CN104225196A - Traditional Chinese medicine effervescent tablet for treating respiratory diseases and preparation method of traditional Chinese medicine effervescent tablet - Google Patents
Traditional Chinese medicine effervescent tablet for treating respiratory diseases and preparation method of traditional Chinese medicine effervescent tablet Download PDFInfo
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- CN104225196A CN104225196A CN201410456497.8A CN201410456497A CN104225196A CN 104225196 A CN104225196 A CN 104225196A CN 201410456497 A CN201410456497 A CN 201410456497A CN 104225196 A CN104225196 A CN 104225196A
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Abstract
The invention provides a traditional Chinese medicine effervescent tablet for treating respiratory diseases. The traditional Chinese medicine effervescent tablet consists of the following components such as extract of lily, platycodon grandiflorum and glycyrrhiza uralensis, an acid agent, an alkaline agent, a filling agent, a surfactant, a binder, a sweetening agent and a lubricant. The invention further provides a method of preparing the traditional Chinese medicine effervescent tablet. The preparation method comprises the following steps: drying and crushing the extract of lily, platycodon grandiflorum and glycyrrhiza uralensis into fine powder; adding dry powder of the acid agent, 60-80% of alkaline agent, the filling agent, the surfactant and the sweetening agent to the fine powder, and uniformly mixing; and dissolving the binder with absolute ethyl alcohol and then adding the mixture into the powder to uniformly mix and pelletize, adding the lubricant and the rest of the alkaline agent into the particles, and tabletting after uniformly mixing the components to form the traditional Chinese medicine effervescent tablet. The traditional Chinese medicine effervescent tablet has the functions of removing heat from the lung to relieve cough and dredging lung qi, is suitable for treating various respiratory diseases, and especially suitable for relieving symptoms such as throat discomfort, dry throat, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, chest distress and asthma, which are caused by air pollution such as haze.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, especially a kind of Chinese medicine effervescent tablet for the treatment of respiratory tract disease, the invention still further relates to its preparation method.
Background technology
Along with the acceleration of Development of Urbanization and process of industrialization, air quality just runs down, the frequency that haze weather phenomenon occurs is more and more higher, under this weather, when people's trip or routine work life, molecule in air (mainly refers to that diameter is less than or equal to the particulate matter of 2.5 microns, i.e. PM2.5, also referred to as entering lung particulate matter) will invade in human respiratory tract and the lobe of the lung when people have no to take precautions against, cause respiratory tract disease, particularly cause haze respiratory system disease, as pharyngolaryngitis, irritated, asthma, rhinitis, sinusitis, emphysema etc., show as throat discomfort, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, breast is vexed, gas such as to kick at the symptom, be in this environment for a long time, also pulmonary carcinoma can be brought out, myocardial ischemia and damage, very large harm is caused to human body.
Lack at present the medicine of this respiratory tract disease caused due to environmental pollution for the treatment of clinically, very large financial burden is caused to patient, and existing pharmaceutical dosage form is single, main based on syrup, granule, cause patient to carry, take inconvenience, the demand of clinical application cannot be met completely.
Summary of the invention
The object of this invention is to provide the Chinese medicine effervescent tablet and preparation method thereof for the treatment of respiratory tract disease of a kind of determined curative effect, taking convenience.
The present invention provide firstly a kind of Chinese medicine effervescent tablet for the treatment of respiratory tract disease, and it is made up of the composition of following weight proportion:
The extract of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is the water extract of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae, and the weight ratio of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is followed successively by 20 ~ 50: 10 ~ 40: 5 ~ 20;
Described surfactant to be HLB value be 20 ~ 40 hydrophilic surfactant.
Preferably, described surfactant is sodium lauryl sulphate.
Primary efficacy composition of the present invention is Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae, side in the sweet micro-hardship of Bulbus Lilii, be slightly cold into lung meridian, have effect of clearing away lung-heat and moistening for dryness to be principal agent; Be aided with Radix Platycodonis, Emperor Xuantong's lung qi, only, sound is opened, and helps with Radix Glycyrrhizae heat-clearing and toxic substances removing in lung qi a surname cough.The party is according to clinical experience for many years, repeatedly use observation, sum up draw, full side has clearing away lung-heat to relieve cough, the function of Emperor Xuantong's lung qi, the symptom such as be applicable to the throat discomfort caused by respiratory tract disease, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, uncomfortable in chest, gas is kicked.
The present invention then provides a kind of method preparing the Chinese medicine effervescent tablet of described treatment respiratory tract disease, it comprises the following steps: the extract crushed after being dried of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is become fine powder, add sour agent, 60 ~ 80% alkaline agent, filler, surfactant, sweeting agent dried powder, mixing; To join in above-mentioned powder after binding agent anhydrous alcohol solution, mixing, granulate, in granule, add lubricant and remaining alkaline agent, tabletting after mixing.
Preferably, described sour agent is citric acid or tartaric acid.
Preferably, described alkaline agent is sodium bicarbonate or sodium carbonate.
Preferably, described filler is sucrose or lactose.
Preferably, described tabletting is pressed into hollow ring segment.
The effervescent tablet adjuvant of the routine that described binding agent, sweeting agent, lubricant all adopt those skilled in the art to grasp.
Extract due to Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae has larger viscosity, adopt the preparation technology of routine to be difficult to obtained energy rapid solution and discharge the effervescent tablet of great amount of carbon dioxide fast, we are for the character of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae extract, have carried out following improvement to the formula of effervescent tablet and preparation technology:
1. alkaline agent is divided into two parts to add, a part adds before granulation, and a part adds after granulation.This is because we find, after water met by effervescent tablet, the soda acid on tablet top layer reacted before this, water penetrates into tablet inside gradually simultaneously, react with the soda acid on internal particle top layer again, thus disintegration of tablet is become granule, last water penetrates into granule interior again, and the soda acid of granule interior is reacted.If all added before granulation by soda acid, so because soda acid is all in granule interior, the acid-base reaction speed that granule occurs outward is very slow, thus has delayed the disintegrate of tablet and the speed of carbon dioxide generation.In addition, a part of alkaline agent is added in extra-granular by the present invention, instead of sour for part agent is added in extra-granular, be because of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae extract entirety in faintly acid, the speed of the outer acid-base reaction of granule can be accelerated with the alkali reaction outside granule thus further.
2. add surfactant in tablets and promote that moisture infiltrates to tablet inside.Owing to containing a small amount of lipid soluble ingredients in Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae extract, these compositions can form one deck " barrier " at particle surface, thus stop the infiltration of moisture, and the surfactant that HLB value is 20 ~ 40 has very strong hydrophilic and short permeability, the seepage velocity of moisture to tablet inside can be improved, thus accelerate disintegrate and the stripping of tablet.
3. tablet is pressed into hollow ring segment.Traditional effervescent tablet is effervescent, disintegrate from outside to inside, after making ring segment can inside and outside while effervescent, disintegrate and add the surface area of tablet, significantly can improve the speed of aerogenesis and disintegrate.
The invention has the beneficial effects as follows:
1) the present invention is evident in efficacy, there is clearing away lung-heat to relieve cough, the function of Emperor Xuantong's lung qi, be applicable to the treatment of various respiratory tract disease, be particularly useful for the alleviation due to the throat discomfort of air pollution caused by haze, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, the symptom such as uncomfortable in chest, gas is kicked.
2) taste of the present invention is sour-sweet, and mouthfeel is good, carries, easy to use, and drug-eluting is fast, and bioavailability is high.There is the aesthetic feeling as soda pop when drinking in entrance, after taking, a large amount of carbon dioxides can be produced in vivo, the noxious substance in respiratory tract can be taken during by having the hiccups and getting rid of external out of, make respiratory tract happier.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail.
Embodiment 1
Treat a Chinese medicine effervescent tablet for respiratory tract disease, it is made up of the composition of following weight proportion:
The extract of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is the water extract of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae, the weight ratio of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is followed successively by 3: 2: 1, the preparation method of described extract is: Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae are decocted with water 3 times, each 1.5 hours, merge decoction liquor, be condensed into extractum, crushed after being dried.
Described sour agent is tartaric acid.
Described alkaline agent is sodium bicarbonate.
Described filler is lactose.
Described surfactant is sodium lauryl sulphate.
Described binding agent is PVP K30.
Described sweeting agent is aspartame.
Described lubricant is polyethylene glycol 6000.
Preparation method is: the extract crushed after being dried of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae become granularity to be 100 object fine powders (referring to the fine powder by 100 eye mesh screens), add sour agent, 70% alkaline agent, filler, surfactant, sweeting agent dried powder, mixing; To join in above-mentioned powder after binding agent anhydrous alcohol solution, mixing, granulate, in granule, add lubricant and 30% remaining alkaline agent, after mixing, be pressed into the ring segment that specification is 0.8g.
After testing: the disintegration of this effervescent tablet is 3 minutes.
Instructions of taking is: every day 2-3 time, and each 1-2 sheet, puts into water, and disintegration of tablet is oral rapidly after melting.
The selection gist of technique:
1) 5 minutes are limited to when not adding the Effervescent tablet disintegration of surfactant (other technique is identical with embodiment 1).
2) by sodium bicarbonate granulate time disposable all add Effervescent tablet disintegration time be limited to 8 minutes (other technique is identical with embodiment 1).
3) 6 minutes are limited to when being pressed into the Effervescent tablet disintegration of common solid sheet (other technique is identical with embodiment 1).
Embodiment 2
Treat a Chinese medicine effervescent tablet for respiratory tract disease, it is made up of the composition of following weight proportion:
The extract of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is the water extract of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae, the weight ratio of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is followed successively by 20: 10: 5, the preparation method of described extract is: Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae are decocted with water 2 times, each 2 hours, merges decoction liquor, be condensed into the clear paste that relative density is 1.08, in clear paste, add ethanol, make alcohol content be 50%, after stirring, leave standstill 24 hours, get supernatant concentration and become extractum, crushed after being dried.
Preparation method is: the extract crushed after being dried of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is become fine powder, add citric acid, 60% sodium bicarbonate, cane sugar powder, sodium lauryl sulphate, stevioside dried powder, mixing; To join in above-mentioned powder after HPMC anhydrous alcohol solution, mixing, granulate, in granule, add Macrogol 4000 and 40% remaining sodium bicarbonate, after mixing, be pressed into the ring segment that specification is 0.7g.
Compared with embodiment 1, the present embodiment has carried out precipitate with ethanol process due to Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae extract, therefore the medicinal liquid after effervescent is clarified bright more, and due to active ingredient enrichment more in the extract after precipitate with ethanol, therefore can correspondingly reduce preparation specification and taking dose, improve medication compliance.
After testing: the disintegration of this effervescent tablet is 2.5 minutes.
Instructions of taking is: every day 2-3 time, and each 1-2 sheet, puts into water, and disintegration of tablet is oral rapidly after melting.
Embodiment 3
Treat a Chinese medicine effervescent tablet for respiratory tract disease, it is made up of the composition of following weight proportion:
The extract of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is the water extract of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae, and the weight ratio of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is followed successively by 5: 4: 2, and decocting cooking method is extracted routinely.
Preparation method is: the extract crushed after being dried of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is become fine powder, add tartaric acid, 80% sodium bicarbonate, lactose, sodium lauryl sulphate, protein sugar dried powder, mixing; To join in above-mentioned powder after carbomer anhydrous alcohol solution, mixing, granulate, in granule, add polyethylene glycol 6000 and 20% remaining sodium carbonate, after mixing, be pressed into the ring segment that specification is 0.7g.
After testing: the disintegration of this effervescent tablet is 3.5 minutes.
Instructions of taking is: every day 2-3 time, and each 1-2 sheet, puts into water, and disintegration of tablet is oral rapidly after melting.
Embodiment 4
The effect of clinical treatment:
This test case is in the Coudé hospital of traditional Chinese hospital, Wuhan through being diagnosed as the patient of haze respiratory system disease, 16 ~ 56 years old age, totally 30 examples, the symptoms such as clinical manifestation is throat discomfort, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, uncomfortable in chest, gas is kicked, find reddish tongue through health check-up, and tongue is BOHUANG slightly, pharyngeal congestion, antiadoncus, two pulmonary respiration sounds are coarse, with dry moist rale.30 routine patients are divided into 2 groups at random, often organize 15 people, each group patient is not statistically significant in sex, age and state of an illness distribution.I group (treatment group) takes effervescent tablet of the present invention, 2 pieces/times, every day 2 times, and in water, disintegrate is oral rapidly after melting, and II group (matched group) takes roxithromycin dispersing tablet, 0.15 gram/times, and every twice-daily is oral.Laboratory observation course for the treatment of is 7 days.Concrete treatment criterion of therapeutical effect is:
Recovery from illness: the Clinical symptom and sign disappearance such as treat throat discomfort in 7 days, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, uncomfortable in chest, gas is kicked;
Effective: Clinical symptom and sign alleviates more than 3/4 to treat throat discomfort in 7 days, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, uncomfortable in chest, gas is kicked etc.;
Effective: Clinical symptom and sign alleviates 1/4 ~ 3/4 to treat throat discomfort in 7 days, dry pharynx, pharyngalgia, nasal obstruction, rhinocnesmus, cough or dry cough, hoarseness, uncomfortable in chest, gas is kicked etc.;
Invalid: to treat symptom in 7 days and be all not improved or increase the weight of.
Treating the result after 7 days is:
Treatment group: fully recover 6 people, effective 5 people, effective 3 people, invalid 1 people, total effective rate is 93.3%.
Matched group: fully recover 5 people, effective 4 people, effective 3 people, invalid 3 people, total effective rate is 80%.
Claims (7)
1. treat a Chinese medicine effervescent tablet for respiratory tract disease, it is characterized in that it is made up of the composition of following weight proportion:
The extract of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is the water extract of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae, and the weight ratio of described Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is followed successively by 20 ~ 50: 10 ~ 40: 5 ~ 20;
Described surfactant to be HLB value be 20 ~ 40 hydrophilic surfactant.
2. the Chinese medicine effervescent tablet for the treatment of respiratory tract disease as claimed in claim 1, is characterized in that: described surfactant is sodium lauryl sulphate.
3. prepare the method for the Chinese medicine effervescent tablet for the treatment of respiratory tract disease described in claim 1 or 2 for one kind, it is characterized in that comprising the following steps: the extract crushed after being dried of Bulbus Lilii, Radix Platycodonis, Radix Glycyrrhizae is become fine powder, add sour agent, 60 ~ 80% alkaline agent, filler, surfactant, sweeting agent dried powder, mixing; To join in above-mentioned powder after binding agent anhydrous alcohol solution, mixing, granulate, in granule, add lubricant and remaining alkaline agent, tabletting after mixing.
4. preparation method as claimed in claim 3, is characterized in that: described sour agent is citric acid or tartaric acid.
5. preparation method as claimed in claim 3, is characterized in that: described alkaline agent is sodium bicarbonate or sodium carbonate.
6. preparation method as claimed in claim 3, is characterized in that: described filler is sucrose or lactose.
7. preparation method as claimed in claim 3, is characterized in that: described tabletting is pressed into hollow ring segment.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904688A (en) * | 2018-08-02 | 2018-11-30 | 王瑞福 | A kind of health-preserving pharynx tea and preparation method thereof |
| CN110638926A (en) * | 2019-09-26 | 2020-01-03 | 宁波德康生物制品有限公司 | Lung moistening and cough relieving substitutional tea and preparation process thereof |
| CN110693999A (en) * | 2019-10-10 | 2020-01-17 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition for treating lung injury, relieving cough, reducing phlegm and improving skin moisture, preparation and application |
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| CN1520863A (en) * | 2003-01-30 | 2004-08-18 | 兰州百合保健食品研究所 | Formula and dosage form of oral preparation with Bulbus Lilii as main material for lung health promotion, skin caring and kidney invigorating |
| CN102100902A (en) * | 2011-02-15 | 2011-06-22 | 江西本草天工科技有限责任公司 | Counterflow cold effervescent tablets |
| CN103127369A (en) * | 2013-03-04 | 2013-06-05 | 高雪 | Traditional Chinese medicine composition for treating respiratory tract haze disoperation and preparation method |
| CN103356891A (en) * | 2013-08-01 | 2013-10-23 | 中国药材公司 | Sugar-free throat-clearing lozenge and preparation method thereof |
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2014
- 2014-09-09 CN CN201410456497.8A patent/CN104225196B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520863A (en) * | 2003-01-30 | 2004-08-18 | 兰州百合保健食品研究所 | Formula and dosage form of oral preparation with Bulbus Lilii as main material for lung health promotion, skin caring and kidney invigorating |
| CN102100902A (en) * | 2011-02-15 | 2011-06-22 | 江西本草天工科技有限责任公司 | Counterflow cold effervescent tablets |
| CN103127369A (en) * | 2013-03-04 | 2013-06-05 | 高雪 | Traditional Chinese medicine composition for treating respiratory tract haze disoperation and preparation method |
| CN103356891A (en) * | 2013-08-01 | 2013-10-23 | 中国药材公司 | Sugar-free throat-clearing lozenge and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904688A (en) * | 2018-08-02 | 2018-11-30 | 王瑞福 | A kind of health-preserving pharynx tea and preparation method thereof |
| CN110638926A (en) * | 2019-09-26 | 2020-01-03 | 宁波德康生物制品有限公司 | Lung moistening and cough relieving substitutional tea and preparation process thereof |
| CN110693999A (en) * | 2019-10-10 | 2020-01-17 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition for treating lung injury, relieving cough, reducing phlegm and improving skin moisture, preparation and application |
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