CN104203245A - 用于治疗和预防铁缺乏症和缺铁性贫血的铁(iii)复合化合物 - Google Patents

用于治疗和预防铁缺乏症和缺铁性贫血的铁(iii)复合化合物 Download PDF

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Publication number
CN104203245A
CN104203245A CN201380018838.7A CN201380018838A CN104203245A CN 104203245 A CN104203245 A CN 104203245A CN 201380018838 A CN201380018838 A CN 201380018838A CN 104203245 A CN104203245 A CN 104203245A
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CN
China
Prior art keywords
iron
iii
group
deficiency
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201380018838.7A
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English (en)
Chinese (zh)
Inventor
托马斯·巴克
威尔姆·布尔
苏珊娜·布尔克哈特
迈克尔·布格特
卡米洛·坎利尼
弗朗茨·迪伦贝格尔
菲力克斯·芬克
彼得·奥托·盖泽
阿里斯·卡洛格拉基斯
西蒙娜·迈耶
埃里克·菲利浦
斯蒂芬·赖姆
黛安娜·西贝尔
耶格·施密特
卡特琳·施瓦尔茨
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Vifor International AG
Original Assignee
Vifor International AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vifor International AG filed Critical Vifor International AG
Publication of CN104203245A publication Critical patent/CN104203245A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN201380018838.7A 2012-04-05 2013-04-04 用于治疗和预防铁缺乏症和缺铁性贫血的铁(iii)复合化合物 Pending CN104203245A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12163308.5 2012-04-05
EP12163308 2012-04-05
PCT/EP2013/057071 WO2013150087A1 (de) 2012-04-05 2013-04-04 Fe (iii) - pyrazin - komplexverbindungen zur behandlung und prophylaxe von eisenmangelerscheinungen und eisenmangelanämien

Publications (1)

Publication Number Publication Date
CN104203245A true CN104203245A (zh) 2014-12-10

Family

ID=48045554

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380018838.7A Pending CN104203245A (zh) 2012-04-05 2013-04-04 用于治疗和预防铁缺乏症和缺铁性贫血的铁(iii)复合化合物

Country Status (12)

Country Link
US (1) US9439910B2 (enExample)
EP (1) EP2833890B1 (enExample)
JP (1) JP2015512436A (enExample)
KR (1) KR20140143832A (enExample)
CN (1) CN104203245A (enExample)
AU (1) AU2013244955A1 (enExample)
CA (1) CA2864577A1 (enExample)
ES (1) ES2623300T3 (enExample)
IN (1) IN2014DN08294A (enExample)
MX (1) MX2014011886A (enExample)
RU (1) RU2014144404A (enExample)
WO (1) WO2013150087A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111714470A (zh) * 2020-05-27 2020-09-29 天津瑞益瑞美生物技术有限公司 一种兽用缓释乙二胺四乙酸铁钠预混剂及其制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114286682A (zh) * 2019-02-09 2022-04-05 法码科思莫斯控股有限公司 治疗具有心血管不良事件风险的个体的铁缺乏以及用于治疗心房颤动的铁
US20250368672A1 (en) * 2022-06-17 2025-12-04 Regents Of The University Of Minnesota Iron complexes and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308055D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
GB8325496D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JUNKO OHKANDA ET AL.: "N-Hydroxyamide-Containing Heterocycles.Part 2.Synthesis and Iron(III)Complex-Forming Tendency of 1-Hydroxy-2(1H)-pyrimidinone and –pyrazinone.Junko OHKANDA et al.The Chemical Society of Japan.1993年第66卷，第841-847页", 《THE CHEMICAL SOCIETY OF JAPAN》 *
JUNKO OHKANDA,ET AL: "Novel Iron Sequestering Agents: Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ö-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine", 《J. ORG. CHEM.》 *
JUNKO OHKANDA,ET AL: "Novel Iron Sequestering Agents: Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ö-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine", 《J. ORG. CHEM.》, vol. 62, 31 December 1997 (1997-12-31), pages 3618 - 3624 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111714470A (zh) * 2020-05-27 2020-09-29 天津瑞益瑞美生物技术有限公司 一种兽用缓释乙二胺四乙酸铁钠预混剂及其制备方法

Also Published As

Publication number Publication date
MX2014011886A (es) 2014-11-12
EP2833890A1 (de) 2015-02-11
CA2864577A1 (en) 2013-10-05
AU2013244955A1 (en) 2014-10-23
IN2014DN08294A (enExample) 2015-05-15
KR20140143832A (ko) 2014-12-17
ES2623300T3 (es) 2017-07-10
US20150119374A1 (en) 2015-04-30
EP2833890B1 (de) 2017-02-01
WO2013150087A1 (de) 2013-10-10
RU2014144404A (ru) 2016-05-27
US9439910B2 (en) 2016-09-13
JP2015512436A (ja) 2015-04-27

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