CN104197645A - Gymnadenia conopsea freeze-drying method - Google Patents
Gymnadenia conopsea freeze-drying method Download PDFInfo
- Publication number
- CN104197645A CN104197645A CN201410418492.6A CN201410418492A CN104197645A CN 104197645 A CN104197645 A CN 104197645A CN 201410418492 A CN201410418492 A CN 201410418492A CN 104197645 A CN104197645 A CN 104197645A
- Authority
- CN
- China
- Prior art keywords
- freeze
- hand ginseng
- drying
- ginseng
- distillation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a gymnadenia conopsea freeze-drying method which is characterized in that fresh gymnadenia conopsea is taken, freeze-drying is conducted till sublimation is finished, the method for drying the gymnadenia conopsea is low in energy consumption, drinking pieces are not prone to breaking, and the product activity is high.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of freeze drying process of hand ginseng, belongs to medical technical field.
Background technology
The piece root that hand ginseng is the orchid family herbaceos perennial hand ginseng (Gymnadenia conopsea R.Br) or gymnadenia crassinervis Finet (Gymnedia crassinernis Finer).Have another name called Buddha's hand ginseng, palm ginseng.Have reinforce the spleen to benefit the lung, the effect such as nourishing blood to promote the production of body fluid, controlling of bleeding with astringents, clinical Chang Peiwu be applied to treatment after being ill weak, rush down for a long time, logical breast, lose blood, be with down, the disease such as chronic hepatitis.Its main chemical composition is mucilaginous substance, protein, glycosides displayed, carbohydrate, volatilization wet goods.
Traditional Chinese medicine drying has very long history in China, the Chinese herbal medicine of drying can keep certain medicinal ingredient and be difficult for putrid and deteriorated, the dry important measures as guaranteeing Chinese herbal medicine quality, it is a requisite technical process in Chinese herbal medicine processing, it is in close relations that dry and Chinese medicine are produced, and dry method will directly affect the quality of product.
The traditional drying method of hand ginseng has two kinds, and a kind of in order hand ginseng is put in cold water and to be cleaned, taking-up is dried, and another kind is that the ginseng of washing one's hands is put in goat milk with 1:1 ratio and boiled to the saturating heart, takes out, and dries.The second is the hand ginseng drying means of modern anaesthetic extensive use.
The freeze-drying process of prior art mainly can be divided into primary drying (lyophilization), and redrying (adsorption stripping and dry) is to dry.The dry run pumpdown time is long, and energy consumption is high.The present invention in freeze dryer without redrying process.Energy consumption is low, through test of many times power consumption, can reduce by 50%.
Below by pharmacodynamic study, further illustrate usefulness of the present invention, test example is intended to further illustrate usefulness of the present invention, but not limitation of the present invention.
To, with a collection of fresh hand ginseng, process by the following method.
1) dry hand ginseng: fresh hand ginseng is put in cold water and cleaned, cut sheet, taking-up is dried;
2) milk hand ginseng: fresh hand ginseng is put in cold water and cleaned, cut rear panel, put in milk and boil to the saturating heart with 1:1 ratio, take out, dry;
3) hand ginseng of the present invention: fresh hand ginseng is put in cold water and cleaned, cut sheet, be refrigerated to below-20 ℃, be evacuated to below drying chamber pressure 45Pa, heating sublimation, the temperature of distillation should be controlled at below 40 ℃, during state before condenser temperature drops to distillation, finish;
4) freeze-drying hand ginseng: fresh hand ginseng, be refrigerated to below-20 ℃, be evacuated to below drying chamber pressure 45Pa, heating sublimation, the temperature of distillation should be controlled at below 40 ℃, and the temperature of resolution phase is controlled at below 45 ℃, dry end when temperature of charge and heating-up temperature approach.
One, the dry hand ginseng of distinct methods friability comparison
1, instrument friability somascope, assay balance, hair-dryer.
2, inspection method
The rotating speed that regulates instrument before 2.1 adjusting instrument speed tests is per minute 25 to turn ± 1 turn, and setting test period is 4 minutes, and the total degree of rotary drum is 100 times.
10 of test samples are got in the each test of the amount of taking of 2.2 test samples, with hair-dryer, blow away surperficial powder, precise weighing.
2.3 check
Test sample after above-mentioned weighed weight is put in cylinder, started motor and rotate 100 times.After rotation finishes, check test sample shatter number, then blow away after powder with hair-dryer, accurate claim kind, be the weight of less loss with the difference of the amount of taking, calculate percentage.
3, result, is shown in 1.
The dry hand ginseng of table 1 distinct methods friability
| ? | Shatter (individual) | Less loss amount (%) |
| Dry | Nothing | 0.71 |
| Dry | Nothing | 0.47 |
| The present invention is dry | Nothing | 0.83 |
| Freeze-drying | 6 | 5.36 |
Table 1 result is known, and hand ginseng friability of the present invention is low, and known antivibration wear resistant ability is strong, and product is non-friable, and storage, transportation easily keep medicine materical crude slice shape, constant product quality.
Two, the dry hand ginseng of distinct methods pharmacodynamics comparison
1. material V-type Microhemagglutination reaction plate; HBsAg adopts HBV hepatitis serum, through anti-phase passive hemagglutination assay strong positive titre (1:3200); The anti-HB-sIgG sensitized erythrocyte of purifying, polyethylene glycol (molecular weight 12000), phosphate buffer dilution cow's serum, suppresses antibody etc.
2. method
2.1 get micro plate at the bottom of 96 hole V-types, respectively ranked first pipette for hole and move into the dry hand ginseng water extraction liquid (1mg/mL) of distinct methods and viral antigen body, shake up.Respectively ranked second Kong Xianyong pipette and add each 25m1 of dilution, then draw medicine-virus liquid doubling dilution from the first hole.Get dilution 5mL, add freeze-drying hepatitis type B virus table and diagnostic antigen with in 1, blood cell, after shaking up, splash into each 25m1 of 2-4 hole, then add dilution 25m1, be placed in 37 ℃ of insulating boxs, 4h observes.
Positive-virus, negative virus, active drug, blank medicine control wells are all established in every batch of experiment of 2.2 groupings.
3. result judges that not aggegation appears in high dilution, and prompting medicine suppresses viral antigen, and 2 times of inhibition are poor efficiency, and 4 times of inhibition are middle effect, and 8 times of inhibition are efficient.High dilution occurs 10000, and RCA is 1 HAU, and not aggegation is negative.
4. after the dry hand ginseng of result distinct methods water extraction liquid 4h, drying hand ginseng and do not occur suppressing, there are 2 times of inhibition in milk hand ginseng, and 4 times of inhibition appear in hand ginseng of the present invention and freeze-drying hand ginseng.But the dry hand ginseng of the inventive method energy consumption is starkly lower than desivac.
Summary of the invention
The freeze drying process that the object of this invention is to provide a kind of hand ginseng, the dry hand ginseng of the method, energy consumption is low, and medicine materical crude slice is non-friable, and Product Activity is high.
The present invention is achieved in that
A freeze drying process for hand ginseng, is characterized in that: get fresh hand ginseng, put in freeze dryer, be refrigerated to below-10 ℃, be evacuated to below drying chamber pressure 30Pa heating sublimation; Sublimation temperature is controlled at below 40 ℃, to distillation end.
The freeze drying process of a kind of hand ginseng of the present invention, is characterized in that: a kind of judgement of distillation in finishing by the following method 1. serviceability temperature Sensor monitoring temperature of charge judge whether the ice in material all distils; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure that approaches freezer unit.
So far completed the present invention, the present invention prepares hand ginseng, and energy consumption is low, and medicine materical crude slice is non-friable, and Product Activity is high.
The specific embodiment
embodiment 1
Get fresh hand ginseng, put in freeze dryer, be refrigerated to-20 ℃, be evacuated to drying chamber pressure 30Pa, heating sublimation, the temperature of distillation is controlled at below 40 ℃, when the ice with in temperature sensor monitors temperature of charge judgement material all distils, finishes.
embodiment 2
Get fresh hand ginseng, put in freeze dryer, be refrigerated to-28 ℃, be evacuated to drying chamber pressure 50Pa, heating sublimation, the temperature of distillation is controlled at 50 ℃, during state before condenser temperature drops to distillation, finishes.
embodiment 3
Get fresh hand ginseng, put in freeze dryer, be refrigerated to-32 ℃, be evacuated to drying chamber pressure 50Pa, heating sublimation, the temperature of distillation is controlled at 50 ℃, when the pressure drop of hothouse is when approaching the pressure of freezer unit, end.
Claims (2)
1. a freeze drying process for hand ginseng, is characterized in that: get fresh hand ginseng, put in freeze dryer, be refrigerated to below-10 ℃, be evacuated to below drying chamber pressure 30Pa heating sublimation; Sublimation temperature is controlled at below 40 ℃, to distillation end.
2. according to the drying means of a kind of hand ginseng of claim 1, it is characterized in that: a kind of judgement of distillation in finishing by the following method 1. serviceability temperature Sensor monitoring temperature of charge judge whether the ice in material all distils; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure that approaches freezer unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418492.6A CN104197645A (en) | 2014-08-25 | 2014-08-25 | Gymnadenia conopsea freeze-drying method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418492.6A CN104197645A (en) | 2014-08-25 | 2014-08-25 | Gymnadenia conopsea freeze-drying method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104197645A true CN104197645A (en) | 2014-12-10 |
Family
ID=52082973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410418492.6A Pending CN104197645A (en) | 2014-08-25 | 2014-08-25 | Gymnadenia conopsea freeze-drying method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104197645A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3835550A (en) * | 1972-08-21 | 1974-09-17 | K Kaneko | Freeze-drying process for producing a dry plant |
| CN103055098A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried yam for preventing and treating cancer |
| CN103054917A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Application for freeze-dried purslane in medicine preparation |
| CN103948652A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for drying lucid ganoderma |
-
2014
- 2014-08-25 CN CN201410418492.6A patent/CN104197645A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3835550A (en) * | 1972-08-21 | 1974-09-17 | K Kaneko | Freeze-drying process for producing a dry plant |
| CN103055098A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried yam for preventing and treating cancer |
| CN103054917A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Application for freeze-dried purslane in medicine preparation |
| CN103948652A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for drying lucid ganoderma |
Non-Patent Citations (1)
| Title |
|---|
| 闫家福等: "冷冻干燥技术及其在中药研究中的应用", 《中国实验方剂学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103083363A (en) | Preparation method and new application of periplaneta americana extract | |
| CN108186690A (en) | A kind of Chinese medicine processing method | |
| WO2016127787A1 (en) | Application of chlorogenic acid in preparing medicines for treating cardiomyopathy | |
| CN104987358B (en) | A kind of preparation method of pilose antler protein extract | |
| CN104197645A (en) | Gymnadenia conopsea freeze-drying method | |
| CN116808147B (en) | A Chinese medicinal composition for treating diabetic nephropathy and its quality detection method | |
| CN104987359A (en) | Velvet antler protein extract and application and medicinal preparation thereof | |
| CN104147372A (en) | Freeze-drying method of rhezoma gymnadeniae | |
| CN102212129A (en) | Method for extracting human fibrinogen from component I through column chromatography | |
| CN106074807B (en) | A kind of preparation method of rotor angle predicting | |
| CN104147373A (en) | Preparation method of high-activity gymnadenia conopsea | |
| EP0480496B1 (en) | Pledget compositions and process for making same | |
| CN101697989B (en) | Application of notoginseng and extract thereof in preparing medicaments for treating and/or preventing coronary artherosclerosis | |
| CN106118996A (en) | A kind of biofermentation health-care white spirit and preparation method thereof | |
| CN109276651A (en) | Gymnadenia conopsea medicine materical crude slice and its concocting method | |
| CN104154709A (en) | Drying method for radix tetrastigme | |
| TWI461190B (en) | Centrifugal Purification Extraction of Effective Components of Chinese Herbal Medicine Decoction | |
| CN113413417B (en) | Peony and liquorice decoction granules | |
| CN108815212B (en) | Processing technology of honey-fried ephedra herb and effective component content calculation method | |
| CN117205264A (en) | A method for preparing radix rehmanniae with salt | |
| CN104161994A (en) | Preparation method of high-activity gymnadenia conopsea | |
| CN106491872A (en) | A kind of health food with auxiliary blood fat reducing and preparation method thereof | |
| CN104161993A (en) | Application of freeze-dried gymnadenia conopsea as high-activity gymnadenia conopsea | |
| CN104154716A (en) | Application of freeze-drying technology in high-activity Gymnadenia conopsea preparation | |
| CN106317066B (en) | The method of protopine and its pharmaceutical preparation is prepared from Chinese medicine decumbent corydalis tuber |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141210 |