CN104188802A - Multicompartment container containing a medical solution - Google Patents

Multicompartment container containing a medical solution Download PDF

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Publication number
CN104188802A
CN104188802A CN201410459356.1A CN201410459356A CN104188802A CN 104188802 A CN104188802 A CN 104188802A CN 201410459356 A CN201410459356 A CN 201410459356A CN 104188802 A CN104188802 A CN 104188802A
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China
Prior art keywords
compartment
filling extent
multicompartment
medicinal liquid
filling
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CN201410459356.1A
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Chinese (zh)
Inventor
A·威斯兰德
P·弗兰克
P·阿尔
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Gambro Lundia AB
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Gambro Lundia AB
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Publication of CN104188802A publication Critical patent/CN104188802A/en
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Abstract

Provided is a flexible multicompartment container provided for storage and mixing toghether of a at least a first and a second single solution. Each single solution is stored in a separate compartment (1, 2) of the container. The compartments are separated by means of seals (5, 6) rupturable by manipulation of the container to thereby mix the contents togheter in a mixing compartment for delivery. The first compartment (1) is filled to a first filling degree, FD1, and the second compartment is filled to a second filling degree, FD2. The first filling degree is larger than the second filling degree. The filling degree in the mixing compartment, FDMC, is larger than the filling degree in the second compartment.

Description

The multicompartment container that comprises medicinal liquid
The application is that to be called " multicompartment container that comprises medicinal liquid ", international filing date be that October 16, international application no in 2006 are that PCT/SE2006/001167, national applications number are dividing an application of 200680038118.7 application for a patent for invention to name.
Technical field
The present invention relates to fill the multicompartment container field of medicinal liquid.Medicinal liquid multicompartment container is arranged to for storing and at least the first single solution and the second single solution of admixing medical solutions, and wherein the first and second single solution are contained in the independent compartment of container and mix and form final medicinal liquid before use.Compartment is separated by pealable seals, and described pealable seals can be destroyed by container handling, so that outlet the first and second single solution are admixed together and by multicompartment container discharges medicinal liquid.
Background of invention
The multicompartment container that is suitable for medicinal liquid is often used.Particularly at medicinal liquid, comprise one or more in the situation that immiscible and thereby the mixture of single solution that must be separated in sterilization or storage process.The single solution that for example comprises glucose should keep and the separating substances that promotes glucose degradation, and remains under low pH further to stablize glucose molecule.Another example is to comprise heavy carbonate or phosphatic single solution should keep and the single solution separating that comprises calcium or magnesium, to avoid precipitation.Another example is that diluent need to keep separated with medicament.Also having another example is that the single solution with high pH need to keep and the single solution separating with low pH.
The medicinal liquid being used by patient should be generally discharged into patient's normal saline and medicament should be in appropriate concentration.Due to this reason, importantly before being discharged into patient by outlet, generally should mix safely single solution.In the situation that one of described exemplary single solution discharges not mixing with other single solution, to patient, be dangerous.
The single solution of medicinal liquid is kept separated needs in the compartment of multicompartment container, in chemistry or Drug therapy for using the aseptic or medicinal liquid of not sterilizing, for nutrition complement, be used for the treatment of and come off, for parenteral admistration or for kidney, treat, the container of for example, hemodialysis, hemodiafiltration, blood filtration or peritoneal dialysis is recognized.
From US5, the example of known many compartments of flexibility solution container in 176,634.US5,176,634 disclose a kind of container, and wherein the separate compartment in container is formed by frangible heat seal.The first compartment comprises diluent; The second compartment comprises mealy medicine, and this mealy medicine can mix with diluent by the frangible seal separation that the first and second compartments are separated.Sealing member separation is by container handling to produce pressure on the diluent in the first compartment, and then the sealing member between hydraulic pressure separating the first and second compartments allows diluent and medicament to mix.The outlet port that contiguous the second compartment three compartment relative with diluents compartment comprise the mixed solution for distributing.Sealing member between the second and the 3rd compartment prevents from using content before the contents mixed of the first and second compartments.After mixing, container handling is to produce pressure on content in addition, thereby destroys the second sealing member, allows to distribute by port containing drug solns.Make with medicament place, relative size between diluents compartment and medicament compartment and less compartment is placed on to larger compartment and the formation of hydraulic coupling is guaranteed in centre lower or outlet compartment, this hydraulic coupling was destroyed the sealing member between diluent and medicament compartment by destroy the second sealing member extremely careful in the situation that before.
Summary of the invention
An object of the present invention is to provide flexible for storing the many compartments solution container with admixing medical solutions, wherein container comprises at least the first and second compartments by the first pealable seals separation, wherein the first single solution is contained in the first compartment and the second single solution is contained in the second compartment, and because the first and second single solution before being opened in the second pealable seals mix and are ready to discharge medicinal liquid, so reliability improves.
Another object of the present invention is to provide flexible many compartments solution container, and wherein this many compartments solution container makes to be difficult to only one of first and second single solution are discharged into patient substantially.
Another object of the present invention is to provide flexible many compartments solution container, wherein because only the second pealable seals just can be destroyed after the first pealable seals is destroyed, reliability is improved.
This multicompartment container comprises medicinal liquid, and this medicinal liquid keeps with the independent single solution in independent compartment in container, until use this medicinal liquid.In use, before by medicinal liquid, the outlet by multicompartment container is discharged into patient, single solution strengthens the mixing of safety.
The concept of using in the document " medicinal liquid " comprises two kinds of possible situations, a kind of is for the solution discharging, may be by the concentrated solution being diluted before being used by patient, another kind is that the solution for discharging may have suitable concentration, and solution can directly be used by patient like this.Concept " medicinal liquid " also comprise may obtain by before being supplied to patient's final medicinal liquid by the solution for discharging mixing with other composition.
One exemplary embodiment of the present invention are the flexible multicompartment containers that comprise first, second, and third compartment.The first compartment comprises the first single solution, and the second compartment comprises the second single solution and the 3rd compartment is sky or basic empty.Substantially empty means that it does not comprise any composition of medicinal liquid, but optionally comprises enough amount of liquid for the object that sterilizes.The first compartment is separated with the second compartment by the first pealable seals.The second compartment is separated with the 3rd compartment by the second pealable seals.
The first compartment is filled the first single solution to the first filling extent.The second compartment is filled the second single solution to the second filling extent.The first filling extent is greater than the second filling extent.The first filling extent is suitable for by container handling is so that destruction the first pealable seals exerts pressure on content in such a way, and such the first pealable seals is destroyed.The second filling extent is unsuitable for destroying the first pealable seals and is also unsuitable for destroying the second pealable seals.
When the broken ring of the first pealable seals, the first and second compartment fluids are communicated with, to obtain mixing compartment.Being blended in mixing compartment of the first and second single solution carried out.Mix compartment and be filled into by mixing the first and second medicinal liquids the 3rd filling extent that is greater than the second filling extent.The 3rd filling extent is suitable for by container handling to exert pressure on content, thereby destroy the second sealing member, allows medicinal liquid to distribute brokenly and encircle the second pealable seals by being arranged in outlet port in the 3rd compartment.
According to an embodiment, flexible many compartments solution container comprises the first main sheet and second main sheet relative with described the first main sheet, wherein the extent of medical liquid container is subject to first at least substantially, second, the restriction of the third and fourth marginal portion, wherein the first marginal portion is positioned to divide relative with described Second Edge edge, it is relative with described the 4th marginal portion that described the 3rd marginal portion is positioned to, wherein said the first and second pealable seals are prolonged the solution container stretching through between described the third and fourth marginal portion, thereby solution container is divided into described first, the second and the 3rd compartment.
In an exemplary embodiment, the first marginal portion has substantially divides identical length with Second Edge edge.Similarly, according to embodiments of the invention, the 3rd marginal portion has the basic length identical with the 4th marginal portion.According to embodiments of the invention, the third and fourth marginal portion is longer than the first and second marginal portions.
In one exemplary embodiment of the present invention, described the first and second sheet materials are welded to one another along at least described the first and second marginal portions.In order to seal the first and second sheet materials, by means of this welding, form the plain mode of making solution container.It should be noted that according to another embodiment, the first and second sheet materials are also welded together along the third and fourth marginal portion.Alternatively, solution container can be made by tubular material.In this case, there is no need along the described first to the 4th all marginal portion sealed solution container.If solution container forms pipe, such the first and second sheet materials are connected to each other along two in described marginal portion.Therefore in this case, do not exist along the strict border between the first and second sheet materials of described the third and fourth marginal portion, because in fact the first and second sheet materials in this case form a part for same pipe fitting.
Term " pealable seals " refers to the sealing member of low-intensity peelable (can destroy), and it can destroy by applying fluid pressure.In the container of storage solutions, pealable seals, preferably has intensity, and the container that wherein manually extruding has liquid and/or an entrapped air provides the pressure that is enough to breakseal part.
In this context, when using the required pressure of medicinal liquid filling compartment to press exponential law increase, compartment is considered to be filled into 100%.Filling extent is defined as the percentage ratio of 100% filling compartment at this.For the reason of processing, compartment is not conventionally filled and is surpassed 85%, namely has 85% filling extent.
According to the structure of many compartments of flexibility medical liquid container of the present invention with fill based on following understanding, filling extent with for destroying the required power/load of pealable seals, be inversely proportional to.Being suitable for described explanation is to be two angle [alpha] between the main sheet material welding together for destroying the main determining factor of pealable seals.According to the present invention, this understanding, for only improving reliability by the first pealable seals of destroying between the first and second compartments, likely applies enough pressure and destroys the second pealable seals to medicinal liquid is discharged into patient.With which, the first and second single solution of medicinal liquid mixed before being released to patient, thereby improved reliability.
From following detailed description and the claim done by reference to the accompanying drawings, will understand other object of the present invention, feature, advantage and preferred embodiment.
Accompanying drawing explanation
Fig. 1 a is the plan view of the exemplary embodiment of flexible medical solution multicompartment container;
Fig. 1 b is by the transverse section of the line AA intercepting of Fig. 1 a; Fig. 1 b is also relevant to Fig. 2 a;
Fig. 1 c is the transverse section when the line AA intercepting by Fig. 1 a when destroyed of the first pealable seals;
Fig. 1 d is the transverse section when the line AA intercepting by Fig. 1 a when destroyed of the first and second pealable seals;
Fig. 2 a is the zoomed-in view of transverse section in Fig. 1 b, and the angle [alpha] between two main sheet that connect together by pealable seals is shown;
Fig. 2 b is the figure that ratio between tensile force and filling extent is shown;
Fig. 3 illustrates for determining the figure of the exemplary measurement of compartment 100% filling extent, and the Y-axis of figure represents that pressure and X-axis represent volume, is defined as 100% filling extent with the X-axis part that meets at right angle;
Fig. 4 a is the plan view of the replaceable exemplary embodiment of medicinal liquid multicompartment container;
Fig. 4 b illustrates to be suitable for the filling extent of the first and second compartments and according to the figure of the filling extent of the mixing compartment of Fig. 4 a embodiment;
Fig. 5 a is the plan view of another replaceable exemplary embodiment of medicinal liquid multicompartment container;
Fig. 5 b illustrates to be suitable for the filling extent of the first and second compartments and according to the figure of the filling extent of the mixing compartment of Fig. 5 a embodiment;
Fig. 6 is the plan view of the replaceable exemplary embodiment of the medicinal liquid multicompartment container that comprises additional compartment.
The specific embodiment
Fig. 1 a illustrates the exemplary embodiment of the multicompartment container that is suitable for medicinal liquid.Container comprises the first compartment 1, the second compartment 2 and the 3rd compartment 3.The first compartment 1 comprises the first single solution, and the second compartment 2 comprises the second single solution and the 3rd compartment 3 is sky or basic empty.The 3rd compartment 3 is provided with outlet port 4, usings as medicinal liquid to patient's outlet.
The first compartment 1 is separated with the second compartment 2 by the first pealable seals 5.The second compartment 2 is separated with the 3rd compartment 3 by the second pealable seals 6.The first compartment 1 is filled the first single solution to the first filling extent, FD 1(not shown).The second compartment 2 is filled the second single solution to the second filling extent, FD 2(not shown).The first filling extent FD 1be greater than the second filling extent FD 2.
In following accompanying drawing, for corresponding feature, use corresponding Reference numeral.
Fig. 1 b illustrates by the transverse section of the line AA intercepting of Fig. 1 a.In Fig. 1 b, the size by the first and second compartments represents respectively, the first filling extent FD 1be greater than the second filling extent FD 2, namely in the first compartment 1, the filling extent of the first single solution is greater than the filling extent of the second single solution in the second compartment 2.
Select by this way the filling extent FD of the first compartment 1 1with the intensity of the first pealable seals 5, make likely manually on the first compartment 1, to apply enough pressure, to destroy the first pealable seals 5 between the first compartment 1 and the second compartment 2.Select by this way the filling extent FD of the second compartment 2, make to become quite difficult by manually exert pressure to destroy the first pealable seals 5 or the second pealable seals 6 on the second compartment 2.
Fig. 1 c illustrates the transverse section when the line AA intercepting by Fig. 1 a when destroyed of the first pealable seals 5.When the first pealable seals 5 broken ring, the first compartment 1 and the second compartment 2 fluids are communicated with, thereby form, mix compartment 7.Within mixing compartment 7, carry out the mixing of the first and second single solution.Mixing compartment 7 is filled into and is greater than the second filling extent FD 2the 3rd filling extent FD mC(not shown).
The filling extent FD that mixes compartment mCselect in such a way with the intensity of the second pealable seals 6, make likely manually on mixing compartment 7, to apply enough pressure, to destroy second pealable seals 6 of mixing between compartment 7 and the 3rd compartment 3.In an exemplary embodiment of the present invention, the intensity of the first peel seal 5 and the second pealable seals 6 is substantially equal.
Fig. 1 d illustrates the transverse section when the first pealable seals 5 and the second pealable seals 6 line AA intercepting by Fig. 1 a when destroyed subsequently.In this stage, multicompartment container comprises outlet compartment 8, and it comprises the medicinal liquid that is ready to release.Medicinal liquid is discharged into patient via outlet port 4.Outlet port 4 can be opened, and for by device for opening, such as valve element, pealable seals or frangible pin, discharges medicinal liquid.
Fig. 2 a illustrates and comprises the first and second main sheet 1a that connect together by pealable seals 5, the amplifier section of Fig. 1 b of 1b.Angulation α between the first and second main sheet.This angle [alpha] in such a way with the first compartment in filling extent FD 1relevant, make higher filling extent present the first and second main sheet 1a, the increase angle [alpha] between 1b.For destroying the actual determiner of the first pealable seals 5, are crackpropagation angle beta.Crackpropagation angle beta is to destroy the first main sheet 1a at place, starting position and the angle between the second main sheet 1b.Crackpropagation angle beta depends on certain material and specific production technology.Like this, the higher filling extent FD in the first compartment 1angle [alpha] between the first main sheet 1a and the second main sheet 1b is increased, thereby when manually pushing the first compartment 1, for surpassing probability and the simplicity of crackpropagation angle beta and destruction pealable seals 5, increase.
Fig. 2 b illustrates the figure of ratio between tensile force F and filling extent FD.Higher filling extent FD needs lower tensile force F.
According to the present invention, need the following ratio between first, second, and third filling extent:
FD 1>FD 2
And
FD MC>FD 2
Wherein:
FD 1the filling extent of the=the first compartment 1
FD 2the filling extent of the=the second compartment 2
FD mCthe filling extent of=mixing compartment 7.
For the reason of processing, the first filling extent FD 1should be greater than 40%, the second filling extent FD 2should be less than 45%, and the 3rd filling extent FD mCshould be greater than 10%.
According to multicompartment container of the present invention, will typically be arranged to enough greatly, to hold the medicinal liquid of 0.5 to 20 liter.When carrying out persistent treatment, for example night treatment, during such as continuous peritoneal dialysis or the treatment relevant to intensive care, the medicinal liquid of large volume is especially favourable.
Two exemplary embodiments and their corresponding filling extents of how to confirm of multicompartment container are below described.
Be identified for the first compartment 1 in multicompartment container, the second compartment 2 and mix each 100% filling extent of compartment 7.Fig. 3 illustrates for determining the diagram figure of compartment 100% filling extent.When using medicinal liquid that compartment is filled into the required pressure P of volume V and increases by exponential law as shown in Figure 3, compartment is thought and is filled into 100%.Corresponding to compartment, be filled into 100% volume and determine by the value that is painted into the normal of exponential curve and reads volume V, at this and X-axis, intersect.
For the reason of processing, corresponding compartment is not conventionally filled into and is greater than 85%, and namely this compartment has 85% filling extent.
Final data, the figure shown in calculation chart 4b and 5b that is identified for that is namely considered to the compartment to be filled into 100% respective volume V provides basic data.For these calculate, apply following formula.
FD MC＝(FD 1×V 1+FD 2×V 2)/V MC
Wherein:
FD mCthe filling extent of=mixing compartment 7
FD 1the filling extent of the=the first compartment 1
FD 2the filling extent of the=the second compartment 2
V 1=corresponding to the liquor capacity of 100% filling extent of the first compartment 1
V 2=corresponding to the liquor capacity of 100% filling extent of the second compartment 2
V mC=corresponding to the liquor capacity that mixes 100% filling extent of compartment 7.
At the final figure shown in Fig. 4 b and 5b, be to determine corresponding filling extent FD 1, FD 2and FD mCpreferred value provide basis.
Fig. 4 a illustrates an exemplary embodiment for the multicompartment container of medicinal liquid, and wherein the first compartment 1 and the second compartment 2 have essentially identical size.Multicompartment container shown in Fig. 4 a is relevant to the figure shown in Fig. 4 b.In Fig. 4 b, the filling extent FD of the first compartment 1be divided into ten segments from 0-100%.X-axis illustrates the filling extent FD of the second compartment 2, Y-axis illustrates the filling extent FD that mixes compartment mC.Draw in the drawings continuous lines.Relevant the first filling extent and the FD that meets the demands of region representation on this continuous lines mC>FD 2the second filling extent.
In one embodiment of the invention, to comprise cumulative volume be the medicinal liquid of 500 milliliters to the multicompartment container shown in Fig. 4 a 1.The first single solution that the first compartment 1 comprises 425 milliliters, and the second compartment 2 the second single solution of comprising 75 milliliters.
In one exemplary embodiment of the present invention, the multicompartment container shown in Fig. 4 a has the filling extent FD of 70%-100% in the first compartment 1and the filling extent FD in the second compartment with 10%-40% 2.In another embodiment, the filling extent FD in the second compartment 2for 10%-35%.
In one exemplary embodiment of the present invention, the multicompartment container shown in Fig. 4 a has the filling extent FD of 80%-90% in the first compartment 1and the filling extent FD in the second compartment with 30%-40% 2.
In one exemplary embodiment of the present invention, the multicompartment container shown in Fig. 4 a has 85% filling extent FD in the first compartment 1, in the second compartment, there is 29% filling extent FD 2, and there is 36% filling extent FD within mixing compartment mC.
In one exemplary embodiment of the present invention, the second compartment 2 of the single medicinal liquid that the multicompartment container shown in Fig. 4 a has the first compartment 1 of the single medicinal liquid that comprises acetic acid and comprises glucose.This exemplary embodiment of the present invention is suitable for being combined with hemodialysis.
Fig. 5 a illustrates an illustrative embodiment of the invention, and wherein to have that the first compartment 1 and the second compartment 2, the first compartments 1 compare with the second compartment 2 be large to multicompartment container, and the second compartment 2 to compare with the first compartment 1 be little.
Fig. 5 b illustrates the figure being suitable for according to the container structure of Fig. 5 a.This figure is corresponding to the figure in conjunction with described in Fig. 4 b.
In one exemplary embodiment of the present invention, it is the medicinal liquid of 5000 milliliters that the multicompartment container 1 shown in Fig. 5 a comprises cumulative volume.The first single solution that the first compartment 1 comprises 4850 milliliters, and the second compartment 2 the second single solution of comprising 150 milliliters.
In one exemplary embodiment of the present invention, the multicompartment container shown in Fig. 5 a has the filling extent FD of 70%-100% in the first compartment 1and the filling extent FD in the second compartment with 10%-40% 2.
In one exemplary embodiment of the present invention, multicompartment container has 80% filling extent FD in the first compartment 1, in the second compartment, there is 33% filling extent FD 2, and there is 64% filling extent FD within mixing compartment mC.
In one exemplary embodiment of the present invention, the multicompartment container shown in Fig. 5 a has the single medicinal liquid that comprises acid, glucose, calcium and magnesium and comprises alkali bicarbonate and the second compartment 2 of the single medicinal liquid of sodium.This exemplary embodiment of the present invention is suitable for being combined with degree of depth nursing for treating.
Fig. 6 illustrates the multicompartment container that is similar to multicompartment container shown in Fig. 5 a, and just this container has the 4th compartment 9 and the 5th compartment 10.In this embodiment of the present invention, the single medicinal liquid that the single medicinal liquid that the first compartment comprises acid, calcium and magnesium and the second compartment comprise alkali bicarbonate, and the container medicinal liquid that comprises 2000 milliliters.The 4th compartment 9 and the 5th compartment 10 comprise variable concentrations, for example the glucose of 50% concentration.First pin 11 that can break is arranged between the 4th compartment 9 and the first compartment 1, and second pin 12 that can break is arranged between the 5th compartment 10 and the first compartment 1.First and second pins 11,12 that can break are arranged to allow respectively between the 4th compartment 9 and the first compartment 1 and the 5th compartment 10 and the first compartment 1 fluid to be communicated with.When admixing medical solutions, in any one of the 4th and the 5th compartment or the use of two middle contents, be optional.This exemplary embodiment of the present invention is suitable for being combined with peritoneal dialysis treatment.
In one exemplary embodiment of the present invention, the 3rd compartment 3 comprises water or the normal saline for the object that sterilizes.By comprise water or normal saline in the 3rd compartment, can be at lower temperature, under about 120 degrees Celsius rather than guarantee the aseptic condition of multicompartment container under about 185 degrees Celsius.
In one exemplary embodiment of the present invention, multicompartment container is formed by non-PVC thin film.
The present invention is not limited to described embodiment, but changes and modification in the scope that can limit in following claim.

Claims (36)

1. a flexible multicompartment container that comprises medicinal liquid, it comprises at least the first compartment (1), the second compartment (2) and the 3rd compartment (3), wherein the first compartment (1) is filled the first single solution to the first filling extent FD 1, the second compartment (2) is filled the second single solution to the second filling extent FD 2the first compartment is separated by the first pealable seals (5) with the second compartment, wherein when the first compartment and the second compartment are arranged to fluid communication with each other by destroying the first pealable seals (5), provide and mix compartment (7), mix compartment (7) separated with the 3rd compartment (3) by the second pealable seals (6), it is characterized in that the first filling extent FD 1be greater than the second filling extent FD 2, and mix the filling extent FD in compartment mCbe greater than the filling extent FD in the second compartment 2, and the first filling extent FD 1be enough to destroy the first pealable seals (5), mix the 3rd filling extent FD in compartment mCbe enough to destroy the second pealable seals (6), wherein the second filling extent is unsuitable for destroying the first pealable seals and is also unsuitable for destroying the second pealable seals, and the first pealable seals (5) and the second pealable seals (6) have essentially identical intensity.
2. multicompartment container according to claim 1, is characterized in that, the first filling extent FD 1be greater than 40%, the second filling extent FD 2be less than 45%, and the 3rd filling extent FD mCbe greater than 10%.
3. multicompartment container according to claim 1, is characterized in that, the first filling extent FD 1>=70%, and the second filling extent FD 2≤ 40%.
4. multicompartment container according to claim 1, is characterized in that, the first filling extent FD 1for 70%-100%, and the second filling extent FD 2for 10%-40%.
5. multicompartment container according to claim 4, is characterized in that, the second filling extent FD 2for 10%-35%.
6. multicompartment container according to claim 1, is characterized in that, the first filling extent FD 1for 80%-90%, and the second filling extent FD 2for 30%-40%.
7. multicompartment container according to claim 1, is characterized in that, the first filling extent FD 1be 85%, the second filling extent FD 2be 29%, and the 3rd filling extent FD mCbe 36%.
8. multicompartment container according to claim 1, is characterized in that, the first filling extent FD 1be 80%, the second filling extent FD 2be 33%, and the 3rd filling extent FD mCbe 64%.
9. according to the multicompartment container described in claim 1 or 4, it is characterized in that, multicompartment container is enough large to can comprise the medicinal liquid of at least 500 milliliters.
10. multicompartment container according to claim 9, is characterized in that, the first single solution that the first compartment (1) comprises 425 milliliters, the second single solution that the second compartment comprises 75 milliliters.
11. according to the multicompartment container described in claim 1 or 7, it is characterized in that, multicompartment container is enough large to can comprise the medicinal liquid of at least 2000 milliliters.
12. according to the multicompartment container described in claim 1 or 7, it is characterized in that, multicompartment container is enough large to can comprise the medicinal liquid of at least 5000 milliliters.
13. multicompartment containers according to claim 12, is characterized in that, the first single solution that the first compartment (1) comprises 4850 milliliters, the second single solution that the second compartment comprises 150 milliliters.
14. according to multicompartment container in any one of the preceding claims wherein, it is characterized in that, the 3rd compartment (3) is provided with outlet port (4).
15. multicompartment containers according to claim 14, is characterized in that, medicinal liquid has a kind of like this concentration, and this medicinal liquid is suitable for being discharged into patient and need not being further diluted by outlet port (4).
16. multicompartment containers according to claim 14, is characterized in that, medicinal liquid is in concentrated form, and medicinal liquid needs to be diluted before being discharged into patient by outlet port like this.
17. 1 kinds of flexible multicompartment containers that comprise medicinal liquid, comprise at least the first compartment (1), the second compartment (2) and the 3rd compartment (3), and wherein the first compartment (1) is filled the first single solution to the first filling extent FD 1, and the second compartment (2) is filled the second single solution to the second filling extent FD 2wherein said the first compartment is separated by the first pealable seals (5) with the second compartment, when the first compartment and the second compartment are arranged to fluid communication with each other by destroying the first pealable seals (5), provide and mix compartment (7), it is characterized in that the first filling extent FD 1be greater than the second filling extent FD 2, and mix the 3rd filling extent FD in compartment mCbe greater than the second filling extent FD in the second compartment 2, wherein the first compartment is substantially the same with the size of the second compartment.
18. multicompartment containers according to claim 17, is characterized in that, the first filling extent FD 1be greater than 40%, the second filling extent FD 2be less than 45%, and the 3rd filling extent FD mCbe greater than 10%.
19. multicompartment containers according to claim 17, is characterized in that, the first filling extent FD 1>=70%, and the second filling extent FD 2≤ 40%.
20. multicompartment containers according to claim 17, is characterized in that, the first filling extent FD 1for 70%-100%, and the second filling extent FD 2for 10%-40%.
21. multicompartment containers according to claim 20, is characterized in that, the second filling extent FD 2for 10%-35%.
22. multicompartment containers according to claim 17, is characterized in that, the first filling extent FD 1for 80%-90%, and the second filling extent FD 2for 30%-40%.
23. multicompartment containers according to claim 17, is characterized in that, the first filling extent FD 1be 85%, the second filling extent FD 2be 29%, and the 3rd filling extent FD mCbe 36%.
24. multicompartment containers according to claim 17, is characterized in that, the first filling extent FD 1be 80%, the second filling extent FD 2be 33%, and the 3rd filling extent FD mCbe 64%.
25. according to the multicompartment container described in claim 17 or 20, it is characterized in that, multicompartment container is enough large to can comprise the medicinal liquid of at least 500 milliliters.
26. multicompartment containers according to claim 25, is characterized in that, the first single solution that the first compartment (1) comprises 425 milliliters, the second single solution that the second compartment comprises 75 milliliters.
27. according to the multicompartment container described in claim 17 or 23, it is characterized in that, multicompartment container is enough large to can comprise the medicinal liquid of at least 2000 milliliters.
28. according to the multicompartment container described in claim 17 or 23, it is characterized in that, multicompartment container is enough large to can comprise the medicinal liquid of at least 5000 milliliters.
29. multicompartment containers according to claim 28, is characterized in that, the first single solution that the first compartment (1) comprises 4850 milliliters, the second single solution that the second compartment comprises 150 milliliters.
30. according to the multicompartment container described in any one in claim 17-29, it is characterized in that, it is separated with mixing compartment (7) that the 3rd compartment (3) is arranged through the second pealable seals (6), and the 3rd compartment (3) is provided with outlet port (4).
31. multicompartment containers according to claim 30, is characterized in that, medicinal liquid has a kind of like this concentration, and this medicinal liquid is suitable for being discharged into patient and need not being further diluted by outlet port (4).
32. multicompartment containers according to claim 30, is characterized in that, medicinal liquid is in concentrated form, and medicinal liquid needs to be diluted before being discharged into patient by outlet port like this.
33. multicompartment containers according to claim 30, is characterized in that, the first filling extent is enough to destroy the first pealable seals (5), and mix the filling extent FD in compartment mCbe enough to destroy the second pealable seals (6).
34. multicompartment containers according to claim 33, is characterized in that, the first pealable seals (5) and the second pealable seals (6) have essentially identical intensity.
35. a flexible multicompartment container that comprises medicinal liquid, it comprises at least the first compartment (1), the second compartment (2) and the 3rd compartment (3), and wherein the first compartment (1) is filled the first single solution to the first filling extent FD 1, the second compartment (2) is filled the second single solution to the second filling extent FD 2the first compartment is separated by the first pealable seals (5) with the second compartment, wherein when the first compartment and the second compartment are arranged to fluid communication with each other by destroying the first pealable seals (5), provide and mix compartment (7), mix compartment (7) separated with the 3rd compartment (3) by the second pealable seals (6), it is characterized in that the first filling extent FD 1be greater than the second filling extent FD 2, and mix the filling extent FD in compartment mCbe greater than the filling extent FD in the second compartment 2, and the first filling extent FD 1be enough to destroy the first pealable seals (5), mix the filling extent FD in compartment mCbe enough to destroy the second pealable seals (6), wherein the first compartment is substantially the same with the size of the second compartment.
36. multicompartment containers according to claim 35, is characterized in that, the first pealable seals (5) and the second pealable seals (6) have essentially identical intensity.
CN201410459356.1A 2005-10-17 2006-10-16 Multicompartment container containing a medical solution Pending CN104188802A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0502365-0 2005-10-17
SE0502365 2005-10-17
US59674605P 2005-10-18 2005-10-18
US60/596,746 2005-10-18

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CN104188802A true CN104188802A (en) 2014-12-10

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CNA2006800381187A Pending CN101287439A (en) 2005-10-17 2006-10-16 Multicompartment container containing a medical solution

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ES (1) ES2525667T3 (en)

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ES2525667T3 (en) 2014-12-29
CN101287439A (en) 2008-10-15

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Application publication date: 20141210