CN104173480A - Traditional Chinese medicine composition for treating infantile suppurative tonsillitis - Google Patents
Traditional Chinese medicine composition for treating infantile suppurative tonsillitis Download PDFInfo
- Publication number
- CN104173480A CN104173480A CN201410453159.9A CN201410453159A CN104173480A CN 104173480 A CN104173480 A CN 104173480A CN 201410453159 A CN201410453159 A CN 201410453159A CN 104173480 A CN104173480 A CN 104173480A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- herba
- medicine composition
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 206010044008 tonsillitis Diseases 0.000 title claims abstract description 33
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 11
- 239000002674 ointment Substances 0.000 claims abstract description 11
- 239000011248 coating agent Substances 0.000 claims description 26
- 238000000576 coating method Methods 0.000 claims description 26
- 239000006071 cream Substances 0.000 claims description 16
- 241000628997 Flos Species 0.000 claims description 14
- 235000021419 vinegar Nutrition 0.000 claims description 9
- 239000000052 vinegar Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 6
- 235000014435 Mentha Nutrition 0.000 claims description 4
- 241001072983 Mentha Species 0.000 claims description 4
- -1 cataplasma Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 6
- 210000000707 wrist Anatomy 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract description 2
- 239000007924 injection Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241001195282 Bidens biternata Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 244000246386 Mentha pulegium Species 0.000 abstract 1
- 235000016257 Mentha pulegium Nutrition 0.000 abstract 1
- 235000004357 Mentha x piperita Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 241000612118 Samolus valerandi Species 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 241001312894 Trollius chinensis Species 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 235000001050 hortel pimenta Nutrition 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 description 11
- 206010015150 Erythema Diseases 0.000 description 10
- 231100000321 erythema Toxicity 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 8
- 231100000614 poison Toxicity 0.000 description 8
- 239000003440 toxic substance Substances 0.000 description 7
- 206010068319 Oropharyngeal pain Diseases 0.000 description 6
- 208000033809 Suppuration Diseases 0.000 description 6
- 201000007100 Pharyngitis Diseases 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000035617 depilation Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010061926 Purulence Diseases 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000021056 liquid food Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 210000002741 palatine tonsil Anatomy 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 208000023409 throat pain Diseases 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 244000104272 Bidens pilosa Species 0.000 description 1
- 235000010662 Bidens pilosa Nutrition 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 206010051814 Eschar Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 240000001619 Prunus glandulosa Species 0.000 description 1
- 235000018992 Prunus glandulosa Nutrition 0.000 description 1
- 235000013999 Prunus japonica Nutrition 0.000 description 1
- 201000002154 Pterygium Diseases 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 201000004238 acute tympanitis Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229960004099 azithromycin Drugs 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960004755 ceftriaxone Drugs 0.000 description 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000333 eschar Toxicity 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 208000022760 infectious otitis media Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 206010025226 lymphangitis Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000003448 neutrophilic effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating infantile suppurative tonsillitis. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-20 parts of bidens biternata, 5-15 parts of dandelion, 3-7 parts of folium isatidis, 1-3 parts of trollius chinensis bunge, 5-10 parts of platycodon grandiflorum, 1-3 parts of peppermint, 1-3 parts of borneol and 2-8 parts of licorice root. The traditional Chinese medicine composition can be produced into application ointment, avoids using antibiotics, does not need injection or administration, is directly applied to wrists or arches, can be easily accepted by infants, has the advantages of excellent clinical treatment effect, no side effect and long drug acting duration, and is convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of the children's's for the treatment of suppurative tonsillitis.
Background technology
Suppurative tonsillitis is usual diseases of childhood, frequently-occurring disease, and it comprises acute follicular tonsillitis and acute lacunar tonsillitis, belongs to the upper respiratory disease of antibacterial due to infecting.Children's's suppurative tonsillitis is treated also certain difficulty, and more early finding to receive treatment effect will be better.The mode of conventional medicament treatment acute tonsillitis is generally to adopt antibiosis anti-inflammatory drug treatment, the shortcoming of this topical therapeutic mode is an antiinflammatory, and can not remove the antibacterial in cryptae tonsillares, once passive protective physical fitness reduces outbreak very easily repeatedly, with the passing of time form chronic lesion.
Suppurative tonsillitis belongs to the traditional Chinese medical science " tonsillitis " category, and its Basic disease cause pathogenesis is exuberant lung-stomach heat.Throat is that department's diet, row are breathed, soniferous organ, the upper oral cavity that connects, and lower logical lung stomach, is again the communications centre of running course of channel.Larynx is, under lung system, to communicate with lung, is the thoroughfare of gas discrepancy; Pharynx, under stomach system, communicates with stomach, is the passage of water paddy.Children's is the body of the young sun of young the moon, gas when susceptible is non-.Clinical take have sore throat, swelling, suppuration is feature.Treatment be take heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, throat pain relieving as main.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition of the children's's for the treatment of suppurative tonsillitis.
A kind of Chinese medicine composition for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
The consumption of composition part of pharmaceutical composition of the present invention is that inventor gets through groping in a large number for a long time to sum up, and each component consumption all has good curative effect at above-mentioned weight portion.
Preferably, a kind of Chinese medicine composition for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae.
Another object of the present invention is to provide a kind of pharmaceutical preparation of Chinese medicine composition of the children's's for the treatment of suppurative tonsillitis.
Chinese medicine composition of the present invention can be made into for oral dosage form.
Chinese medicine composition of the present invention can boil with decocting according to conventional method, makes for oral decoction.
Chinese medicine composition of the present invention adds various conventional adjuvant required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc. is prepared into any conventional oral formulations with conventional method of Chinese medicinal, such as being capsule, tablet, granule etc.
A kind of pharmaceutical preparation for the treatment of the Chinese medicine composition of children's's suppurative tonsillitis provided by the invention, is characterized in that, said preparation is exterior-applied formulation.
The exterior-applied formulation that Chinese medicine composition of the present invention is made is one or more in unguentum, cataplasma, paste, powder, coating unguentum, gel.
Preferably, the exterior-applied formulation that Chinese medicine composition of the present invention is made is coating unguentum.
A kind of Chinese medicine coating unguentum for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, by the Chinese medicine of following weight portion, made: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
Preferably, a kind of Chinese medicine coating unguentum for the treatment of children's's suppurative tonsillitis provided by the invention, it is characterized in that, by the Chinese medicine of following weight portion, made: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine coating cream of the children's's for the treatment of suppurative tonsillitis.
A kind of preparation method for the treatment of the Chinese medicine coating cream of children's's suppurative tonsillitis provided by the invention, it is characterized in that, take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part, remove impurity, grind to form fine powder, cross 80 mesh sieves; Then form according to the weight ratio mix of 1:1.0-3.0 with tablet vinegar, obtain coating cream of the present invention.
During use, this can be applied to the position that cream is coated on the easier Transdermal absorption such as wrist or arch of the foot, can further use together with gauze or adhesive tape, prevent pollution clothes simultaneously.
Preferably, a kind of preparation method for the treatment of the middle drug application cream of children's's suppurative tonsillitis provided by the invention, it is characterized in that, take the Chinese medicine of following weight portion: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae, remove impurity, grind to form fine powder, cross 80 mesh sieves; Then form according to the weight ratio mix of 1:1.0-3.0 with tablet vinegar, obtain coating cream of the present invention.
The external application of Chinese medicine is by local application, makes the efficacy of a drug focus of go directly, and effect is concentrated.
Chinese medicine composition of the present invention can be used for the medicine of preparation treatment suppurative tonsillitis.
Chinese medicine composition of the present invention can be used for the medicine of preparation treatment children's suppurative tonsillitis.
The present Research of the related medical material of Chinese medicine of the present invention is as follows:
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae): for the herb of feverfew bidens pilosa or gold dish silver small cup, sweet, light, flat.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.For throat pain, acute appendicitis, acute jaundice, vomits and diarrhoea, rheumatic arthritis, malaria, furuncle, venom, treating swelling and pain by traumatic injury.
The effect of Herba Taraxaci is: nature and flavor are sweet, bitter, cold, has heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, antiinflammatory, removing heat from blood, diuresis, function of gallbladder promoting, protects the liver, the several functions such as hypocatharsis, stomach invigorating, anti-cancer.
The curative effect of Folium Isatidis is: heat-clearing and toxic substances removing, and blood cooling and ecchymoses removing, and record the main pyrotoxic dysentery of Folium Isatidis, jaundice, sore throat, erysipelas etc. in < < Compendium of Materia Medica > >.
Flos Trollii: heat-clearing and toxic substances removing.Control sense, tonsillitis, pharyngitis, acute otitis media, acute myringitis, acute conjunctivitis, acute lymphangitis, aphtha, furuncle.
Radix Platycodonis: bitter, pungent, flat.Return lung meridian.Function with cure mainly: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Herba Menthae: pungent, cool.Dispelling wind, heat radiation, ward off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria
Borneolum Syntheticum: acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian; Delicate fragrance a surname is loose, has the refreshment of having one's ideas straightened out, the loose poison of heat clearing away, and the effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer is hoodwinked key clearly, and sore throat is deaf, and aphtha tooth is swollen, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, harmonizing drug.
Beneficial effect of the present invention:
(1) can avoid antibiotic use,
(2) do not have an injection, do not take medicine, be applied directly to wrist or arch of the foot, be easy to infant and accept,
(3) clinical therapeutic efficacy is excellent, have no side effect,
(4) drug treating time is long, easy to use.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.The present invention's herbal component used all can Cong Ge medium-height grass pharmacy obtain.
Embodiment 1
Take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 15g, Herba Taraxaci 10g, Folium Isatidis 5g, Flos Trollii 2g, Radix Platycodonis 8g, Herba Menthae 2g, Borneolum Syntheticum 2g, Radix Glycyrrhizae 5g, remove impurity, grind to form fine powder, cross 80 mesh sieves, then form according to the weight ratio mix of 1:1.5 with tablet vinegar, obtain coating cream of the present invention.
Embodiment 2
Take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10g, Herba Taraxaci 5g, Folium Isatidis 3g, Flos Trollii 1g, Radix Platycodonis 5g, Herba Menthae 1g, Borneolum Syntheticum 1g, Radix Glycyrrhizae 2g, remove impurity, grinds to form fine powder, crosses 80 mesh sieves, then form according to the weight ratio mix of 1:1.5 with tablet vinegar, obtain coating cream of the present invention.
Embodiment 3
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20g, Herba Taraxaci 15g, Folium Isatidis 7g, Flos Trollii 3g, Radix Platycodonis 10g, Herba Menthae 3g, Borneolum Syntheticum 3g, Radix Glycyrrhizae 8g, remove impurity, grinds to form fine powder, crosses 80 mesh sieves; Then form according to the weight ratio mix of 1:3.0 with tablet vinegar, obtain coating cream of the present invention.
The irritant experiment of more than 4 coating of embodiment to skin
Experimental technique: select 12 of healthy New Zealand white rabbit, body weight 1.5～2.5kg, is divided into each 6 of normal skin group and skin injury groups, adopts consubstantiality left and right sides self-contrast method, male and female half and half.The test Qian24hDui administration district processing of lose hair or feathers, respectively one of left and right, unhairing scope 3cm * 3cm.Damaged skin group is drawn " well " word at agents area, take and ooze out blood as degree.Every group of left side depilation place is coated with the coating cream 5g left and right (being equivalent to the more than 20 times of human body medication effective dose) of embodiment of the present invention 1-3, and right side is coated with tablet vinegar contrast.Application time 24h, every day 1 time, continuously 7d.Stick after end at every turn, remove test sample and with warm water or nonirritant solvent cleaned medicine-feeding part.Before each coating, examine coating place skin and have or not erythema, edema, after drug withdrawal, continue to observe 3d, by the requirement of new drug toxicity technical specification, carry out skin irritation evaluation.While bark fetching Fu Zuo tissue pathology checking.
Skin irritation is evaluated:
(1) standards of grading: erythema: without erythema 0 minute; Slight erythema (visible reluctantly) 1 minute; The red class of moderate (obviously visible) 2 minutes; Severe erythema 3 minutes; Aubergine erythema forms 4 minutes to slight eschar.Edema: without edema 0 minute; Mild edema (visible reluctantly) 1 minute; Intermediate edema (obviously protuberance) 2 minutes; Severe edema (cutaneous protuberance 1mm, profile is clear) 3 minutes; Serious edema (cutaneous protuberance >lmm also has expansion) 4 minutes.Highest point total value 8 minutes.
(2) skin irritation intensity evaluation standard: 0-0.49 divides nonirritant; 0.50～2.99 minute slight zest; 3.00～5.99 minutes moderate zests; 6.00～8.00 minutes strong and stimulatings.
Result: two groups of rabbit of duration of test are spiritual, sign is good, and appetite activity is normal; Without dead, also have no any untoward reaction; Hematological examination, biochemical investigation are showed no extremely; System becomes celestial and each internal organs histopathology no abnormality seen; Restorative observation has no retardance toxic reaction, detection index normal value with reference to people and rabbit, above result is all within normal range, two groups of more equal nonsignificances (P>0.05), show that rabbit does not produce toxic reaction with the coating cream of embodiment of the present invention 1-3 for a long time.
The allergic experiment of 5 pairs of skins of embodiment
Experimental technique: 50 of Cavia porcelluss, body weight 250-330g, is divided into 30 of the coating cream groups of embodiment of the present invention 1-3, and 10 every group, tablet vinegar matched group 10 only reach 10 of DNFB positive controls, and male and female half and half, shave off skin of back.After 24h, press grouping by medicine 0.5g/cm
2be coated in depilation district, Cavia porcellus left side sensitization, after 3h, repeat coating once, to guarantee medicament contact 6h, within the 7th day and the 14th day, repeat coating sensitization. in last administration 14d, by grouping, medicine is applied to depilation district, Cavia porcellus right side again and excites, after 6h, remove tested material, observe erythema and edema situation, Continuous Observation 3d. marks by skin allergy standard.
Skin irritation is evaluated: with reference to embodiment 4, carry out
Result: experimental result shows all very obvious (erythema 3.23 minutes of positive controls erythema and edema, edema 2.12 minutes), the coating cream group of tablet vinegar matched group and embodiment of the present invention 1-3 skin smooth, without erythema, without edema (being 0 minute), do not show any anaphylaxis.
Embodiment 6 clinical datas
Physical data: select year April in May, 2013 to 2014 in my Out-patient Department and the suppurative tonsillitis infant of being in hospital totally 80 examples, be divided at random treatment group and matched group by medical order.Treatment group 40 examples, male 21 examples wherein, female's 19 examples; 5.08 years old mean age.Matched group 40 examples, male 18 examples wherein, female's 22 examples; 5.82 years old mean age.Two groups of courses of disease are all in 3d.Two groups of infant sexes, age and incidences are learned processing by statistics, and difference no statistical significance (P > 0.05), has comparability.
Diagnostic criteria: with reference to all good fortune Chinese bush cherries of < < practical paidonosology > > diagnostic criteria: heating, pharyngalgia and dysphagia, accompany or do not accompany cough, antiadoncus, there are pus point or pus tongue, two lungs are not heard and rale, and total white blood cells and neutrophilic granulocyte raise, and get rid of lower respiratory infection.
Treatment and care method: treatment group infant is in the coating cream of preparing by each 0.2g/kg coating embodiment of the present invention 1 in two wrists inner sides and two foot arches of the foot, once a day; Matched group adds 10% Glucose Liquid medium-sized vein drop with ceftriaxone, while oral azithromycin 10mg/kg.d, every day 1 time.Two groups of anti symptom treatment are identical.All treat after 7 days for two groups and judge curative effect.
Infant should take in sail, and air keeps certain humidity, to keep sick child's nasopharynx part moistening, keeps room air fresh, reduces pharyngeal stimulation.In acute stage, should eat light polytrophic liquid food easy to digest or half liquid food to infant.Treat that convalescent period eats normal food.During hyperpyrexia, available physical cooling, as forehead cold compress, warm sponge bath, alcohol bath etc.
Criterion of therapeutical effect:
Effective: temperature recovery is normal, pharyngalgia, pharyngeal hyperemia, tonsil purulence thing disappear or substantially disappear.
Take a turn for the better: more first the examining of body temperature decreases, but do not recover normal, symptom, the signs such as pharyngalgia, pharyngeal hyperemia, tonsil purulence thing alleviate.
Invalid: clinical symptoms, sign are without improving or aggravation.
Therapeutic outcome: patient treatment is observe the curative effect after 7 days, treatment group 40 examples, effective 35 examples (87.5%) wherein, 5 examples (12.5%) that take a turn for the better, invalid 0 example (0%), total effective rate 100%; Matched group 40 examples, effective 25 examples (62.5%) wherein, 11 examples (27.5%) that take a turn for the better, invalid 4 examples (10%), total effective rate 90%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
Claims (8)
1. a Chinese medicine composition for the treatment of children's's suppurative tonsillitis, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
2. the Chinese medicine composition for the treatment of as claimed in claim 1 children's suppurative tonsillitis, it is characterized in that, this Chinese medicine composition is made by the Chinese medicine of following weight portion: 15 parts of Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)s, 10 parts of Herba Taraxacis, 5 parts of Folium Isatidiss, 2 parts of Flos Trolliis, 8 parts of Radix Platycodoniss, 2 parts of Herba Menthaes, 2 parts of Borneolum Syntheticums, 5 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 1 or 2, is characterized in that, the dosage form of this Chinese medicine composition is exterior-applied formulation.
4. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 3, is characterized in that, the exterior-applied formulation of this Chinese medicine composition is one or more in unguentum, cataplasma, paste, powder, coating cream, gel.
5. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 4, is characterized in that, the exterior-applied formulation of this Chinese medicine composition is coating unguentum.
6. a Chinese medicine for the treatment of children's's suppurative tonsillitis applies unguentum, it is characterized in that, this Chinese medicine coating unguentum is made by the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part.
7. the Chinese medicine of a treatment children's suppurative tonsillitis as claimed in claim 6 applies the preparation method of unguentum, it is characterized in that, take the Chinese medicine of following weight portion: Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Herba Taraxaci 5-15 part, Folium Isatidis 3-7 part, Flos Trollii 1-3 part, Radix Platycodonis 5-10 part, Herba Menthae 1-3 part, Borneolum Syntheticum 1-3 part, Radix Glycyrrhizae 2-8 part, remove impurity, grind to form fine powder, cross 80 mesh sieves; Then form according to the weight ratio mix of 1:1.0-3.0 with tablet vinegar, obtain coating cream of the present invention.
8. the Chinese medicine composition for the treatment of children's suppurative tonsillitis as claimed in claim 1 or 2, is characterized in that, the application of this Chinese medicine composition in treatment treatment children's suppurative tonsillitis medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410453159.9A CN104173480B (en) | 2014-09-05 | 2014-09-05 | Traditional Chinese medicine composition for treating infantile suppurative tonsillitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410453159.9A CN104173480B (en) | 2014-09-05 | 2014-09-05 | Traditional Chinese medicine composition for treating infantile suppurative tonsillitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104173480A true CN104173480A (en) | 2014-12-03 |
| CN104173480B CN104173480B (en) | 2015-06-03 |
Family
ID=51955003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410453159.9A Expired - Fee Related CN104173480B (en) | 2014-09-05 | 2014-09-05 | Traditional Chinese medicine composition for treating infantile suppurative tonsillitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104173480B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983941A (en) * | 2015-08-10 | 2015-10-21 | 孙霞 | Traditional Chinese medicine for treating child suppurative tonsillitis |
| CN105147971A (en) * | 2015-10-20 | 2015-12-16 | 张军 | Traditional Chinese medicine preparation for treating infantile suppurative tonsillitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566061A (en) * | 2012-07-26 | 2014-02-12 | 张夏思 | Chinese medicinal composition for treating acute suppurative tonsillitis and preparation thereof |
| CN103585336A (en) * | 2013-11-19 | 2014-02-19 | 钱家美 | Drug composition for treating acute pharyngitis |
-
2014
- 2014-09-05 CN CN201410453159.9A patent/CN104173480B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566061A (en) * | 2012-07-26 | 2014-02-12 | 张夏思 | Chinese medicinal composition for treating acute suppurative tonsillitis and preparation thereof |
| CN103585336A (en) * | 2013-11-19 | 2014-02-19 | 钱家美 | Drug composition for treating acute pharyngitis |
Non-Patent Citations (2)
| Title |
|---|
| 安扬: "小儿急性乳蛾证治体会", 《新疆中医药》 * |
| 李洪岭等: "乳蛾证治", 《河北中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983941A (en) * | 2015-08-10 | 2015-10-21 | 孙霞 | Traditional Chinese medicine for treating child suppurative tonsillitis |
| CN105147971A (en) * | 2015-10-20 | 2015-12-16 | 张军 | Traditional Chinese medicine preparation for treating infantile suppurative tonsillitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104173480B (en) | 2015-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103405596B (en) | A kind of Chinese medicine for the treatment of sinusitis | |
| CN102139030B (en) | Oral Chinese herbal preparation for treating gingivitis and preparation method thereof | |
| CN101979041B (en) | Chinese medicinal preparation for treating various dermatoses | |
| CN101537107A (en) | External use liniment capable of treating dermatomycosis and preparation method thereof | |
| CN104173480B (en) | Traditional Chinese medicine composition for treating infantile suppurative tonsillitis | |
| CN107095905A (en) | A kind of healthful moxibustion bar and moxibustion cream | |
| CN104940729A (en) | Traditional Chinese medicine for treating cholelithiasis | |
| CN104706953A (en) | Traditional Chinese medicine preparation for treating chronic cervicitis | |
| CN105998840A (en) | External use ointment used for treating insect bite dermatitis and preparation method | |
| CN102579975A (en) | Traditional Chinese medicine mixture for treating psoriasis | |
| CN104666799A (en) | Blood circulation activating and blood stasis removing medicinal liquor for soft tissue injury and preparation method of medicinal liqour | |
| CN103494924B (en) | Chinese medicine composition for treating damp-heat stagnation acne | |
| CN103623111A (en) | Traditional Chinese medicine for treating urticaria | |
| CN102872210B (en) | Traditional Chinese medicine for treating urticaria | |
| CN105147909A (en) | Chinese herb decoction for treating meningitis and preparation method thereof | |
| CN106924578A (en) | A kind of Chinese medicine for treating carbuncle furuncle poison | |
| CN106421087A (en) | Pharmaceutical preparation for treating acute eczema, and use of pharmaceutical preparation | |
| CN100406035C (en) | Chinese medicine preparation for treating protrasion of lumbar intervertebral disc | |
| CN105168847A (en) | Traditional Chinese medicine for treating helicobacter pylori infected peptic ulcer | |
| CN106138628A (en) | A kind of strong medicine ZHICHUANG GAO and preparation method thereof | |
| CN104958530A (en) | Traditional Chinese medicinal composition for treating infantile pneumonia | |
| CN104997949A (en) | Traditional Chinese medicine for treating rhinitis and preparation method thereof | |
| CN105596590A (en) | Traditional Chinese medicine preparation for treating herpes labialis and preparation method thereof | |
| CN104606406A (en) | External traditional Chinese medicine unguent for preventing allergic rhinitis and preparation method thereof | |
| CN104740403A (en) | Medicine for treating blood-insufficiency and yin-deficiency recurrent oral ulceration and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: CHEN HONG Free format text: FORMER OWNER: WANG SHENJIAN Effective date: 20150327 |
|
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Qin Inventor before: Wang Shenjian |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: WANG SHENJIAN TO: ZHANG QIN Free format text: CORRECT: ADDRESS; FROM: 276017 LINYI, SHANDONG PROVINCE TO: 266000 QINGDAO, SHANDONG PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20150327 Address after: Qingdao City, Shandong province 266000 flood ditch cleaning village 106 2 Applicant after: Chen Hong Address before: 276017 Luozhuang Province, Linyi District, Zhao Zhao Road, No. 1072 Applicant before: Wang Shenjian |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB02 | Change of applicant information |
Inventor after: Ye Yuling Inventor before: Zhang Qin |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20161221 Address after: Xinghua City, Jiangsu province 225721 Taizhou City Road No. 31 Nan Zhen Dai health Patentee after: Ye Yuling Address before: Qingdao City, Shandong province 266000 flood ditch cleaning village 106 2 Patentee before: Chen Hong |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150603 Termination date: 20200905 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |