CN104208638A - Traditional Chinese medicine preparation for treating emphysema - Google Patents
Traditional Chinese medicine preparation for treating emphysema Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating emphysema. The preparation is prepared from the following medicinal raw materials by weight: 10-20g of ephedra, 10-20g of poria cocos, 10-20g of schisandra chinensis, 10-20g of pinellia ternata, 10-20g of raw ginger, 10-20g of radix rehmanniae praeparata, 10-20g of cortex mori radicis, 8-12g of aster auriculatus franch, 8-12g of Japanese pagoda tree fruit, 8-12g of radix aucklandiae, 8-12g of pollen typhae carbonisatus, 8-12g of lily, 8-12g of fritillaria, 8-12g of angelica sinensis and 8-12g of fructus aurantii. The medicinal raw materials are well matched to take effects of clearing heat, removing toxicity, freeing lung, relieving asthma, strengthening spleen, excreting dampness, relieving cough and diminishing swelling. Clinical application proves that the traditional Chinese medicine preparation has the advantages of exact curative effect, no side effect, high cure rate, low relapse rate and the like when used for treating emphysema; thus, the traditional Chinese medicine preparation is worthy of clinical popularization and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, one can treat emophysematous Chinese medicine preparation specifically.
Background technology
The emphysema mainly whole last bronchus distal portions of lung tissue comprise the expansion of respiratory bronchioles, alveolar duct, alveolar sac and alveolar and excessively inflate, and cause lung tissue elastic force to go down, volume increases.Because its morbidity is slow, the course of disease is longer, therefore is called chronic obstructive emphysema.At the sickness rate of China greatly between 0.6%-4.3%.
This type of disease belong to more Chinese medicine the syndrome of dyspnea, breathe heavily swollen, dyspnea with chest distension, asthma, lose heart, phlegm retention, cough, the disease category such as cough with dyspnea.Main clinical manifestation be dyspnea with rapid breath or breast feel suffocated short, cough up phlegm, cough etc.At present clinically, patient often goes to a doctor, before medical with emphysema companion intrapulmonary infection, patient is often from clothes or intramuscular injection common antibiotics, and produce drug resistance to antibiotic, clinical treatment is very difficult, side effect and relapse rate are relatively high, if merge cardiac disorder, its treatment is more thorny.
Summary of the invention
Instant invention overcomes the technical deficiency existed in treatment emphysema at present, provide a kind of determined curative effect, have no side effect, the high and Chinese medicine preparation not easily recurred of cure rate.
The technical solution adopted in the present invention is: one treats emophysematous Chinese medicine preparation, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Herba Ephedrae 10-20 gram, Poria 10-20 gram, Fructus Schisandrae Chinensis 10-20 gram, Rhizoma Pinelliae 10-20 gram, Rhizoma Zingiberis Recens 10-20 gram, Radix Rehmanniae Preparata 10-20 gram, Cortex Mori 10-20 gram, 8-12 gram, Radix Asteris ear, Fructus sophorae 8-12 gram, Radix Aucklandiae 8-12 gram, Pollen Tyjphae (parched) 8-12 gram, Bulbus Lilii 8-12 gram, Bulbus Fritillariae Uninbracteatae 8-12 gram, Radix Angelicae Sinensis 8-12 gram, Fructus Aurantii 8-12 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the raw material of following weight portion:
10 grams, Herba Ephedrae, Poria 10 grams, Fructus Schisandrae Chinensis 10 grams, the Rhizoma Pinelliae 10 grams, 10 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 10 grams, Cortex Mori 10 grams, 8 grams, Radix Asteris ear, Fructus sophorae 8 grams, the Radix Aucklandiae 8 grams, Pollen Tyjphae (parched) 8 grams, Bulbus Lilii 8 grams, Bulbus Fritillariae Uninbracteatae 8 grams, Radix Angelicae Sinensis 8 grams, Fructus Aurantii 8 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the raw material of following weight portion:
15 grams, Herba Ephedrae, Poria 15 grams, Fructus Schisandrae Chinensis 15 grams, the Rhizoma Pinelliae 15 grams, 15 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 15 grams, Cortex Mori 15 grams, 10 grams, Radix Asteris ear, Fructus sophorae 10 grams, the Radix Aucklandiae 10 grams, Pollen Tyjphae (parched) 10 grams, Bulbus Lilii 10 grams, Bulbus Fritillariae Uninbracteatae 10 grams, Radix Angelicae Sinensis 10 grams, Fructus Aurantii 10 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the raw material of following weight portion:
20 grams, Herba Ephedrae, Poria 20 grams, Fructus Schisandrae Chinensis 20 grams, the Rhizoma Pinelliae 20 grams, 20 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 20 grams, Cortex Mori 20 grams, 12 grams, Radix Asteris ear, Fructus sophorae 12 grams, the Radix Aucklandiae 12 grams, Pollen Tyjphae (parched) 12 grams, Bulbus Lilii 12 grams, Bulbus Fritillariae Uninbracteatae 12 grams, Radix Angelicae Sinensis 12 grams, Fructus Aurantii 12 grams.
The instructions of taking of Chinese medicine preparation of the present invention is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, traditionally the method for fried Chinese medicine gets its medicine juice, every day 1 dose, and point morning, late 2 decoction being taken warmly 10 days were 1 course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Herba Ephedrae, acrid in the mouth, hardship, warm in nature; Return lung, urinary bladder channel.There is diaphoresis cold expelling, depressed lung-energy dispersing, effect of inducing diuresis to remove edema.
Poria, sweet in the mouth, property is put down; GUIXIN, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.
Fructus Schisandrae Chinensis, sour in the mouth, warm in nature; Return lung, kidney, heart channel.There is supplementing QI for promoting the production of body fluid, the effect of nourishing kidney of astringing the lung.
The Rhizoma Pinelliae, acrid in the mouth, warm in nature; Return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass.
Rhizoma Zingiberis Recens, acrid in the mouth, warm in nature; Return lung, spleen channel.There is relieving the exterior syndrome by diaphoresis, warming middle-JIAO to stop vomiting, effect of warming the lung to relieve cough.
Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature; Return liver, kidney channel.Have YIN nourishing of enriching blood, beneficial essence fills out effect of marrow.
Cortex Mori, sweet in the mouth, cold in nature; Return lung meridian.There is eliminating pathogen from the lung for relieving asthma, effect of line water detumescence.
Radix Asteris ear, acrid in the mouth, hardship, warm in nature; Return lung meridian.There is nourishing the lung to keep the adverse QI downward, effect of stopping coughing and removing phlegm.
Fructus sophorae, bitter in the mouth, cold in nature; Return liver, large intestine channel.There is clearing away heat-fire, effect of cooling blood for hemostasis.
The Radix Aucklandiae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There are promoting the circulation of QI to relieve pain, effect of intestinal stasis relieving in tune.
Pollen Tyjphae (parched), sweet in the mouth, property is put down; Return liver, heart channel.There is hemostasia and dissipation blood stasis, effect that promoting the circulation of blood is treating stranguria.
Bulbus Lilii, sweet in the mouth, property is put down; GUIXIN, lung meridian.There is nourishing the lung to arrest cough, effect of mind tranquilizing and the heart calming.
Bulbus Fritillariae Uninbracteatae, sweet in the mouth, cold nature; GUIXIN, lung meridian.There are clearing heat and moistening lung, effect of preventing phlegm from forming and stopping coughing.
Radix Angelicae Sinensis, sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.There is promoting blood circulation and stopping pain, tonifying blood and regulating menstruation, effect of loosening bowel to relieve constipation.
Fructus Aurantii, bitter in the mouth, pungent, cool in nature; Return lung, spleen, large intestine channel.There is the capable expectorant of dispelling the stagnated QI, effect of promoting digestion and removing stagnation.
The category that emphysema are summarized in by tcm theory " the syndrome of dyspnea, abdominal distention ", based on insufficiency of lung-QI, feel exopathogen again, normal simulataneous insufficiency and excessive, cold and heat are tied mutually, and sick position, at lung, affects the function of spleen, kidney, the heart then.Clinical manifestation is dynamic then more so with tachypnea of coughing; Sputum stops up resistance, and costa sternales distension is feature.After prolonged illness, the positive deficiency of vital energy of body declines the deficiency of the lung, failure of defensive QI to protect the body against pathogen, more easily causes cold-evil, pathogenic dryness invasion, so touching difficulty more, treatment is when with strengthening the body resistance, and strengthening spleen, tonifying kidney, lung qi dispersing cough-relieving, drying dampness to eliminate phlegm is principle.In Chinese medicine preparation of the present invention, Herba Ephedrae, Rhizoma Zingiberis Recens can relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, warming the lung to relieve cough; Poria, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata can supplementing QI for promoting the production of body fluid, YIN nourishing of enriching blood, nourishing kidney of astringing the lung, invigorating the spleen and regulating the stomach; Cortex Mori, Radix Asteris ear can eliminating pathogen from the lung for relieving asthma, stopping coughing and removing phlegm; The Radix Aucklandiae, the Rhizoma Pinelliae, Fructus Aurantii can drying dampness to eliminate phlegm, the capable expectorant of dispelling the stagnated QI, dissolving lump and resolving mass; Bulbus Lilii, Bulbus Fritillariae Uninbracteatae can clearing heat and moistening lung, preventing phlegm from forming and stopping coughing; Fructus sophorae, Radix Angelicae Sinensis, Pollen Tyjphae (parched) can promoting blood flow to regulate menstruation, hemostasia and dissipation blood stasis, clearing away heat-fire.All medicine compatibilities are superior, play heat-clearing and toxic substances removing altogether, depressed lung-energy dispersing, spleen invigorating eliminating dampness by diuresis, cough-relieving is subsided a swelling, effect of the body resistance strengthening and constitution consolidating, effectively can not only improve patients ' life quality, delays and symptom management, reduce emophysematous complication, the gas that can also improve lung kidney returns root functionality, so eliminate cough, expectorant, breathe heavily, the symptom such as swollen, reach and thoroughly cure emophysematous object.
For investigating the clinical efficacy of medicine of the present invention further, we have selected 100 routine emphysema patient, be divided into treatment group and matched group at random, treatment group 50 example is man 29 example wherein, female 21 example, age 45-85 year, year mean age (66.72 ± 5.02), average course of disease (4.35 ± 2.86); Matched group 50 example, wherein man 28 example, female 22 example, age 46-85 year, the mean age (66.65 ± 5.05) year, average course of disease (4.45 ± 2.91; All patients all meet emophysematous diagnostic criteria, are divided into state of an illness difference: 1, pure chronic bronchitis Bing emphysema; 2, asthmatic chronic bronchitis Bing emphysema; 3, bronchial asthma Bing emphysema.Two groups of cases are in sex, and at the age, the state of an illness, the aspect no significant difference such as the course of disease (p > 0.05), have comparability.
Therapeutic Method:
Matched group uses western medicine, all gives and sucks SCH 1000 (the accurate word of traditional Chinese medicines is H20033863), 40 μ g/ time, 3 times/day; Oral administered compound aminophylline (the accurate word of traditional Chinese medicines is H31022648), 1 tablet/time, 1 times/day; Inhalation of budesonide powders for inhalation (the accurate word H20080249 of traditional Chinese medicines), 200 μ g/ time, 2 times/day; Relieving asthma according to conditions of patients conbined usage spasmolytic, the medicine such as antiinflammatory treats, part patient with severe symptoms can coordinate oxygen inhalation therapy.Treatment group takes Chinese medicine preparation of the present invention, treats according to dialectical plus-minus, decocting twice collecting decoction, day 1 dose, point sooner or later twice decoction being taken warmly, within 10 days, is 1 course for the treatment of, continuously 3 courses for the treatment of of treatment, observes and compares the difference of two groups of patient clinical effects.
Criterion of therapeutical effect:
Effective: clinically to cough, expectorant, to breathe heavily and pulmonary's wheezing sound transference cure, more than 1 year without recurrence;
Effective: clinically to cough, expectorant, to breathe heavily and pulmonary's wheezing sound symptom obviously alleviates or attack times reduces;
Invalid: clinically to cough, expectorant, to breathe heavily and pulmonary's wheezing sound symptom is not improved or slightly takes a turn for the better, but namely recur after drug withdrawal.
Efficacy result:
1. Clinical efficacy comparison:
After treatment, effective 19 examples for the treatment of group, effective 28 examples, invalid 3 examples, total effective rate (obvious effective rate+effective percentage) is 94%, effective 12 examples of matched group, and effective 24 examples, invalid 14 examples, total effective rate is 72%.Treatment group curative effect is obviously better than matched group, and two groups of comparing differences have statistical significance (P < 0.05), and detailed results is in table 1.
Table 1: two groups of patient clinical efficacy result synopsis
| Group | Case n | Effective n (%) | Effective n (%) | Invalid n (%) | Total effective rate (%) |
| Treatment group | 50 | 19(38.0) | 28(56.0) | 3(6.0) | 94.0 |
| Matched group | 50 | 12(24.0) | 24(48.0) | 14(28.0) | 72.0 |
2. side effect is compared:
Relatively two groups of patient clinical untoward reaction, treatment group only has 3 routine patient's gastrointestinal tract reactions, matched group then has 11 routine patients to occur gastrointestinal reaction, hypotension and cardiopalmus, treatment group is significantly better than matched group, and two groups of comparing differences have statistical significance (P < 0.05).
3. relapse rate compares:
Follow up a case by regular visits to 1 year to all effective patients, no case was recurrence for treatment group, and matched group recurrence 6 example, rear conversion Chinese medicine preparation of the present invention carries out treating rear rehabilitation.
The advantages such as result shows, Chinese medicine preparation of the present invention is used for the treatment of emphysema and has evident in efficacy, and adverse reaction rate is low, and relapse rate is low, and patient satisfaction rate is high, are suitable for clinical expansion and use.
Detailed description of the invention
Embodiment 1: one treats emophysematous Chinese medicine preparation, chooses 10 grams, Herba Ephedrae, Poria 10 grams, Fructus Schisandrae Chinensis 10 grams, the Rhizoma Pinelliae 10 grams, 10 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 10 grams, Cortex Mori 10 grams, 8 grams, Radix Asteris ear, Fructus sophorae 8 grams, the Radix Aucklandiae 8 grams, Pollen Tyjphae (parched) 8 grams, Bulbus Lilii 8 grams, Bulbus Fritillariae Uninbracteatae 8 grams, Radix Angelicae Sinensis 8 grams, Fructus Aurantii 8 grams.
Embodiment 2: one treats emophysematous Chinese medicine preparation, chooses 15 grams, Herba Ephedrae, Poria 15 grams, Fructus Schisandrae Chinensis 15 grams, the Rhizoma Pinelliae 15 grams, 15 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 15 grams, Cortex Mori 15 grams, 10 grams, Radix Asteris ear, Fructus sophorae 10 grams, the Radix Aucklandiae 10 grams, Pollen Tyjphae (parched) 10 grams, Bulbus Lilii 10 grams, Bulbus Fritillariae Uninbracteatae 10 grams, Radix Angelicae Sinensis 10 grams, Fructus Aurantii 10 grams.
Embodiment 3: one treats emophysematous Chinese medicine preparation, chooses 20 grams, Herba Ephedrae, Poria 20 grams, Fructus Schisandrae Chinensis 20 grams, the Rhizoma Pinelliae 20 grams, 20 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 20 grams, Cortex Mori 20 grams, 12 grams, Radix Asteris ear, Fructus sophorae 12 grams, the Radix Aucklandiae 12 grams, Pollen Tyjphae (parched) 12 grams, Bulbus Lilii 12 grams, Bulbus Fritillariae Uninbracteatae 12 grams, Radix Angelicae Sinensis 12 grams, Fructus Aurantii 12 grams.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
Stone, female, 67 years old.Patient because of cough with asthma repeatedly, pants uncomfortable in chest the year before, and lip slightly cyanosis and remove examination in hospital, is diagnosed as emphysema, gives low discharge, oxygen uptake infection, antiinflammatory are relievingd asthma, the relieving cough and resolving phlegm treatment a few days has no improvement, conscious uncomfortable in chest, breast is swollen, poor appetite, sleep are bad.Introduce through friend, take Chinese medicine preparation of the present invention and treat, after taking a week, cough, expectorant, the symptom such as to breathe heavily and be improved greatly, continue to take to 3 courses for the treatment of, patient respiratory is smooth and easy, through hospital's CT examination: lung fibrosis shade disappears, and pulmonary function recovers normal.Follow up a case by regular visits to and do not recur for 1 year.
Case 2
Liu, man, 76 years old.Suffers from the emphysema several years, productive cough does not go out, chronic cough is not healed, and throat always has expectorant, eats expectorant and don't work, from FeBruary last aggravation, can not work, it is breathless that Zou Dian suppresses on road, seeks medical advice everywhere also to have no improvement by medicine treatment, all the year round with medicines such as aerosol, aminophylline, terbutalines in the hope of respite, very painful.Take Chinese medicine preparation of the present invention by friend's introduction to treat, take symptom after 2 weeks and subtract greatly, cough with asthma symptom is obviously improved, and continues to take 2 courses for the treatment of, and patient no longer feels suffocated on foot, and spirit is happy, happy, and quality of life significantly improves.Follow up a case by regular visits to and do not recur for 1 year.
Case 3
Revive certain, man, 74 years old.This patient suffers from the bronchitis several years, and February last year occurs dyspnea because catching a cold, and Progressive symmetric erythrokeratodermia increases the weight of, and without alleviation during rest, activity postemphasis, accompanies uncomfortable in chest.Remove hospital admission, after chest film inspection, doctor says it is emphysema.So hospitalization, after the week, the state of an illness has no sign of improvement.Take Chinese medicine preparation of the present invention treatment after being introduced, after taking 10 days, breathe happy, symptom uncomfortable in chest obtains alleviation, and patient is full of confidence, actively coordinates, and after continuing to take 1 course for the treatment of, symptom all disappears, lab testing, recovers normal.Follow up a case by regular visits to and do not recur for 1 year.
Case 4
Thank certain, man, 72 years old, patient because of recurrent cough, to tire out gas tight more than 10 years for the expectoration companion heart, recurrence increases the weight of then to go to see a doctor for 3 days, and treatments such as " the multiple infection in full pool, ambroxol eliminate the phlegm " that rabat prompting " emphysema, " emergency treatment gives, symptom is without obvious alleviation.Take Chinese medicine preparation of the present invention treatment upon somebody's introduction, after taking for two weeks, cough alleviates, and other symptom is also improved, and after continuing to take 2 courses for the treatment of, coughs, expectorant, breathes heavily disappearance, lab testing, pulmonary's wheezing sound transference cure.Follow up a case by regular visits to 1 year without recurrence.
Claims (4)
1. treat an emophysematous Chinese medicine preparation, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Herba Ephedrae 10-20 gram, Poria 10-20 gram, Fructus Schisandrae Chinensis 10-20 gram, Rhizoma Pinelliae 10-20 gram, Rhizoma Zingiberis Recens 10-20 gram, Radix Rehmanniae Preparata 10-20 gram, Cortex Mori 10-20 gram, 8-12 gram, Radix Asteris ear, Fructus sophorae 8-12 gram, Radix Aucklandiae 8-12 gram, Pollen Tyjphae (parched) 8-12 gram, Bulbus Lilii 8-12 gram, Bulbus Fritillariae Uninbracteatae 8-12 gram, Radix Angelicae Sinensis 8-12 gram, Fructus Aurantii 8-12 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
10 grams, Herba Ephedrae, Poria 10 grams, Fructus Schisandrae Chinensis 10 grams, the Rhizoma Pinelliae 10 grams, 10 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 10 grams, Cortex Mori 10 grams, 8 grams, Radix Asteris ear, Fructus sophorae 8 grams, the Radix Aucklandiae 8 grams, Pollen Tyjphae (parched) 8 grams, Bulbus Lilii 8 grams, Bulbus Fritillariae Uninbracteatae 8 grams, Radix Angelicae Sinensis 8 grams, Fructus Aurantii 8 grams.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
15 grams, Herba Ephedrae, Poria 15 grams, Fructus Schisandrae Chinensis 15 grams, the Rhizoma Pinelliae 15 grams, 15 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 15 grams, Cortex Mori 15 grams, 10 grams, Radix Asteris ear, Fructus sophorae 10 grams, the Radix Aucklandiae 10 grams, Pollen Tyjphae (parched) 10 grams, Bulbus Lilii 10 grams, Bulbus Fritillariae Uninbracteatae 10 grams, Radix Angelicae Sinensis 10 grams, Fructus Aurantii 10 grams.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
20 grams, Herba Ephedrae, Poria 20 grams, Fructus Schisandrae Chinensis 20 grams, the Rhizoma Pinelliae 20 grams, 20 grams, Rhizoma Zingiberis Recens, Radix Rehmanniae Preparata 20 grams, Cortex Mori 20 grams, 12 grams, Radix Asteris ear, Fructus sophorae 12 grams, the Radix Aucklandiae 12 grams, Pollen Tyjphae (parched) 12 grams, Bulbus Lilii 12 grams, Bulbus Fritillariae Uninbracteatae 12 grams, Radix Angelicae Sinensis 12 grams, Fructus Aurantii 12 grams.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1506100A (en) * | 2002-12-10 | 2004-06-23 | 辛文华 | Medicine for treating acute and chronic bronchitis, asthma and pulmonary emphysema |
| WO2010013925A2 (en) * | 2008-07-31 | 2010-02-04 | Dong-A Pharmaceutical. Co., Ltd. | Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof |
-
2014
- 2014-09-19 CN CN201410482413.8A patent/CN104208638A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1506100A (en) * | 2002-12-10 | 2004-06-23 | 辛文华 | Medicine for treating acute and chronic bronchitis, asthma and pulmonary emphysema |
| WO2010013925A2 (en) * | 2008-07-31 | 2010-02-04 | Dong-A Pharmaceutical. Co., Ltd. | Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof |
Non-Patent Citations (2)
| Title |
|---|
| 姜宁等: "《呼吸系统疾病诊治绝招》", 31 August 2008 * |
| 鲍艳举等: "《经方时方"六经辨证"应用案解》", 31 July 2011 * |
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Application publication date: 20141217 |