CN104174252B - A kind of device eliminating alkali metal vapour in hyperpolarized gas - Google Patents
A kind of device eliminating alkali metal vapour in hyperpolarized gas Download PDFInfo
- Publication number
- CN104174252B CN104174252B CN201410438496.0A CN201410438496A CN104174252B CN 104174252 B CN104174252 B CN 104174252B CN 201410438496 A CN201410438496 A CN 201410438496A CN 104174252 B CN104174252 B CN 104174252B
- Authority
- CN
- China
- Prior art keywords
- valve
- operated pneumatic
- pfa
- alkali metal
- ultra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention discloses a kind of device eliminating alkali metal vapour in hyperpolarized gas of the present invention, the welding of spiral glass tube two ends has vacuum glass valve, is arranged in ultra-low temperature constant temperature groove; PFA threeway connects PFA pipeline, vacuum glass valve, ultra-low temperature constant temperature groove, aluminium alloy fixed mount, spiral glass tube, pipeline, operated pneumatic valve, electromagnetic valve, pressure gauge, gas cylinder; Computer instruction electromagnetic valve conducting gases at high pressure drive the switch of operated pneumatic valve, control the glide path of hyperpolarized gas.Apparatus of the present invention structure is simple, easy to operate, purified pool is integrated, the highly purified hyperpolarized gas that circulation secondary condensation alkali metal vapour obtains, can meet the requirement of organism magnetic resonance imaging.
Description
Technical field
Patent of the present invention relates to spin-exchange optical pumping and hyperpolarized gas NMR imaging field, and the hyperpolarized gas more specifically related to for toy and human body imaging is collected and breathes interventional systems, is applicable to the apparatus system eliminating alkali metal vapour in hyperpolarized gas.
Background technology
Spin-exchange optical pumping technology can produce the inert gas of height thermal nonequilibrium polarization, and its nuclear spin polarization degree 4 ~ 5 magnitudes larger than the value of thermal poling under the same terms, therefore, are referred to as hyperpolarized gas.It can make magnetic resonance signal be greatly improved as a kind of gasgraphy agent, and compensate for conventional magnetic resonance imaging and can not obtain the sorry of organism lung information.
Hyperpolarized gas mr imaging technique is based on the physical basis of spin-exchange optical pumping, and it mainly comprises two parts: generation and the collection of hyperpolarized gas (such as, the inert gas xenon of hyperpolarization) store, and supersensitive gas magnetic resonance imaging.The generation of hyperpolarized gas is obtained by the xenon in working gas (being generally the mist of xenon+nitrogen+helium) and the optical pumping alkali metal atom spin exohange collision process to high degree of polarization (polarizability ~ 100%); Magnetic resonance imaging mainly carries out imaging by being imported/sucking by gas interventional systems in tested organism by hyperpolarized gas.
In high efficiency spin-exchange optical pumping process, require to use working gas to mix fully with alkali metal vapour.And in the magnetic resonance imaging of organism hyperpolarized gas, need the completely pure hyperpolarized gas using alkali-free metal vapors.In hyperpolarization system, the mode of usual employing glass pipe+room temperature or U-shaped pipe+frozen water Dewar, considerably reduces the alkali metal vapour content in hyperpolarized gas, but, still have the alkali metal vapour of micro residue in hyperpolarized gas, its technology details and in-problem reason are:
Glass pipe+room temperature technology, usually the glass pipe of a section longer is connected in the outlet of optical pumping bubble, utilize glass pipe to be positioned at the room temperature environment steeping operating temperature far below optical pumping, make the cooling of the alkali metal vapour in the working gas flowed, be adsorbed onto on glass pipe inwall.But because use the length of glass pipe to limit in hyperpolarization system, and room temperature is usually enough not low, the impossible total condensation of the alkali metal vapour contained in hyperpolarized gas is on glass inner wall;
U-shaped pipe+frozen water Dewar technology is an improvement of technology (1).A U-shaped glass tube is positioned in frozen water Dewar, utilizes bending U-shaped glass tube and the temperature environment of frozen water ~ 273K, make more alkali metal vapour depart from working gas and be condensate in U-shaped glass tube inwall.But the working gas of high flow velocities has still taken away a small amount of alkali metal vapour;
Afterwards, a small amount of alkali metal vapour can flow into working gas to be collected in storage device, although the collection storage device of hyperpolarized gas works in the liquid nitrogen temperature of ultralow temperature usually, but the solid hyperpolarised xenon of storage still has some alkali metal vapours and is blended in hyperpolarized gas in sublimation process.
Because alkali metal and water can release heat by vigorous reaction, so even if micro-in the extreme, it also may cause certain injury to tested organism.Therefore, from vital protection organism security standpoint, reducing the amount (generally lower than 0.5ng) entering alkali metal vapour in the hyperpolarized gas of tested organism as far as possible needs effective method and technology more.
The present invention proposes a kind of device eliminating alkali metal vapour in hyperpolarized gas, and its concrete technology is:
Use spiral glass tube, add the surface area of glass inner wall, allow the alkali metal vapour with hyperpolarized gas flow touch glass container inwall more;
Utilize the temperature of ultra-low temperature constant temperature groove (such as 243K), make condensation alkali metal vapour more effectively;
Use the method for circulation B-grade condensation alkali metal vapour, secondarily purified hyperpolarized gas.
Thus, last traces alkali metal vapour object in elimination flowing hyperpolarized gas is reached.
Summary of the invention
For above problem, the object of the present invention is to provide a kind of device eliminating alkali metal vapour in hyperpolarized gas, its structure is simple, easy to operate.The high-purity hyperpolarized gas of contrast preparation can be provided as the gas magnetic resonance imaging of organism.
For achieving the above object, the present invention adopts following technical measures:
Its technical conceive is: when the mist (such as hyperpolarization xenon+nitrogen+helium) comprising micro-alkali metal vapour flows through apparatus of the present invention, due to the ultra low temperature (243K) that apparatus of the present invention operating point is being arranged, alkali metal vapour can be condensate on spiral glass tube inwall, and its temperature can not the arbitrary gas of xenon, nitrogen and helium in condensation mist, thus reach the object that alkali metal vapour is separated with mist.In apparatus of the present invention, spiral glass tube and mist have large gross contact area, are on the spiral glass tube inwall of ultralow temperature therefore, it is possible to the alkali metal vapour making mist include has more multimachine to condense to.Then, the mist through one-level purifying flows out apparatus of the present invention, enters hyperpolarized xenon gathering system, and under liquid nitrogen temperature condition, hyperpolarization xenon is separated with the nitrogen in mist, helium, and solidifies.After collection completes, need distil to solid hyperpolarised xenon, after this process, the hyperpolarized gas of distillation carries out circulation B-grade condensation alkali metal vapour process by apparatus of the present invention again, purifying hyperpolarized gas further, then alkali-free metal vapors, highly purified hyperpolarized gas are exported apparatus of the present invention, enter and collect airbag and be applied to organism magnetic resonance imaging.
A kind of device eliminating alkali metal vapour in hyperpolarized gas, comprise ultra-low temperature constant temperature groove, spiral glass tube is provided with in ultra-low temperature constant temperature groove, spiral glass tube one end is communicated with the one end of the first vacuum glass valve be arranged on ultra-low temperature constant temperature groove, the spiral glass tube other end is communicated with the one end of the second vacuum glass valve be arranged on ultra-low temperature constant temperature groove, the other end of the first vacuum glass valve is communicated with the second link of a PFA threeway by a PFA pipeline, first link of the one PFA threeway is provided with the first operated pneumatic valve, 3rd link of the one PFA threeway is provided with the 3rd operated pneumatic valve, the other end of the second vacuum glass valve is communicated with the first link of the 2nd PFA threeway by the 2nd PFA pipeline, second link of the 2nd PFA threeway is provided with the second operated pneumatic valve, 3rd link of the 2nd PFA threeway is provided with the 4th operated pneumatic valve.
A kind of device eliminating alkali metal vapour in hyperpolarized gas, also comprise gas cylinder, also comprise by the first electromagnetic valve of computer operated switch, the second electromagnetic valve, the 3rd electromagnetic valve and the 4th electromagnetic valve, first electromagnetic valve controls the break-make of gas cylinder and the first operated pneumatic valve, second electromagnetic valve controls the break-make of gas cylinder and the 3rd operated pneumatic valve, 3rd electromagnetic valve controls the break-make of gas cylinder and the 4th operated pneumatic valve, and the 4th electromagnetic valve controls the break-make of gas cylinder and the second operated pneumatic valve.
First vacuum glass valve as above and the second vacuum glass valve and spiral glass tube connected mode are welding.
First vacuum glass valve one end as above to be extend in ultra-low temperature constant temperature groove and is fixed on the inwall of ultra-low temperature constant temperature groove by the first aluminium alloy fixed mount, and second vacuum glass valve one end to be extend in ultra-low temperature constant temperature groove and is fixed on the inwall of ultra-low temperature constant temperature groove by the second aluminium alloy fixed mount.
Apparatus of the present invention by the following technical solutions with measure:
(1) spiral glass tube is placed in ultra-low temperature constant temperature groove makes it be operated in ultra-low temperature surroundings, can alkali metal vapour effectively in condensation gas coming through;
(2) adopt spiral glass tube, make the contact area increasing gas and glass container inwall in less space, improve the efficiency of alkali metal vapour in condensed gas;
(3) switch operated pneumatic valve is removed by computer instruction electromagnetic valve conducting gases at high pressure, control the passage of hyperpolarized gas flow, realize operated from a distance and B-grade condensation is carried out to alkali metal vapour in hyperpolarized gas, thus obtaining the secondary purifying of hyperpolarized gas.
The workflow of this device is: be first fused on spiral glass container by two vacuum glass valves respectively according to normal glass processing mode; Again other one end of two vacuum glass valves is connected with PFA threeway respectively by PFA pipeline; Then, two vacant pipelines in each PFA threeway are connected with operated pneumatic valve; The control interface of each operated pneumatic valve is connected with electromagnetic valve by pipeline, and controls the switch of operated pneumatic valve by electromagnetic valve conducting gases at high pressure.During apparatus of the present invention work, spiral glass tube is fixed in ultra-low temperature constant temperature groove (243K) by aluminium alloy fixed mount, the optical pumping again hyperpolarized gas being produced system bubbles out mouth and is connected with operated pneumatic valve, then, open two vacuum glass valves of spiral glass container, controlled the switch of operated pneumatic valve by Controlling solenoid valve door conducting gases at high pressure, and then the purified stream of formation hyperpolarized gas is through passage.When apparatus of the present invention are in collection purge process, control corresponding one group of operated pneumatic valve by group electromagnetic valve conducting gases at high pressure of in apparatus of the present invention to open, mist (such as, hyperpolarization xenon+nitrogen+helium) together flow through with alkali metal vapour the spiral glass tube being in ultra-low temperature surroundings, thus realize the one-level condensation of alkali metal vapour.Then, the mist of one-level purifying flows out apparatus of the present invention, enters hyperpolarized gas gathering system, there, due to the effect of liquid nitrogen temperature, nitrogen and helium separated, only hyperpolarized gas is by solid-state collection; When the present invention is used for sublimation purification, opened by the corresponding operated pneumatic valve of other one group of electromagnetic valve conducting drive of high-pressure gas, hyperpolarized gas flows through spiral glass tube again, and in hyperpolarized gas, last traces alkali metal vapour is by B-grade condensation, hyperpolarized gas is carried out secondarily purified.
The present invention has the following advantages and effect:
The feature that structure is simple, easy to operate, purified pool is integrated.In elimination hyperpolarized gas provided by the invention, the device of alkali metal vapour, significant for organism magnetic resonance imaging, especially, for lung and the brain magnetic resonance imaging of human body, has very important application prospect and practical value.It also can meet the requirement carrying out magnetic resonant wave spectrometry and imaging research that other needs such as such as porous material, surface etc. use hyperpolarized gas.Concrete be presented as following some:
Apparatus of the present invention structure is simple, integrated design, and the spiral glass tube under utilizing to work in ultralow temperature, carries out circulation B-grade condensation to the alkali metal vapour in hyperpolarized gas, thus, realize the secondarily purified function of hyperpolarized gas;
Apparatus of the present invention pass through computer instruction electromagnetic valve conducting gases at high pressure, driving switch operated pneumatic valve, the automation that purifying is collected in realization, sublimation purification operates and sequencing;
When apparatus of the present invention and hyperpolarized gas produce system, gathering system, sublimation system associated working, the high-purity hyperpolarized gas of alkali-free metal vapors can be provided, provide safe guarantee for hyperpolarized gas is used for organism magnetic resonance imaging.
Accompanying drawing explanation
Fig. 1 is a kind of device schematic diagram eliminating alkali metal vapour in hyperpolarized gas.
Wherein: 1-first operated pneumatic valve, 2-the one PFA threeway, 3-the one PFA pipeline, 4-first vacuum glass valve, 5-first aluminium alloy fixed mount, 6-ultra-low temperature constant temperature groove, 7-spiral glass tube, 8-second aluminium alloy fixed mount, 9-second vacuum glass valve, 10-the 2nd PFA pipeline, 11-the 2nd PFA threeway, 12-second operated pneumatic valve, 13-the 3rd operated pneumatic valve, 14-the 4th operated pneumatic valve, 15-first electromagnetic valve, 16-second electromagnetic valve, 17-cable, 18-computer, 19-the 3rd electromagnetic valve, 20-the 4th electromagnetic valve, 21-pipeline, 22-pressure gauge, 23-gas cylinder.
Fig. 2 is that apparatus of the present invention implement legend.
G1-produces mist (hyperpolarized gas+nitrogen+helium), the hyperpolarized gas of G3-after the hyperpolarized gas after gathering system and sublimation system, G4-secondary purifying after the mist (hyperpolarized gas+nitrogen+helium) of system, G2-one-level purifying from hyperpolarized gas.
Detailed description of the invention
Embodiment 1:
Below in conjunction with Fig. 1 and Fig. 2, the present invention is described in further detail:
First, the material of each parts of a kind of device for eliminating residual alkali steam in hyperpolarized gas, shape and structure are described:
A kind of device for eliminating residual alkali steam in hyperpolarized gas of the present invention, comprise the first operated pneumatic valve 1, one PFA threeway 2, one PFA pipeline 3, first vacuum glass valve 4, first aluminium alloy fixed mount 5, ultra-low temperature constant temperature groove 6, spiral glass tube 7, second aluminium alloy fixed mount 8, second vacuum glass valve 9, 2nd PFA pipeline 10, 2nd PFA threeway 11, second operated pneumatic valve 12, 3rd operated pneumatic valve 13, 4th operated pneumatic valve 14, first electromagnetic valve 15, second electromagnetic valve 16, cable 17, computer 18, 3rd electromagnetic valve 19, 4th electromagnetic valve 20, pipeline 21, pressure gauge 22, gas cylinder 23.
First operated pneumatic valve 1 connects a PFA threeway 2, PFA pipeline 3, a first vacuum glass valve 4, ultra-low temperature constant temperature groove 6, first aluminium alloy fixed mount 5, spiral glass tube 7, second aluminium alloy fixed mount 8, second vacuum glass valve 9, the 2nd PFA pipeline 10, the 2nd PFA threeway 11, second operated pneumatic valve 12 successively; Wherein other one end of a PFA threeway 2 is connected with the 3rd operated pneumatic valve 13, and other one end of the 2nd PFA threeway 11 is connected with the 4th operated pneumatic valve 14; Together with first vacuum glass valve 4 and the second vacuum glass valve 9 are fused to spiral glass tube 7; First vacuum glass valve 4 and the second vacuum glass valve 9 and the spiral glass tube 7 that is connected are fixed in ultra-low temperature constant temperature groove 6 by the first aluminium alloy fixed mount 5 and the second aluminium alloy fixed mount 8; First operated pneumatic valve 1, second operated pneumatic valve 12, the 3rd operated pneumatic valve 13, the 4th operated pneumatic valve 14 connect the first electromagnetic valve 15, the 4th electromagnetic valve 20, second electromagnetic valve 16, the 3rd electromagnetic valve 19 respectively by pipeline 21, and are connected with pressure gauge 22, gas cylinder 23;
Spiral glass tube 7 is arranged on ultra-low temperature constant temperature groove 6 li, when the hyperpolarized gas flow containing micro-alkali metal vapour is by spiral glass tube 7, alkali metal vapour can condense on the glass inner wall of spiral glass tube 7, thus reaches the object eliminating residual alkali steam.
The passage of hyperpolarized gas flow be by computer 18 instruction first, the 4th, second, third electromagnetic valve (15,20,16,19) conducting gases at high pressure drive the switch of first, second, third, fourth operated pneumatic valve (1,12,13,14) to realize respectively, operated pneumatic valve without ferromagnetic material can not cause the decay of the non-equilibrium nuclear spin polarization degree of hyperpolarized gas, and the operation of alkali metal vapour is eliminated in the automation achieving a kind of harmless polarizability.
By cable 17 by computer 18 and first, second, 3rd, 4th electromagnetic valve (15, 16, 19, 20) be connected, during work, by control first, 4th, second, 3rd electromagnetic valve (15, 20, 16, 19) conducting gases at high pressure switch first respectively, second, 3rd, 4th operated pneumatic valve (1, 12, 13, 14) hyperpolarized gas is guided to flow into the spiral glass tube 7 being positioned at ultra-low temperature constant temperature groove 6 li, when hyperpolarized gas flows through spiral glass tube 7, the residual alkali devaporation included is on the glass inner wall of spiral glass tube 7, thus reach the object of elimination.
Being described in detail as follows of its each parts:
The model of the first operated pneumatic valve 1 is PMDP-2K-1/4UG, nonmagnetic, and material is PEEK, and the mist G1 as hyperpolarized gas generation system flows into the arrival end of apparatus of the present invention;
One PFA threeway 2, model is SwagelokPFA-420-3, and material is polytetrafluoroethylplastic plastic, for connecting the first, the 3rd operated pneumatic valve (1,13), and a PFA pipeline 3, also as the passage of gas flowing bilateral.
One PFA pipeline 3, model is SwagelokPFA-T4-047, and material is polytetrafluoroethylplastic plastic, and its port is through cutting process, and two ends can be tightly connected with PFA threeway 2, a first vacuum glass valve 4 respectively;
The material of the first vacuum glass valve 4 is Pyrex glass, and model is Kimble/kontesHI-VAC826651, and it act as the air-flow in precise hard_drawn tuhes inflow spiral glass tube 7;
The fixing spiral glass tube 7 that act as of the first aluminium alloy fixed mount 5 makes in its environment being in ultra-low temperature constant temperature groove 6, and ensures the stable of this region gas path pipe, and it is self-control;
The effect of ultra-low temperature constant temperature groove 6 is for spiral glass tube 7 provides working at ultra-low temperature environment, and usual working at ultra-low temperature scope is 200-265K.In the invention process, the ultra-low temperature constant temperature grooved of use number for XC-100B(operating temperature range be 243-373K), and use it to be operated in the minimum temperature of 243K;
Spiral glass tube 7 is used as the condensation pipe eliminating last traces alkali metal vapour in laser pre-polarizing gas, and material is Pyrex glass, and the glass caliber of use, diameter, length, the number of turns depend on the capacity of used ultra-low temperature constant temperature groove 6.In embodiments of the present invention, spiral glass tube 7 uses and directly makes through the Pyrex glass tube of 10mm, and the overall diameter of spiral glass tube 7 is 100mm, and length is 200mm, and the spiral number of turns is 8.；
Second aluminium alloy fixed mount 8 is identical with the effect of the first aluminium alloy fixed mount 5, and both use in pairs;
Material, the model of the second vacuum glass valve 9 and the first vacuum glass valve 4 are identical, for controlling the gas flow flowing out spiral glass tube 7;
The effect of the 2nd PFA pipeline 10, material, model are identical with a PFA pipeline 3, are tightly connected respectively with the second vacuum glass valve 9, the 2nd PFA threeway 11;
2nd PFA threeway 11 is identical with PFA threeway 2 model, for connecting the second, the 4th operated pneumatic valve 12,14, and the 2nd PFA pipeline 10,
Second, third, the model of the 4th operated pneumatic valve (12,13,14) and the first operated pneumatic valve 1, act on together, respectively by the 4th, second, third electromagnetic valve (20,16,19) conducting gases at high pressure correspondence controls to open or close, what guide hyperpolarized gas flows through route;
First, second, third, fourth electromagnetic valve (15,16,19,20) is all accurate electromagnetic valve, and model is Airtec4V210-08, goes for conducting gases at high pressure the opening and closing controlling operated pneumatic valve.
Cable 17, connected electromagnetic valve door and computer 18, such that computer 18 can drive electromagnetic valve work, conducting gases at high pressure go to drive operated pneumatic valve switch;
The operation acting as programming and hardware double control, realize four magnetic valves of computer 18, conducting gases at high pressure remove the corresponding operated pneumatic valve of switch;
Pipeline 21 is as gases at high pressure flowing passage, and material is stainless steel, and copper pipe or teflon pipe also can be used to substitute;
High-pressure gas pressure monitored by pressure gauge 22, uses conventional nitrogen pressure meter;
Gas cylinder 23 provides the gases at high pressure needed for operated pneumatic valve switch, and detachable after using, the gas cylinder more renewed, uses nitrogen cylinder here, also can use pressure-air;
Alkali metal can be potassium, sodium, rubidium or caesium.
The connection of apparatus of the present invention: first the first vacuum glass valve 4, second vacuum glass valve 9 is fused to spiral glass tube 7 respectively; Again spiral glass tube 7 being fixed on ultra-low temperature constant temperature groove 6(operating temperature by first, second aluminium alloy fixed mount (5,8) is 243K) in; Other one end of first vacuum glass valve 4, second vacuum glass valve 9 is connected with a PFA pipeline 3, the 2nd PFA pipeline 10 respectively; Three ports of the one PFA threeway 2 connect the first operated pneumatic valve 1, the 3rd operated pneumatic valve 13 and a PFA pipeline 3 respectively; Three ports of the 2nd PFA threeway 11 connect the 2nd PFA pipeline 10, the 4th operated pneumatic valve 14, second operated pneumatic valve 12 respectively; The control interface of first, second, third, fourth operated pneumatic valve (1,2,13,14) via pipeline 21 respectively with first, the 4th, second, third electromagnetic valve (15,20,16,19) is connected, and is connected to pressure gauge 22, gas cylinder 23.During apparatus of the present invention work, first the first vacuum glass valve 4, second vacuum glass valve 9 of spiral glass tube 7 is opened, then by the command switch electromagnetic valve conducting gases at high pressure of computer 18 control corresponding operated pneumatic valve open or close so that realize hyperpolarized gas flow through route.
A kind of device eliminating alkali metal vapour in hyperpolarized gas of the present invention, its workflow is described below:
When apparatus of the present invention be in collect purification work state time, produce the mist G1(hyperpolarized gas+nitrogen+helium of system from hyperpolarized gas) be communicated to the first operated pneumatic valve 1 of apparatus of the present invention arrival end.When the first electromagnetic valve 15 control conducting gases at high pressure remove unlatching the first operated pneumatic valve 1 time, make G1 to enter apparatus of the present invention, meanwhile, the second operated pneumatic valve 12 is opened, and the 3rd, the 4th operated pneumatic valve 13,14 is in closed condition.G1 is in the spiral glass tube 7 in ultra-low temperature constant temperature groove 6 via a PFA threeway 2, PFA pipeline 3, first vacuum glass valve 4 inflow, and the alkali metal vapour in G1 is by one-level condensation, and G1 is by one-level purifying; Mist G2 after one-level purifying flows out apparatus of the present invention turnover via the second vacuum glass valve 9, the 2nd PFA pipeline 10, the 2nd PFA threeway 11, second operated pneumatic valve 12, enters the outer follow-up hyperpolarized gas gathering system of apparatus of the present invention and sublimation system.In the present embodiment, spiral glass tube 7 uses and directly makes through the Pyrex glass tube of 10mm, and the overall diameter of spiral glass tube 7 is 100mm, and length is 200mm, and the spiral number of turns is 8.When it is in sublimation gases purification work pattern, first, second operated pneumatic valve (1,12) is in closed condition, three, the 4th operated pneumatic valve (13,14) is unlocked, the hyperpolarized gas G3 of distillation enters apparatus of the present invention again via the 3rd operated pneumatic valve 13, and be in the spiral glass tube 7 in ultra-low temperature constant temperature groove 6 through a PFA threeway 2, PFA pipeline 3, first vacuum glass valve 4 inflow successively, alkali metal vapour in G3 is condensed, and G3 is purified and obtains highly purified hyperpolarized gas G4; Highly purified hyperpolarized gas G4 flows out apparatus of the present invention via the second vacuum glass valve 9, the 2nd PFA pipeline 10, the 2nd PFA threeway 11, the 4th operated pneumatic valve 14 again, enter in follow-up collection airbag, be then directly used in organism MRI investigation.
Below in conjunction with accompanying drawing 1 and Fig. 2, use optical pumping Alkali Metal Rb steam for hyperpolarization system, working gas be xenon (1%), the mist (5atm) of helium (90%), nitrogen (9%), a kind of device, implementation process eliminating alkali metal vapour in hyperpolarized gas of apparatus of the present invention is described in further detail:
First, the first operated pneumatic valve 1 and the hyperpolarized gas of apparatus of the present invention are produced system and is connected, the second operated pneumatic valve 12 is connected with follow-up hyperpolarized gas gathering system, and open the first vacuum glass valve 4, second vacuum glass valve 9.When hyperpolarized gas xenon generation device running hours, produce mist G1(hyperpolarization xenon+nitrogen+helium), meanwhile, in the gas G1 of flowing, include Alkali Metal Rb steam.Computer 18 controls the first electromagnetic valve 15, the 4th electromagnetic valve 20 conducting gases at high pressure drive the first operated pneumatic valve 1, second operated pneumatic valve 12 to open respectively.Spiral glass tube 7, the second vacuum glass valve 9 under the first operated pneumatic valve 1, a PFA threeway 2, PFA pipeline 3, a first vacuum glass valve 4, ultralow temperature (243K) working environment, the 2nd PFA pipeline 10, the 2nd PFA threeway 11, second operated pneumatic valve 12 is made to form a gas flow channel.
In collection purge process, mist G1 flows into apparatus of the present invention through the first operated pneumatic valve 1, and flows through this passage.Because spiral glass tube 7 is in the ultra low temperature of 243K, and the setting temperature of Alkali Metal Rb is far above this temperature, then the Alkali Metal Rb steam in mist G1 can be carried out condensation, hyperpolarization xenon in mist, nitrogen, helium can not be solidified, and therefore achieve the purifying of mist G1.Gas after one-level purifying is marked as mist G2(hyperpolarization xenon+nitrogen+helium), eventually pass the second operated pneumatic valve 12 controlled by the 4th electromagnetic valve 20 and flow out apparatus of the present invention, enter into follow-up hyperpolarized gas gathering system.In gathering system, the nitrogen in mist G2 and helium separated, only retain solid hyperpolarised xenon.
In sublimation purification process, hyperpolarized gas sublimation system is directly connected with the 3rd operated pneumatic valve 13 by pipeline, and hyperpolarized gas is collected airbag and is connected with the 4th operated pneumatic valve 14 by pipeline.Control the first electromagnetic valve 15 by computer 18, the 4th electromagnetic valve 20 closes the first operated pneumatic valve 1, second operated pneumatic valve 12, meanwhile, computer 18 controls the second magnetic valve 16, the 3rd electromagnetic valve 19 conducting gases at high pressure remove unlatching the 3rd operated pneumatic valve 13, the 4th operated pneumatic valve 14 respectively.Hyperpolarization xenon G3 after distillation flows into apparatus of the present invention from the 3rd operated pneumatic valve 13, and then flow over a PFA threeway 2, one PFA pipeline 3, first vacuum glass valve 4, spiral glass tube 7 under ultra low temperature (243K) working environment, residual minim Alkali Metal Rb steam in spiral glass tube 7 couples of hyperpolarization xenon G3 carries out condensation, hyperpolarization xenon after purifying G3 is labeled as G4, it flows through the second vacuum glass valve 9, 2nd PFA pipeline 10, 2nd PFA threeway 11, apparatus of the present invention are flowed out finally by by the 4th operated pneumatic valve 14, enter into hyperpolarization xenon collecting bag, the hyperpolarized gas G4 of circulation secondary purifying will be directly used in organism (toy, human lung and brain etc.) magnetic resonance imaging.The technical scheme of the application 243K temperature carry out secondarily purified after gas essentially eliminate vapour of an alkali metal, can organism be directly acted on.
Apparatus of the present invention are parts in total hyperpolarization system, and front and back are connected to multiple different member passage, can be implemented in purge process and are communicated with in sublimation process or disconnect, and two processes can utilize same ultra-low temperature constant temperature groove.
Apparatus of the present invention and hyperpolarized gas produce system, gathering system, sublimation system conbined usage, organism magnetic resonance imaging can be met (such as, the imaging research of human lung and brain) for the requirement of highly purified (here special for: not containing alkali metal) of hyperpolarized gas, therefore, there is the prospect of very important practical value and potential application.
Specific embodiment described herein is only to the explanation for example of the present invention's spirit.Those skilled in the art can make various amendment or supplement or adopt similar mode to substitute to described specific embodiment, but can't depart from spirit of the present invention or surmount the scope that appended claims defines.
Claims (4)
1. eliminate the device of alkali metal vapour in hyperpolarized gas for one kind, comprise ultra-low temperature constant temperature groove (6), it is characterized in that: in ultra-low temperature constant temperature groove (6), be provided with spiral glass tube (7), spiral glass tube (7) one end is communicated with the one end of the first vacuum glass valve (4) be arranged on ultra-low temperature constant temperature groove (6), spiral glass tube (7) other end is communicated with the one end of the second vacuum glass valve (9) be arranged on ultra-low temperature constant temperature groove (6), the other end of the first vacuum glass valve (4) is communicated with the second link of a PFA threeway (2) by a PFA pipeline (3), first link of the one PFA threeway (2) is provided with the first operated pneumatic valve (1), 3rd link of the one PFA threeway (2) is provided with the 3rd operated pneumatic valve (13), the other end of the second vacuum glass valve (9) is communicated with the first link of the 2nd PFA threeway (11) by the 2nd PFA pipeline (10), second link of the 2nd PFA threeway (11) is provided with the second operated pneumatic valve (12), 3rd link of the 2nd PFA threeway (11) is provided with the 4th operated pneumatic valve (14), the operating temperature range of ultra-low temperature constant temperature groove (6) is 200-265K.
2. a kind of device eliminating alkali metal vapour in hyperpolarized gas according to claim 1, it is characterized in that, also comprise gas cylinder (23), also comprise by first electromagnetic valve (15) of computer (18) gauge tap, second electromagnetic valve (16), 3rd electromagnetic valve (19) and the 4th electromagnetic valve (20), first electromagnetic valve (15) controls the break-make of gas cylinder (23) and the first operated pneumatic valve (1), second electromagnetic valve (16) controls the break-make of gas cylinder (23) and the 3rd operated pneumatic valve (13), 3rd electromagnetic valve (19) controls the break-make of gas cylinder (23) and the 4th operated pneumatic valve (14), 4th electromagnetic valve (20) controls the break-make of gas cylinder (23) and the second operated pneumatic valve (12).
3. a kind of device eliminating alkali metal vapour in hyperpolarized gas according to claim 1, it is characterized in that, the first described vacuum glass valve (4) and the second vacuum glass valve (9) are welding with spiral glass tube (7) connected mode.
4. a kind of device eliminating alkali metal vapour in hyperpolarized gas according to claim 1, it is characterized in that, first described vacuum glass valve (4) one end extend into the inwall being also fixed on ultra-low temperature constant temperature groove (6) in ultra-low temperature constant temperature groove (6) by the first aluminium alloy fixed mount (5), and second vacuum glass valve (9) one end extend into the inwall being also fixed on ultra-low temperature constant temperature groove (6) in ultra-low temperature constant temperature groove (6) by the second aluminium alloy fixed mount (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410438496.0A CN104174252B (en) | 2014-08-29 | 2014-08-29 | A kind of device eliminating alkali metal vapour in hyperpolarized gas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410438496.0A CN104174252B (en) | 2014-08-29 | 2014-08-29 | A kind of device eliminating alkali metal vapour in hyperpolarized gas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104174252A CN104174252A (en) | 2014-12-03 |
| CN104174252B true CN104174252B (en) | 2016-03-23 |
Family
ID=51955764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410438496.0A Active CN104174252B (en) | 2014-08-29 | 2014-08-29 | A kind of device eliminating alkali metal vapour in hyperpolarized gas |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104174252B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110609055A (en) * | 2018-06-15 | 2019-12-24 | 中国科学院大连化学物理研究所 | Hyperpolarization rare inert gas generating device |
| CN114408266B (en) * | 2022-01-24 | 2023-11-21 | 散裂中子源科学中心 | Glass pipeline device for preparing helium three-neutron polarized glass air chamber and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003245263A (en) * | 2002-02-26 | 2003-09-02 | National Institute Of Advanced Industrial & Technology | Apparatus for producing nuclear spin polarized rare gas and method of producing polarized rare gas using the same |
| CN102818116A (en) * | 2012-08-29 | 2012-12-12 | 上海磊诺工业气体有限公司 | Purification system and purification process of high-pressure high-flow and high-purity gas filling equipment |
| CN103301741A (en) * | 2013-05-13 | 2013-09-18 | 中国科学院武汉物理与数学研究所 | Method and device for highly purifying gas |
| WO2013172148A1 (en) * | 2012-05-14 | 2013-11-21 | 株式会社 日立メディコ | Magnetic resonance imaging device, gas recovery unit for magnetic resonance imaging device, and method for operating magnetic resonance imaging device |
-
2014
- 2014-08-29 CN CN201410438496.0A patent/CN104174252B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003245263A (en) * | 2002-02-26 | 2003-09-02 | National Institute Of Advanced Industrial & Technology | Apparatus for producing nuclear spin polarized rare gas and method of producing polarized rare gas using the same |
| WO2013172148A1 (en) * | 2012-05-14 | 2013-11-21 | 株式会社 日立メディコ | Magnetic resonance imaging device, gas recovery unit for magnetic resonance imaging device, and method for operating magnetic resonance imaging device |
| CN102818116A (en) * | 2012-08-29 | 2012-12-12 | 上海磊诺工业气体有限公司 | Purification system and purification process of high-pressure high-flow and high-purity gas filling equipment |
| CN103301741A (en) * | 2013-05-13 | 2013-09-18 | 中国科学院武汉物理与数学研究所 | Method and device for highly purifying gas |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104174252A (en) | 2014-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104174252B (en) | A kind of device eliminating alkali metal vapour in hyperpolarized gas | |
| CN107621393B (en) | A kind of concentration determination method using sulfur trioxide sampling apparatus in flue gas | |
| Ruset et al. | Optical pumping system design for large production of hyperpolarized Xe 129 | |
| CN202974980U (en) | Total organic carbon detection device | |
| CN107132103A (en) | A kind of vacuum constant temperature oil and gas separating system | |
| CN106896065B (en) | A kind of polarization cavity systems and its application method based on hyperpolarized gas | |
| CN109701296A (en) | Corrosion-resistant more working method supercritical carbon dioxide extracting systems | |
| CN105997264A (en) | Hyperpolarization gas based vacuum pumping inflation system | |
| CN103301741B (en) | Method and device for highly purifying gas | |
| KR101462022B1 (en) | Sample combustion apparatuse using microwave | |
| CN213528579U (en) | Parahydrogen preparation system | |
| CN106969256B (en) | A kind of device and method of integrated storage laser-polarization xenon | |
| Del Fiore et al. | Production of oxygen-15, nitrogen-13 and carbon-11 and of their low molecular weight derivatives for biomedical applications | |
| CN209446543U (en) | Residual oxygen analysis system | |
| CN206960160U (en) | A kind of hydrogen isotope cryogenic rectification sampling system | |
| CN205831750U (en) | The pipe control system of endoscope | |
| CN105385856A (en) | Novel alkali metal purifying filter and purifying method | |
| CN115234829B (en) | Air filling station and application thereof | |
| KR101495517B1 (en) | Heating Device using during carbothermal reduction of ghraphitizion processing apparatus | |
| KR101801311B1 (en) | Gas condensate collection device | |
| CN108479393A (en) | The minimizing technology of protium in a kind of isotope gas containing hydrogen tritide | |
| JP2001083054A (en) | Exhaust gas sample collecting method and device | |
| CN208239302U (en) | A kind of characteristics of contaminated respiratory droplets nitric oxide gas detection device | |
| Feuerstein et al. | TRITEX, a forced convection loop with Pb-17Li | |
| US11679979B2 (en) | Systems and methods for production of Xenon-133 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180515 Address after: 430000 318 Friendship Avenue, Wuchang District, Wuhan, Hubei. Patentee after: Wuhan Zhongke polarization Medical Technology Co., Ltd. Address before: 430071 Xiaohong Shanxi No. 30, Wuchang District, Wuhan, Hubei Patentee before: Wuhan Inst. of Physics and Mathematics, Chinese Academy of Sciences |
|
| TR01 | Transfer of patent right |