the sidewall of U-shaped base 1 is provided with X arm 5, Y arm 6 and Z arm 7, X arm 5 is provided with clamper 8, wherein: also comprise catheter 9, in one end of catheter 9, micro-injection pump 10 is installed, at the other end of catheter 9, locking pin 11 is installed, locking pin 11 installs a capillary quartz ampoule 12, and be marked with scale 13 at the outer surface subscript of capillary quartz ampoule 12, on the outer surface of catheter 9, also mark has scale 13, described catheter 9, locking pin 11 and capillary quartz ampoule 12 communicate, wherein the internal diameter of capillary quartz ampoule 3 is 0.35mm, external diameter is 0.5mm.
Embodiment 2
The inner side estrangement (medial septum, MS) of basal ganglia:
For 1 μ l medicine (as pontamine sky-blue) is injected in the inner side estrangement of an adult SD rats Basal ganglia:
First be full of normal saline by Wicresoft's administration needle, catheter tail end is connected on micro-injection pump, first inhales 0.5 μ l air, at suction 1 μ pontamine sky-blue.By adult SD rats chloral hydrate or urethane anesthesia, be fixed on stereotaxic instrument 6, after cropping sterilization, expose skull.0.7mm after bregma, side open 2mm position bore open skull after, the Wicresoft's administration needle fixed slowly is inserted intracranial 6mm, and in order to not injure cerebrovascular, the clamper of brain solid positioner tilts 18 ° laterally.The injection speed regulating micro-injection pump is 0.1 μ l/min, carries out administration.The results are shown in Figure 3: in figure 3, the darker region of the middle and lower part color of figure is the inner side estrangement of rat.Capillary quartz ampoule 12 is a dark fine rule, and the injection point at its tip is high-visible, injection point be positioned at inner side estrangement center.
Embodiment 3
Rat hippocampus administration
For 1 μ l medicine (as pontamine sky-blue) being injected in an adult SD rats Hippocampus core group:
First be full of normal saline by Wicresoft's administration needle, tail end is connected on micro-injection pump, first inhales 0.5 μ l air, at suction 1 μ pontamine sky-blue.By adult SD rats chloral hydrate or urethane anesthesia, be fixed on stereotaxic instrument, after cropping sterilization, expose skull.3.0mm after bregma, side open 2.2mm position bore open skull after, the Wicresoft's administration needle fixed slowly is inserted intracranial 3.0mm.The injection speed regulating micro-injection pump is 0.1 μ l/min, carries out administration.The results are shown in Figure 4: in the diagram, the region that the bottom color of figure is brighter is the Hippocampus of rat.Capillary quartz ampoule 12 is a dark fine rule, and the injection point at its tip is high-visible, and injection point is positioned at the center of Hippocampus.
Claims (2)
1. a visual minimal removed of intracranial doser, comprise U-shaped base (1), an ear bar (2) is respectively set in the both sides of U-shaped base (1) opening, adapter (3) is provided with at the closed end of U-shaped base (1), front tooth folder (4) is provided with in adapter (3) front end, the sidewall of U-shaped base (1) is provided with X arm (5), Y arm (6) and Z arm (7), X arm (5) is provided with clamper (8), it is characterized in that: also comprise catheter (9), in one end of catheter (9), micro-injection pump (10) is installed, at the other end of catheter (9), locking pin (11) is installed, the upper installation capillary quartz ampoule (12) of locking pin (11), and be marked with scale (13) at the outer surface subscript of capillary quartz ampoule (12), on the outer surface of catheter (9), also mark has scale (13), described catheter (9), locking pin (11) and capillary quartz ampoule (12) communicate.
2. the visual minimal removed of intracranial doser of one according to claim 1, is characterized in that: the internal diameter of described capillary quartz ampoule (12) is 0.35mm, and external diameter is 0.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410495649.5A CN104225772B (en) | 2014-09-25 | 2014-09-25 | A kind of visual minimal removed of intracranial doser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410495649.5A CN104225772B (en) | 2014-09-25 | 2014-09-25 | A kind of visual minimal removed of intracranial doser |
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| Publication Number | Publication Date |
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| CN104225772A true CN104225772A (en) | 2014-12-24 |
| CN104225772B CN104225772B (en) | 2016-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410495649.5A Expired - Fee Related CN104225772B (en) | 2014-09-25 | 2014-09-25 | A kind of visual minimal removed of intracranial doser |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971400A (en) * | 2015-07-15 | 2015-10-14 | 广西南宁灵康赛诺科生物科技有限公司 | Method for long-term intracerebral pump injection of drugs in great quantity used for primate |
| CN105056351A (en) * | 2015-07-31 | 2015-11-18 | 京东方科技集团股份有限公司 | Automatic needle inserting device |
| CN106361416A (en) * | 2016-09-26 | 2017-02-01 | 张广柱 | Intracerebral minimally invasive microscale multi-target-point injection system for stereoscopic direction navigation equipment |
| WO2021097963A1 (en) * | 2019-11-18 | 2021-05-27 | 中国科学院深圳先进技术研究院 | Disposable impermeable intracranial drug administration device |
Citations (4)
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| US20060052666A1 (en) * | 2004-09-03 | 2006-03-09 | Atul Kumar | Electromagnetically controlled tissue cavity distending system |
| CN203043080U (en) * | 2013-01-05 | 2013-07-10 | 陈双成 | Neurosurgical craniocerebral effusion drainage device |
| CN203576643U (en) * | 2013-11-15 | 2014-05-07 | 先健科技(深圳)有限公司 | Brain treatment system and fixing device thereof |
| CN204106824U (en) * | 2014-09-25 | 2015-01-21 | 山西医科大学 | A kind of visual minimal removed of intracranial doser |
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2014
- 2014-09-25 CN CN201410495649.5A patent/CN104225772B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060052666A1 (en) * | 2004-09-03 | 2006-03-09 | Atul Kumar | Electromagnetically controlled tissue cavity distending system |
| CN203043080U (en) * | 2013-01-05 | 2013-07-10 | 陈双成 | Neurosurgical craniocerebral effusion drainage device |
| CN203576643U (en) * | 2013-11-15 | 2014-05-07 | 先健科技(深圳)有限公司 | Brain treatment system and fixing device thereof |
| CN204106824U (en) * | 2014-09-25 | 2015-01-21 | 山西医科大学 | A kind of visual minimal removed of intracranial doser |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971400A (en) * | 2015-07-15 | 2015-10-14 | 广西南宁灵康赛诺科生物科技有限公司 | Method for long-term intracerebral pump injection of drugs in great quantity used for primate |
| CN105056351A (en) * | 2015-07-31 | 2015-11-18 | 京东方科技集团股份有限公司 | Automatic needle inserting device |
| CN106361416A (en) * | 2016-09-26 | 2017-02-01 | 张广柱 | Intracerebral minimally invasive microscale multi-target-point injection system for stereoscopic direction navigation equipment |
| CN106361416B (en) * | 2016-09-26 | 2018-10-19 | 张广柱 | The minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment |
| WO2021097963A1 (en) * | 2019-11-18 | 2021-05-27 | 中国科学院深圳先进技术研究院 | Disposable impermeable intracranial drug administration device |
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| Publication number | Publication date |
|---|---|
| CN104225772B (en) | 2016-08-31 |
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