CN104222105A - Compound preservative containing dimethyl 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione and preparation method thereof - Google Patents
Compound preservative containing dimethyl 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione and preparation method thereof Download PDFInfo
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- CN104222105A CN104222105A CN201410398651.0A CN201410398651A CN104222105A CN 104222105 A CN104222105 A CN 104222105A CN 201410398651 A CN201410398651 A CN 201410398651A CN 104222105 A CN104222105 A CN 104222105A
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- compound preservative
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- dihydroxymethyl glycolylurea
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Abstract
The invention discloses a compound preservative containing dimethyl 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione. The compound preservative is composed of the following components in mass percent: 10.0%-50.0% of dimethyl 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, 0.1%-2.0% of chloromethyisothiazolinone or methylisothiazolinone, 0.1%-1.0% of a synergist and the balance of de-ionized water or purified water. A preparation method comprises the following steps: adding a quantitative amount of the synergist into the de-ionized water or the purified water; agitating and dissolving until the solution is clarified; then adding dimethyl 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione into the solution and uniformly agitating and mixing; and finally, adding chloromethyisothiazolinone or methylisothiazolinone and uniformly agitating and mixing to obtain the compound preservative. The compound preservative has the advantages of broad-spectrum antibacterial property, low irritation and no resistance.
Description
Technical field
The invention belongs to preservative field, be specifically related to a kind of compound preservative containing dimethyl dihydroxymethyl glycolylurea and preparation method thereof.
Background technology
The current state-of-the-art technology direction of preservative is spectrum antibacterial, no or low excitant, without or lower microorganism drug resistance.The preservative of single-activity composition can not reach above-mentioned all technical requirements.
Summary of the invention
The present invention is directed to the shortcoming of existing preservative, an object of the present invention is to provide a kind of compound preservative containing dimethyl dihydroxymethyl glycolylurea, what be intended to solution is comprehensive problem, namely solve the preservative of single-activity composition the broad-spectrum antiseptic that can not comprehensively possess, no or low excitant, the problem of no or low drug resistance.
One aspect of the present invention, there is provided a kind of compound preservative containing dimethyl dihydroxymethyl glycolylurea, the mass percent of each component consists of: dimethyl dihydroxymethyl glycolylurea 10.0% ~ 50.0%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.1% ~ 2.0%, synergist 0.1% ~ 1.0%, surplus are deionized water or purified water.Wherein,
The above-mentioned compound preservative containing dimethyl dihydroxymethyl glycolylurea, the mass percent composition of each component is preferably: dimethyl dihydroxymethyl glycolylurea 15.0% ~ 30.0%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.2% ~ 1.8%, synergist 0.2% ~ 0.8%, surplus are deionized water or purified water.
The above-mentioned compound preservative containing dimethyl dihydroxymethyl glycolylurea, the mass percent composition of each component most preferably is: dimethyl dihydroxymethyl glycolylurea 20.0% ~ 26.0%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.5% ~ 1.5%, synergist 0.4% ~ 0.6%, surplus are deionized water or purified water.
The above-mentioned compound preservative containing dimethyl dihydroxymethyl glycolylurea, is characterized in that: described synergist is fatty alcohol-polyoxyethylene ether AEO-9.
Containing the preparation method of the compound preservative of dimethyl dihydroxymethyl glycolylurea, method is as follows: first quantitative synergist is added stirring and dissolving extremely clarification in deionized water or purified water, then dimethyl dihydroxymethyl glycolylurea is added in above-mentioned solution and be uniformly mixed, be uniformly mixed after finally chlormethylisothiazo,ine ketone or methylisothiazolinone being added.
The compound preservative containing dimethyl dihydroxymethyl glycolylurea that the embodiment of the present invention provides, for main active ingredient with preservative active ingredient dimethyl dihydroxymethyl glycolylurea, be equipped with the one that chlormethylisothiazo,ine ketone or methylisothiazolinone and synergist form and there is broad-spectrum antiseptic, the low and preservative blends had no drug resistance of excitant.Sterilization antiseptic active ingredient wherein has different Antibacterial Mechanisms, works in coordination with mutually, thus can be issued to good sterilization and anticorrosion effect at low using dosage, and then reduces sterilization antiseptic excitant.The composite drug resistance problems solving microorganism of various sterilization active component.
Embodiment
Embodiment 1
Preparation is deionized water or purified water containing dimethyl dihydroxymethyl glycolylurea 15%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.2%, synergist 0.2%, surplus.
Can be specifically: the formula containing the compound preservative of dimethyl dihydroxymethyl glycolylurea: dimethyl dihydroxymethyl glycolylurea 1.5kg, methylisothiazolinone 0.02kg, synergist 0.02kg, deionized water 8.46kg.
The preparation method of compound preservative: first 0.02kg synergist is added in 8.46kg deionized water, stirring and dissolving is to clarification, then 1.5kg dimethyl dihydroxymethyl glycolylurea is added in above-mentioned solution and be uniformly mixed, be uniformly mixed after finally 0.02kg methylisothiazolinone being added.
Embodiment 2
Preparation is deionized water or purified water containing dimethyl dihydroxymethyl glycolylurea 26%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.15%, synergist 0.6%, surplus.
Can be specifically: the formula containing the compound preservative of dimethyl dihydroxymethyl glycolylurea: dimethyl dihydroxymethyl glycolylurea 2.6kg, methylisothiazolinone 0.15kg, synergist 0.06kg, purified water 7.19kg.
Can be specifically: the preparation method of compound preservative: first 0.06kg synergist is added in 7.19kg deionized water, stirring and dissolving is to clarification, then 2.6kg dimethyl dihydroxymethyl glycolylurea is added in above-mentioned solution and be uniformly mixed, be uniformly mixed after finally 0.15kg methylisothiazolinone being added.
Embodiment 3
Preparation is deionized water or purified water containing dimethyl dihydroxymethyl glycolylurea 50%, chlormethylisothiazo,ine ketone or methylisothiazolinone 2%, synergist 1%, surplus.
Formula containing the compound preservative of dimethyl dihydroxymethyl glycolylurea: dimethyl dihydroxymethyl glycolylurea 5.0kg, chlormethylisothiazo,ine ketone 0.2kg, synergist 0.1kg, deionized water 4.7kg.
The preparation method of compound preservative: first 0.1kg synergist is added in 4.7kg deionized water, stirring and dissolving is to clarification, then 5.0kg dimethyl dihydroxymethyl glycolylurea is added in above-mentioned solution and be uniformly mixed, be uniformly mixed after finally 0.2kg chlormethylisothiazo,ine ketone being added.
In above embodiment, synergist is fatty alcohol-polyoxyethylene ether AEO-9.
Be used for corrosion-resistant effect below in conjunction with test to the compound preservative containing dimethyl dihydroxymethyl glycolylurea that the embodiment of the present invention proposes to be described, refer to table one.
Table one
From the data of table one, the compound preservative containing dimethyl dihydroxymethyl glycolylurea that the present invention proposes has good antiseptic effect.
Above to invention has been detailed introduction, applying specific case herein and setting forth principle of the present invention and embodiment, the explanation of above embodiment just understands method of the present invention and core concept thereof for helping; Meanwhile, for one of ordinary skill in the art, according to thought of the present invention, all will change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.
Claims (5)
1., containing the compound preservative of dimethyl dihydroxymethyl glycolylurea, it is characterized in that: the mass percent of each component consists of: dimethyl dihydroxymethyl glycolylurea 10.0% ~ 50.0%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.1% ~ 2.0%, synergist 0.1% ~ 1.0%, surplus are deionized water or purified water.
2. the compound preservative containing dimethyl dihydroxymethyl glycolylurea as claimed in claim 1, is characterized in that: the mass percent of each component consists of: dimethyl dihydroxymethyl glycolylurea 15.0% ~ 30.0%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.2% ~ 1.8%, synergist 0.2% ~ 0.8%, surplus are deionized water or purified water.
3. the compound preservative containing dimethyl dihydroxymethyl glycolylurea as claimed in claim 1 or 2, is characterized in that: the mass percent of each component consists of: dimethyl dihydroxymethyl glycolylurea 20.0% ~ 26.0%, chlormethylisothiazo,ine ketone or methylisothiazolinone 0.5% ~ 1.5%, synergist 0.4% ~ 0.6%, surplus are deionized water or purified water.
4. the compound preservative containing dimethyl dihydroxymethyl glycolylurea as claimed in claim 3, is characterized in that: described synergist is fatty alcohol-polyoxyethylene ether AEO-9.
5. the preparation method of the compound preservative containing dimethyl dihydroxymethyl glycolylurea according to claim 1, it is characterized in that method is as follows: first quantitative synergist is added stirring and dissolving extremely clarification in deionized water or purified water, then dimethyl dihydroxymethyl glycolylurea is added in above-mentioned solution and be uniformly mixed, be uniformly mixed after finally chlormethylisothiazo,ine ketone or methylisothiazolinone being added.
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CN201410398651.0A CN104222105A (en) | 2014-08-13 | 2014-08-13 | Compound preservative containing dimethyl 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione and preparation method thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107836453A (en) * | 2017-10-17 | 2018-03-27 | 四川国光农化股份有限公司 | A kind of Chinese prickly ash moss scavenger composition and its application |
CN112493239A (en) * | 2020-12-18 | 2021-03-16 | 湖南幻影三陆零科技有限公司 | Space disinfectant, space disinfection composition and application thereof |
CN112586498A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, composition containing disinfectant and application of composition |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1338537A (en) * | 2001-09-07 | 2002-03-06 | 中国人民解放军济南军区联勤部军事医学研究所 | Process for preparing antibacterial fabric |
WO2014002020A2 (en) * | 2012-06-29 | 2014-01-03 | Kimberly-Clark Worldwide, Inc. | Stable emulsion for prevention of skin irritation and items using same |
CN103520029A (en) * | 2013-09-22 | 2014-01-22 | 天津市中科健新材料技术有限公司 | Method for producing dry disinfection towel |
-
2014
- 2014-08-13 CN CN201410398651.0A patent/CN104222105A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1338537A (en) * | 2001-09-07 | 2002-03-06 | 中国人民解放军济南军区联勤部军事医学研究所 | Process for preparing antibacterial fabric |
WO2014002020A2 (en) * | 2012-06-29 | 2014-01-03 | Kimberly-Clark Worldwide, Inc. | Stable emulsion for prevention of skin irritation and items using same |
CN103520029A (en) * | 2013-09-22 | 2014-01-22 | 天津市中科健新材料技术有限公司 | Method for producing dry disinfection towel |
Non-Patent Citations (1)
Title |
---|
李程碑: ""使用日化防腐剂减少微生物的抗药性"", 《应用化工》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107836453A (en) * | 2017-10-17 | 2018-03-27 | 四川国光农化股份有限公司 | A kind of Chinese prickly ash moss scavenger composition and its application |
CN112493239A (en) * | 2020-12-18 | 2021-03-16 | 湖南幻影三陆零科技有限公司 | Space disinfectant, space disinfection composition and application thereof |
CN112586498A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, composition containing disinfectant and application of composition |
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Application publication date: 20141224 |