CN104188983A - 闭花木酮Cleistanone的O-(吗啉基)乙基衍生物在制备抗心衰药物中的应用 - Google Patents
闭花木酮Cleistanone的O-(吗啉基)乙基衍生物在制备抗心衰药物中的应用 Download PDFInfo
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- CN104188983A CN104188983A CN201410393725.1A CN201410393725A CN104188983A CN 104188983 A CN104188983 A CN 104188983A CN 201410393725 A CN201410393725 A CN 201410393725A CN 104188983 A CN104188983 A CN 104188983A
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- morpholinyl
- ethyl derivative
- heart failure
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- XURLTFUKDPZAPN-QFIPXVFZSA-N Cleistanone Natural products O(C)[C@H]1OC(=O)c2c(-c3cc4OCOc4cc3)c3c(c(O)c12)cc(OC)c(OC)c3 XURLTFUKDPZAPN-QFIPXVFZSA-N 0.000 title claims abstract description 64
- GEIFQLXIDUDMNZ-PCJVTFPHSA-N (4aR,4bR,6aR,8S,10aR,10bR,12R,12aR)-12-hydroxy-1,1,1',1',4a,10a,10b-heptamethyl-3'-methylidenespiro[3,4,4b,5,6,6a,7,9,10,11,12,12a-dodecahydrochrysene-8,2'-cyclopentane]-2-one Chemical compound CC1(C)CCC(=C)[C@@]11C[C@@H](CC[C@H]2[C@]3(C[C@@H](O)[C@H]4C(C)(C)C(=O)CC[C@@]42C)C)[C@@]3(C)CC1 GEIFQLXIDUDMNZ-PCJVTFPHSA-N 0.000 title claims abstract description 50
- 206010019280 Heart failures Diseases 0.000 title claims abstract description 23
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 8
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- MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 description 3
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 3
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- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 3
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 2
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN201410393725.1A CN104188983B (zh) | 2014-08-11 | 2014-08-11 | 闭花木酮Cleistanone的O-(吗啉基)乙基衍生物在制备抗心衰药物中的应用 |
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CN201410393725.1A CN104188983B (zh) | 2014-08-11 | 2014-08-11 | 闭花木酮Cleistanone的O-(吗啉基)乙基衍生物在制备抗心衰药物中的应用 |
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CN104188983A true CN104188983A (zh) | 2014-12-10 |
CN104188983B CN104188983B (zh) | 2016-08-17 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104814968A (zh) * | 2015-04-15 | 2015-08-05 | 南京广康协生物医药技术有限公司 | 闭花木酮的o-(1h-四氮唑基)乙基衍生物在制备抗心衰药物中的应用 |
CN104887665A (zh) * | 2015-05-12 | 2015-09-09 | 南京广康协生物医药技术有限公司 | Daphmalenine A衍生物在制备抗心衰药物中的应用 |
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2014
- 2014-08-11 CN CN201410393725.1A patent/CN104188983B/zh active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104814968A (zh) * | 2015-04-15 | 2015-08-05 | 南京广康协生物医药技术有限公司 | 闭花木酮的o-(1h-四氮唑基)乙基衍生物在制备抗心衰药物中的应用 |
CN104887665A (zh) * | 2015-05-12 | 2015-09-09 | 南京广康协生物医药技术有限公司 | Daphmalenine A衍生物在制备抗心衰药物中的应用 |
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CN104188983B (zh) | 2016-08-17 |
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Effective date of registration: 20160708 Address after: 100190 Beijing, Zhongguancun, north of No. two, No. 1, No. Applicant after: Lv Piping Address before: No. 163 Xianlin University City Xianlin Avenue in Qixia District of Nanjing City, Jiangsu province 210093 Applicant before: Nanjing University |
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Effective date of registration: 20161009 Address after: 100021 Chaoyang District, Beijing, North Pine Road, No. seven hospital 11-535 Patentee after: Shao Hua Address before: 100190 Beijing, Zhongguancun, north of No. two, No. 1, No. Patentee before: Lv Piping |
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