CN104194978A - Enteroscope detergent - Google Patents
Enteroscope detergent Download PDFInfo
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- CN104194978A CN104194978A CN201410445757.1A CN201410445757A CN104194978A CN 104194978 A CN104194978 A CN 104194978A CN 201410445757 A CN201410445757 A CN 201410445757A CN 104194978 A CN104194978 A CN 104194978A
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- enteroscope
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Abstract
The invention relates to a gastroendoscope cleaning product and particularly relates to an enteroscope detergent. The enteroscope detergent is prepared from water, dioctadecyl pentaerythritol diphosphite ester, ethyl (1-methyl propyl) diethyl malonate, 2, 5-bi (1, 1-dimethyl propyl)-1, 4-propanediol, N, N, N-trimethyl-2-[(dimethylamine) phenylammonium methanesulfonate, 5-ethyl-5-phenyl-1-methyl-2, 4, 6-(1H, 3H, 5H)-pyrimidinetrione, tri (2-ethyl hexyl) phosphate and the like. The enteroscope detergent has a good removing effect to dirt in oral cavity and digestive tract by means of interaction and mutual effect of related chemical components and particularly has a remarkable sterilizing effect to bacteria susceptible to the enteroscope while reducing stains, thereby ensuring cleanness of the enteroscope in stain reduction and sterilization.
Description
Technical field
The present invention relates to a kind of sanitising agent of digestive endoscopy cleaning supplies, particularly enteroscope.
background technology
Small intestinal endoscopy is applicable to doubt into small intestine pathology, and position is positioned at the intestinal segment that can not arrive with gastroscope, ERCP or colonoscopy, small intestine tube chamber long and dissociate, tortuous, be digester tube the longest in human body, be positioned at gastral stage casing, approximately 5 ~ 7 meters of adult's total lengths.And because enteron aisle is very long having many bends or curves, therefore patient's mouth and anus all will enter the territory, conventionally enter mirror from mouth to make marks to certain position, and then enter the territory from anus, arrive mark position and check.Though be patient oral cavity, digestion esophagus or anus all more or less there is dirt or bacterium, enteroscope is polluted, thereby all need enteroscope thoroughly to clean targetedly after each small intestinal endoscopy, to ensure each hygienic safety checking, avoid cross infection.
Summary of the invention
The object of the present invention is to provide a kind of cleaning capacity strong and with the enteroscope sanitising agent of biocidal efficacies.
Technical problem of the present invention, is achieved by following technical proposals:
Enteroscope sanitising agent, special character is to be prepared from by the raw material of following weight part proportioning: 85 parts, water, distearyl pentaerythritol diphosphite 28-32 part, ethyl (1-methyl-propyl) diethyl malonate 22-24 part, 2, 5-two (1, 1-dimethyl propyl)-1, 4-Benzenediol 10-12 part, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 18-22 part, 5-ethyl-5-phenyl-1-methyl-2, 4, 6-(1H, 3H, 5H)-pyrimidine trione 15-19 part, three (2-ethylhexyl) phosphoric acid ester 12-15 part, N-carbobenzoxy-(Cbz)-D-phenylalaninol 4-6 part, 3-hydroxy-estra-1, 3, 5 (10)-triolefins-17b-alcohol-3-benzoic ether 2-4 part.
Preparation method of the present invention: add deionized water, add while stirring two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediols of 2,5-, continue to be stirred to and be uniformly dispersed, be then heated to 60-80 DEG C; Slowly add distearyl pentaerythritol diphosphite, ethyl (1-methyl-propyl) diethyl malonate, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate, stirs and makes it to dissolve; Add 5-ethyl-5-phenyl-1-methyl-2,4,6-(1H, 3H, 5H)-pyrimidine trione, three (2-ethylhexyl) phosphoric acid ester, N-carbobenzoxy-(Cbz)-D-phenylalaninol, 3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether, stirs; Be cooled to 25-30 DEG C, obtain required enteroscope sanitising agent.
This enteroscope sanitising agent, utilize interaction between related chemical constituents, influence each other, there is good removing effect for oral cavity and digestive tube dirt, particularly in going stain, there is obvious sterilization effect for the susceptible bacterium of enteroscope, in going stain and sterilization to ensure on both side the clean of enteroscope.
Embodiment
Below provide the specific embodiment of the present invention, be used for the present invention to be further described.In the present invention, if no special instructions, each raw material is all taking working substance content as 100%.
In following examples and comparative example, raw material introduction:
Distearyl pentaerythritol diphosphite, CAS accession number is: 3806-34-6;
Ethyl (1-methyl-propyl) diethyl malonate, CAS accession number is: 76-71-1;
Two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediols of 2,5-, CAS accession number is: 79-74-3;
N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate, 51-60-5;
5-ethyl-5-phenyl-1-methyl-2,4,6-(1H, 3H, 5H)-pyrimidine trione, CAS accession number is: 50-06-6;
Three (2-ethylhexyl) phosphoric acid ester, CAS accession number is: 78-42-2;
N-carbobenzoxy-(Cbz)-D-phenylalaninol, CAS accession number is: 58917-85-4;
3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether, CAS accession number is: 50-50-0.
Embodiment 1
Weigh: water 85kg, distearyl pentaerythritol diphosphite 30kg, ethyl (1-methyl-propyl) diethyl malonate 22kg, 2, 5-two (1, 1-dimethyl propyl)-1, 4-Benzenediol 12kg, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 18kg, 5-ethyl-5-phenyl-1-methyl-2, 4, 6-(1H, 3H, 5H)-pyrimidine trione 17kg, three (2-ethylhexyl) phosphoric acid ester 15kg, N-carbobenzoxy-(Cbz)-D-phenylalaninol 5kg, 3-hydroxy-estra-1, 3, 5 (10)-triolefins-17b-alcohol-3-benzoic ether 4kg.
The preparation method of this embodiment enteroscope sanitising agent: add deionized water, add while stirring two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediols of 2,5-, continue to be stirred to and be uniformly dispersed, be then heated to 60-80 DEG C; Slowly add distearyl pentaerythritol diphosphite, ethyl (1-methyl-propyl) diethyl malonate, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate, stirs and makes it to dissolve; Add 5-ethyl-5-phenyl-1-methyl-2,4,6-(1H, 3H, 5H)-pyrimidine trione, three (2-ethylhexyl) phosphoric acid ester, N-carbobenzoxy-(Cbz)-D-phenylalaninol, 3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether, stirs; Be cooled to 25-30 DEG C, obtain required enteroscope sanitising agent.
The present embodiment product performance:
Sterilizing power: intestinal bacteria 98.7%, Bacillus proteus 99.2%, Salmonellas 97.6%.
Embodiment 2
Weigh: water 85kg, distearyl pentaerythritol diphosphite 28kg, ethyl (1-methyl-propyl) diethyl malonate 20kg, 2, 5-two (1, 1-dimethyl propyl)-1, 4-Benzenediol 10kg, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 20kg, 5-ethyl-5-phenyl-1-methyl-2, 4, 6-(1H, 3H, 5H)-pyrimidine trione 15kg, three (2-ethylhexyl) phosphoric acid ester 12kg, N-carbobenzoxy-(Cbz)-D-phenylalaninol 4kg, 3-hydroxy-estra-1, 3, 5 (10)-triolefins-17b-alcohol-3-benzoic ether 3kg.
The preparation method of this embodiment enteroscope sanitising agent is with embodiment 1.
The present embodiment product performance:
Sterilizing power: intestinal bacteria 98.5%, Bacillus proteus 99.4%, Salmonellas 97.2%.
Embodiment 3
Weigh: water 85kg, distearyl pentaerythritol diphosphite 32kg, ethyl (1-methyl-propyl) diethyl malonate 24kg, 2, 5-two (1, 1-dimethyl propyl)-1, 4-Benzenediol 11kg, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 22kg, 5-ethyl-5-phenyl-1-methyl-2, 4, 6-(1H, 3H, 5H)-pyrimidine trione 19kg, three (2-ethylhexyl) phosphoric acid ester 14kg, N-carbobenzoxy-(Cbz)-D-phenylalaninol 6kg, 3-hydroxy-estra-1, 3, 5 (10)-triolefins-17b-alcohol-3-benzoic ether 2kg.
The preparation method of this embodiment enteroscope sanitising agent is with embodiment 1.
The present embodiment product performance:
Sterilizing power: intestinal bacteria 99.5%, Bacillus proteus 98.7%, Salmonellas 98.2%.
Comparative example 1
Weigh: water 85kg, distearyl pentaerythritol diphosphite 30kg, 2, two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediol 12kg of 5-, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 18kg, 5-ethyl-5-phenyl-1-methyl-2,4,6-(1H, 3H, 5H)-pyrimidine trione 17kg, three (2-ethylhexyl) phosphoric acid ester 15kg, 3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether 4kg.
The preparation method of this comparative example enteroscope sanitising agent: add deionized water, add while stirring two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediols of 2,5-, continue to be stirred to and be uniformly dispersed, be then heated to 60-80 DEG C; Slowly add distearyl pentaerythritol diphosphite, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate, stirs and makes it to dissolve; Add 5-ethyl-5-phenyl-1-methyl-2,4,6-(1H, 3H, 5H)-pyrimidine trione, three (2-ethylhexyl) phosphoric acid ester, 3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether, stirs; Be cooled to 25-30 DEG C, obtain this comparative example enteroscope sanitising agent.
This comparative example product performance:
Sterilizing power: intestinal bacteria 72.7%, Bacillus proteus 68.3%, Salmonellas 71.1%.
Comparative example 2
Weigh: water 85kg, ethyl (1-methyl-propyl) diethyl malonate 22kg, 2, two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediol 12kg of 5-, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 18kg, three (2-ethylhexyl) phosphoric acid ester 15kg, N-carbobenzoxy-(Cbz)-D-phenylalaninol 5kg, 3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether 4kg.
The preparation method of this comparative example enteroscope sanitising agent: add deionized water, add while stirring two (1, the 1-dimethyl propyl)-Isosorbide-5-Nitrae-Benzenediols of 2,5-, continue to be stirred to and be uniformly dispersed, be then heated to 60-80 DEG C; Slowly add ethyl (1-methyl-propyl) diethyl malonate, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate, stirs and makes it to dissolve; Add three (2-ethylhexyl) phosphoric acid ester, N-carbobenzoxy-(Cbz)-D-phenylalaninol, 3-hydroxy-estra-1,3,5 (10)-triolefins-17b-alcohol-3-benzoic ether, stirs; Be cooled to 25-30 DEG C, obtain this comparative example enteroscope sanitising agent.
This comparative example product performance:
Sterilizing power: intestinal bacteria 46.5%, Bacillus proteus 38.8%, Salmonellas 42.3%.
Carry out detergency test with embodiment 1-3 and comparative example 1-2 gained finished product, concrete steps are as follows:
1) preparation of artificial dirt
Mixing oil formula: taking butter, lard, vegetables oil mass ratio as 0.5:0.5:1 configuration, and add the glyceryl monostearate of its total mass 5%, this is artificial dirt.
Artificial dirt is put on electric furnace and is heated to 220 DEG C, stir and keep this temperature 15min, beaker is moved to magnetic stirrer and stir, naturally cool to temperature required for subsequent use.The temperature reference of defiling: in the time that room temperature is 20 DEG C, need 80 DEG C of oil temperatures; When room temperature is 25 DEG C, need 45 DEG C of oil temperatures; When room temperature is lower than 17 DEG C or during higher than 27 DEG C, test should not be carried out, and need under temperature adapt circumstance, carry out.Should use if desired the Terg-O-Tometer of attached freezing plant.
2) defile
Clean enteroscope is put and weighed on frame taking five as one group, be accurately weighed as W0 with balance, the enteroscope after weighing is placed on rack one by one.
In the time that greasy dirt remains in stable temperature, one by one enteroscope is got on to take off from rack, all immerse in greasy dirt and keep 2-3s, slowly take out, after the lower speed of greasy dirt is slack-off, put back to original rack, prepare successively dirty mould bases.After the greasy dirt on enteroscope solidifies, enteroscope is taken off and corner or the unnecessary greasy dirt of side wiped with filter paper or absorbent cotton.Under room temperature, leaving standstill after 4h, is W1 weighing on frame with balance accurate weighing.
3) testing sequence
The enteroscope of known greasy dirt amount is inserted in corresponding wash stand and prepared to wash.
Spotter is switched on power, and wash temperature is set to 32 DEG C, and velocity of rotation is set to 150r/min, and washing time is set to 5min.
Take 5.0g sample to be tested in 2500ml hard water, after shaking up, measure respectively 800ml test solution in five washing becks of Terg-O-Tometer, in the time that test solution temperature rises to 32 DEG C, rapidly the enteroscope of known weight is put into washing beck accordingly together with wash stand, after putting into washing beck, last enteroscope starts to count soak time, rapidly agitator is installed simultaneously, while soaking 1min, start spotter, start washing, when 5min, machine auto stop, rapidly agitator is taken off, take out wash stand, to wash rear enteroscope is placed on rack one by one, after standing 3h, mould bases being put to corresponding weighing frame weighs as W2.
Test result is as shown in the table:
Soil removal efficiency=[(W1-W2)/(W1-W0)] * 100%
| ? | Soil removal efficiency, % |
| Embodiment 1 | 95.8 |
| Embodiment 2 | 95.4 |
| Embodiment 3 | 95.6 |
| Comparative example 1 | 76.8 |
| Comparative example 2 | 61.6 |
Claims (1)
1. enteroscope sanitising agent, it is characterized in that being prepared from by the raw material of following weight part proportioning: 85 parts, water, distearyl pentaerythritol diphosphite 28-32 part, ethyl (1-methyl-propyl) diethyl malonate 22-24 part, 2, 5-two (1, 1-dimethyl propyl)-1, 4-Benzenediol 10-12 part, N, N, N-trimethylammonium-2-[(dimethylamino) methanoyl] puratized agricultural spray mesylate 18-22 part, 5-ethyl-5-phenyl-1-methyl-2, 4, 6-(1H, 3H, 5H)-pyrimidine trione 15-19 part, three (2-ethylhexyl) phosphoric acid ester 12-15 part, N-carbobenzoxy-(Cbz)-D-phenylalaninol 4-6 part, 3-hydroxy-estra-1, 3, 5 (10)-triolefins-17b-alcohol-3-benzoic ether 2-4 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410445757.1A CN104194978A (en) | 2014-09-03 | 2014-09-03 | Enteroscope detergent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410445757.1A CN104194978A (en) | 2014-09-03 | 2014-09-03 | Enteroscope detergent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104194978A true CN104194978A (en) | 2014-12-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410445757.1A Pending CN104194978A (en) | 2014-09-03 | 2014-09-03 | Enteroscope detergent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104194978A (en) |
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2014
- 2014-09-03 CN CN201410445757.1A patent/CN104194978A/en active Pending
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Application publication date: 20141210 |